Trametinib inhibits RAS -mutant MLL -rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo von Kerstjens, Mark, Pinhancos, Sandra S, Castro, Patricia Garrido, Schneider, Pauline, Wander, Priscilla, Pieters, Rob, Stam, Ronald W

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MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations von Kerstjens, Mark, Driessen, Emma M C, Willekes, Merel, Pinhanços, Sandra S, Schneider, Pauline, Pieters, Rob, Stam, Ronald W

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AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation von Hoogendijk, Arie J., Pinhanços, Sandra S., van der Poll, Tom, Wieland, Catharina W.

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Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL-Rearranged Acute Lymphoblastic Leukemia von Kerstjens, Mark, Garrido Castro, Patricia, Pinhanços, Sandra S., Schneider, Pauline, Wander, Priscilla, Pieters, Rob, Stam, Ronald W.

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Decitabine mildly attenuates MLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer von Schneider, Pauline, Castro, Patricia Garrido, Pinhanços, Sandra M., Kerstjens, Mark, Roon, Eddy H., Essing, Anke H.W., Dolman, M. Emmy M., Molenaar, Jan J., Pieters, Rob, Stam, Ronald W.

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TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status von Ramos Rego, Inês, Silvério, Daniela, Eufrásio, Maria Isabel, Pinhanços, Sandra Sofia, Lopes da Costa, Bruna, Teixeira, José, Fernandes, Hugo, Kong, Yang, Li, Yao, Tsang, Stephen H, Oliveira, Paulo J, Fernandes, Rosa, Quinn, Peter M J, Santos, Paulo Fernando, Ambrósio, António Francisco, Alves, Celso Henrique

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Serum homocysteine: Interplay with other circulating and genetic factors in association to Alzheimer's type dementia von Cascalheira, José F., João, Sara S., Pinhanços, Sandra S., Castro, Rita, Palmeira, Manuela, Almeida, Sofia, Faria, Maria C., Domingues, Fernanda C.

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Versican expression is an adverse prognostic factor in MLL- rearranged infant acute lymphoblastic leukaemia von Driessen, Emma M.C, Pinhanços, Sandra S. Mimoso, Schneider, Pauline, de Lorenzo, Paola, Valsecchi, Maria G, Pieters, Rob, Stam, Ronald W

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Selective Inhibition of Class II HDAC Isoforms 4 and 5 Provides a Promising Therapeutic Intervention for MLL-Rearranged Acute Lymphoblastic Leukemia in Infants von Verbeek, Tamara C.A.I., Arentsen-Peters, Susan, Garrido Castro, Patricia, Pinhancos, Sandra, Vrenken, Kirsten, Varela-Moreira, Aida, Dolman, M. Emmy, Koopmans, Bianca, Pieters, Rob, Stam, Ronald W.

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Glucocorticoid sensitisation in Mixed Lineage Leukaemia -rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101 von Spijkers-Hagelstein, Jill A.P, Schneider, Pauline, Pinhanços, Sandra Mimoso, Garrido Castro, Patricia, Pieters, Rob, Stam, Ronald W

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Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia von Wander, Priscilla, Cheung, Laurence C., Pinhanҫos, Sandra S., Jones, Luke, Kerstjens, Mark, Arentsen-Peters, Susan T.C.J.M., Singh, Sajla, Chua, Grace-Alyssa, Castro, Patricia Garrido, Schneider, Pauline, Dolman, M. Emmy M., Koopmans, Bianca, Molenaar, Jan J., Pieters, Rob, Zwaan, C. Michel, Kotecha, Rishi S., Stam, Ronald W.

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Intrapulmonary administration of a p38 mitogen activated protein kinase inhibitor partially prevents pulmonary inflammation von Hoogendijk, Arie Johan, Pinhanços, Sandra Sofia, van der Poll, Tom, Wieland, Catharina Wilhelmina

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MEK Inhibition Is a Promising Therapeutic Strategy for MLL-Rearranged Infant ALL Patients Carrying RAS Mutations von Kerstjens, Mark JB, Driessen, Emma MC, Willekes, Merel, Mimoso Pinhancos, Sandra S, Pieters, Rob, Stam, Ronald

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High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia von Wander, Priscilla, Arentsen-Peters, Susan T.C.J.M., Pinhanҫos, Sandra S., Koopmans, Bianca, Dolman, M.Emmy M., Ariese, Rijndert, Bos, Frank L., Castro, Patricia Garrido, Jones, Luke, Schneider, Pauline, Navarro, Miriam Guillen, Molenaar, Jan J., Rios, Anne C., Zwaan, C. Michel, Stam, Ronald W.

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The Histone Deacetylase Inhibitor Panobinostat (LBH-589) Exerts Anti-Leukaemic Activity in a MLL-Rearranged ALL Xenograft Mouse Model von Garrido Castro, Patricia, Van Roon, Eddy HJ, Mimoso Pinhancos, Sandra S, Schneider, Pauline, Kerstjens, Mark JB, Willekes, Merel, Pieters, Rob, Stam, Ronald

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Unravelling the Mirnome of MLL-Rearranged Acute Lymphoblastic Leukemia von Garrido Castro, Patricia, Bueno, Clara, van Roon, Eddy HJ, Mimoso Pinhancos, Sandra S, Schneider, Pauline, Willekes, Merel, Menendez, Pablo, Pieters, Rob, Stam, Ronald

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High-Throughput Drug Library Screening in Primary KMT2A -Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling von Wander, Priscilla, Arentsen-Peters, Susan T C J M, Vrenken, Kirsten S, Pinhanҫos, Sandra Mimoso, Koopmans, Bianca, Dolman, M Emmy M, Jones, Luke, Garrido Castro, Patricia, Schneider, Pauline, Kerstjens, Mark, Molenaar, Jan J, Pieters, Rob, Zwaan, Christian Michel, Stam, Ronald W

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Irinotecan Induces Complete Remission in MLL -Rearranged Acute Lymphoblastic Leukemia Xenografts von Garrido Castro, Patricia, Kerstjens, Mark, Pinhanços, Sandra S, Schneider, Pauline, Wander, Priscilla, Pieters, Rob, Stam, Ronald

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Abstract 1925: High-throughput drug library screening identifies potent drugs and novel drug targets for high-risk acute leukemia in children von Wander, Priscilla, Pinhanços, Sandra S., Koopmans, Bianca, Dolman, M. Emmy M., Schneider, Pauline, Castro, Patricia Garrido, Jones, Luke, Arentsen-Peters, Susan T.C.J.M., Kerstjens, Mark, Molenaar, Jan, Caron, Huib N., Pieters, Rob, Zwaan, Michel C., Stam, Ronald W.

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