Lessons from crystal structures of kainate receptors von Møllerud, Stine, Frydenvang, Karla, Pickering, Darryl S., Kastrup, Jette Sandholm

Volltext

The Presence of Calcitonin Gene-Related Peptide and Its Receptors in Rat, Pig and Human Brain: Species Differences in Calcitonin Gene-Related Peptide Pharmacology von Warfvinge, Karin, Edvinsson, Lars, Pickering, Darryl S., Sheykhzade, Majid

Volltext

Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs von Gynther, Mikko, Pickering, Darryl S, Spicer, Julie A, Denny, William A, Huttunen, Kristiina M

Volltext

Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2 von Krintel, Christian, Francotte, Pierre, Pickering, Darryl S., Juknaitė, Lina, Pøhlsgaard, Jacob, Olsen, Lars, Frydenvang, Karla, Goffin, Eric, Pirotte, Bernard, Kastrup, Jette S.

Volltext

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype von Chałupnik, Paulina, Vialko, Alina, Pickering, Darryl S, Hinkkanen, Markus, Donbosco, Stephanie, Møller, Thor C, Jensen, Anders A, Nielsen, Birgitte, Bay, Yasmin, Kristensen, Anders S, Johansen, Tommy N, Łątka, Kamil, Bajda, Marek, Szymańska, Ewa

Volltext

Binding and functional pharmacological characteristics of gepant-type antagonists in rat brain and mesenteric arteries von Sheykhzade, Majid, Amandi, Nilofar, Pla, Monica Vidal, Abdolalizadeh, Bahareh, Sams, Anette, Warfvinge, Karin, Edvinsson, Lars, Pickering, Darryl S

Volltext

The Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate von Kristensen, Ole, Kristensen, Lise Baadsgaard, Møllerud, Stine, Frydenvang, Karla, Pickering, Darryl S., Kastrup, Jette Sandholm

Volltext

Structural basis for positive allosteric modulation of AMPA and kainate receptors von Frydenvang, Karla, Pickering, Darryl S., Kastrup, Jette Sandholm

Volltext

Chemoenzymatic Synthesis of New 2,4-syn-Functionalized (S)‑Glutamate Analogues and Structure–Activity Relationship Studies at Ionotropic Glutamate Receptors and Excitatory Amino Ac... von Assaf, Zeinab, Larsen, Anja P, Venskutonytė, Raminta, Han, Liwei, Abrahamsen, Bjarke, Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette S, Jensen, Anders A, Pickering, Darryl S, Frydenvang, Karla, Gefflaut, Thierry, Bunch, Lennart

Volltext

Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests von Andreasen, Jesper T., Gynther, Mikko, Rygaard, Allan, Bøgelund, Trine, Nielsen, Simon D., Clausen, Rasmus P., Mogensen, Jesper, Pickering, Darryl S.

Volltext

Ionotropic glutamate-like receptor δ2 binds D-serine and glycine von Naur, Peter, Hansen, Kasper B, Kristensen, Anders S, Dravid, Shashank M, Pickering, Darryl S, Olsen, Lars, Vestergaard, Bente, Egebjerg, Jan, Gajhede, Michael, Traynelis, Stephen F, Kastrup, Jette S

Volltext

The positive allosteric modulator BPAM344 and L‐glutamate introduce an active‐like structure of the ligand‐binding domain of GluK2 von Bay, Yasmin, Egeberg Jeppesen, Mie, Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Pickering, Darryl S., Kristensen, Anders Skov, Kastrup, Jette Sandholm

Volltext

Studies on an (S)‑2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid (AMPA) Receptor Antagonist IKM-159: Asymmetric Synthesis, Neuroactivity, and Structural Characterization... von Juknaitė, Lina, Sugamata, Yutaro, Tokiwa, Kazuya, Ishikawa, Yuichi, Takamizawa, Satoshi, Eng, Andrew, Sakai, Ryuichi, Pickering, Darryl S, Frydenvang, Karla, Swanson, Geoffrey T, Kastrup, Jette S, Oikawa, Masato

Volltext

Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5) von Buschbom-Helmke, Silke, Wang, Pengfei, Alcaide, Anna, Miguez-Cabello, Federico, Carta, Mario, Viotti, Julio S., Nielsen, Birgitte, Mulle, Christophe, Bowie, Derek, Jørgensen, Flemming Steen, Pickering, Darryl S., Bunch, Lennart

Volltext

Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538 von Bay, Yasmin, Cabello, Federico Javier Miguez, Koens, Chloe C., Frantsen, Stine M., Pickering, Darryl S., Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Kristensen, Anders S., Bowie, Derek, Kastrup, Jette Sandholm

Volltext

Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideo... von Frydenvang, Karla, Lash, L. Leanne, Naur, Peter, Postila, Pekka A., Pickering, Darryl S., Smith, Caleb M., Gajhede, Michael, Sasaki, Makoto, Sakai, Ryuichi, Pentikaïnen, Olli T., Swanson, Geoffrey T., Kastrup, Jette S.

Volltext

Small‐molecule positive allosteric modulation of homomeric kainate receptors GluK1‐3: development of screening assays and insight into GluK3 structure von Bay, Yasmin, Venskutonytė, Raminta, Frantsen, Stine M., Thorsen, Thor S., Musgaard, Maria, Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Biggin, Philip C., Kristensen, Anders S., Boesen, Thomas, Pickering, Darryl S., Gajhede, Michael, Kastrup, Jette S.

Volltext

4-Hydroxy-1,2,5-oxadiazol-3-yl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Molecular Pharmacological Characterization at Ionotropic Glutamate... von Lolli, Marco L, Giordano, Cecilia, Pickering, Darryl S, Rolando, Barbara, Hansen, Kasper B, Foti, Antonio, Contreras-Sanz, Alberto, Amir, Ahmad, Fruttero, Roberta, Gasco, Alberto, Nielsen, Birgitte, Johansen, Tommy N

Volltext

Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators von Francotte, Pierre, Bay, Yasmin, Goffin, Eric, Colson, Thomas, Lesenfants, Cindy, Dorosz, Jerzy, Laulumaa, Saara, Fraikin, Pierre, de Tullio, Pascal, Beaufour, Caroline, Botez, Iuliana, Pickering, Darryl S, Frydenvang, Karla, Danober, Laurence, Kristensen, Anders Skov, Kastrup, Jette Sandholm, Pirotte, Bernard

Volltext

A pharmacological profile of the high-affinity GluK5 kainate receptor von Møllerud, Stine, Kastrup, Jette Sandholm, Pickering, Darryl S.

Volltext