Cytokine receptor signaling is required for the survival of ALK− anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations von Chen, Jing, Zhang, Yong, Petrus, Michael N., Xiao, Wenming, Nicolae, Alina, Raffeld, Mark, Pittaluga, Stefania, Bamford, Richard N., Nakagawa, Masao, Ouyang, Sunny Tianyi, Epstein, Alan L., Kadin, Marshall E., Del Mistro, Annarose, Woessner, Richard, Jaffe, Elaine S., Waldmann, Thomas A.

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Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2–dependent adult T-cell leukemia von Zhang, Meili, Griner, Lesley A. Mathews, Ju, Wei, Duveau, Damien Y., Guha, Rajarshi, Petrus, Michael N., Wen, Bernard, Maeda, Michiyuki, Shinn, Paul, Ferrer, Marc, Conlon, Kevin D., Bamford, Richard N., O’Shea, John J., Thomas, Craig J., Waldmann, Thomas A.

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Essential role of the linear ubiquitin chain assembly complex and TAK1 kinase in A20 mutant Hodgkin lymphoma von Song, Zhihui, Wei, Wei, Xiao, Wenming, Al-Saleem, Essel D., Nejati, Reza, Chen, Liqi, Yin, Jiejing, Fabrizio, Joseph, Petrus, Michael N., Waldmann, Thomas A., Yang, Yibin

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Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin’s lymphoma von Ju, Wei, Zhang, Meili, Wilson, Kelli M., Petrus, Michael N., Bamford, Richard N., Zhang, Xiaohu, Guha, Rajarshi, Ferrer, Marc, Thomas, Craig J., Waldmann, Thomas A.

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Germinal epimutation of Fragile Histidine Triad (FHIT) gene is associated with progression to acute and chronic adult T-cell leukemia diseases von Bellon, Marcia, Bialuk, Izabela, Galli, Veronica, Bai, Xue-Tao, Farre, Lourdes, Bittencourt, Achilea, Marcais, Ambroise, Petrus, Michael N., Ratner, Lee, Waldmann, Thomas A., Asnafi, Vahid, Gessain, Antoine, Matsuoka, Masao, Franchini, Genoveffa, Hermine, Olivier, Watanabe, Toshiki, Nicot, Christophe

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Short-course IL-15 given as a continuous infusion led to a massive expansion of effective NK cells: implications for combination therapy with antitumor antibodies von Dubois, Sigrid P, Miljkovic, Milos D, Fleisher, Thomas A, Pittaluga, Stefania, Hsu-Albert, Jennifer, Bryant, Bonita R, Petrus, Michael N, Perera, Liyanage P, Müller, Jürgen R, Shih, Joanna H, Waldmann, Thomas A, Conlon, Kevin C

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Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia von Daenthanasanmak, Anusara, Lin, Yuquan, Zhang, Meili, Bryant, Bonita R., Petrus, Michael N., Bamford, Richard N., Thomas, Craig J., Miljkovic, Milos D., Conlon, Kevin C., Waldmann, Thomas A.

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Chimeric antigen receptor modified T cells that target chemokine receptor CCR4 as a therapeutic modality for T‐cell malignancies von Perera, Liyanage P., Zhang, Meili, Nakagawa, Masao, Petrus, Michael N., Maeda, Michiyuki, Kadin, Marshall E., Waldmann, Thomas A., Perera, Pin‐Yu

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Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma von Nakagawa, Masao, Shaffer, Arthur L., Ceribelli, Michele, Zhang, Meili, Wright, George, Huang, Da Wei, Xiao, Wenming, Powell, John, Petrus, Michael N., Yang, Yibin, Phelan, James D., Kohlhammer, Holger, Dubois, Sigrid P., Yoo, Hee Min, Bachy, Emmanuel, Webster, Daniel E., Yang, Yandan, Xu, Weihong, Yu, Xin, Zhao, Hong, Bryant, Bonita R., Shimono, Joji, Ishio, Takashi, Maeda, Michiyuki, Green, Patrick L., Waldmann, Thomas A., Staudt, Louis M.

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Genome-wide CRISPR screen identifies CDK6 as a therapeutic target in adult T-cell leukemia/lymphoma von Ishio, Takashi, Kumar, Sarvesh, Shimono, Joji, Daenthanasanmak, Anusara, Dubois, Sigrid, Lin, Yuquan, Bryant, Bonita, Petrus, Michael N., Bachy, Emmanuel, Huang, Da Wei, Yang, Yandan, Green, Patrick L., Hasegawa, Hiroo, Maeda, Michiyuki, Goto, Hideki, Endo, Tomoyuki, Yokota, Takashi, Hatanaka, Kanako C., Hatanaka, Yutaka, Tanaka, Shinya, Matsuno, Yoshihiro, Yang, Yibin, Hashino, Satoshi, Teshima, Takanori, Waldmann, Thomas A., Staudt, Louis M., Nakagawa, Masao

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A novel model of alternative NF-κB pathway activation in anaplastic large cell lymphoma von Wang, Hongbo, Wei, Wei, Zhang, Jing-Ping, Song, Zhihui, Li, Yangyang, Xiao, Wenming, Liu, Yijun, Zeng, Mu-Sheng, Petrus, Michael N., Thomas, Craig J., Kadin, Marshall E., Nakagawa, Masao, Waldmann, Thomas A., Yang, Yibin

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IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti–IL-2Rα therapies von Volkó, Julianna, Kenesei, Ádám, Zhang, Meili, Várnai, Péter, Mocsár, Gábor, Petrus, Michael N., Jambrovics, Károly, Balajthy, Zoltán, Müller, Gabriele, Bodnár, Andrea, Tóth, Katalin, Waldmann, Thomas A., Vámosi, György

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Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia von Waldmann, Thomas A., Conlon, Kevin C., Stewart, Donn M., Worthy, TatYana A., Janik, John E., Fleisher, Thomas A., Albert, Paul S., Figg, William D., Spencer, Shawn D., Raffeld, Mark, Decker, Jean R., Goldman, Carolyn K., Bryant, Bonita R., Petrus, Michael N., Creekmore, Stephen P., Morris, John C.

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Triple combination of BET plus PI3K and NF-κB inhibitors exhibit synergistic activity in adult T-cell leukemia/lymphoma von Daenthanasanmak, Anusara, Bamford, Richard N., Yoshioka, Makoto, Yang, Shyh-Ming, Homan, Philip, Karim, Baktiar, Bryant, Bonita R., Petrus, Michael N., Thomas, Craig J., Green, Patrick L., Miljkovic, Milos D., Conlon, Kevin C., Waldmann, Thomas A.

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Development of an IL-15–autocrine CD8 T-cell leukemia in IL-15–transgenic mice requires the cis expression of IL-15Rα von Sato, Noriko, Sabzevari, Helen, Fu, Song, Ju, Wei, Petrus, Michael N., Bamford, Richard N., Waldmann, Thomas A., Tagaya, Yutaka

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A new domain in the Toll/IL-1R domain-containing adaptor inducing interferon-β factor protein amino terminus is important for tumor necrosis factor-α receptor-associated factor 3 a... von Nguyen, Vinh-Phuc, Chen, Jing, Petrus, Michael N, Goldman, Carolyn K, Kruhlak, Michael J, Bamford, Richard N, Waldmann, Thomas A

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Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model von Yu, P, Petrus, M N, Ju, W, Zhang, M, Conlon, K C, Nakagawa, M, Maeda, M, Bamford, R N, Waldmann, T A

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A20 and RBX1 regulate brentuximab vedotin sensitivity in Hodgkin Lymphoma identified by a sensitization CRISPR screen von Wei, Wei, Lin, Yuquan, Song, Zhihui, Xiao, Wenming, Chen, Liqi, Yin, Jiejing, Zhou, Yan, Barta, Stefan K., Petrus, Michael N., Waldmann, Thomas A., Yang, Yibin

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A novel model of alternative NF-[kappa]B pathway activation in anaplastic large cell lymphoma von Wang, Hongbo, Wei, Wei, Zhang, Jing-Ping, Song, Zhihui, Li, Yangyang, Xiao, Wenming, Liu, Yijun, Zeng, Mu-Sheng, Petrus, Michael N, Thomas, Craig J, Kadin, Marshall E, Nakagawa, Masao, Waldmann, Thomas A, Yang, Yibin

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Genome-Wide CRISPR Library Screening Identifies CDK6 As Genetic Vulnerability in Adult T-Cell Leukemia/Lymphoma von Ishio, Takashi, Shimono, Joji, Kumar, Sarvesh, Lin, Yuquan, Bachy, Emmanuel, Petrus, Michael N., Yang, Yandan, Maeda, Michiyuki, Goto, Hideki, Hashino, Satoshi, Teshima, Takanori, Waldmann, Thomas A., Staudt, Louis, Nakagawa, Masao

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