Genetic Convergence Brings Clarity to the Enigmatic Red Line in ALS von Cook, Casey, Petrucelli, Leonard

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Converging pathways in neurodegeneration, from genetics to mechanisms von Gan, Li, Cookson, Mark R., Petrucelli, Leonard, La Spada, Albert R.

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Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons von Lopez-Gonzalez, Rodrigo, Lu, Yubing, Gendron, Tania F., Karydas, Anna, Tran, Helene, Yang, Dejun, Petrucelli, Leonard, Miller, Bruce L., Almeida, Sandra, Gao, Fen-Biao

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Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains von Arakhamia, Tamta, Lee, Christina E., Carlomagno, Yari, Kumar, Mukesh, Duong, Duc M., Wesseling, Hendrik, Kundinger, Sean R., Wang, Kevin, Williams, Dewight, DeTure, Michael, Dickson, Dennis W., Cook, Casey N., Seyfried, Nicholas T., Petrucelli, Leonard, Steen, Judith A., Fitzpatrick, Anthony W.P.

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Cellular and pathological heterogeneity of primary tauopathies von Chung, Dah-eun Chloe, Roemer, Shanu, Petrucelli, Leonard, Dickson, Dennis W.

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The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons von Wang, Wenzhang, Li, Li, Lin, Wen-Lang, Dickson, Dennis W, Petrucelli, Leonard, Zhang, Teng, Wang, Xinglong

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GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport von Freibaum, Brian D., Lu, Yubing, Lopez-Gonzalez, Rodrigo, Kim, Nam Chul, Almeida, Sandra, Lee, Kyung-Ha, Badders, Nisha, Valentine, Marc, Miller, Bruce L., Wong, Philip C., Petrucelli, Leonard, Kim, Hong Joo, Gao, Fen-Biao, Taylor, J. Paul

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TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics von Mackenzie, Ian R., Nicholson, Alexandra M., Sarkar, Mohona, Messing, James, Purice, Maria D., Pottier, Cyril, Annu, Kavya, Baker, Matt, Perkerson, Ralph B., Kurti, Aishe, Matchett, Billie J., Mittag, Tanja, Temirov, Jamshid, Hsiung, Ging-Yuek R., Krieger, Charles, Murray, Melissa E., Kato, Masato, Fryer, John D., Petrucelli, Leonard, Zinman, Lorne, Weintraub, Sandra, Mesulam, Marsel, Keith, Julia, Zivkovic, Sasha A., Hirsch-Reinshagen, Veronica, Roos, Raymond P., Züchner, Stephan, Graff-Radford, Neill R., Petersen, Ronald C., Caselli, Richard J., Wszolek, Zbigniew K., Finger, Elizabeth, Lippa, Carol, Lacomis, David, Stewart, Heather, Dickson, Dennis W., Kim, Hong Joo, Rogaeva, Ekaterina, Bigio, Eileen, Boylan, Kevin B., Taylor, J. Paul, Rademakers, Rosa

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The role of tau in neurodegeneration von Gendron, Tania F, Petrucelli, Leonard

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Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau von Kang, Silvia S, Ebbert, Mark T W, Baker, Kelsey E, Cook, Casey, Wang, Xuewei, Sens, Jonathon P, Kocher, Jeanne-Pierre, Petrucelli, Leonard, Fryer, John D

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TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A von Ma, X. Rosa, Prudencio, Mercedes, Koike, Yuka, Vatsavayai, Sarat C., Kim, Garam, Harbinski, Fred, Briner, Adam, Rodriguez, Caitlin M., Guo, Caiwei, Akiyama, Tetsuya, Schmidt, H. Broder, Cummings, Beryl B., Wyatt, David W., Kurylo, Katherine, Miller, Georgiana, Mekhoubad, Shila, Sallee, Nathan, Mekonnen, Gemechu, Ganser, Laura, Rubien, Jack D., Jansen-West, Karen, Cook, Casey N., Pickles, Sarah, Oskarsson, Björn, Graff-Radford, Neill R., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Dickson, Dennis W., Shorter, James, Myong, Sua, Green, Eric M., Seeley, William W., Petrucelli, Leonard, Gitler, Aaron D.

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TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A von Koike, Yuka, Pickles, Sarah, Estades Ayuso, Virginia, Jansen-West, Karen, Qi, Yue A, Li, Ziyi, Daughrity, Lillian M, Yue, Mei, Zhang, Yong-Jie, Cook, Casey N, Dickson, Dennis W, Ward, Michael, Petrucelli, Leonard, Prudencio, Mercedes

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Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72 von Zhu, Qiang, Jiang, Jie, Gendron, Tania F., McAlonis-Downes, Melissa, Jiang, Lulin, Taylor, Amy, Diaz Garcia, Sandra, Ghosh Dastidar, Somasish, Rodriguez, Maria J., King, Patrick, Zhang, Yongjie, La Spada, Albert R., Xu, Huaxi, Petrucelli, Leonard, Ravits, John, Da Cruz, Sandrine, Lagier-Tourenne, Clotilde, Cleveland, Don W.

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Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis von Brettschneider, Johannes, Toledo, Jon B, Van Deerlin, Vivianna M, Elman, Lauren, McCluskey, Leo, Lee, Virginia M-Y, Trojanowski, John Q

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Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs von Jiang, Jie, Zhu, Qiang, Gendron, Tania F., Saberi, Shahram, McAlonis-Downes, Melissa, Seelman, Amanda, Stauffer, Jennifer E., Jafar-nejad, Paymaan, Drenner, Kevin, Schulte, Derek, Chun, Seung, Sun, Shuying, Ling, Shuo-Chien, Myers, Brian, Engelhardt, Jeffery, Katz, Melanie, Baughn, Michael, Platoshyn, Oleksandr, Marsala, Martin, Watt, Andy, Heyser, Charles J., Ard, M. Colin, De Muynck, Louis, Daughrity, Lillian M., Swing, Deborah A., Tessarollo, Lino, Jung, Chris J., Delpoux, Arnaud, Utzschneider, Daniel T., Hedrick, Stephen M., de Jong, Pieter J., Edbauer, Dieter, Van Damme, Philip, Petrucelli, Leonard, Shaw, Christopher E., Bennett, C. Frank, Da Cruz, Sandrine, Ravits, John, Rigo, Frank, Cleveland, Don W., Lagier-Tourenne, Clotilde

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Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1 von Krebiehl, Guido, Ruckerbauer, Sabine, Burbulla, Lena F, Kieper, Nicole, Maurer, Brigitte, Waak, Jens, Wolburg, Hartwig, Gizatullina, Zemfira, Gellerich, Frank N, Woitalla, Dirk, Riess, Olaf, Kahle, Philipp J, Proikas-Cezanne, Tassula, Krüger, Rejko

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TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD von Chou, Ching-Chieh, Zhang, Yi, Umoh, Mfon E., Vaughan, Spencer W., Lorenzini, Ileana, Liu, Feilin, Sayegh, Melissa, Donlin-Asp, Paul G., Chen, Yu Han, Duong, Duc M., Seyfried, Nicholas T., Powers, Maureen A., Kukar, Thomas, Hales, Chadwick M., Gearing, Marla, Cairns, Nigel J., Boylan, Kevin B., Dickson, Dennis W., Rademakers, Rosa, Zhang, Yong-Jie, Petrucelli, Leonard, Sattler, Rita, Zarnescu, Daniela C., Glass, Jonathan D., Rossoll, Wilfried

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ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43 von Stoica, Radu, De Vos, Kurt J., Paillusson, Sébastien, Mueller, Sarah, Sancho, Rosa M., Lau, Kwok-Fai, Vizcay-Barrena, Gema, Lin, Wen-Lang, Xu, Ya-Fei, Lewis, Jada, Dickson, Dennis W., Petrucelli, Leonard, Mitchell, Jacqueline C., Shaw, Christopher E., Miller, Christopher C. J.

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Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance von Cook, Casey, Carlomagno, Yari, Gendron, Tania F, Dunmore, Judy, Scheffel, Kristyn, Stetler, Caroline, Davis, Mary, Dickson, Dennis, Jarpe, Matthew, DeTure, Michael, Petrucelli, Leonard

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Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia von Prudencio, Mercedes, Humphrey, Jack, Pickles, Sarah, Brown, Anna-Leigh, Hill, Sarah E., Kachergus, Jennifer M., Shi, J., Heckman, Michael G., Spiegel, Matthew R., Cook, Casey, Song, Yuping, Yue, Mei, Daughrity, Lillian M., Carlomagno, Yari, Jansen-West, Karen, Fernandez de Castro, Cristhoper, DeTure, Michael, Koga, Shunsuke, Wang, Ying-Chih, Sivakumar, Prasanth, Bodo, Cristian, Candalija, Ana, Talbot, Kevin, Selvaraj, Bhuvaneish T., Burr, Karen, Chandran, Siddharthan, Newcombe, Jia, Lashley, Tammaryn, Hubbard, Isabel, Catalano, Demetra, Kim, Duyang, Propp, Nadia, Fennessey, Samantha, Fagegaltier, Delphine, Phatnani, Hemali, Secrier, Maria, Mc Fisher, Elizabeth, Oskarsson, Bjoern, van Blitterswijk, Marka, Rademakers, Rosa, Graff-Radford, Neil R., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Josephs, Keith A., Thompson, E. Aubrey, Raj, Towfique, Ward, Michael, Dickson, Dennis W., Gendron, Tania F., Fratta, Pietro, Petrucelli, Leonard

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