Chemical activation of the mechanotransduction channel Piezo1 von Syeda, Ruhma, Xu, Jie, Dubin, Adrienne E, Coste, Bertrand, Mathur, Jayanti, Huynh, Truc, Matzen, Jason, Lao, Jianmin, Tully, David C, Engels, Ingo H, Petrassi, H Michael, Schumacher, Andrew M, Montal, Mauricio, Bandell, Michael, Patapoutian, Ardem

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Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic von Chin, Emily N., Yu, Chenguang, Vartabedian, Vincent F., Jia, Ying, Kumar, Manoj, Gamo, Ana M., Vernier, William, Ali, Sabrina H., Kissai, Mildred, Lazar, Daniel C., Nhan Nguyen, Pereira, Laura E., Benish, Brent, Woods, Ashley K., Joseph, Sean B., Chu, Alan, Johnson, Kristen A., Sander, Philipp N., Martinez-Pena, Francisco, Hampton, Eric N., Young, Travis S., Wolan, Dennis W., Chatterjee, Arnab K., Schultz, Peter G., Petrassi, H. Michael, Teijaro, John R., Lairson, Luke L.

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The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis von Janes, Jeff, Young, Megan E., Chen, Emily, Rogers, Nicole H., Burgstaller-Muehlbacher, Sebastian, Hughes, Laura D., Love, Melissa S., Hull, Mitchell V., Kuhen, Kelli L., Woods, Ashley K., Joseph, Sean B., Petrassi, H. Michael, McNamara, Case W., Tremblay, Matthew S., Su, Andrew I., Schultz, Peter G., Chatterjee, Arnab K.

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Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury von Brand, Martin D., Goncalves, Renata L.S., Orr, Adam L., Vargas, Leonardo, Gerencser, Akos A., Borch Jensen, Martin, Wang, Yves T., Melov, Simon, Turk, Carolina N., Matzen, Jason T., Dardov, Victoria J., Petrassi, H. Michael, Meeusen, Shelly L., Perevoshchikova, Irina V., Jasper, Heinrich, Brookes, Paul S., Ainscow, Edward K.

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Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis von Wilburn, Kaley M, Montague, Christine R, Qin, Bo, Woods, Ashley K, Love, Melissa S, McNamara, Case W, Schultz, Peter G, Southard, Teresa L, Huang, Lu, Petrassi, H Michael, VanderVen, Brian C

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The Tuberculosis Drug Accelerator at year 10: what have we learned? von Aldridge, Bree B., Barros-Aguirre, David, Barry, Clifton E., Bates, Robert H., Berthel, Steven J., Boshoff, Helena I., Chibale, Kelly, Chu, Xin-Jie, Cooper, Christopher B., Dartois, Véronique, Duncan, Ken, Fotouhi, Nader, Gusovsky, Fabian, Hipskind, Philip A., Kempf, Dale J., Lelièvre, Joël, Lenaerts, Anne J., McNamara, Case W., Mizrahi, Valerie, Nathan, Carl, Olsen, David B., Parish, Tanya, Petrassi, H. Michael, Pym, Alexander, Rhee, Kyu Y., Robertson, Gregory T., Rock, Jeremy Michael, Rubin, Eric J., Russell, Betsy, Russell, David G., Sacchettini, James C., Schnappinger, Dirk, Schrimpf, Michael, Upton, Anna M., Warner, Peter, Wyatt, Paul Graham, Yuan, Ying

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Iron limitation in M. tuberculosis has broad impact on central carbon metabolism von Theriault, Monique E., Pisu, Davide, Wilburn, Kaley M., Lê-Bury, Gabrielle, MacNamara, Case W., Michael Petrassi, H., Love, Melissa, Rock, Jeremy M., VanderVen, Brian C., Russell, David G.

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Discovery, Optimization, and Biological Evaluation of 5‑(2-(Trifluoromethyl)phenyl)­indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists von Rooney, Lisa, Vidal, Agnès, D’Souza, Anne-Marie, Devereux, Nick, Masick, Brian, Boissel, Valerie, West, Ryan, Head, Victoria, Stringer, Rowan, Lao, Jianmin, Petrus, Matt J, Patapoutian, Ardem, Nash, Mark, Stoakley, Natalie, Panesar, Moh, Verkuyl, J. Martin, Schumacher, Andrew M, Petrassi, H. Michael, Tully, David C

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Suppressors of superoxide production from mitochondrial complex III von Orr, Adam L, Vargas, Leonardo, Turk, Carolina N, Baaten, Janine E, Matzen, Jason T, Dardov, Victoria J, Attle, Stephen J, Li, Jing, Quackenbush, Douglas C, Goncalves, Renata L S, Perevoshchikova, Irina V, Petrassi, H Michael, Meeusen, Shelly L, Ainscow, Edward K, Brand, Martin D

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Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design von Yan, Nicholas L, Santos-Martins, Diogo, Nair, Reji, Chu, Alan, Wilson, Ian A, Johnson, Kristen A, Forli, Stefano, Morgan, Gareth J, Petrassi, H. Michael, Kelly, Jeffery W

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Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis von Yan, Nicholas L., Morgan, Gareth J., Petrassi, H. Michael, Wilson, Ian A., Kelly, Jeffery W.

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Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models von Hübner, Marc P., Gunderson, Emma, Vogel, Ian, Bulman, Christina A., Lim, K.C., Koschel, Marianne, Ehrens, Alexandra, Frohberger, Stefan J., Fendler, Martina, Tricoche, Nancy, Voronin, Denis, Steven, Andrew, Chi, Victor, Bakowski, Malina A., Woods, Ashley K., Petrassi, H. Michael, McNamara, Case W., Beerntsen, Brenda, Chappell, Laura, Sullivan, William, Taylor, Mark J., Turner, Joseph D., Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A.

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Suppressors of superoxide production from mitochondrial complex III von Orr, Adam L, Vargas, Leonardo, Turk, Carolina N, Baaten, Janine E, Matzen, Jason T, Dardov, Victoria J, Attle, Stephen J, Li, Jing, Quackenbush, Douglas C, Goncalves, Renata L S, Perevoshchikova, Irina V, Petrassi, H Michael, Meeusen, Shelly L, Ainscow, Edward K, Brand, Martin D

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Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury von Brand, Martin D, Goncalves, Renata L S, Orr, Adam L, Vargas, Leonardo, Gerencser, Akos A, Borch Jensen, Martin, Wang, Yves T, Melov, Simon, Turk, Carolina N, Matzen, Jason T, Dardov, Victoria J, Petrassi, H Michael, Meeusen, Shelly L, Perevoshchikova, Irina V, Jasper, Heinrich, Brookes, Paul S, Ainscow, Edward K

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Bisaryloxime Ethers as Potent Inhibitors of Transthyretin Amyloid Fibril Formation von Johnson, Steven M, Petrassi, H. Michael, Palaninathan, Satheesh K, Mohamedmohaideen, Nilofar N, Purkey, Hans E, Nichols, Christopher, Chiang, Kyle P, Walkup, Traci, Sacchettini, James C, Sharpless, K. Barry, Kelly, Jeffery W

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Targeted Disruption of Myc–Max Oncoprotein Complex by a Small Molecule von Choi, Seung H, Mahankali, Madhupriya, Lee, Sang Jun, Hull, Mitchell, Petrassi, H. Michael, Chatterjee, Arnab K, Schultz, Peter G, Jones, Katherine A, Shen, Weijun

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Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6‑Azaindole Derivative GNF2133 von Liu, Yahu A, Jin, Qihui, Zou, Yefen, Ding, Qiang, Yan, Shanshan, Wang, Zhicheng, Hao, Xueshi, Nguyen, Bao, Zhang, Xiaoyue, Pan, Jianfeng, Mo, Tingting, Jacobsen, Kate, Lam, Thanh, Wu, Tom Y.-H, Petrassi, H. Michael, Bursulaya, Badry, DiDonato, Michael, Gordon, W. Perry, Liu, Bo, Baaten, Janine, Hill, Robert, Nguyen-Tran, Vân, Qiu, Minhua, Zhang, You-Qing, Kamireddy, Anwesh, Espinola, Sheryll, Deaton, Lisa, Ha, Sukwon, Harb, George, Jia, Yong, Li, Jing, Shen, Weijun, Schumacher, Andrew M, Colman, Karyn, Glynne, Richard, Pan, Shifeng, McNamara, Peter, Laffitte, Bryan, Meeusen, Shelly, Molteni, Valentina, Loren, Jon

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Discovery and SAR of a series of 4,6-diamino-1,3,5-triazin-2-ol as novel non-nucleoside reverse transcriptase inhibitors of HIV-1 von Liu, Bin, Lee, Younghee, Zou, Jinming, Petrassi, H. Michael, Joseph, Rhoda W., Chao, Wenchun, Michelotti, Enrique L., Bukhtiyarova, Marina, Springman, Eric B., Dorsey, Bruce D.

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Synthesis and structure–activity relationships of aryl fluorosulfate-based inhibitors as novel antitubercular agents von Yang, Baiyuan, Sukheja, Paridhi, Qin, Bo, Li, Gencheng, Bare, Grant A.L., Cascioferro, Alessandro, Love, Melissa S., Petrassi, H. Michael, Sharpless, K. Barry, McNamara, Case W., Chatterjee, Arnab K.

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Potent and Selective Structure-Based Dibenzofuran Inhibitors of Transthyretin Amyloidogenesis:  Kinetic Stabilization of the Native State von Petrassi, H. Michael, Johnson, Steven M, Purkey, Hans E, Chiang, Kyle P, Walkup, Traci, Jiang, Xin, Powers, Evan T, Kelly, Jeffery W

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