β-Catenin and its new partner FOXO3 shake T-ALL von Calvo, Julien, Pflumio, Françoise

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Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells von Karamitros, Dimitris, Stoilova, Bilyana, Aboukhalil, Zahra, Hamey, Fiona, Reinisch, Andreas, Samitsch, Marina, Quek, Lynn, Otto, Georg, Repapi, Emmanouela, Doondeea, Jessica, Usukhbayar, Batchimeg, Calvo, Julien, Taylor, Stephen, Goardon, Nicolas, Six, Emmanuelle, Pflumio, Francoise, Porcher, Catherine, Majeti, Ravindra, Göttgens, Berthold, Vyas, Paresh

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Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia von Alonso-Pérez, Verónica, Galant, Klaudia, Boudia, Fabien, Robert, Elie, Aid, Zakia, Renou, Laurent, Barroca, Vilma, Devanand, Saryiami, Babin, Loélia, Rouiller-Fabre, Virginie, Moison, Delphine, Busso, Didier, Piton, Guillaume, Metereau, Christophe, Abermil, Nassera, Ballerini, Paola, Hirsch, Pierre, Haddad, Rima, Martinovic, Jelena, Petit, Arnaud, Lapillonne, Hélène, Brunet, Erika, Mercher, Thomas, Pflumio, Françoise

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Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL von Passet, Marie, Kim, Rathana, Gachet, Stéphanie, Sigaux, François, Chaumeil, Julie, Galland, Ava, Sexton, Thomas, Quentin, Samuel, Hernandez, Lucie, Larcher, Lise, Bergugnat, Hugo, Ye, Tao, Karasu, Nezih, Caye, Aurélie, Heizmann, Beate, Duluc, Isabelle, Chevallier, Patrice, Rousselot, Philippe, Huguet, Françoise, Leguay, Thibaut, Hunault, Mathilde, Pflumio, Françoise, Freund, Jean-Noël, Lobry, Camille, Lhéritier, Véronique, Dombret, Hervé, Domon-Dell, Claire, Soulier, Jean, Boissel, Nicolas, Clappier, Emmanuelle

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ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia von Thirant, Cécile, Ignacimouttou, Cathy, Lopez, Cécile K., Diop, M’Boyba, Le Mouël, Lou, Thiollier, Clarisse, Siret, Aurélie, Dessen, Phillipe, Aid, Zakia, Rivière, Julie, Rameau, Philippe, Lefebvre, Céline, Khaled, Mehdi, Leverger, Guy, Ballerini, Paola, Petit, Arnaud, Raslova, Hana, Carmichael, Catherine L., Kile, Benjamin T., Soler, Eric, Crispino, John D., Wichmann, Christian, Pflumio, Françoise, Schwaller, Jürg, Vainchenker, William, Lobry, Camille, Droin, Nathalie, Bernard, Olivier A., Malinge, Sébastien, Mercher, Thomas

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Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia von Lopez, Cécile K, Noguera, Esteve, Stavropoulou, Vaia, Robert, Elie, Aid, Zakia, Ballerini, Paola, Bilhou-Nabera, Chrystèle, Lapillonne, Hélène, Boudia, Fabien, Thirant, Cécile, Fagnan, Alexandre, Arcangeli, Marie-Laure, Kinston, Sarah J, Diop, M'Boyba, Job, Bastien, Lecluse, Yann, Brunet, Erika, Babin, Loélia, Villeval, Jean Luc, Delabesse, Eric, Peters, Antoine H F M, Vainchenker, William, Gaudry, Muriel, Masetti, Riccardo, Locatelli, Franco, Malinge, Sébastien, Nerlov, Claus, Droin, Nathalie, Lobry, Camille, Godin, Isabelle, Bernard, Olivier A, Göttgens, Berthold, Petit, Arnaud, Pflumio, Françoise, Schwaller, Juerg, Mercher, Thomas

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CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia von Cardoso, Bruno A, Duque, Mafalda, Gírio, Ana, Fragoso, Rita, Oliveira, Mariana L, Allen, James R, Martins, Leila R, Correia, Nádia C, Silveira, André Bortolini, Veloso, Alexandra, Kimura, Shunsuke, Demoen, Lisa, Matthijssens, Filip, Jeha, Sima, Cheng, Cheng, Pui, Ching-Hon, Grosso, Ana R, Neto, João L, De Almeida, Sérgio F, Van Vlieberghe, Pieter, Mullighan, Charles G, Yunes, J Andres, Langenau, David M, Pflumio, Françoise, Barata, João T

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Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia von Nguyen, Tra Ly, Nokin, Marie‐Julie, Terés, Silvia, Tomé, Mercedes, Bodineau, Clément, Galmar, Oriane, Pasquet, Jean‐Max, Rousseau, Benoit, Liempd, Sebastian, Falcon‐Perez, Juan Manuel, Richard, Elodie, Muzotte, Elodie, Rezvani, Hamid‐Reza, Priault, Muriel, Bouchecareilh, Marion, Redonnet‐Vernhet, Isabelle, Calvo, Julien, Uzan, Benjamin, Pflumio, Françoise, Fuentes, Patricia, Toribio, Maria L., Khatib, Abdel‐Majid, Soubeyran, Pierre, Murdoch, Piedad del Socorro, Durán, Raúl V.

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Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models von Thiollier, Clarisse, Lopez, Cécile K, Gerby, Bastien, Ignacimouttou, Cathy, Poglio, Sandrine, Duffourd, Yannis, Guégan, Justine, Rivera-Munoz, Paola, Bluteau, Olivier, Mabialah, Vinciane, Diop, M'boyba, Wen, Qiang, Petit, Arnaud, Bauchet, Anne-Laure, Reinhardt, Dirk, Bornhauser, Beat, Gautheret, Daniel, Lecluse, Yann, Landman-Parker, Judith, Radford, Isabelle, Vainchenker, William, Dastugue, Nicole, de Botton, Stéphane, Dessen, Philippe, Bourquin, Jean-Pierre, Crispino, John D, Ballerini, Paola, Bernard, Olivier A, Pflumio, Françoise, Mercher, Thomas

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The ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300‐dependent stemness program von Fagnan, Alexandre, Aid, Zakia, Baille, Marie, Drakul, Aneta, Robert, Elie, Lopez, Cécile K., Thirant, Cécile, Lecluse, Yann, Rivière, Julie, Ignacimouttou, Cathy, Salmoiraghi, Silvia, Anguita, Eduardo, Naimo, Audrey, Marzac, Christophe, Pflumio, Françoise, Malinge, Sébastien, Wichmann, Christian, Huang, Yun, Lobry, Camille, Chaumeil, Julie, Soler, Eric, Bourquin, Jean‐Pierre, Nerlov, Claus, Bernard, Olivier A., Schwaller, Juerg, Mercher, Thomas

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Assessment of human multi-potent hematopoietic stem/progenitor cell potential using a single in vitro screening system von Calvo, Julien, BenYoucef, Aissa, Baijer, Jan, Rouyez, Marie-Christine, Pflumio, Francoise

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Interleukin‐18 produced by bone marrow‐derived stromal cells supports T‐cell acute leukaemia progression von Uzan, Benjamin, Poglio, Sandrine, Gerby, Bastien, Wu, Ching‐Lien, Gross, Julia, Armstrong, Florence, Calvo, Julien, Cahu, Xavier, Deswarte, Caroline, Dumont, Florent, Passaro, Diana, Besnard‐Guérin, Corinne, Leblanc, Thierry, Baruchel, André, Landman‐Parker, Judith, Ballerini, Paola, Baud, Véronique, Ghysdael, Jacques, Baleydier, Frédéric, Porteu, Francoise, Pflumio, Francoise

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PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells von Naudin, Cécile, Hattabi, Aurore, Michelet, Fabio, Miri-Nezhad, Ayda, Benyoucef, Aissa, Pflumio, Françoise, Guillonneau, François, Fichelson, Serge, Vigon, Isabelle, Dusanter-Fourt, Isabelle, Lauret, Evelyne

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Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia von Sánchez-Martínez, Diego, Baroni, Matteo L., Gutierrez-Agüera, Francisco, Roca-Ho, Heleia, Blanch-Lombarte, Oscar, González-García, Sara, Torrebadell, Montserrat, Junca, Jordi, Ramírez-Orellana, Manuel, Velasco-Hernández, Talía, Bueno, Clara, Fuster, José Luís, Prado, Julia G., Calvo, Julien, Uzan, Benjamin, Cools, Jan, Camos, Mireia, Pflumio, Françoise, Toribio, María Luisa, Menéndez, Pablo

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Human hematopoietic stem/progenitor cells display reactive oxygen species-dependent long-term hematopoietic defects after exposure to low doses of ionizing radiations von Henry, Elia, Souissi-Sahraoui, Ines, Deynoux, Margaux, Lefevre, Andreas, Barroca, Vilma, Campalans, Anna, Menard, Veronique, Calvo, Julien, Pflumio, Francoise, Arcangeli, Marie-Laure

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Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse von Clappier, Emmanuelle, Gerby, Bastien, Sigaux, François, Delord, Marc, Touzri, Farah, Hernandez, Lucie, Ballerini, Paola, Baruchel, André, Pflumio, Françoise, Soulier, Jean

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Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors von Thirant, Cécile, Bessette, Barbara, Varlet, Pascale, Puget, Stéphanie, Cadusseau, Josette, Tavares, Silvina Dos Reis, Studler, Jeanne-Marie, Silvestre, David Carlos, Susini, Aurélie, Villa, Chiara, Miquel, Catherine, Bogeas, Alexandra, Surena, Anne-Laure, Dias-Morais, Amélia, Léonard, Nadine, Pflumio, Françoise, Bièche, Ivan, Boussin, François D, Sainte-Rose, Christian, Grill, Jacques, Daumas-Duport, Catherine, Chneiweiss, Hervé, Junier, Marie-Pierre

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T-cell acute lymphoblastic leukemia progression is supported by inflammatory molecules including hepatocyte growth factor von Le Maout, Charly, Fahy, Lucine, Renou, Laurent, Devanand, Caroline, Duwat, Charlotte, Barroca, Vilma, Le Gall, Morgane, Ballerini, Paola, Petit, Arnaud, Calvo, Julien, Uzan, Benjamin, Pflumio, Françoise, Petit, Vanessa

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CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia von Allouch, Awatef, Voisin, Laurent, Zhang, Yanyan, Raza, Syed Qasim, Lecluse, Yann, Calvo, Julien, Selimoglu-Buet, Dorothée, de Botton, Stéphane, Louache, Fawzia, Pflumio, Françoise, Solary, Eric, Perfettini, Jean-Luc

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REDD1 is a gatekeeper of murine hematopoietic stem cell functions during stress responses von Barroca, Vilma, Henry, Elia, Dechamps, Nathalie, Renou, Laurent, Chaintreuil, Paul, Kulkarni, Rohan, Devanand, Saiyirami, Jacquel, Arnaud, Robert, Guillaume, Auberger, Patrick, Pflumio, Françoise, Arcangeli, Marie-Laure

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