EPEN-18. Oncogenic 3D genome conformations identify novel therapeutic targets in ependymoma von Okonechnikov, Konstantin, Camgöz, Aylin, Park, Donglim Esther, Chapman, Owen, Hübner, Jens-Martin, Jenseit, Anne, Chakraborty, Abhijit, Pagadala, Meghana, Bump, Rosalind, Chandran, Sahaana, Kraft, Katherina, Hidalgo, Rocio Acuna, Reid, Derek, Juarez, Edwin F, Robinson, James T, Pajtler, Kristian W, Milde, Till, Coufal, Nicole, Levy, Michael, Malicki, Denise, Nahas, Shareef, Snuderl, Matija, Crawford, John, Wechsler-Reya, Robert, Mundlos, Stefan, Schmitt, Anthony, Carter, Hannah, Michealraj, Kulandaimanuvel Antony, Kumar, Sachin A, Taylor, Michael D, Rich, Jeremy, Mesirov, Jill, Pfister, Stefan P, Ay, Ferhat, Dixon, Jesse, Kool, Marcel, Chavez, Lukas

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Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking von Weischenfeldt, Joachim, Dubash, Taronish, Drainas, Alexandros P, Mardin, Balca R, Chen, Yuanyuan, Stütz, Adrian M, Waszak, Sebastian M, Bosco, Graziella, Halvorsen, Ann Rita, Raeder, Benjamin, Efthymiopoulos, Theocharis, Erkek, Serap, Siegl, Christine, Brenner, Hermann, Brustugun, Odd Terje, Dieter, Sebastian M, Northcott, Paul A, Petersen, Iver, Pfister, Stefan M, Schneider, Martin, Solberg, Steinar K, Thunissen, Erik, Weichert, Wilko, Zichner, Thomas, Thomas, Roman, Peifer, Martin, Helland, Aslaug, Ball, Claudia R, Jechlinger, Martin, Sotillo, Rocio, Glimm, Hanno, Korbel, Jan O

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Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups von Archer, Tenley C., Ehrenberger, Tobias, Mundt, Filip, Gold, Maxwell P., Krug, Karsten, Mah, Clarence K., Mahoney, Elizabeth L., Daniel, Colin J., LeNail, Alexander, Ramamoorthy, Divya, Mertins, Philipp, Mani, D.R., Zhang, Hailei, Gillette, Michael A., Clauser, Karl, Noble, Michael, Tang, Lauren C., Pierre-François, Jessica, Silterra, Jacob, Jensen, James, Tamayo, Pablo, Korshunov, Andrey, Pfister, Stefan M., Kool, Marcel, Northcott, Paul A., Sears, Rosalie C., Lipton, Jonathan O., Carr, Steven A., Mesirov, Jill P., Pomeroy, Scott L., Fraenkel, Ernest

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Medulloblastoma von Northcott, Paul A., Robinson, Giles W., Kratz, Christian P., Mabbott, Donald J., Pomeroy, Scott L., Clifford, Steven C., Rutkowski, Stefan, Ellison, David W., Malkin, David, Taylor, Michael D., Gajjar, Amar, Pfister, Stefan M.

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Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas von Kool, Marcel, Korshunov, Andrey, Remke, Marc, Jones, David T. W., Schlanstein, Maria, Northcott, Paul A., Cho, Yoon-Jae, Koster, Jan, Schouten-van Meeteren, Antoinette, van Vuurden, Dannis, Clifford, Steven C., Pietsch, Torsten, von Bueren, Andre O., Rutkowski, Stefan, McCabe, Martin, Collins, V. Peter, Bäcklund, Magnus L., Haberler, Christine, Bourdeaut, Franck, Delattre, Olivier, Doz, Francois, Ellison, David W., Gilbertson, Richard J., Pomeroy, Scott L., Taylor, Michael D., Lichter, Peter, Pfister, Stefan M.

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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations von Pugh, Trevor J., Weeraratne, Shyamal Dilhan, Archer, Tenley C., Pomeranz Krummel, Daniel A., Auclair, Daniel, Bochicchio, James, Carneiro, Mauricio O., Carter, Scott L., Cibulskis, Kristian, Erlich, Rachel L., Greulich, Heidi, Lawrence, Michael S., Lennon, Niall J., McKenna, Aaron, Meldrim, James, Ramos, Alex H., Ross, Michael G., Russ, Carsten, Shefler, Erica, Sivachenko, Andrey, Sogoloff, Brian, Stojanov, Petar, Tamayo, Pablo, Mesirov, Jill P., Amani, Vladimir, Teider, Natalia, Sengupta, Soma, Francois, Jessica Pierre, Northcott, Paul A., Taylor, Michael D., Yu, Furong, Crabtree, Gerald R., Kautzman, Amanda G., Gabriel, Stacey B., Getz, Gad, Jäger, Natalie, Jones, David T. W., Lichter, Peter, Pfister, Stefan M., Roberts, Thomas M., Meyerson, Matthew, Pomeroy, Scott L., Cho, Yoon-Jae

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γ-secretase directly sheds the survival receptor BCMA from plasma cells von Laurent, Sarah A., Hoffmann, Franziska S., Kuhn, Peer-Hendrik, Cheng, Qingyu, Chu, Yuanyuan, Schmidt-Supprian, Marc, Hauck, Stefanie M., Schuh, Elisabeth, Krumbholz, Markus, Rübsamen, Heike, Wanngren, Johanna, Khademi, Mohsen, Olsson, Tomas, Alexander, Tobias, Hiepe, Falk, Pfister, Hans-Walter, Weber, Frank, Jenne, Dieter, Wekerle, Hartmut, Hohlfeld, Reinhard, Lichtenthaler, Stefan F., Meinl, Edgar

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BRCA1/2 potential founder variants in the Jordanian population: an opportunity for a customized screening panel von Ahmad, Olfat, Sutter, Christian, Hirsch, Steffen, Pfister, Stefan M, Schaaf, Christian P

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Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas von Fontebasso, Adam M., Schwartzentruber, Jeremy, Khuong-Quang, Dong-Anh, Liu, Xiao-Yang, Sturm, Dominik, Korshunov, Andrey, Jones, David T. W., Witt, Hendrik, Kool, Marcel, Albrecht, Steffen, Fleming, Adam, Hadjadj, Djihad, Busche, Stephan, Lepage, Pierre, Montpetit, Alexandre, Staffa, Alfredo, Gerges, Noha, Zakrzewska, Magdalena, Zakrzewski, Krzystof, Liberski, Pawel P., Hauser, Peter, Garami, Miklos, Klekner, Almos, Bognar, Laszlo, Zadeh, Gelareh, Faury, Damien, Pfister, Stefan M., Jabado, Nada, Majewski, Jacek

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Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours von Jones, David T. W., Banito, Ana, Grünewald, Thomas G. P., Haber, Michelle, Jäger, Natalie, Kool, Marcel, Milde, Till, Molenaar, Jan J., Nabbi, Arash, Pugh, Trevor J., Schleiermacher, Gudrun, Smith, Malcolm A., Westermann, Frank, Pfister, Stefan M.

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Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma von Lee, Catherine, Rudneva, Vasilisa A., Erkek, Serap, Zapatka, Marc, Chau, Lianne Q., Tacheva-Grigorova, Silvia K., Garancher, Alexandra, Rusert, Jessica M., Aksoy, Ozlem, Lea, Robin, Mohammad, Helai P., Wang, Jianxun, Weiss, William A., Grimes, H. Leighton, Pfister, Stefan M., Northcott, Paul A., Wechsler-Reya, Robert J.

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A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era von Pfister, Stefan M, Reyes-Múgica, Miguel, Chan, John K C, Hasle, Henrik, Lazar, Alexander J, Rossi, Sabrina, Ferrari, Andrea, Jarzembowski, Jason A, Pritchard-Jones, Kathy, Hill, D Ashley, Jacques, Thomas S, Wesseling, Pieter, López Terrada, Dolores H, von Deimling, Andreas, Kratz, Christian P, Cree, Ian A, Alaggio, Rita

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A cell‐based model system links chromothripsis with hyperploidy von Mardin, Balca R, Drainas, Alexandros P, Waszak, Sebastian M, Weischenfeldt, Joachim, Isokane, Mayumi, Stütz, Adrian M, Raeder, Benjamin, Efthymiopoulos, Theocharis, Buccitelli, Christopher, Segura‐Wang, Maia, Northcott, Paul, Pfister, Stefan M, Lichter, Peter, Ellenberg, Jan, Korbel, Jan O

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Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome von Kratz, Christian P, Achatz, Maria Isabel, Brugières, Laurence, Frebourg, Thierry, Garber, Judy E, Greer, Mary-Louise C, Hansford, Jordan R, Janeway, Katherine A, Kohlmann, Wendy K, McGee, Rose, Mullighan, Charles G, Onel, Kenan, Pajtler, Kristian W, Pfister, Stefan M, Savage, Sharon A, Schiffman, Joshua D, Schneider, Katherine A, Strong, Louise C, Evans, D Gareth R, Wasserman, Jonathan D, Villani, Anita, Malkin, David

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The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity von Hoffmann, Franziska S, Kuhn, Peer-Hendrik, Laurent, Sarah A, Hauck, Stefanie M, Berer, Kerstin, Wendlinger, Simone A, Krumbholz, Markus, Khademi, Mohsen, Olsson, Tomas, Dreyling, Martin, Pfister, Hans-Walter, Alexander, Tobias, Hiepe, Falk, Kümpfel, Tania, Crawford, Howard C, Wekerle, Hartmut, Hohlfeld, Reinhard, Lichtenthaler, Stefan F, Meinl, Edgar

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Recommendations for Cancer Surveillance in Individuals with RASopathies and Other Rare Genetic Conditions with Increased Cancer Risk von Villani, Anita, Greer, Mary-Louise C, Kalish, Jennifer M, Nakagawara, Akira, Nathanson, Katherine L, Pajtler, Kristian W, Pfister, Stefan M, Walsh, Michael F, Wasserman, Jonathan D, Zelley, Kristin, Kratz, Christian P

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Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile von Solomon, David A., Korshunov, Andrey, Sill, Martin, Jones, David T. W., Kool, Marcel, Pfister, Stefan M., Fan, Xuemo, Bannykh, Serguei, Hu, Jethro, Danielpour, Moise, Li, Rong, Johnston, James, Cham, Elaine, Cooney, Tabitha, Sun, Peter P., Oberheim Bush, Nancy Ann, McDermott, Michael, Van Ziffle, Jessica, Onodera, Courtney, Grenert, James P., Bastian, Boris C., Villanueva-Meyer, Javier E., Pekmezci, Melike, Bollen, Andrew W., Perry, Arie

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Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma von Olar, Adriana, Wani, Khalida M., Wilson, Charmaine D., Zadeh, Gelareh, DeMonte, Franco, Jones, David T. W., Pfister, Stefan M., Sulman, Erik P., Aldape, Kenneth D.

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The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets von van Tilburg, Cornelis M., Pfaff, Elke, Pajtler, Kristian W., Langenberg, Karin P. S., Fiesel, Petra, Jones, Barbara C., Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D., Blattner-Johnson, Mirjam, Schramm, Kathrin, Dikow, Nicola, Hirsch, Steffen, Sutter, Christian, Grund, Kerstin, von Stackelberg, Arend, Kulozik, Andreas E., Lissat, Andrej, Borkhardt, Arndt, Meisel, Roland, Reinhardt, Dirk, Klusmann, Jan-Henning, Fleischhack, Gudrun, Tippelt, Stephan, von Schweinitz, Dietrich, Schmid, Irene, Kramm, Christof M., von Bueren, Andre O., Calaminus, Gabriele, Vorwerk, Peter, Graf, Norbert, Westermann, Frank, Fischer, Matthias, Eggert, Angelika, Burkhardt, Birgit, Woessmann, Wilhelm, Nathrath, Michaela, Hecker-Nolting, Stefanie, Fruehwald, Michael C., Schneider, Dominik T., Brecht, Ines B., Ketteler, Petra, Fulda, Simone, Koscielniak, Ewa, Meister, Michael T., Scheer, Monika, Hettmer, Simone, Schwab, Matthias, Tremmel, Roman, Ora, Ingrid, Hutter, Caroline, Gerber, Nicolas U., Lohi, Olli, Kazanowska, Bernarda, Kattamis, Antonis, Filippidou, Maria, Goemans, Bianca, Zwaan, C. Michel, Milde, Till, Jaeger, Natalie, Wolf, Stephan, Reuss, David, Sahm, Felix, von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Kopp-Schneider, Annette, Jones, David T. W., Molenaar, Jan J., Capper, David, Pfister, Stefan M., Witt, Olaf

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MYCN amplification drives an aggressive form of spinal ependymoma von Ghasemi, David R., Sill, Martin, Okonechnikov, Konstantin, Korshunov, Andrey, Yip, Stephen, Schutz, Peter W., Scheie, David, Kruse, Anders, Harter, Patrick N., Kastelan, Marina, Wagner, Marlies, Hartmann, Christian, Benzel, Julia, Maass, Kendra K., Khasraw, Mustafa, Sträter, Ronald, Thomas, Christian, Paulus, Werner, Kratz, Christian P., Witt, Hendrik, Kawauchi, Daisuke, Herold-Mende, Christel, Sahm, Felix, Brandner, Sebastian, Kool, Marcel, Jones, David T. W., von Deimling, Andreas, Pfister, Stefan M., Reuss, David E., Pajtler, Kristian W.

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