DIPG-70. NQO1 AS A RESISTANCE DRIVER AND THERAPEUTIC TARGET IN DMG von Lupien, Leslie E, Morin, Eric, Zhang, Daren F, Novikov, Dana R, Chacon, Madison S, Khuu, Nicholas, Keshishian, Hasmik, Seidel, Olivia, Carr, Steven A, Goodale, Amy, Persky, Nicole S, Root, David E, Cusick, Margaret, Ligon, Keith L, Beroukhim, Rameen, Phoenix, Timothy M, Rendo, Veronica, Bandopadhayay, Pratiti

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IL-21 Receptor Modulates Autoimmune Responses and Expression of Experimental Autoimmune Encephalomyelitis von Liu, Ruolan, Postdoctoral, Barrow Neurological Institute, Neurology, Phoenix, AZ, La Cava, Antoni, Associate Professor, David Geffen School of Medicine, Los Angeles, CA, Young, Debbie, Professor, Wyeth Research, Inflammation, Cambridge, MA, Collins, Mary, Scientist, Wyeth Research, Cambridge, MA, Campagnolo, Denise, Neurologist, Barrow Neurological Institute, Neurology, Phoenix, AZ, Vollmer, Timothy, Neurologist, Barrow Neurological Institute, Neurology, Phoenix, MA, Shi, Fu-Dong, Scientist, Barrow Neurological Institute, Neurology, Phoenix, AZ

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Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype von Phoenix, Timothy N., Patmore, Deanna M., Boop, Scott, Boulos, Nidal, Jacus, Megan O., Patel, Yogesh T., Roussel, Martine F., Finkelstein, David, Goumnerova, Liliana, Perreault, Sebastien, Wadhwa, Elizabeth, Cho, Yoon-Jae, Stewart, Clinton F., Gilbertson, Richard J.

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C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma von Parker, Matthew, Mohankumar, Kumarasamypet M., Punchihewa, Chandanamali, Weinlich, Ricardo, Dalton, James D., Li, Yongjin, Lee, Ryan, Tatevossian, Ruth G., Phoenix, Timothy N., Thiruvenkatam, Radhika, White, Elsie, Tang, Bo, Orisme, Wilda, Gupta, Kirti, Rusch, Michael, Chen, Xiang, Li, Yuxin, Nagahawhatte, Panduka, Hedlund, Erin, Finkelstein, David, Wu, Gang, Shurtleff, Sheila, Easton, John, Boggs, Kristy, Yergeau, Donald, Vadodaria, Bhavin, Mulder, Heather L., Becksfort, Jared, Gupta, Pankaj, Huether, Robert, Ma, Jing, Song, Guangchun, Gajjar, Amar, Merchant, Thomas, Boop, Frederick, Smith, Amy A., Ding, Li, Lu, Charles, Ochoa, Kerri, Zhao, David, Fulton, Robert S., Fulton, Lucinda L., Mardis, Elaine R., Wilson, Richard K., Downing, James R., Green, Douglas R., Zhang, Jinghui, Ellison, David W., Gilbertson, Richard J.

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Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach von Liddelow, Shane A, Temple, Sally, Møllgård, Kjeld, Gehwolf, Renate, Wagner, Andrea, Bauer, Hannelore, Bauer, Hans-Christian, Phoenix, Timothy N, Dziegielewska, Katarzyna M, Saunders, Norman R

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Generation of diffuse intrinsic pontine glioma mouse models by brainstem-targeted in utero electroporation von Patel, Smruti K, Hartley, Rachel M, Wei, Xin, Furnish, Robin, Escobar-Riquelme, Fernanda, Bear, Heather, Choi, Kwangmin, Fuller, Christine, Phoenix, Timothy N

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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory von Ausejo-Mauleon, Iker, Labiano, Sara, de la Nava, Daniel, Laspidea, Virginia, Zalacain, Marta, Marrodán, Lucía, García-Moure, Marc, González-Huarriz, Marisol, Hervás-Corpión, Irati, Dhandapani, Laasya, Vicent, Silvestre, Collantes, Maria, Peñuelas, Iván, Becher, Oren J., Filbin, Mariella G., Jiang, Li, Labelle, Jenna, de Biagi-Junior, Carlos A.O., Nazarian, Javad, Laternser, Sandra, Phoenix, Timothy N., van der Lugt, Jasper, Kranendonk, Mariette, Hoogendijk, Raoull, Mueller, Sabine, De Andrea, Carlos, Anderson, Ana C., Guruceaga, Elizabeth, Koschmann, Carl, Yadav, Viveka Nand, Gállego Pérez-Larraya, Jaime, Patiño-García, Ana, Pastor, Fernando, Alonso, Marta M.

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A Review of Approaches to Potentiate the Activity of Temozolomide against Glioblastoma to Overcome Resistance von Karve, Aniruddha S, Desai, Janki M, Gadgil, Sidharth N, Dave, Nimita, Wise-Draper, Trisha M, Gudelsky, Gary A, Phoenix, Timothy N, DasGupta, Biplab, Yogendran, Lalanthica, Sengupta, Soma, Plas, David R, Desai, Pankaj B

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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation von Khadka, Prasidda, Reitman, Zachary J., Lu, Sophie, Buchan, Graham, Gionet, Gabrielle, Dubois, Frank, Carvalho, Diana M., Shih, Juliann, Zhang, Shu, Greenwald, Noah F., Zack, Travis, Shapira, Ofer, Pelton, Kristine, Hartley, Rachel, Bear, Heather, Georgis, Yohanna, Jarmale, Spandana, Melanson, Randy, Bonanno, Kevin, Schoolcraft, Kathleen, Miller, Peter G., Condurat, Alexandra L., Gonzalez, Elizabeth M., Qian, Kenin, Morin, Eric, Langhnoja, Jaldeep, Lupien, Leslie E., Rendo, Veronica, Digiacomo, Jeromy, Wang, Dayle, Zhou, Kevin, Kumbhani, Rushil, Guerra Garcia, Maria E., Sinai, Claire E., Becker, Sarah, Schneider, Rachel, Vogelzang, Jayne, Krug, Karsten, Goodale, Amy, Abid, Tanaz, Kalani, Zohra, Piccioni, Federica, Beroukhim, Rameen, Persky, Nicole S., Root, David E., Carcaboso, Angel M., Ebert, Benjamin L., Fuller, Christine, Babur, Ozgun, Kieran, Mark W., Jones, Chris, Keshishian, Hasmik, Ligon, Keith L., Carr, Steven A., Phoenix, Timothy N., Bandopadhayay, Pratiti

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Novel mutations target distinct subgroups of medulloblastoma von Robinson, Giles, Parker, Matthew, Kranenburg, Tanya A., Lu, Charles, Chen, Xiang, Ding, Li, Phoenix, Timothy N., Hedlund, Erin, Wei, Lei, Zhu, Xiaoyan, Chalhoub, Nader, Baker, Suzanne J., Huether, Robert, Kriwacki, Richard, Curley, Natasha, Thiruvenkatam, Radhika, Wang, Jianmin, Wu, Gang, Rusch, Michael, Hong, Xin, Becksfort, Jared, Gupta, Pankaj, Ma, Jing, Easton, John, Vadodaria, Bhavin, Onar-Thomas, Arzu, Lin, Tong, Li, Shaoyi, Pounds, Stanley, Paugh, Steven, Zhao, David, Kawauchi, Daisuke, Roussel, Martine F., Finkelstein, David, Ellison, David W., Lau, Ching C., Bouffet, Eric, Hassall, Tim, Gururangan, Sridharan, Cohn, Richard, Fulton, Robert S., Fulton, Lucinda L., Dooling, David J., Ochoa, Kerri, Gajjar, Amar, Mardis, Elaine R., Wilson, Richard K., Downing, James R., Zhang, Jinghui, Gilbertson, Richard J.

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Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole von Karve, Aniruddha S., Desai, Janki M., Dave, Nimita, Wise-Draper, Trisha M., Gudelsky, Gary A., Phoenix, Timothy N., DasGupta, Biplab, Sengupta, Soma, Plas, David R., Desai, Pankaj B.

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Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma von Meel, Michaël H, de Gooijer, Mark C, Metselaar, Dennis S, Sewing, A Charlotte P, Zwaan, Kenn, Waranecki, Piotr, Breur, Marjolein, Buil, Levi C M, Lagerweij, Tonny, Wedekind, Laurine E, Twisk, Jos W R, Koster, Jan, Hashizume, Rintaro, Raabe, Eric H, Montero Carcaboso, Ángel, Bugiani, Marianna, Phoenix, Timothy N, van Tellingen, Olaf, van Vuurden, Dannis G, Kaspers, Gertjan J L, Hulleman, Esther

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Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma von Miklja, Zachary, Yadav, Viveka Nand, Cartaxo, Rodrigo T, Siada, Ruby, Thomas, Chase C, Cummings, Jessica R, Mullan, Brendan, Stallard, Stefanie, Paul, Alyssa, Bruzek, Amy K, Wierzbicki, Kyle, Yang, Tao, Garcia, Taylor, Wolfe, Ian, Leonard, Marcia, Robertson, Patricia L, Garton, Hugh Jl, Wahl, Daniel R, Parmar, Hemant, Sarkaria, Jann N, Kline, Cassie, Mueller, Sabine, Nicolaides, Theodore, Glasser, Chana, Leary, Sarah Es, Venneti, Sriram, Kumar-Sinha, Chandan, Chinnaiyan, Arul M, Mody, Rajen, Pai, Manjunath P, Phoenix, Timothy N, Marini, Bernard L, Koschmann, Carl

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Resolving medulloblastoma cellular architecture by single-cell genomics von Hovestadt, Volker, Smith, Kyle S., Bihannic, Laure, Filbin, Mariella G., Shaw, McKenzie L., Baumgartner, Alicia, DeWitt, John C., Groves, Andrew, Mayr, Lisa, Weisman, Hannah R., Richman, Alyssa R., Shore, Marni E., Goumnerova, Liliana, Rosencrance, Celeste, Carter, Robert A., Phoenix, Timothy N., Hadley, Jennifer L., Tong, Yiai, Houston, Jim, Ashmun, Richard A., DeCuypere, Michael, Sharma, Tanvi, Flasch, Diane, Silkov, Antonina, Ligon, Keith L., Pomeroy, Scott L., Rivera, Miguel N., Rozenblatt-Rosen, Orit, Rusert, Jessica M., Wechsler-Reya, Robert J., Li, Xiao-Nan, Peyrl, Andreas, Gojo, Johannes, Kirchhofer, Dominik, Lötsch, Daniela, Czech, Thomas, Dorfer, Christian, Haberler, Christine, Geyeregger, Rene, Halfmann, Angela, Gawad, Charles, Easton, John, Pfister, Stefan M., Regev, Aviv, Gajjar, Amar, Orr, Brent A., Slavc, Irene, Robinson, Giles W., Bernstein, Bradley E., Suvà, Mario L., Northcott, Paul A.

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Transpiration from subarctic deciduous woodlands: Environmental controls and contribution to ecosystem evapotranspiration von Sabater, Ana M., Ward, Helen C., Hill, Timothy C., Gornall, Jemma L., Wade, Thomas J., Evans, Jonathan G., Prieto‐Blanco, Ana, Disney, Mathias, Phoenix, Gareth K., Williams, Mathew, Huntley, Brian, Baxter, Robert, Mencuccini, Maurizio, Poyatos, Rafael

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The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models von de la Nava, Daniel, Ausejo-Mauleon, Iker, Laspidea, Virginia, Gonzalez-Huarriz, Marisol, Lacalle, Andrea, Casares, Noelia, Zalacain, Marta, Marrodan, Lucía, García-Moure, Marc, Ochoa, Maria C, Tallon-Cobos, Antonio Carlos, Hernandez-Osuna, Reyes, Marco-Sanz, Javier, Dhandapani, Laasya, Hervás-Corpión, Irati, Becher, Oren J, Nazarian, Javad, Mueller, Sabine, Phoenix, Timothy N, van der Lugt, Jasper, Hernaez, Mikel, Guruceaga, Elizabeth, Koschmann, Carl, Venneti, Sriram, Allen, Joshua E, Dun, Matthew D, Fueyo, Juan, Gomez-Manzano, Candelaria, Gallego Perez-Larraya, Jaime, Patiño-García, Ana, Labiano, Sara, Alonso, Marta M

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Orthotopic models of pediatric brain tumors in zebrafish von Eden, C J, Ju, B, Murugesan, M, Phoenix, T N, Nimmervoll, B, Tong, Y, Ellison, D W, Finkelstein, D, Wright, K, Boulos, N, Dapper, J, Thiruvenkatam, R, Lessman, C A, Taylor, M R, Gilbertson, R J

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An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma von Atkinson, Jennifer M., Shelat, Anang A., Carcaboso, Angel Montero, Kranenburg, Tanya A., Arnold, Leggy A., Boulos, Nidal, Wright, Karen, Johnson, Robert A., Poppleton, Helen, Mohankumar, Kumarasamypet M., Féau, Clementine, Phoenix, Timothy, Gibson, Paul, Zhu, Liqin, Tong, Yiai, Eden, Chris, Ellison, David W., Priebe, Waldemar, Koul, Dimpy, Yung, W. K. Alfred, Gajjar, Amar, Stewart, Clinton F., Guy, R. Kiplin, Gilbertson, Richard J.

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FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits von Tsai, Jessica W, Cejas, Paloma, Wang, Dayle K, Patel, Smruti, Wu, David W, Arounleut, Phonepasong, Wei, Xin, Zhou, Ningxuan, Syamala, Sudeepa, Dubois, Frank P B, Crane, Alexander, Pelton, Kristine, Vogelzang, Jayne, Sousa, Cecilia, Baguette, Audrey, Chen, Xiaolong, Condurat, Alexandra L, Dixon-Clarke, Sarah E, Zhou, Kevin N, Lu, Sophie D, Gonzalez, Elizabeth M, Chacon, Madison S, Digiacomo, Jeromy J, Kumbhani, Rushil, Novikov, Dana, Hunter, J'Ya, Tsoli, Maria, Ziegler, David S, Dirksen, Uta, Jager, Natalie, Balasubramanian, Gnana Prakash, Kramm, Christof M, Nathrath, Michaela, Bielack, Stefan, Baker, Suzanne J, Zhang, Jinghui, McFarland, James M, Getz, Gad, Aguet, François, Jabado, Nada, Witt, Olaf, Pfister, Stefan M, Ligon, Keith L, Hovestadt, Volker, Kleinman, Claudia L, Long, Henry, Jones, David T W, Bandopadhayay, Pratiti, Phoenix, Timothy N

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IMMU-48. CRACKING THE ROLE OF ONCOMETABOLITES IN VIROIMMUNOTHERAPY FOR PEDIATRIC MALIGNANT BRAIN TUMORS von Moure, Marc Garcia, Lopez-Rivas, Andres R, Parthasarathy, Akhila, Shin, Dong Ho, Jiang, Hong, He, Jiasen, Tran, Han Nhat, Yun, Kyuson, Hernandez-Osuna, Reyes, Alonso, Marta M, Phoenix, Timothy N, Wainwright, Derek A, Fueyo, Juan, Gomez-Manzano, Candelaria

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