Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation von Corbet, Cyril, Pinto, Adán, Martherus, Ruben, Santiago de Jesus, João Pedro, Polet, Florence, Feron, Olivier

Volltext

Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes von Herrero, Ana, Pinto, Adán, Colón-Bolea, Paula, Casar, Berta, Jones, Mary, Agudo-Ibáñez, Lorena, Vidal, Rebeca, Tenbaum, Stephan P., Nuciforo, Paolo, Valdizán, Elsa M., Horvath, Zoltan, Orfi, Laszlo, Pineda-Lucena, Antonio, Bony, Emilie, Keri, Gyorgy, Rivas, Germán, Pazos, Angel, Gozalbes, Rafael, Palmer, Héctor G., Hurlstone, Adam, Crespo, Piero

Volltext

Essential Role of ERK Dimers in the Activation of Cytoplasmic but Not Nuclear Substrates by ERK-Scaffold Complexes von Casar, Berta, Pinto, Adán, Crespo, Piero

Volltext

DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets von Pinto-Fernandez, Adan, Kessler, Benedikt M

Volltext

The deubiquitylase USP9X controls ribosomal stalling von Clancy, Anne, Heride, Claire, Pinto-Fernández, Adán, Elcocks, Hannah, Kallinos, Andreas, Kayser-Bricker, Katherine J, Wang, Weiping, Smith, Victoria, Davis, Simon, Fessler, Shawn, McKinnon, Crystal, Katz, Marie, Hammonds, Tim, Jones, Neil P, O'Connell, Jonathan, Follows, Bruce, Mischke, Steven, Caravella, Justin A, Ioannidis, Stephanos, Dinsmore, Christopher, Kim, Sunkyu, Behrens, Axel, Komander, David, Kessler, Benedikt M, Urbé, Sylvie, Clague, Michael J

Volltext

USP18 is an essential regulator of muscle cell differentiation and maturation von Olie, Cyriel Sebastiaan, Pinto-Fernández, Adán, Damianou, Andreas, Vendrell, Iolanda, Mei, Hailiang, den Hamer, Bianca, van der Wal, Erik, de Greef, Jessica C., Raz, Vered, Kessler, Benedikt M.

Volltext

ERK dimers and scaffold proteins: Unexpected partners for a forgotten (cytoplasmic) task von Casar, Berta, Pinto, Adán, Crespo, Piero

Volltext

Editorial: Beyond protein degradation and lysine modification: novel insights into non-canonical ubiquitination von Sapmaz, Aysegul, Gan, Jin, O'Brien, Darragh P, Pinto-Fernández, Adán

Volltext

Preclinical Evaluation of White Led-Activated Non-porphyrinic Photosensitizer OR141 in 3D Tumor Spheroids and Mouse Skin Lesions von Doix, Bastien, Bastien, Estelle, Rambaud, Alix, Pinto, Adán, Louis, Caroline, Grégoire, Vincent, Riant, Olivier, Feron, Olivier

Volltext

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics von Pinto-Fernández, Adán, Davis, Simon, Schofield, Abigail B, Scott, Hannah C, Zhang, Ping, Salah, Eidarus, Mathea, Sebastian, Charles, Philip D, Damianou, Andreas, Bond, Gareth, Fischer, Roman, Kessler, Benedikt M

Volltext

ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context von Jones, Hannah B L, Heilig, Raphael, Fischer, Roman, Kessler, Benedikt M, Pinto-Fernández, Adán

Volltext

Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19 von Vere, George, Alam, Md Rashadul, Farrar, Sam, Kealy, Rachel, Kessler, Benedikt M, O'Brien, Darragh P, Pinto-Fernández, Adán

Volltext

Type I interferon regulation by USP18 is a key vulnerability in cancer von Jové, Veronica, Wheeler, Heather, Lee, Chiachin Wilson, Healy, David R., Levine, Kymberly, Ralph, Erik C., Yamaguchi, Masaya, Jiang, Ziyue Karen, Cabral, Edward, Xu, Yingrong, Stock, Jeffrey, Yang, Bing, Giddabasappa, Anand, Loria, Paula, Casimiro-Garcia, Agustin, Kessler, Benedikt M., Pinto-Fernández, Adán, Frattini, Véronique, Wes, Paul D., Wang, Feng

Volltext

Validation of a SPE HPLC–UV method for the quantification of a new ER-specific photosensitizer OR-141 in blood serum using total error concept von Bony, Emilie, Mace, Yohan, Pinto, Adán, Delvaux, David, Kiss, Robert, Riant, Olivier, Feron, Olivier, Quetin-Leclercq, Joëlle

Volltext

The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators von Kaokhum, Nitchakarn, Pinto-Fernández, Adán, Wilkinson, Mark, Kessler, Benedikt M., Ismail, Heba M.

Volltext

Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6 von Dietz, Larissa, Ellison, Cara J, Riechmann, Carlos, Cassidy, C Keith, Felfoldi, F Daniel, Pinto-Fernández, Adán, Kessler, Benedikt M, Elliott, Paul R

Volltext

Targeted Mass Spectrometry Reveals Interferon-Dependent Eicosanoid and Fatty Acid Alterations in Chronic Myeloid Leukaemia von Scott, Hannah C, Draganov, Simeon D, Yu, Zhanru, Kessler, Benedikt M, Pinto-Fernández, Adán

Volltext

Ras Subcellular Localization Defines Extracellular Signal-Regulated Kinase 1 and 2 Substrate Specificity through Distinct Utilization of Scaffold Proteins von Casar, Berta, Arozarena, Imanol, Sanz-Moreno, Victoria, Pinto, Adán, Agudo-Ibáñez, Lorena, Marais, Richard, Lewis, Robert E., Berciano, María T., Crespo, Piero

Volltext

ABPP-HT-Deep Meets Fast for Activity-Based Profiling of Deubiquitylating Enzymes Using Advanced DIA Mass Spectrometry Methods von Jones, Hannah B L, Heilig, Raphael, Davis, Simon, Fischer, Roman, Kessler, Benedikt M, Pinto-Fernández, Adán

Volltext

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides von O'Brien, Darragh P., Jones, Hannah B.L., Guenther, Franziska, Murphy, Emma J., England, Katherine S., Vendrell, Iolanda, Anderson, Malcolm, Brennan, Paul E., Davis, John B., Pinto-Fernández, Adán, Turnbull, Andrew P., Kessler, Benedikt M.

Volltext