RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain von Picaud, Sarah, Wells, Christopher, Felletar, Ildiko, Brotherton, Deborah, Martin, Sarah, Savitsky, Pavel, Diez-Dacal, Beatriz, Philpott, Martin, Bountra, Chas, Lingard, Hannah, Fedorov, Oleg, Müller, Susanne, Brennan, Paul E., Knapp, Stefan, Filippakopoulos, Panagis

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Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy von Picaud, Sarah, Fedorov, Oleg, Thanasopoulou, Angeliki, Leonards, Katharina, Jones, Katherine, Meier, Julia, Olzscha, Heidi, Monteiro, Octovia, Martin, Sarah, Philpott, Martin, Tumber, Anthony, Filippakopoulos, Panagis, Yapp, Clarence, Wells, Christopher, Che, Ka Hing, Bannister, Andrew, Robson, Samuel, Kumar, Umesh, Parr, Nigel, Lee, Kevin, Lugo, Dave, Jeffrey, Philip, Taylor, Simon, Vecellio, Matteo L, Bountra, Chas, Brennan, Paul E, O'Mahony, Alison, Velichko, Sharlene, Müller, Susanne, Hay, Duncan, Daniels, Danette L, Urh, Marjeta, La Thangue, Nicholas B, Kouzarides, Tony, Prinjha, Rab, Schwaller, Jürg, Knapp, Stefan

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Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains von Hay, Duncan A, Fedorov, Oleg, Martin, Sarah, Singleton, Dean C, Tallant, Cynthia, Wells, Christopher, Picaud, Sarah, Philpott, Martin, Monteiro, Octovia P, Rogers, Catherine M, Conway, Stuart J, Rooney, Timothy P. C, Tumber, Anthony, Yapp, Clarence, Filippakopoulos, Panagis, Bunnage, Mark E, Müller, Susanne, Knapp, Stefan, Schofield, Christopher J, Brennan, Paul E

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Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells von Cribbs, Adam, Hookway, Edward S., Wells, Graham, Lindow, Morten, Obad, Susanna, Oerum, Henrik, Prinjha, Rab K., Athanasou, Nick, Sowman, Aneka, Philpott, Martin, Penn, Henry, Soderstrom, Kalle, Feldmann, Marc, Oppermann, Udo

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Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism von Cribbs, Adam P., Terlecki-Zaniewicz, Stefan, Philpott, Martin, Baardman, Jeroen, Ahern, David, Lindow, Morten, Obad, Susanna, Oerum, Henrik, Sampey, Brante, Mander, Palwinder K., Penn, Henry, Wordsworth, Paul, Bowness, Paul, de Winther, Menno, Prinjha, Rab K., Feldmann, Marc, Oppermann, Udo

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3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands von Hewings, David S, Wang, Minghua, Philpott, Martin, Fedorov, Oleg, Uttarkar, Sagar, Filippakopoulos, Panagis, Picaud, Sarah, Vuppusetty, Chaitanya, Marsden, Brian, Knapp, Stefan, Conway, Stuart J, Heightman, Tom D

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Structural analysis of human KDM5B guides histone demethylase inhibitor development von Johansson, Catrine, Velupillai, Srikannathasan, Tumber, Anthony, Szykowska, Aleksandra, Hookway, Edward S, Nowak, Radoslaw P, Strain-Damerell, Claire, Gileadi, Carina, Philpott, Martin, Burgess-Brown, Nicola, Wu, Na, Kopec, Jola, Nuzzi, Andrea, Steuber, Holger, Egner, Ursula, Badock, Volker, Munro, Shonagh, LaThangue, Nicholas B, Westaway, Sue, Brown, Jack, Athanasou, Nick, Prinjha, Rab, Brennan, Paul E, Oppermann, Udo

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Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming von Ebrahimi, Ayyub, Sevinç, Kenan, Gürhan Sevinç, Gülben, Cribbs, Adam P., Philpott, Martin, Uyulur, Fırat, Morova, Tunç, Dunford, James E., Göklemez, Sencer, Arı, Şule, Oppermann, Udo, Önder, Tamer T.

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PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains von PICAUD, Sarah, DA COSTA, David, BRADNER, James E, TANIERE, Philippe, O'SULLIVAN, Brendan, MÜLLER, Susanne, SCHWALLER, Juerg, STANKOVIC, Tatjana, KNAPP, Stefan, THANASOPOULOU, Angeliki, FILIPPAKOPOULOS, Panagis, FISH, Paul V, PHILPOTT, Martin, FEDOROV, Oleg, BRENNAN, Paul, BUNNAGE, Mark E, OWEN, Dafydd R

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Interleukin-17A Causes Osteoarthritis-Like Transcriptional Changes in Human Osteoarthritis-Derived Chondrocytes and Synovial Fibroblasts In Vitro von Mimpen, Jolet Y., Baldwin, Mathew J., Cribbs, Adam P., Philpott, Martin, Carr, Andrew J., Dakin, Stephanie G., Snelling, Sarah J.B.

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Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy von Lechner, Matt, Schartinger, Volker H., Steele, Christopher D., Nei, Wen Long, Ooft, Marc Lucas, Schreiber, Liesa-Marie, Pipinikas, Christodoulos P., Chung, Grace Tin-Yun, Chan, Yuk Yu, Wu, Feng, To, Ka-Fai, Tsang, Chi Man, Pearce, Wayne, Morelli, Daniele, Philpott, Martin, Masterson, Liam, Nibhani, Reshma, Wells, Graham, Bell, Christopher G., Koller, Julia, Delecluse, Susanne, Yip, Yim Ling, Liu, Jacklyn, Forde, Cillian T., Forster, Martin D., Jay, Amrita, Dudás, József, Krapp, Annika, Wan, Simon, Uprimny, Christian, Sprung, Susanne, Haybaeck, Johannes, Fenton, Tim R., Chester, Kerry, Thirlwell, Christina, Royle, Gary, Marafioti, Teresa, Gupta, Rajeev, Indrasari, Sagung Rai, Herdini, Camelia, Slim, Mohd Afiq Mohd, Indrawati, I., Sutton, Liam, Fles, Renske, Tan, Bing, Yeong, Joe, Jain, Amit, Han, Shuting, Wang, Haitao, Loke, Kelvin S. H., He, Wan, Xu, Ruilian, Jin, Hongtao, Cheng, Zhiqiang, Howard, David, Hwang, Peter H., Le, Quynh-Thu, Tay, Joshua K., West, Robert B., Tsao, Sai Wah, Meyer, Tim, Riechelmann, Herbert, Oppermann, Udo, Delecluse, Henri-Jacques, Willems, Stefan M., Chua, Melvin L. K., Busson, Pierre, Lo, Kwok Wai, Wollmann, Guido, Pillay, Nischalan, Vanhaesebroeck, Bart, Lund, Valerie J.

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Identification of a Chemical Probe for Bromo and Extra C‑Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit von Fish, Paul V, Filippakopoulos, Panagis, Bish, Gerwyn, Brennan, Paul E, Bunnage, Mark E, Cook, Andrew S, Federov, Oleg, Gerstenberger, Brian S, Jones, Hannah, Knapp, Stefan, Marsden, Brian, Nocka, Karl, Owen, Dafydd R, Philpott, Martin, Picaud, Sarah, Primiano, Michael J, Ralph, Michael J, Sciammetta, Nunzio, Trzupek, John D

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Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain von Ferguson, Fleur M, Fedorov, Oleg, Chaikuad, Apirat, Philpott, Martin, Muniz, Joao R. C, Felletar, Ildiko, von Delft, Frank, Heightman, Tom, Knapp, Stefan, Abell, Chris, Ciulli, Alessio

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PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo von Brown, Elizabeth J., Balaguer-Lluna, Leire, Cribbs, Adam P., Philpott, Martin, Campo, Leticia, Browne, Molly, Wong, Jong Fu, Oppermann, Udo, Carcaboso, Ángel M., Bullock, Alex N., Farnie, Gillian

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Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs von Larrouture, Quitterie C., Cribbs, Adam P., Rao, Srinivasa R., Philpott, Martin, Snelling, Sarah J., Knowles, Helen J.

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Olfactory Disorders Questionnaire: Scaling severity of quality‐of‐life impact von Garden, Elizabeth Mairenn, Kumaresan, Kala, Clark, Allan, Philpott, Carl Martin

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Nutrition and Mutagenesis von Ferguson, Lynnette R, Philpott, Martin

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Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function von Cribbs, Adam P, Filippakopoulos, Panagis, Philpott, Martin, Wells, Graham, Penn, Henry, Oerum, Henrik, Valge-Archer, Viia, Feldmann, Marc, Oppermann, Udo

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Design, Synthesis and Characterization of Covalent KDM5 Inhibitors von Vazquez‐Rodriguez, Saleta, Wright, Miranda, Rogers, Catherine M., Cribbs, Adam P., Velupillai, Srikannathasan, Philpott, Martin, Lee, Henry, Dunford, James E., Huber, Kilian V. M., Robers, Matthew B., Vasta, James D., Thezenas, Marie‐Laetitia, Bonham, Sarah, Kessler, Benedikt, Bennett, James, Fedorov, Oleg, Raynaud, Florence, Donovan, Adam, Blagg, Julian, Bavetsias, Vassilios, Oppermann, Udo, Bountra, Chas, Kawamura, Akane, Brennan, Paul E.

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Dietary cancer and prevention using antimutagens von Ferguson, Lynnette R, Philpott, Martin, Karunasinghe, Nishi

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