TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer von Gonzalvez, Francois, Lawrence, David, Yang, Becky, Yee, Sharon, Pitti, Robert, Marsters, Scot, Pham, Victoria C., Stephan, Jean-Philippe, Lill, Jennie, Ashkenazi, Avi

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Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling von Jin, Zhaoyu, Li, Yun, Pitti, Robert, Lawrence, David, Pham, Victoria C., Lill, Jennie R., Ashkenazi, Avi

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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition von Vande Walle, Lieselotte, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubrt, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed

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Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation von Dey, Anwesha, Seshasayee, Dhaya, Noubade, Rajkumar, French, Dorothy M., Liu, Jinfeng, Chaurushiya, Mira S., Kirkpatrick, Donald S., Pham, Victoria C., Lill, Jennie R., Bakalarski, Corey E., Wu, Jiansheng, Phu, Lilian, Katavolos, Paula, LaFave, Lindsay M., Abdel-Wahab, Omar, Modrusan, Zora, Seshagiri, Somasekar, Dong, Ken, Lin, Zhonghua, Balazs, Mercedesz, Suriben, Rowena, Newton, Kim, Hymowitz, Sarah, Garcia-Manero, Guillermo, Martin, Flavius, Levine, Ross L., Dixit, Vishva M.

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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy von Tom, Irene, Pham, Victoria C., Katschke, Kenneth J., Li, Wei, Liang, Wei-Ching, Gutierrez, Johnny, Young, Andrew Ah, Figueroa, Isabel, Eshghi, Shadi Toghi, Lee, ChingWei V., Kanodia, Jitendra, Snipas, Scott J., Salvesen, Guy S., Lai, Phillip, Honigberg, Lee, van Lookeren Campagne, Menno, Kirchhofer, Daniel, Baruch, Amos, Lill, Jennie R.

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The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology von Astarita, Jillian L, Keerthivasan, Shilpa, Husain, Bushra, Şenbabaoğlu, Yasin, Verschueren, Erik, Gierke, Sarah, Pham, Victoria C, Peterson, Sean M, Chalouni, Cecile, Pierce, Andrew A, Lill, Jennie R, Gonzalez, Lino C, Martinez-Martin, Nadia, Turley, Shannon J

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RIPK1 inhibits ZBP1-driven necroptosis during development von Newton, Kim, Wickliffe, Katherine E., Maltzman, Allie, Dugger, Debra L., Strasser, Andreas, Pham, Victoria C., Lill, Jennie R., Roose-Girma, Merone, Warming, Søren, Solon, Margaret, Ngu, Hai, Webster, Joshua D., Dixit, Vishva M.

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Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition von Walle, Lieselotte Vande, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubr, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed

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Integration of innate immune signalling by caspase-8 cleavage of N4BP1 von Gitlin, Alexander D., Heger, Klaus, Schubert, Alexander F., Reja, Rohit, Yan, Donghong, Pham, Victoria C., Suto, Eric, Zhang, Juan, Kwon, Youngsu C., Freund, Emily C., Kang, Jing, Pham, Anna, Caothien, Roger, Bacarro, Natasha, Hinkle, Trent, Xu, Min, McKenzie, Brent S., Haley, Benjamin, Lee, Wyne P., Lill, Jennie R., Roose-Girma, Merone, Dohse, Monika, Webster, Joshua D., Newton, Kim, Dixit, Vishva M.

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Polyubiquitination of Insulin-like Growth Factor I Receptor (IGF-IR) Activation Loop Promotes Antibody-induced Receptor Internalization and Down-regulation von Mao, Yifan, Shang, Yonglei, Pham, Victoria C., Ernst, James A., Lill, Jennie R., Scales, Suzie J., Zha, Jiping

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The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function von Oberbeck, Nina, Pham, Victoria C., Webster, Joshua D., Reja, Rohit, Huang, Christine S., Zhang, Yue, Roose-Girma, Merone, Warming, Søren, Li, Qingling, Birnberg, Andrew, Wong, Weng, Sandoval, Wendy, Kőműves, László G., Yu, Kebing, Dugger, Debra L., Maltzman, Allie, Newton, Kim, Dixit, Vishva M.

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TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery From DNA Damage von Calses, Philamer C., Pham, Victoria C., Guarnaccia, Alissa D., Choi, Meena, Verschueren, Erik, Bakker, Sietske T., Pham, Trang H., Hinkle, Trent, Liu, Chad, Chang, Matthew T., Kljavin, Noelyn, Bakalarski, Corey, Haley, Benjamin, Zou, Jianing, Yan, Cuicui, Song, Xia, Lin, Xiaoyan, Rowntree, Rebecca, Ashworth, Alan, Dey, Anwesha, Lill, Jennie R.

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Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action von Chan, Jocelyn, Chan, Joyce, Shao, Lily, Stawicki, Scott S., Pham, Victoria C., Akita, Rob W., Hafner, Marc, Crocker, Lisa, Yu, Kebing, Koerber, James T., Schaefer, Gabriele, Comps-Agrar, Laetitia

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Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways von Pham, Trang H, Hagenbeek, Thijs J, Lee, Ho-June, Li, Jason, Rose, Christopher M, Lin, Eva, Yu, Mamie, Martin, Scott E, Piskol, Robert, Lacap, Jennifer A, Sampath, Deepak, Pham, Victoria C, Modrusan, Zora, Lill, Jennie R, Klijn, Christiaan, Malek, Shiva, Chang, Matthew T, Dey, Anwesha

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Complementary Proteomic Tools for the Dissection of Apoptotic Proteolysis Events von Pham, Victoria C, Pitti, Robert, Anania, Veronica G, Bakalarski, Corey E, Bustos, Daisy, Jhunjhunwala, Suchit, Phung, Qui T, Yu, Kebing, Forrest, William F, Kirkpatrick, Donald S, Ashkenazi, Avi, Lill, Jennie R

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Targeting MCL‐1 and BCL‐2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non‐Hodgkin lymphoma: Results from preclinical models and a Phase Ib study... von Lasater, Elisabeth A., Amin, Dhara N., Bannerji, Rajat, Mali, Raghuveer Singh, Barrett, Kathy, Rys, Ryan N., Oeh, Jason, Lin, Eva, Sterne‐Weiler, Tim, Ingalla, Ellen Rei, Go, MaryAnn, Yu, Shang‐Fan, Krem, Maxwell M., Arthur, Chris, Hahn, Uwe, Johnston, Anna, Karur, Vinit, Khan, Nadia, Marlton, Paula, Phillips, Tycel, Gritti, Giuseppe, Seymour, John F., Tani, Monica, Yuen, Sam, Martin, Scott, Chang, Matthew T., Rose, Christopher M., Pham, Victoria C., Polson, Andrew G., Chang, YiMeng, Wever, Claudia, Johnson, Nathalie A., Jiang, Yanwen, Hirata, Jamie, Sampath, Deepak, Musick, Lisa, Flowers, Christopher R., Wertz, Ingrid E.

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Peptide Level Immunoaffinity Enrichment Enhances Ubiquitination Site Identification on Individual Proteins von Anania, Veronica G., Pham, Victoria C., Huang, XiaoDong, Masselot, Alexandre, Lill, Jennie R., Kirkpatrick, Donald S.

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ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway von Rodvold, Jeffrey J, Grimmer, Matthew, Ruiz, Karen, Marsters, Scot A, Oikonomidi, Ioanna, Tan-Aristy, Eileen, Pham, Victoria C, Sarkar, Tamal, Harnoss, Jonathan M, Shatz-Binder, Whitney, Modrusan, Zora D, Wu, Thomas D, Lill, Jennie R, Villemure, Elisia, Rudolph, Joachim, de Sousa E Melo, Felipe, Ashkenazi, Avi

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Resurrection of a clinical antibody: Template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin-α antibody von Castellana, Natalie E, McCutcheon, Krista, Pham, Victoria C, Harden, Kristin, Nguyen, Allen, Young, Judy, Adams, Camellia, Schroeder, Kurt, Arnott, David, Bafna, Vineet, Grogan, Jane L, Lill, Jennie R

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Recent developments in microwave-assisted protein chemistries – can this be integrated into the drug discovery and validation process? von Sandoval, Wendy N., Pham, Victoria C., Lill, Jennie R.

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