Clinical remission in patients with moderate-to-severe Crohn's disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebo-contro... von Vermeire, Séverine, Prof, Schreiber, Stefan, Prof, Petryka, Robert, MD, Kuehbacher, Tanja, Prof, Hebuterne, Xavier, Prof, Roblin, Xavier, MD, Klopocka, Maria, PhD, Goldis, Adrian, MD, Wisniewska-Jarosinska, Maria, MD, Baranovsky, Andrey, Prof, Sike, Robert, MD, Stoyanova, Kremena, MD, Tasset, Chantal, PhD, Van der Aa, Annegret, PhD, Harrison, Pille, DPhil

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Effect of filgotinib, a selective JAK 1 inhibitor, with and without methotrexate in patients with rheumatoid arthritis: patient-reported outcomes von Genovese, Mark, Westhovens, Rene, Meuleners, Luc, Van der Aa, Annegret, Harrison, Pille, Tasset, Chantal, Kavanaugh, Arthur

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Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility von Barton, Anne, Thomson, Wendy, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Gibbons, Laura, Plant, Darren, Wilson, Anthony G., Marinou, Ioanna, Morgan, Ann, Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M., Wordsworth, Paul, Harrison, Pille, Worthington, Jane

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Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13 von Barton, Anne, Thomson, Wendy, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Plant, Darren, Gibbons, Laura J, Wilson, Anthony G, Bax, Deborah E, Morgan, Ann W, Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M, Wordsworth, Paul, Harrison, Pille, Worthington, Jane

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Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23 von Orozco, Gisela, Hinks, Anne, Eyre, Steve, Ke, Xiayi, Gibbons, Laura J., Bowes, John, Flynn, Edward, Martin, Paul, Wilson, Anthony G., Bax, Deborah E., Morgan, Ann W., Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M., Wordsworth, Paul, Harrison, Pille, Thomson, Wendy, Barton, Anne, Worthington, Jane

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Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease von Eyre, Stephen, Hinks, Anne, Bowes, John, Flynn, Edward, Martin, Paul, Wilson, Anthony G, Morgan, Ann W, Emery, Paul, Steer, Sophia, Hocking, Lynne J, Reid, David M, Harrison, Pille, Wordsworth, Paul, Thomson, Wendy, Worthington, Jane, Barton, Anne

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Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active psoriatic arthritis (EQUATOR): results from a randomised, placebo-controlled, phase... von Mease, Philip, Coates, Laura C, Helliwell, Philip S, Stanislavchuk, Mykola, Rychlewska-Hanczewska, Anna, Dudek, Anna, Abi-Saab, Walid, Tasset, Chantal, Meuleners, Luc, Harrison, Pille, Besuyen, Robin, Van der Aa, Annegret, Mozaffarian, Neelufar, Greer, Joy M, Kunder, Rebecca, Van den Bosch, Filip, Gladman, Dafna D

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Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor von Namour, Florence, Fagard, Liesbeth, Van der Aa, Annegret, Harrison, Pille, Xin, Yan, Tasset, Chantal

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Phase 1 Study in Healthy Adults of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ALPN-303, a Dual BAFF/APRIL Antagonist for the Treatment of Autoimmune Glomer... von Dillon, Stacey R., Harrison, Pille, Lickliter, Jason, Manjarrez, Kristi L., Smith, Alina, Lessig, Mary C., Sanderson, Russell J., Chunyk, Allison G., Lewis, Katherine, Zayed, Hany, Davies, Rupert H., Peng, Stanford

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Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus von Orozco, Gisela, Eyre, Steve, Hinks, Anne, Bowes, John, Morgan, Ann W, Wilson, Anthony G, Wordsworth, Paul, Steer, Sophia, Hocking, Lynne, Thomson, Wendy, Worthington, Jane, Barton, Anne

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O02. FILGOTINIB, AN ORAL JAK1 SELECTIVE INHIBITOR WITH A RAPID ONSET OF ACTION: RESULTS FROM THE DARWIN 1 STUDY IN METHOTREXATE INADEQUATE RESPONSE RHEUMATOID ARTHRITIS PATIENTS von Taylor, Peter C., Westhovens, René, Vyncke, Veerle, Meuleners, Luc, Van der Aa, Annegret, Harrison, Pille, Tasset, Chantal

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Su1930 - Maintenance of Clinical Effect in Patients with Moderate-to-Severe Crohn’s Disease Treated with Filgotinib, a Selective jak1 Inhibitor: Exploratory 20-Week Data Analysis o... von Vermeire, Severine, Schreiber, Stefan, Petryka, Robert, Kuehbacher, Tanja, Hebuterne, Xavier, Roblin, Xavier, Klopocka, Maria, Goldis, Adrian, Wisniewska-Jarosinska, Maria A., Baranovsky, Andrei, Sike, Robert, Stoyanova, Kremena, Meuleners, Luc, Tasset, Chantal T., Van der Aa, Annegret, Harrison, Pille

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Su1920 - Efficacy of Filgotinib, a Selective jak1 Inhibitor, is Independent of Prior Anti-TNF Exposure: Subgroup Analysis of the Phase 2 Fitzroy Study in Moderate-To-Severe Crohn’s... von D'Haens, Geert R., Schreiber, Stefan, Petryka, Robert, Kuehbacher, Tanja, Hebuterne, Xavier, Roblin, Xavier, Klopocka, Maria, Goldis, Adrian, Wisniewska-Jarosinska, Maria A., Baranovsky, Andrei, Sike, Robert, Stoyanova, Kremena, Meuleners, Luc, Tasset, Chantal T., Van der Aa, Annegret, Harrison, Pille, Vermeire, Severine

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Maintenance of Clinical Effect in Patients with Moderate-to-Severe Crohn’s Disease Treated with Filgotinib, a Selective jak1 Inhibitor: Exploratory 20-Week Data Analysis of the Pha... von Vermeire, Severine, Schreiber, Stefan, Petryka, Robert, Kuehbacher, Tanja, Hebuterne, Xavier, Roblin, Xavier, Klopocka, Maria, Goldis, Adrian, Wisniewska-Jarosinska, Maria A., Baranovsky, Andrei, Sike, Robert, Stoyanova, Kremena, Meuleners, Luc, Tasset, Chantal T., Van der Aa, Annegret, Harrison, Pille

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Su1933 - Filgotinib (GLPG0634, GS-6034), a JAK-1 Selective Inhibitor, Significantly Reduces gut Tissue PSTAT3 in Crohn’s Disease Patients von Sandborn, William J., Feagan, Brian G., De Hertogh, Gert, Chen, Guang, French, Dorothy M., Huntzicker, Erik G., Van der Aa, Annegret, Van Kaem, Tim, Harrison, Pille, Tasset, Chantal T., Galien, Rene, Pan, Yang, Vermeire, Severine

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Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis von Harrison, P., Pointon, J. J., Chapman, K., Roddam, A., Wordsworth, B. P.

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Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes von Barton, Anne, Eyre, Steve, Ke, Xiayi, Hinks, Anne, Bowes, John, Flynn, Edward, Martin, Paul, Wilson, Anthony G., Morgan, Ann W., Emery, Paul, Steer, Sophia, Hocking, Lynne J., Reid, David M., Harrison, Pille, Wordsworth, Paul, Thomson, Wendy, Worthington, Jane

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Maintenance of Clinical Effect in Patients with Moderateto-Severe Crohn’s Disease Treated with Filgotinib, a Selective jak1 Inhibitor: Exploratory 20-Week Data Analysis of the Phas... von Vermeire, Severine, Schreiber, Stefan, Petryka, Robert, Kuehbacher, Tanja, Hebuterne, Xavier, Roblin, Xavier, Klopocka, Maria, Goldis, Adrian, Wisniewska-Jarosinska, Maria A, Baranovsky, Andrei, Sike, Robert, Stoyanova, Kremena, Meuleners, Luc, Tasset, Chantal T, Van der Aa, Annegret, Harrison, Pille

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Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis von Bowes, John, Lawrence, Robert, Eyre, Stephen, Panoutsopoulou, Kalliope, Orozco, Gisela, Elliott, Katherine S, Ke, Xiayi, Morris, Andrew P, Thomson, Wendy, Worthington, Jane, Barton, Anne, Zeggini, Eleftheria

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PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian Population von Burr, Marian L, Naseem, Haris, Hinks, Anne, Eyre, Steve, Gibbons, Laura, Bowes, John, Consortium, BIRAC, Consortium, YEAR, Wilson, Anthony G, Maxwell, James, Morgan, Ann W, Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M, Wordsworth, B Paul, Harrison, Pille, Thomson, Wendy, Worthington, Jane, Barton, Anne

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