A Physiologically‐Based Pharmacokinetic Model for the Prediction of “Half‐Life Extension” and “Catch and Release” Monoclonal Antibody Pharmacokinetics von Jones, Hannah M., Tolsma, John, Zhang, Zhiwei, Jasper, Paul, Luo, Haobin, Weber, Gregory L., Wright, Katherine, Bard, Joel, Bell, Robert, Messing, Dean, Kelleher, Kerry, Piche‐Nicholas, Nicole, Webster, Robert

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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics von Avery, Lindsay B, Wade, Jason, Wang, Mengmeng, Tam, Amy, King, Amy, Piche-Nicholas, Nicole, Kavosi, Mania S, Penn, Steve, Cirelli, David, Kurz, Jeffrey C, Zhang, Minlei, Cunningham, Orla, Jones, Rhys, Fennell, Brian J, McDonnell, Barry, Sakorafas, Paul, Apgar, James, Finlay, William J, Lin, Laura, Bloom, Laird, O'Hara, Denise M

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Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics von Piche-Nicholas, Nicole M, Avery, Lindsay B, King, Amy C, Kavosi, Mania, Wang, Mengmeng, O'Hara, Denise M, Tchistiakova, Lioudmila, Katragadda, Madan

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Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain von Müller, Mischa R., Saunders, Kenneth, Grace, Christopher, Jin, Macy, Piche-Nicholas, Nicole, Steven, John, O'Dwyer, Ronan, Wu, Leeying, Khetemenee, Lam, Vugmeyster, Yulia, Hickling, Timothy P., Tchistiakova, Lioudmila, Olland, Stephane, Gill, Davinder, Jensen, Allan, Barelle, Caroline J.

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NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells von Geles, Kenneth G., Gao, Yijie, Giannakou, Andreas, Sridharan, Latha, Yamin, Ting-Ting, Zhang, Jing, Karim, Riyez, Bard, Joel, Piche-Nicholas, Nicole, Charati, Manoj, Maderna, Andreas, Lucas, Judy, Golas, Jonathon, Guffroy, Magali, Pirie-Shepherd, Steven, Roy, Marc, Qian, Jessie, Franks, Tania, Zhong, Wenyan, O’Donnell, Christopher J., Tchistiakova, Lioudmila, Gerber, Hans-Peter, Sapra, Puja

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A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia von Christaki, Eirini, Opal, Steven M, Keith, Jr, James C, Kessimian, Nubar, Palardy, John E, Parejo, Nicolas A, Tan, Xiang Yang, Piche-Nicholas, Nicole, Tchistiakova, Lioudmila, Vlasuk, George P, Shields, Kathleen M, Feldman, Jeffrey L, Lavallie, Edward R, Arai, Maya, Mounts, William, Pittman, Debra D

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Mechanistic Investigation of the Preclinical Pharmacokinetics and Interspecies Scaling of PF-05231023, a Fibroblast Growth Factor 21–Antibody Protein Conjugate von Giragossian, Craig, Vage, Chandra, Li, Jun, Pelletier, Kathleen, Piché-Nicholas, Nicole, Rajadhyaksha, Manoj, Liras, Jennifer, Logan, Alison, Calle, Roberto A, Weng, Yan

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Embryo-Fetal Transfer of Bevacizumab (Avastin) in the Rat Over the Course of Gestation and the Impact of Neonatal Fc Receptor (FcRn) Binding von Thorn, Mitchell, Piche-Nicholas, Nicole, Stedman, Donald, Davenport, Scott W., Zhang, Ning, Collinge, Mark, Bowman, Christopher J.

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Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia von Han, Yoon-Chi, Kahler, Jennifer, Piche-Nicholas, Nicole, Hu, Wenyue, Thibault, Stephane, Jiang, Fan, Leal, Mauricio, Katragadda, Madan, Maderna, Andreas, Dushin, Russell, Prashad, Nadira, Charati, Manoj B., Clark, Tracey, Tumey, L. Nathan, Tan, Xingzhi, Giannakou, Andreas, Rosfjord, Edward, Gerber, Hans-Peter, Tchistiakova, Lioudmila, Loganzo, Frank, O'Donnell, Christopher J., Sapra, Puja

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Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis von Kovalenko, Oleg V., Olland, Andrea, Piché-Nicholas, Nicole, Godbole, Adarsh, King, Daniel, Svenson, Kristine, Calabro, Valerie, Müller, Mischa R., Barelle, Caroline J., Somers, William, Gill, Davinder S., Mosyak, Lidia, Tchistiakova, Lioudmila

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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors von Root, Adam R., Guntas, Gurkan, Katragadda, Madan, Apgar, James R., Narula, Jatin, Chang, Chew Shun, Hanscom, Sara, McKenna, Matthew, Wade, Jason, Meade, Caryl, Ma, Weijun, Guo, Yongjing, Liu, Yan, Duan, Weili, Hendershot, Claire, King, Amy C., Zhang, Yan, Sousa, Eric, Tam, Amy, Benard, Susan, Yang, Han, Kelleher, Kerry, Jin, Fang, Piche-Nicholas, Nicole, Keating, Sinead E., Narciandi, Fernando, Lawrence-Henderson, Rosemary, Arai, Maya, Stochaj, Wayne R., Svenson, Kristine, Mosyak, Lidia, Lam, Khetemcnee, Francis, Christopher, Marquette, Kimberly, Wroblewska, Liliana, Zhu, H. Lily, Sheehan, Alfredo Darmanin, LaVallie, Edward R., D'Antona, Aaron M., Betts, Alison, King, Lindsay, Rosfjord, Edward, Cunningham, Orla, Lin, Laura, Sapra, Puja, Tchistiakova, Lioudmila, Mathur, Divya, Bloom, Laird

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Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complemen... von Finlay, William J., Cunningham, Orla, Lambert, Matthew A., Darmanin-Sheehan, Alfredo, Liu, Xuemei, Fennell, Brian J., Mahon, Ciara M., Cummins, Emma, Wade, Jason M., O'Sullivan, Cliona M., Tan, Xiang Yang, Piche, Nicole, Pittman, Debra D., Paulsen, Janet, Tchistiakova, Lioudmila, Kodangattil, Sreekumar, Gill, Davinder, Hufton, Simon E.

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Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates von Tumey, L. Nathan, Li, Fengping, Rago, Brian, Han, Xiaogang, Loganzo, Frank, Musto, Sylvia, Graziani, Edmund I., Puthenveetil, Sujiet, Casavant, Jeffrey, Marquette, Kimberly, Clark, Tracey, Bikker, Jack, Bennett, Eric M., Barletta, Frank, Piche-Nicholas, Nicole, Tam, Amy, O’Donnell, Christopher J., Gerber, Hans Peter, Tchistiakova, Lioudmila

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Abstract 935: Generation and preclinical characterization of CD123-CPI antibody-drug conjugate (ADC) von Han, Yoon-Chi, Jiang, Fan, Piche-Nicholas, Nicole, Katragadda, Madan, Prashad, Nadira, Charati, Manoj, Hu, Wendy, Leal, Mauricio, Tumey, Nathan, Maderna, Andreas, Dushin, Russell, Kim, Kenny, Lemon, LuAnna, Damelin, Marc, Gerber, HP, Tchistiakova, Lioudmila, Loganza, Frank, O'Donnell, Chris, Sapra, Puja

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Embryo‐Fetal Transfer of Bevacizumab ( A vastin) in the Rat Over the Course of Gestation and the Impact of Neonatal F c Receptor ( F c R n) Binding von Thorn, Mitchell, Piche‐Nicholas, Nicole, Stedman, Donald, Davenport, Scott W., Zhang, Ning, Collinge, Mark, Bowman, Christopher J.

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ANTIBODIES AND ANTIBODY-DRUG CONJUGATES SPECIFIC FOR CD123 AND USES THEREOF von HAN, YOONI, KATRAGADDA, MADAN, TUMEY, LAWRENCE NATHAN, CHARATI, MANOJ BABURAO, PICHE-NICHOLAS, NICOLE MELISSA

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Systems and methods for protein production von Lu, Zhijian, Piche, Nicole M, Kriz, Ronald, Geng, Mei, Zhong, Xiaotian, Gao, Yijie, Herrmann, Stephen H

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ANTI-TL1A ANTIBODIES AND METHODS OF USE THEREOF von APGAR, James Reasoner, KARLSSON, Fridrik, TCHISTIAKOVA, Lioudmila, BLOOM, Laird, JIN, Fang, MIN DEBARTOLO, Jessica Haewon, PICHE-NICHOLAS, Nicole Melissa, MARQUETTE, Kimberly Ann

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SEAL SYSTEMS FOR USE IN TURBOMACHINES AND METHODS OF FABRICATING THE SAME von PICHE, Nicole Barbara, GIANNOZZI, Massimo, THOMAS, Paul Matthew, GRAY, Dennis Michael, SHENG, Nuo, GHASRIPOOR, Farshad, GIOVANNETTI, Iacopo, LEBLANC, Luc Stephane, ANAND, Krishnamurthy, NELSON, Warren Arthus, HASZ, Wayne Charles

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SYSTEMS AND METHODS FOR PROTEIN PRODUCTION von LU, Zhijian, PICHE, Nicole, M, GAO, Yijie, KRIZ, Ronald, HERRMANN, Stephen, H, ZHONG, Xiaotian, GENG, Mei

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