The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids von Prill, Sebastian, Caddeo, Andrea, Baselli, Guido, Jamialahmadi, Oveis, Dongiovanni, Paola, Rametta, Raffaela, Kanebratt, Kajsa P., Pujia, Arturo, Pingitore, Piero, Mancina, Rosellina Margherita, Lindén, Daniel, Whatling, Carl, Janefeldt, Annika, Kozyra, Mikael, Ingelman-Sundberg, Magnus, Valenti, Luca, Andersson, Tommy B., Romeo, Stefano

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Human Multilineage 3D Spheroids as a Model of Liver Steatosis and Fibrosis von Pingitore, Piero, Sasidharan, Kavitha, Ekstrand, Matias, Prill, Sebastian, Lindén, Daniel, Romeo, Stefano

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LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol von Caddeo, Andrea, Hedfalk, Kristina, Romeo, Stefano, Pingitore, Piero

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The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent von Mancina, Rosellina Margherita, Dongiovanni, Paola, Petta, Salvatore, Pingitore, Piero, Meroni, Marica, Rametta, Raffaela, Borén, Jan, Montalcini, Tiziana, Pujia, Arturo, Wiklund, Olov, Hindy, George, Spagnuolo, Rocco, Motta, Benedetta Maria, Pipitone, Rosaria Maria, Craxì, Antonio, Fargion, Silvia, Nobili, Valerio, Käkelä, Pirjo, Kärjä, Vesa, Männistö, Ville, Pihlajamäki, Jussi, Reilly, Dermot F, Castro-Perez, Jose, Kozlitina, Julia, Valenti, Luca, Romeo, Stefano

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Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker von Baselli, Guido Alessandro, Dongiovanni, Paola, Rametta, Raffaela, Meroni, Marica, Pelusi, Serena, Maggioni, Marco, Badiali, Sara, Pingitore, Piero, Maurotti, Samantha, Montalcini, Tiziana, Taliento, Alice Emma, Prati, Daniele, Rossi, Giorgio, Fracanzani, Anna Ludovica, Mancina, Rosellina Margherita, Romeo, Stefano, Valenti, Luca

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Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function von Pingitore, Piero, Pirazzi, Carlo, Mancina, Rosellina M., Motta, Benedetta M., Indiveri, Cesare, Pujia, Arturo, Montalcini, Tiziana, Hedfalk, Kristina, Romeo, Stefano

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The role of PNPLA3 in health and disease von Pingitore, Piero, Romeo, Stefano

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Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice von Lindén, Daniel, Ahnmark, Andrea, Pingitore, Piero, Ciociola, Ester, Ahlstedt, Ingela, Andréasson, Anne-Christine, Sasidharan, Kavitha, Madeyski-Bengtson, Katja, Zurek, Magdalena, Mancina, Rosellina M., Lindblom, Anna, Bjursell, Mikael, Böttcher, Gerhard, Ståhlman, Marcus, Bohlooly-Y, Mohammad, Haynes, William G., Carlsson, Björn, Graham, Mark, Lee, Richard, Murray, Sue, Valenti, Luca, Bhanot, Sanjay, Åkerblad, Peter, Romeo, Stefano

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The rs2294918 E434K variant modulates patatin‐like phospholipase domain‐containing 3 expression and liver damage von Donati, Benedetta, Motta, Benedetta Maria, Pingitore, Piero, Meroni, Marica, Pietrelli, Alessandro, Alisi, Anna, Petta, Salvatore, Xing, Chao, Dongiovanni, Paola, del Menico, Benedetta, Rametta, Raffaela, Mancina, Rosellina Margherita, Badiali, Sara, Fracanzani, Anna Ludovica, Craxì, Antonio, Fargion, Silvia, Nobili, Valerio, Romeo, Stefano, Valenti, Luca

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Transport mechanism and regulatory properties of the human amino acid transporter ASCT2 (SLC1A5) von Scalise, Mariafrancesca, Pochini, Lorena, Panni, Simona, Pingitore, Piero, Hedfalk, Kristina, Indiveri, Cesare

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Natural Extracts as Modifiers of Intracellular Lipid Handling von Mancina, Rosellina Margherita, Pingitore, Piero

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Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris — functional and kinetic asymmetry revealed in proteoliposomes von Pingitore, Piero, Pochini, Lorena, Scalise, Mariafrancesca, Galluccio, Michele, Hedfalk, Kristina, Indiveri, Cesare

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Analysis of aquaporins from the euryhaline barnacle Balanus improvisus reveals differential expression in response to changes in salinity von Lind, Ulrika, Järvå, Michael, Alm Rosenblad, Magnus, Pingitore, Piero, Karlsson, Emil, Wrange, Anna-Lisa, Kamdal, Emelie, Sundell, Kristina, André, Carl, Jonsson, Per R, Havenhand, Jon, Eriksson, Leif A, Hedfalk, Kristina, Blomberg, Anders

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Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings von Schwartz, Brian E., Rajagopal, Vaishnavi, Smith, Cynthia, Cohick, Evan, Whissell, Gavin, Gamboa, Mario, Pai, Rutuja, Sigova, Alla, Grossman, Iris, Bumcrot, David, Sasidharan, Kavitha, Romeo, Stefano, Sehgal, Alfica, Pingitore, Piero

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Cloning, Large Scale Over-Expression in E. coli and Purification of the Components of the Human LAT 1 (SLC7A5) Amino Acid Transporter von Galluccio, Michele, Pingitore, Piero, Scalise, Mariafrancesca, Indiveri, Cesare

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Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver von Dongiovanni, P., Stender, S., Pietrelli, A., Mancina, R. M., Cespiati, A., Petta, S., Pelusi, S., Pingitore, P., Badiali, S., Maggioni, M., Mannisto, V., Grimaudo, S., Pipitone, R. M., Pihlajamaki, J., Craxi, A., Taube, M., Carlsson, L. M.S., Fargion, S., Romeo, S., Kozlitina, J., Valenti, L.

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Cysteine is not a substrate but a specific modulator of human ASCT2 (SLC1A5) transporter von Scalise, Mariafrancesca, Pochini, Lorena, Pingitore, Piero, Hedfalk, Kristina, Indiveri, Cesare

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MBOAT7 is anchored to endomembranes by six transmembrane domains von Caddeo, Andrea, Jamialahmadi, Oveis, Solinas, Giovanni, Pujia, Arturo, Mancina, Rosellina Margherita, Pingitore, Piero, Romeo, Stefano

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PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis von Pingitore, Piero, Dongiovanni, Paola, Motta, Benedetta Maria, Meroni, Marica, Lepore, Saverio Massimo, Mancina, Rosellina Margherita, Pelusi, Serena, Russo, Cristina, Caddeo, Andrea, Rossi, Giorgio, Montalcini, Tiziana, Pujia, Arturo, Wiklund, Olov, Valenti, Luca, Romeo, Stefano

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PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells von Pirazzi, Carlo, Valenti, Luca, Motta, Benedetta Maria, Pingitore, Piero, Hedfalk, Kristina, Mancina, Rosellina Margherita, Burza, Maria Antonella, Indiveri, Cesare, Ferro, Yvelise, Montalcini, Tiziana, Maglio, Cristina, Dongiovanni, Paola, Fargion, Silvia, Rametta, Raffaela, Pujia, Arturo, Andersson, Linda, Ghosal, Saswati, Levin, Malin, Wiklund, Olov, Iacovino, Michelina, Borén, Jan, Romeo, Stefano

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