Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations von Dehay, Benjamin, PhD, Bourdenx, Mathieu, MS, Gorry, Philippe, MD, Przedborski, Serge, Prof, Vila, Miquel, MD, Hunot, Stéphane, PhD, Singleton, Andrew, PhD, Olanow, C Warren, Prof, Merchant, Kalpana M, PhD, Bezard, Erwan, Prof, Petsko, Gregory A, Prof, Meissner, Wassilios G, Prof

Volltext

Chemically stable fluorescent proteins for advanced microscopy von Campbell, Benjamin C., Paez-Segala, Maria G., Looger, Loren L., Petsko, Gregory A., Liu, Ce Feng

Volltext

Crystal Cryocooling Distorts Conformational Heterogeneity in a Model Michaelis Complex of DHFR von Keedy, Daniel A., van den Bedem, Henry, Sivak, David A., Petsko, Gregory A., Ringe, Dagmar, Wilson, Mark A., Fraser, James S.

Volltext

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations von Intlekofer, Andrew M., Shih, Alan H., Wang, Bo, Nazir, Abbas, Rustenburg, Ariën S., Albanese, Steven K., Patel, Minal, Famulare, Christopher, Correa, Fabian M., Takemoto, Naofumi, Durani, Vidushi, Liu, Hui, Taylor, Justin, Farnoud, Noushin, Papaemmanuil, Elli, Cross, Justin R., Tallman, Martin S., Arcila, Maria E., Roshal, Mikhail, Petsko, Gregory A., Wu, Bin, Choe, Sung, Konteatis, Zenon D., Biller, Scott A., Chodera, John D., Thompson, Craig B., Levine, Ross L., Stein, Eytan M.

Volltext

Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy von Bassil, Fares, Fernagut, Pierre-Olivier, Bezard, Erwan, Pruvost, Alain, Leste-Lasserre, Thierry, Hoang, Quyen Q., Ringe, Dagmar, Petsko, Gregory A., Meissner, Wassilios G.

Volltext

Intrinsic motions along an enzymatic reaction trajectory von HENZLER-WILDMAN, Katherine A, THAI, Vu, HÜBNER, Christian G, KERN, Dorothee, MING LEI, OTT, Maria, WOLF-WATZ, Magnus, FENN, Tim, POZHARSKI, Ed, WILSON, Mark A, PETSKO, Gregory A, KARPLUS, Martin

Volltext

soluble α-synuclein construct forms a dynamic tetramer von Wang, Wei, Perovic, Iva, Chittuluru, Johnathan, Kaganovich, Alice, Nguyen, Linh T. T, Liao, Jingling, Auclair, Jared R, Johnson, Derrick, Landeru, Anuradha, Simorellis, Alana K, Ju, Shulin, Cookson, Mark R, Asturias, Francisco J, Agar, Jeffrey N, Webb, Brian N, Kang, ChulHee, Ringe, Dagmar, Petsko, Gregory A, Pochapsky, Thomas C, Hoang, Quyen Q

Volltext

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease von Kim, Chun-Hyung, Han, Baek-Soo, Moon, Jisook, Kim, Deog-Joong, Shin, Joon, Rajan, Sreekanth, Nguyen, Quoc Toan, Sohn, Mijin, Kim, Won-Gon, Han, Minjoon, Jeong, Inhye, Kim, Kyoung-Shim, Lee, Eun-Hye, Tu, Yupeng, Naffin-Olivos, Jacqueline L., Park, Chang-Hwan, Ringe, Dagmar, Yoon, Ho Sup, Petsko, Gregory A., Kim, Kwang-Soo

Volltext

25-Hydroxycholesterol amplifies microglial IL-1 beta production in an apoE isoform-dependent manner von Wong, Man Ying, Lewis, Michael, Doherty, James J., Shi, Yang, Cashikar, Anil G., Amelianchik, Anna, Tymchuk, Svitlana, Sullivan, Patrick M., Qian, Mingxing, Covey, Douglas F., Petsko, Gregory A., Holtzman, David M., Paul, Steven M., Luo, Wenjie

Volltext

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function von Rajan, Sreekanth, Jang, Yongwoo, Kim, Chun-Hyung, Kim, Woori, Toh, Hui Ting, Jeon, Jeha, Song, Bin, Serra, Aida, Lescar, Julien, Yoo, Jun Yeob, Beldar, Serap, Ye, Hong, Kang, Congbao, Liu, Xue-Wei, Feitosa, Melissa, Kim, Yeahan, Hwang, Dabin, Goh, Geraldine, Lim, Kah-Leong, Park, Hye Min, Lee, Choong Hwan, Oh, Sungwhan F., Petsko, Gregory A., Yoon, Ho Sup, Kim, Kwang-Soo

Volltext

Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1 von Barmada, Sami J, Shulin Ju, Arpana Arjun, Anthony Batarse, Hilary C. Archbold, Daniel Peisach, Xingli Li, Yuxi Zhang, Elizabeth M. H. Tank, Haiyan Qiu, Eric J. Huang, Dagmar Ringe, Gregory A. Petsko, Steven Finkbeiner

Volltext

Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models von Choi, Min Sik, Nakamura, Tomohiro, Cho, Seung-Je, Han, Xuemei, Holland, Emily A, Qu, Jing, Petsko, Gregory A, Yates, 3rd, John R, Liddington, Robert C, Lipton, Stuart A

Volltext

A yeast model of FUS/TLS-dependent cytotoxicity von Ju, Shulin, Tardiff, Daniel F, Han, Haesun, Divya, Kanneganti, Zhong, Quan, Maquat, Lynne E, Bosco, Daryl A, Hayward, Lawrence J, Brown, Jr, Robert H, Lindquist, Susan, Ringe, Dagmar, Petsko, Gregory A

Volltext

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein von Young, Jessica E., Fong, Lauren K., Frankowski, Harald, Petsko, Gregory A., Small, Scott A., Goldstein, Lawrence S.B.

Volltext

Induced pluripotent stem cells: a tool for modeling Parkinson’s disease von Bose, Anindita, Petsko, Gregory A., Studer, Lorenz

Volltext

RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shortening von Ghosh, Shrestha, Nguyen, Mileena T., Choi, Ha Eun, Stahl, Maximilian, Kühn, Annemarie Luise, Van der Auwera, Sandra, Grabe, Hans J., Völzke, Henry, Homuth, Georg, Myers, Samuel A., Hogaboam, Cory M., Noth, Imre, Martinez, Fernando J., Petsko, Gregory A., Glimcher, Laurie H.

Volltext

The Parkinson's Disease Protein DJ-1 Is Neuroprotective Due to Cysteine-Sulfinic Acid-Driven Mitochondrial Localization von Canet-Avilés, Rosa M., Wilson, Mark A., Miller, David W., Ahmad, Rili, McLendon, Chris, Bandyopadhyay, Sourav, Baptista, Melisa J., Ringe, Dagmar, Petsko, Gregory A., Cookson, Mark R.

Volltext

“Sleeping Beauty”: Quiescence in Saccharomyces cerevisiae von GRAY, Joseph V, PETSKO, Gregory A, JOHNSTON, Gerald C, RINGE, Dagmar, SINGER, Richard A, WERNER-WASHBURNE, Margaret

Volltext

Targeted stabilization of Munc18‐1 function via pharmacological chaperones von Abramov, Debra, Guiberson, Noah Guy Lewis, Daab, Andrew, Na, Yoonmi, Petsko, Gregory A, Sharma, Manu, Burré, Jacqueline

Volltext

Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability von Lieberman, Raquel L, D’aquino, J. Alejandro, Ringe, Dagmar, Petsko, Gregory A

Volltext