Relationship between hydraulic efficiency and phosphorus removal in a submerged aquatic vegetation-dominated treatment wetland von Dierberg, Forrest E., Juston, John J., DeBusk, Thomas A., Pietro, Kathy, Gu, Binhe

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Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers von Mars, Nina, Koskela, Jukka T., Ripatti, Pietari, Kiiskinen, Tuomo T. J., Havulinna, Aki S., Lindbohm, Joni V., Ahola-Olli, Ari, Kurki, Mitja, Karjalainen, Juha, Palta, Priit, Neale, Benjamin M., Daly, Mark, Salomaa, Veikko, Palotie, Aarno, Widén, Elisabeth, Ripatti, Samuli

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Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells von Bao, Erik L., Nandakumar, Satish K., Liao, Xiaotian, Bick, Alexander G., Karjalainen, Juha, Tabaka, Marcin, Gan, Olga I., Havulinna, Aki S., Kiiskinen, Tuomo T. J., Lareau, Caleb A., de Lapuente Portilla, Aitzkoa L., Li, Bo, Emdin, Connor, Codd, Veryan, Nelson, Christopher P., Walker, Christopher J., Churchhouse, Claire, de la Chapelle, Albert, Klein, Daryl E., Nilsson, Björn, Wilson, Peter W. F., Cho, Kelly, Pyarajan, Saiju, Gaziano, J. Michael, Samani, Nilesh J., Regev, Aviv, Palotie, Aarno, Neale, Benjamin M., Dick, John E., Natarajan, Pradeep, O’Donnell, Christopher J., Daly, Mark J., Milyavsky, Michael, Kathiresan, Sekar, Sankaran, Vijay G.

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Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial von Lv, Jicheng, Wong, Muh Geot, Hladunewich, Michelle A, Jha, Vivekanand, Hooi, Lai Seong, Monaghan, Helen, Zhao, Minghui, Barbour, Sean, Jardine, Meg J, Reich, Heather N, Cattran, Daniel, Glassock, Richard, Levin, Adeera, Wheeler, David C, Woodward, Mark, Billot, Laurent, Stepien, Sandrine, Rogers, Kris, Chan, Tak Mao, Liu, Zhi-Hong, Johnson, David W, Cass, Alan, Feehally, John, Floege, Jürgen, Remuzzi, Giuseppe, Wu, Yangfeng, Agarwal, Rajiv, Zhang, Hong, Perkovic, Vlado

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Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries von Gharahkhani, Puya, Jorgenson, Eric, Hysi, Pirro, Khawaja, Anthony P., Pendergrass, Sarah, Han, Xikun, Ong, Jue Sheng, Hewitt, Alex W., Segrè, Ayellet V., Rouhana, John M., Hamel, Andrew R., Igo, Robert P., Choquet, Helene, Qassim, Ayub, Josyula, Navya S., Cooke Bailey, Jessica N., Bonnemaijer, Pieter W. M., Iglesias, Adriana, Siggs, Owen M., Young, Terri L., Vitart, Veronique, Thiadens, Alberta A. H. J., Karjalainen, Juha, Uebe, Steffen, Melles, Ronald B., Nair, K. Saidas, Luben, Robert, Simcoe, Mark, Amersinghe, Nishani, Cree, Angela J., Hohn, Rene, Poplawski, Alicia, Chen, Li Jia, Rong, Shi-Song, Aung, Tin, Vithana, Eranga Nishanthie, Tamiya, Gen, Shiga, Yukihiro, Yamamoto, Masayuki, Nakazawa, Toru, Currant, Hannah, Birney, Ewan, Wang, Xin, Auton, Adam, Lupton, Michelle K., Martin, Nicholas G., Ashaye, Adeyinka, Olawoye, Olusola, Williams, Susan E., Akafo, Stephen, Ramsay, Michele, Hashimoto, Kazuki, Kamatani, Yoichiro, Akiyama, Masato, Momozawa, Yukihide, Foster, Paul J., Khaw, Peng T., Morgan, James E., Strouthidis, Nicholas G., Kraft, Peter, Kang, Jae H., Pang, Chi Pui, Pasutto, Francesca, Mitchell, Paul, Lotery, Andrew J., Palotie, Aarno, van Duijn, Cornelia, Haines, Jonathan L., Hammond, Chris, Pasquale, Louis R., Klaver, Caroline C. W., Hauser, Michael, Khor, Chiea Chuen, Mackey, David A., Kubo, Michiaki, Cheng, Ching-Yu, Craig, Jamie E., MacGregor, Stuart, Wiggs, Janey L.

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Transfer of the Cystic Fibrosis Transmembrane Conductance Regulator to Human Cystic Fibrosis Cells Mediated by Extracellular Vesicles von Vituret, Cyrielle, Gallay, Kathy, Confort, Marie-Pierre, Ftaich, Najate, Matei, Constantin I, Archer, Fabienne, Ronfort, Corinne, Mornex, Jean-François, Chanson, Marc, Di Pietro, Attilio, Boulanger, Pierre, Hong, Saw See

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TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype von Tricarico, Rossella, Madzo, Jozef, Scher, Gabrielle, Cohen, Maya, Jelinek, Jaroslav, Maegawa, Shinji, Nagarathinam, Rajeswari, Scher, Carly, Chang, Wen-Chi, Nicolas, Emmanuelle, Slifker, Michael, Zhou, Yan, Devarajan, Karthik, Cai, Kathy Q., Kwok, Tim, Nakajima, Pamela, Xu, Jinfei, Mancuso, Pietro, Doneddu, Valentina, Bagella, Luigi, Williams, Riley, Balachandran, Siddharth, Maskalenko, Nicholas, Campbell, Kerry, Ma, Xueying, Cañadas, Israel, Viana-Errasti, Julen, Moreno, Victor, Valle, Laura, Grivennikov, Sergei, Peshkova, Iuliia, Kurilenko, Natalia, Mazitova, Aleksandra, Koltsova, Ekaterina, Lee, Hayan, Walsh, Martin, Duttweiler, Reuben, Whetstine, Johnathan R., Yen, Timothy J., Issa, Jean-Pierre, Bellacosa, Alfonso

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Genetic architecture of human plasma lipidome and its link to cardiovascular disease von Tabassum, Rubina, Rämö, Joel T., Ripatti, Pietari, Koskela, Jukka T., Kurki, Mitja, Karjalainen, Juha, Palta, Priit, Hassan, Shabbeer, Nunez-Fontarnau, Javier, Kiiskinen, Tuomo T. J., Söderlund, Sanni, Matikainen, Niina, Gerl, Mathias J., Surma, Michal A., Klose, Christian, Stitziel, Nathan O., Laivuori, Hannele, Havulinna, Aki S., Service, Susan K., Salomaa, Veikko, Pirinen, Matti, Jauhiainen, Matti, Daly, Mark J., Freimer, Nelson B., Palotie, Aarno, Taskinen, Marja-Riitta, Simons, Kai, Ripatti, Samuli

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Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19 von Sinnberg, Tobias, Lichtensteiger, Christa, Ali, Omar Hasan, Pop, Oltin T, Jochum, Ann-Kristin, Risch, Lorenz, Brugger, Silvio D, Velic, Ana, Bomze, David, Kohler, Philipp, Vernazza, Pietro, Albrich, Werner C, Kahlert, Christian R, Abdou, Marie-Therese, Wyss, Nina, Hofmeister, Kathrin, Niessner, Heike, Zinner, Carl, Gilardi, Mara, Tzankov, Alexandar, Röcken, Martin, Dulovic, Alex, Shambat, Srikanth Mairpady, Ruetalo, Natalia, Buehler, Philipp K, Scheier, Thomas C, Jochum, Wolfram, Kern, Lukas, Henz, Samuel, Schneider, Tino, Kuster, Gabriela M, Lampart, Maurin, Siegemund, Martin, Bingisser, Roland, Schindler, Michael, Schneiderhan-Marra, Nicole, Kalbacher, Hubert, McCoy, Kathy D, Spengler, Werner, Brutsche, Martin H, Maček, Boris, Twerenbold, Raphael, Penninger, Josef M, Matter, Matthias S, Flatz, Lukas

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Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis von Liu, Jimmy Z, Hov, Johannes Roksund, Folseraas, Trine, Ellinghaus, Eva, Rushbrook, Simon M, Doncheva, Nadezhda T, Andreassen, Ole A, Weersma, Rinse K, Weismüller, Tobias J, Eksteen, Bertus, Invernizzi, Pietro, Hirschfield, Gideon M, Gotthardt, Daniel Nils, Pares, Albert, Ellinghaus, David, Shah, Tejas, Juran, Brian D, Milkiewicz, Piotr, Rust, Christian, Schramm, Christoph, Müller, Tobias, Srivastava, Brijesh, Dalekos, Georgios, Nöthen, Markus M, Herms, Stefan, Winkelmann, Juliane, Mitrovic, Mitja, Braun, Felix, Ponsioen, Cyriel Y, Croucher, Peter J P, Sterneck, Martina, Teufel, Andreas, Mason, Andrew L, Saarela, Janna, Leppa, Virpi, Dorfman, Ruslan, Alvaro, Domenico, Floreani, Annarosa, Onengut-Gumuscu, Suna, Rich, Stephen S, Thompson, Wesley K, Schork, Andrew J, Næss, Sigrid, Thomsen, Ingo, Mayr, Gabriele, König, Inke R, Hveem, Kristian, Cleynen, Isabelle, Gutierrez-Achury, Javier, Ricaño-Ponce, Isis, van Heel, David, Björnsson, Einar, Sandford, Richard N, Durie, Peter R, Melum, Espen, Vatn, Morten H, Silverberg, Mark S, Duerr, Richard H, Padyukov, Leonid, Brand, Stephan, Sans, Miquel, Annese, Vito, Achkar, Jean-Paul, Boberg, Kirsten Muri, Marschall, Hanns-Ulrich, Chazouillères, Olivier, Bowlus, Christopher L, Wijmenga, Cisca, Schrumpf, Erik, Vermeire, Severine, Albrecht, Mario, Rioux, John D, Alexander, Graeme, Bergquist, Annika, Cho, Judy, Schreiber, Stefan, Manns, Michael P, Färkkilä, Martti, Dale, Anders M, Chapman, Roger W, Lazaridis, Konstantinos N, Franke, Andre, Anderson, Carl A, Karlsen, Tom H

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Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study von Paulsen, Jane S, Dr Prof, Long, Jeffrey D, Prof, Ross, Christopher A, Prof, Harrington, Deborah L, Prof, Erwin, Cheryl J, JD, Williams, Janet K, Prof, Westervelt, Holly James, PhD, Johnson, Hans J, PhD, Aylward, Elizabeth H, PhD, Zhang, Ying, Prof, Bockholt, H Jeremy, BS, Barker, Roger A, Prof

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An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease von Ruotsalainen, Sanni E, Partanen, Juulia J, Cichonska, Anna, Lin, Jake, Benner, Christian, Surakka, Ida, Reeve, Mary Pat, Palta, Priit, Salmi, Marko, Jalkanen, Sirpa, Ahola-Olli, Ari, Palotie, Aarno, Salomaa, Veikko, Daly, Mark J, Pirinen, Matti, Ripatti, Samuli, Koskela, Jukka

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Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size von Rasmussen, Thomas A, Ahuja, Sunil K, Kuwanda, Locadiah, Vjecha, Michael J, Hudson, Fleur, Lal, Luxshimi, Rhodes, Ajantha, Chang, Judy, Palmer, Sarah, Auberson-Munderi, Paula, Mugerwa, Henry, Wood, Robin, Badal-Faesen, Sharlaa, Pillay, Sandy, Mngqibisa, Rosie, LaRosa, Alberto, Hildago, Jose, Petoumenos, Kathy, Chiu, Chris, Lutaakome, Joseph, Kitonsa, Jonathan, Kabaswaga, Esther, Pala, Pietro, Ganoza, Carmela, Fisher, Katie, Chang, Christina, Lewin, Sharon R, Wright, Edwina J

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Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size von Rasmussen, Thomas A, Ahuja, Sunil K, Kuwanda, Locadiah, Vjecha, Michael J, Hudson, Fleur, Lal, Luxshimi, Rhodes, Ajantha, Chang, Judy, Palmer, Sarah, Auberson-Munderi, Paula, Mugerwa, Henry, Wood, Robin, Badal-Faesen, Sharlaa, Pillay, Sandy, Mngqibisa, Rosie, LaRosa, Alberto, Hildago, Jose, Petoumenos, Kathy, Chiu, Chris, Lutaakome, Joseph, Kitonsa, Jonathan, Kabaswaga, Esther, Pala, Pietro, Ganoza, Carmela, Fisher, Katie, Chang, Christina, Lewin, Sharon R, Wright, Edwina J

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Measurement challenge: protocol for international case–control comparison of mammographic measures that predict breast cancer risk von Dench, Evenda, Bond-Smith, Daniela, Darcey, Ellie, Lee, Grant, Aung, Ye K, Chan, Ariane, Cuzick, Jack, Ding, Ze Y, Evans, Chris F, Harvey, Jennifer, Highnam, Ralph, Hsieh, Meng-Kang, Kontos, Despina, Li, Shuai, Mariapun, Shivaani, Nickson, Carolyn, Nguyen, Tuong L, Pertuz, Said, Procopio, Pietro, Rajaram, Nadia, Repich, Kathy, Tan, Maxine, Teo, Soo-Hwang, Trinh, Nhut Ho, Ursin, Giske, Wang, Chao, dos-Santos-Silva, Isabel, McCormack, Valerie, Nielsen, Mads, Shepherd, John, Hopper, John L, Stone, Jennifer

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NI‐0801, an anti‐chemokine (C‐X‐C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid von de Graaf, Kathy L., Lapeyre, Geneviève, Guilhot, Florence, Ferlin, Walter, Curbishley, Stuart M., Carbone, Marco, Richardson, Paul, Moreea, Sulleman, McCune, C. Anne, Ryder, Stephen D., Chapman, Roger W., Floreani, Annarosa, Jones, David E., de Min, Cristina, Adams, David H., Invernizzi, Pietro

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Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis von Tricarico, Rossella, Cortellino, Salvatore, Riccio, Antonio, Jagmohan-Changur, Shantie, Van der Klift, Heleen, Wijnen, Juul, Turner, David, Ventura, Andrea, Rovella, Valentina, Percesepe, Antonio, Lucci-Cordisco, Emanuela, Radice, Paolo, Bertario, Lucio, Pedroni, Monica, Ponz de Leon, Maurizio, Mancuso, Pietro, Devarajan, Karthik, Cai, Kathy Q, Klein-Szanto, Andres J P, Neri, Giovanni, Møller, Pål, Viel, Alessandra, Genuardi, Maurizio, Fodde, Riccardo, Bellacosa, Alfonso

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How to improve efficiency in cancer care: Dimensions, methods, and areas of evaluation von Ferrara, Lucia, Otto, Monica, Aapro, Matti, Albreht, Tit, Jonsson, Bengt, Oberst, Simon, Oliver, Kathy, Pisani, Eduardo, Presti, Pietro, Rubio, Isabel T., Terkola, Robert, Tarricone, Rosanna

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Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells von SELEVER, Jennifer, GUOWEI GU, BOUMENDJEL, Ahcene, ALBAIN, Kathy, MIELE, Lucio, WEISS, Heidi, BARONE, Ines, ANDO, Sebastiano, FUQUA, Suzanne A. W, LEWIS, Michael T, BEYER, Amanda, HERYNK, Matthew H, COVINGTON, Kyle R, TSIMELZON, Anna, DONTU, Gabriela, PROVOST, Patrick, DI PIETRO, Attilio

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Genome-wide structural variant analysis identifies risk loci for non-Alzheimer’s dementias von Kaivola, Karri, Ding, Jinhui, Fujita, Masashi, Menon, Vilas, Walton, Ronald L., Collins, Ryan L., Billingsley, Kimberley, Talkowski, Michael, Dewan, Ramita, Ray, Anindita, Alvarez Jerez, Pilar, Albert, Marilyn S., Resnick, Susan M., Sukumar, Gauthaman, Lott, Nathaniel, Tuck, Meila, Bacikova, Dagmar, Adeleye, Adelani, Black, Sandra E., Gan-Or, Ziv, Rogaeva, Ekaterina, Lesage, Suzanne, Xiromerisiou, Georgia, Calvo, Andrea, Canosa, Antonio, Logroscino, Giancarlo, Clarimon, Jordi, Brett, Francesca, Aarsland, Dag, Al-Sarraj, Safa, Attems, Johannes, McKeith, Ian G., Morris, Christopher M., Morris, Huw R., Pickering-Brown, Stuart, Ryten, Mina, Thomas, Alan J., Troakes, Claire, Albert, Marilyn S., Barrett, Matthew J., Bennett, David A., Dickson, Dennis W., Faber, Kelley, Ferrucci, Luigi, Flanagan, Margaret E., Foroud, Tatiana M., Ghetti, Bernardino, Gibbs, J. Raphael, Goate, Alison, Graff-Radford, Neill R., Kaufmann, Horacio, Kukull, Walter A., Lopez, Grisel, Mao, Qinwen, Masliah, Eliezer, Pletnikova, Olga, Renton, Alan E., Ross, Owen A., Serrano, Geidy E., Sidransky, Ellen, Tayebi, Nahid, Torkamani, Ali, Wszolek, Zbigniew K., Broach, James, Drory, Vivian E., Dunckley, Travis L., Gerhard, Glenn, Gibson, Summer B., Heiman-Patterson, Terry D., Jansson, Lilja, Kwan, Justin, Laaksovirta, Hannu, Landers, John E., Landi, Francesco, Le Ber, Isabelle, Lumbroso, Serge, MacGowan, Daniel J.L., Maragakis, Nicholas J., Myllykangas, Liisa, Orrell, Richard W., Pamphlett, Roger, Pulst, Stefan M., Rothstein, Jeffrey D., Shaw, Pamela J., Sidle, Katie C., Simmons, Zachary, Stone, David J., Van Deerlin, Vivianna M., Van Den Bosch, Ludo, Topol, Eric, Ghetti, Bernardino, Landers, John E., Morris, Huw R., Hardy, John A., Moglia, Cristina, Calvo, Andrea, Beach, Thomas G., Ferman, Tanis, Bennett, David A., Traynor, Bryan J.

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