Organoid Cultures as Preclinical Models of Non-Small Cell Lung Cancer von Shi, Ruoshi, Radulovich, Nikolina, Ng, Christine, Liu, Ni, Notsuda, Hirotsugu, Cabanero, Michael, Martins-Filho, Sebastiao N., Raghavan, Vibha, Li, Quan, Mer, Arvind Singh, Rosen, Joshua C., Li, Ming, Wang, Yu-Hui, Tamblyn, Laura, Nhu-An Pham, Haibe-Kains, Benjamin, Liu, Geoffrey, Moghal, Nadeem, Tsao, Ming-Sound

Volltext

Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes von Mirhadi, Shideh, Tam, Shirley, Li, Quan, Moghal, Nadeem, Pham, Nhu-An, Tong, Jiefei, Golbourn, Brian J., Krieger, Jonathan R., Taylor, Paul, Li, Ming, Weiss, Jessica, Martins-Filho, Sebastiao N., Raghavan, Vibha, Mamatjan, Yasin, Khan, Aafaque A., Cabanero, Michael, Sakashita, Shingo, Huo, Kugeng, Agnihotri, Sameer, Ishizawa, Kota, Waddell, Thomas K., Zadeh, Gelareh, Yasufuku, Kazuhiro, Liu, Geoffrey, Shepherd, Frances A., Moran, Michael F., Tsao, Ming-Sound

Volltext

Integrated Omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact von Li, Lei, Wei, Yuhong, To, Christine, Zhu, Chang-Qi, Tong, Jiefei, Pham, Nhu-An, Taylor, Paul, Ignatchenko, Vladimir, Ignatchenko, Alex, Zhang, Wen, Wang, Dennis, Yanagawa, Naoki, Li, Ming, Pintilie, Melania, Liu, Geoffrey, Muthuswamy, Lakshmi, Shepherd, Frances A., Tsao, Ming Sound, Kislinger, Thomas, Moran, Michael F.

Volltext

Molecular heterogeneity of non‐small cell lung carcinoma patient‐derived xenografts closely reflect their primary tumors von Wang, Dennis, Pham, Nhu‐An, Tong, Jiefei, Sakashita, Shingo, Allo, Ghassan, Kim, Lucia, Yanagawa, Naoki, Raghavan, Vibha, Wei, Yuhong, To, Christine, Trinh, Quang M., Starmans, Maud H.W., Chan‐Seng‐Yue, Michelle A., Chadwick, Dianne, Li, Lei, Zhu, Chang‐Qi, Liu, Ni, Li, Ming, Lee, Sharon, Ignatchenko, Vladimir, Strumpf, Dan, Taylor, Paul, Moghal, Nadeem, Liu, Geoffrey, Boutros, Paul C., Kislinger, Thomas, Pintilie, Melania, Jurisica, Igor, Shepherd, Frances A., McPherson, John D., Muthuswamy, Lakshmi, Moran, Michael F., Tsao, Ming‐Sound

Volltext

A Clinical and Molecular Phase II Trial of Oral ENMD-2076 in Ovarian Clear Cell Carcinoma (OCCC): A Study of the Princess Margaret Phase II Consortium von Lheureux, Stephanie, Tinker, Anna, Clarke, Blaise, Ghatage, Prafull, Welch, Stephen, Weberpals, Johanne I, Dhani, Neesha C, Butler, Marcus O, Tonkin, Katia, Tan, Qian, Tan, David S P, Brooks, Kelly, Ramsahai, Janelle, Wang, Lisa, Pham, Nhu-An, Shaw, Patricia A, Tsao, Ming S, Garg, Swati, Stockley, Tracey, Oza, Amit M

Volltext

Cancer proteome and metabolite changes linked to SHMT2 von Tong, Jiefei, Krieger, Jonathan R., Taylor, Paul, Bagshaw, Rick, Kang, Jae, Jeedigunta, Swathi, Wybenga-Groot, Leanne E., Zhang, Wen, Badr, Heba, Mirhadi, Shideh, Nhu-An Pham, Coyaud, Etienne, Yu, Man, Li, Ming, Cabanero, Michael, Raught, Brian, Maynes, Jason T., Hawkins, Cynthia, Tsao, Ming Sound, Moran, Michael F.

Volltext

Single-Cell Analysis Reveals Transcriptomic Features of Drug-Tolerant Persisters and Stromal Adaptation in a Patient-Derived EGFR-Mutated Lung Adenocarcinoma Xenograft Model von Moghal, Nadeem, Li, Quan, Stewart, Erin L., Navab, Roya, Mikubo, Masashi, D’Arcangelo, Elisa, Martins-Filho, Sebastiao N., Raghavan, Vibha, Pham, Nhu-An, Li, Ming, Shepherd, Frances A., Liu, Geoffrey, Tsao, Ming-Sound

Volltext

Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers von Pham, Nhu-An, Radulovich, Nikolina, Ibrahimov, Emin, Martins-Filho, Sebastiao N., Li, Quan, Pintilie, Melania, Weiss, Jessica, Raghavan, Vibha, Cabanero, Michael, Denroche, Robert E., Wilson, Julie M., Metran-Nascente, Cristiane, Borgida, Ayelet, Hutchinson, Shawn, Dodd, Anna, Begora, Michael, Chadwick, Dianne, Serra, Stefano, Knox, Jennifer J., Gallinger, Steven, Hedley, David W., Muthuswamy, Lakshmi, Tsao, Ming-Sound

Volltext

BRAF V600E mutation and MET amplification as resistance pathways of the second-generation anaplastic lymphoma kinase (ALK) inhibitor alectinib in lung cancer von Shi, Ruoshi, Filho, Sebastiao N. Martins, Li, Ming, Fares, Aline, Weiss, Jessica, Pham, Nhu-An, Ludkovski, Olga, Raghavan, Vibha, Li, Quan, Ravi, Deepti, Cabanero, Michael, Moghal, Nadeem, Leighl, Natasha B., Bradbury, Penelope, Sacher, Adrian, Shepherd, Frances A., Yasufuku, Kazuhiro, Tsao, Ming-Sound, Liu, Geoffrey

Volltext

The Ability to Form Primary Tumor Xenografts Is Predictive of Increased Risk of Disease Recurrence in Early-Stage Non-Small Cell Lung Cancer von JOHN, Thomas, KOHLER, Derek, TSAO, Ming-Sound, PINTILIE, Melania, YANAGAWA, Naoki, PHAM, Nhu-An, MING LI, PANCHAL, Devang, HUI, Frances, FANNONG MENG, SHEPHERD, Frances A

Volltext

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma von Stewart, Erin L, Mascaux, Celine, Pham, Nhu-An, Sakashita, Shingo, Sykes, Jenna, Kim, Lucia, Yanagawa, Naoki, Allo, Ghassan, Ishizawa, Kota, Wang, Dennis, Zhu, Chang-Qi, Li, Ming, Ng, Christine, Liu, Ni, Pintilie, Melania, Martin, Petra, John, Tom, Jurisica, Igor, Leighl, Natasha B, Neel, Benjamin G, Waddell, Thomas K, Shepherd, Frances A, Liu, Geoffrey, Tsao, Ming-Sound

Volltext

A drug discovery platform to identify compounds that inhibit EGFR triple mutants von Saraon, Punit, Snider, Jamie, Kalaidzidis, Yannis, Wybenga-Groot, Leanne E., Weiss, Konstantin, Rai, Ankit, Radulovich, Nikolina, Drecun, Luka, Vučković, Nika, Vučetić, Adriana, Wong, Victoria, Thériault, Brigitte, Pham, Nhu-An, Park, Jin H., Datti, Alessandro, Wang, Jenny, Pathmanathan, Shivanthy, Aboualizadeh, Farzaneh, Lyakisheva, Anna, Yao, Zhong, Wang, Yuhui, Joseph, Babu, Aman, Ahmed, Moran, Michael F., Prakesch, Michael, Poda, Gennady, Marcellus, Richard, Uehling, David, Samaržija, Miroslav, Jakopović, Marko, Tsao, Ming-Sound, Shepherd, Frances A., Sacher, Adrian, Leighl, Natasha, Akhmanova, Anna, Al-awar, Rima, Zerial, Marino, Stagljar, Igor

Volltext

CT Radiomics and Whole Genome Sequencing in Patients with Pancreatic Ductal Adenocarcinoma: Predictive Radiogenomics Modeling von Hinzpeter, Ricarda, Kulanthaivelu, Roshini, Kohan, Andres, Avery, Lisa, Pham, Nhu-An, Ortega, Claudia, Metser, Ur, Haider, Masoom, Veit-Haibach, Patrick

Volltext

Proteomic profiles of human lung adeno and squamous cell carcinoma using super-SILAC and label-free quantification approaches von Zhang, Wen, Wei, Yuhong, Ignatchenko, Vladimir, Li, Lei, Sakashita, Shingo, Pham, Nhu-An, Taylor, Paul, Tsao, Ming Sound, Kislinger, Thomas, Moran, Michael F.

Volltext

Optimizing Drug Response Study Design in Patient-Derived Tumor Xenografts von Weiss, Jessica, Pham, Nhu-An, Pintilie, Melania, Li, Ming, Liu, Geoffrey, Shepherd, Frances A, Tsao, Ming-Sound, Xu, Wei

Volltext

Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15 von Yao, Junlin, Ly, Dalam, Dervovic, Dzana, Fang, Linan, Lee, Jong Bok, Kang, Hyeonjeong, Wang, Yu-Hui, Pham, Nhu-An, Pan, Hongming, Tsao, Ming-Sound, Zhang, Li

Volltext

Antitumor efficacy of XPO1 inhibitor Selinexor in KRAS-mutant lung adenocarcinoma patient-derived xenografts von Rosen, Joshua C., Weiss, Jessica, Pham, Nhu-An, Li, Quan, Martins-Filho, Sebastiao N., Wang, Yuhui, Tsao, Ming-Sound, Moghal, Nadeem

Volltext

EGFR-mutated lung adenocarcinomas from patients who progressed on EGFR-inhibitors show high engraftment rates in xenograft models von Martins-Filho, Sebastiao N., Weiss, Jessica, Pham, Nhu-An, Li, Quan, Cabanero, Michael, Fares, Aline, Stewart, Erin L., Shi, Ruoshi, Patel, Devalben, Pal, Prodipto, McConnell, Judy, Bradbury, Penelope Ann, Sacher, Adrian G., Leighl, Natasha B., Grindlay, Alexandria, Allison, Frances, Li, Ming, Yasufuku, Kazuhiro, Shepherd, Frances A., Moghal, Nadeem, Tsao, Ming-Sound, Liu, Geoffrey

Volltext

Novel combinations of PI3K-mTOR inhibitors with dacomitinib or chemotherapy in PTEN-deficient patient-derived tumor xenografts von Brana, Irene, Pham, Nhu-An, Kim, Lucia, Sakashita, Shingo, Li, Ming, Ng, Christine, Wang, Yuhui, Loparco, Peter, Sierra, Rafael, Wang, Lisa, Clarke, Blaise A, Neel, Benjamin G, Siu, Lillian L, Tsao, Ming-Sound

Volltext

Patient-derived tumor xenograft models established from samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration von Nakajima, Takahiro, Geddie, William, Anayama, Takashi, Ko, Hyang Mi, da Cunha Santos, Gilda, Boerner, Scott, Wang, Tao, Wang, Yu-hui, Li, Ming, Pham, Nhu-An, Tsao, Ming Sound, Yasufuku, Kazuhiro

Volltext