Highly efficient therapeutic gene editing of human hematopoietic stem cells von Wu, Yuxuan, Zeng, Jing, Roscoe, Benjamin P., Liu, Pengpeng, Yao, Qiuming, Lazzarotto, Cicera R., Clement, Kendell, Cole, Mitchel A., Luk, Kevin, Baricordi, Cristina, Shen, Anne H., Ren, Chunyan, Esrick, Erica B., Manis, John P., Dorfman, David M., Williams, David A., Biffi, Alessandra, Brugnara, Carlo, Biasco, Luca, Brendel, Christian, Pinello, Luca, Tsai, Shengdar Q., Wolfe, Scot A., Bauer, Daniel E.

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Therapeutic base editing of human hematopoietic stem cells von Zeng, Jing, Wu, Yuxuan, Ren, Chunyan, Bonanno, Jasmine, Shen, Anne H., Shea, Devlin, Gehrke, Jason M., Clement, Kendell, Luk, Kevin, Yao, Qiuming, Kim, Rachel, Wolfe, Scot A., Manis, John P., Pinello, Luca, Joung, J. Keith, Bauer, Daniel E.

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Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM von Chen, Huidong, Albergante, Luca, Hsu, Jonathan Y., Lareau, Caleb A., Lo Bosco, Giosuè, Guan, Jihong, Zhou, Shuigeng, Gorban, Alexander N., Bauer, Daniel E., Aryee, Martin J., Langenau, David M., Zinovyev, Andrei, Buenrostro, Jason D., Yuan, Guo-Cheng, Pinello, Luca

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CRISPResso2 provides accurate and rapid genome editing sequence analysis von Clement, Kendell, Rees, Holly, Canver, Matthew C., Gehrke, Jason M., Farouni, Rick, Hsu, Jonathan Y., Cole, Mitchel A., Liu, David R., Joung, J. Keith, Bauer, Daniel E., Pinello, Luca

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PrimeDesign software for rapid and simplified design of prime editing guide RNAs von Hsu, Jonathan Y., Grünewald, Julian, Szalay, Regan, Shih, Justine, Anzalone, Andrew V., Lam, Kin Chung, Shen, Max W., Petri, Karl, Liu, David R., Joung, J. Keith, Pinello, Luca

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Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing von Tang, Qin, Iyer, Sowmya, Lobbardi, Riadh, Moore, John C, Chen, Huidong, Lareau, Caleb, Hebert, Christine, Shaw, McKenzie L, Neftel, Cyril, Suva, Mario L, Ceol, Craig J, Bernards, Andre, Aryee, Martin, Pinello, Luca, Drummond, Iain A, Langenau, David M

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Assessment of computational methods for the analysis of single-cell ATAC-seq data von Chen, Huidong, Lareau, Caleb, Andreani, Tommaso, Vinyard, Michael E, Garcia, Sara P, Clement, Kendell, Andrade-Navarro, Miguel A, Buenrostro, Jason D, Pinello, Luca

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Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing von Kleinstiver, Benjamin P., Sousa, Alexander A., Walton, Russell T., Tak, Y. Esther, Hsu, Jonathan Y., Clement, Kendell, Welch, Moira M., Horng, Joy E., Malagon-Lopez, Jose, Scarfò, Irene, Maus, Marcela V., Pinello, Luca, Aryee, Martin J., Joung, J. Keith

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CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells von Petri, Karl, Zhang, Weiting, Ma, Junyan, Schmidts, Andrea, Lee, Hyunho, Horng, Joy E., Kim, Daniel Y., Kurt, Ibrahim C., Clement, Kendell, Hsu, Jonathan Y., Pinello, Luca, Maus, Marcela V., Joung, J. Keith, Yeh, Jing-Ruey Joanna

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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis von Canver, Matthew C., Smith, Elenoe C., Sher, Falak, Pinello, Luca, Sanjana, Neville E., Shalem, Ophir, Chen, Diane D., Schupp, Patrick G., Vinjamur, Divya S., Garcia, Sara P., Luc, Sidinh, Kurita, Ryo, Nakamura, Yukio, Fujiwara, Yuko, Maeda, Takahiro, Yuan, Guo-Cheng, Zhang, Feng, Orkin, Stuart H., Bauer, Daniel E.

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LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity von Wu, Gengze, Cai, Jin, Han, Yu, Chen, Jinghai, Huang, Zhan-Peng, Chen, Caiyu, Cai, Yue, Huang, Hefei, Yang, Yujia, Liu, Yukai, Xu, Zaicheng, He, Duofen, Zhang, Xiaoqun, Hu, Xiaoyun, Pinello, Luca, Zhong, Dan, He, Fengtian, Yuan, Guo-Cheng, Wang, Da-Zhi, Zeng, Chunyu

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BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair von Hatchi, Elodie, Skourti-Stathaki, Konstantina, Ventz, Steffen, Pinello, Luca, Yen, Angela, Kamieniarz-Gdula, Kinga, Dimitrov, Stoil, Pathania, Shailja, McKinney, Kristine M., Eaton, Matthew L., Kellis, Manolis, Hill, Sarah J., Parmigiani, Giovanni, Proudfoot, Nicholas J., Livingston, David M.

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Predicting chromatin organization using histone marks von Huang, Jialiang, Marco, Eugenio, Pinello, Luca, Yuan, Guo-Cheng

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Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms von Hu, Haichuan, Piotrowska, Zofia, Hare, Patricia J., Chen, Huidong, Mulvey, Hillary E., Mayfield, Aislinn, Noeen, Sundus, Kattermann, Krystina, Greenberg, Max, Williams, August, Riley, Amanda K., Wilson, Jarad J., Mao, Ying-Qing, Huang, Ruo-Pan, Banwait, Mandeep K., Ho, Jeffrey, Crowther, Giovanna S., Hariri, Lida P., Heist, Rebecca S., Kodack, David P., Pinello, Luca, Shaw, Alice T., Mino-Kenudson, Mari, Hata, Aaron N., Sequist, Lecia V., Benes, Cyril H., Niederst, Matthew J., Engelman, Jeffrey A.

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GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs von Tognon, Manuel, Bonnici, Vincenzo, Garrison, Erik, Giugno, Rosalba, Pinello, Luca

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Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells von Jadhav, Unmesh, Nalapareddy, Kodandaramireddy, Saxena, Madhurima, O’Neill, Nicholas K., Pinello, Luca, Yuan, Guo-Cheng, Orkin, Stuart H., Shivdasani, Ramesh A.

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CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML von Vinyard, Michael E., Su, Cindy, Siegenfeld, Allison P., Waterbury, Amanda L., Freedy, Allyson M., Gosavi, Pallavi M., Park, Yongho, Kwan, Eugene E., Senzer, Benjamin D., Doench, John G., Bauer, Daniel E., Pinello, Luca, Liau, Brian B.

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Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis von Sher, Falak, Hossain, Mir, Seruggia, Davide, Schoonenberg, Vivien A. C., Yao, Qiuming, Cifani, Paolo, Dassama, Laura M. K., Cole, Mitchel A., Ren, Chunyan, Vinjamur, Divya S., Macias-Trevino, Claudio, Luk, Kevin, McGuckin, Connor, Schupp, Patrick G., Canver, Matthew C., Kurita, Ryo, Nakamura, Yukio, Fujiwara, Yuko, Wolfe, Scot A., Pinello, Luca, Maeda, Takahiro, Kentsis, Alex, Orkin, Stuart H., Bauer, Daniel E.

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Deep mendelian randomization: Investigating the causal knowledge of genomic deep learning models von Malina, Stephen, Cizin, Daniel, Knowles, David A

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Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions von Xu, Jian, Shao, Zhen, Li, Dan, Xie, Huafeng, Kim, Woojin, Huang, Jialiang, Taylor, Jordan E., Pinello, Luca, Glass, Kimberly, Jaffe, Jacob D., Yuan, Guo-Cheng, Orkin, Stuart H.

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