5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis von Jin, Sha, Cojocari, Dan, Purkal, Julie J, Popovic, Relja, Talaty, Nari N, Xiao, Yu, Solomon, Larry R, Boghaert, Erwin R, Leverson, Joel D, Phillips, Darren C

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Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models von Han, Lina, Zhang, Qi, Dail, Monique, Shi, Ce, Cavazos, Antonio, Ruvolo, Vivian R, Zhao, Yang, Kim, Eugene, Rahmani, Mohamed, Mak, Duncan H, Jin, Sha S, Chen, Jun, Phillips, Darren C, Koller, Paul Bottecelli, Jacamo, Rodrigo, Burks, Jared K, DiNardo, Courtney, Daver, Naval, Jabbour, Elias, Wang, Jing, Kantarjian, Hagop M, Andreeff, Michael, Grant, Steven, Leverson, Joel D, Sampath, Deepak, Konopleva, Marina

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MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor von Xiao, Yu, Nimmer, Paul, Sheppard, George S, Bruncko, Milan, Hessler, Paul, Lu, Xin, Roberts-Rapp, Lisa, Pappano, William N, Elmore, Steven W, Souers, Andrew J, Leverson, Joel D, Phillips, Darren C

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Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia von Cojocari, Dan, Smith, Brianna N, Purkal, Julie J, Arrate, Maria P, Huska, Jason D, Xiao, Yu, Gorska, Agnieszka, Hogdal, Leah J, Ramsey, Haley E, Boghaert, Erwin R, Phillips, Darren C, Savona, Michael R

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A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies von Phillips, Darren C., Jin, Sha, Gregory, Gareth P., Zhang, Qi, Xue, John, Zhao, Xiaoxian, Chen, Jun, Tong, Yunsong, Zhang, Haichao, Smith, Morey, Tahir, Stephen K., Clark, Rick F., Penning, Thomas D., Devlin, Jennifer R., Shortt, Jake, Hsi, Eric D., Albert, Daniel H., Konopleva, Marina, Johnstone, Ricky W., Leverson, Joel D., Souers, Andrew J.

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Activity of eftozanermin alfa plus venetoclax in preclinical models and patients with acute myeloid leukemia von Tahir, Stephen K., Calvo, Emiliano, Carneiro, Benedito A., Yuda, Junichiro, Shreenivas, Aditya, Jongen-Lavrencic, Mojca, Gort, Eelke, Ishizawa, Kenichi, Morillo, Daniel, Biesdorf, Carla, Smith, Morey, Cheng, Dong, Motwani, Monica, Sharon, David, Uziel, Tamar, Modi, Dimple A., Buchanan, Fritz G., Morgan-Lappe, Susan, Medeiros, Bruno C., Phillips, Darren C.

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Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors von Phillips, Darren C, Buchanan, Fritz G, Cheng, Dong, Solomon, Larry R, Xiao, Yu, Xue, John, Tahir, Stephen K, Smith, Morey L, Zhang, Haichao, Widomski, Deborah, Abraham, Vivek C, Xu, Nan, Liu, Zhihong, Zhou, Li, DiGiammarino, Enrico, Lu, Xin, Rudra-Ganguly, Nandini, Trela, Bruce, Morgan-Lappe, Susan E

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Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity von Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

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Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemia von Cathelin, Severine, Sharon, David, Subedi, Amit, Cojocari, Dan, Phillips, Darren C., Leverson, Joel D., MacBeth, Kyle J., Nicolay, Brandon, Narayanaswamy, Rohini, Ronseaux, Sebastien, Liu, Guowen, Chan, Steven M.

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MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma von Fu, Dechen, Pfannenstiel, Luke, Demelash, Abeba, Phoon, Yee Peng, Mayell, Cameron, Cabrera, Claudia, Liu, Caini, Zhao, Junjie, Dermawan, Josephine, Patil, Deepa, DeVecchio, Jennifer, Kalady, Matthew, Souers, Andrew J., Phillips, Darren C., Li, Xiaoxia, Gastman, Brian

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Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells von Bodo, Juraj, Zhao, Xiaoxian, Durkin, Lisa, Souers, Andrew J, Phillips, Darren C, Smith, Mitchell R, Hsi, Eric D

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Biotechnology Entrepreneurship: Leading, Managing and Commercializing Innovative Technologies von Phillips, Darren

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Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity von Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

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"Biotechnology Entrepreneurship: Leading, Managing and Commercializing Innovative Technologies" : Edited by Craig Shimasaki (BioSource Consulting Group, USA), 2nd Edition, Elsevier... von Phillips, Darren

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Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention von Phillips, Darren C, Dias, H K Irundika, Kitas, George D, Griffiths, Helen R

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Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers von Salem, Ahmed Hamed, Tao, Zhi-Fu, Bueno, Orlando F, Chen, Jie, Chen, Shuang, Edalji, Rohinton, Elmore, Steven W, Fournier, Keith M, Harper, Kaid C, Hong, Richard, Jenkins, Gary J, Ji, Jianguo, Judge, Russell A, Kalvass, John C, Klix, Russell C, Ku, Yi-Yin, Leverson, Joel D, Marks, Richard A, Marsh, Kennan C, Menon, Rajeev M, Park, Chang H, Phillips, Darren C, Pu, Yu-Ming, Rosenberg, Saul H, Sanzgiri, Yeshwant D, Sheikh, Ahmad Y, Shi, Yi, Stolarik, Deanne, Suleiman, Ahmed A, Wang, Xilu, Zhang, Geoff G Z, Catron, Nathaniel D, Souers, Andrew J

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Structure-Based Design of A-1293102, a Potent and Selective BCL-X L Inhibitor von Tao, Zhi-Fu, Wang, Xilu, Chen, Jun, Ingram, Justin P, Jin, Sha, Judge, Russell A, Kovar, Peter J, Park, Chang, Sun, Chaohong, Wakefield, Brian D, Zhou, Li, Zhang, Haichao, Elmore, Steven W, Phillips, Darren C, Judd, Andrew S, Leverson, Joel D, Souers, Andrew J

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The effect of mark enhancement techniques on the subsequent detection of semen/spermatozoa von Simmons, Rory, Deacon, Paul, Phillips, Darren J, Farrugia, Kevin

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The anti‐inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species von Phillips, Darren C, Woollard, Kevin J, Griffiths, Helen R

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Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex component... von MARTIN, Sophie, PHILLIPS, Darren C, SZEKELY-SZUCS, Kinga, ELGHAZI, Lynda, DESMOTS, Fabienne, HOUGHTON, Janet A

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