Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase von Petersen, Nikolaj H.T., Olsen, Ole D., Groth-Pedersen, Line, Ellegaard, Anne-Marie, Bilgin, Mesut, Redmer, Susanne, Ostenfeld, Marie S., Ulanet, Danielle, Dovmark, Tobias H., Lønborg, Andreas, Vindeløv, Signe D., Hanahan, Douglas, Arenz, Christoph, Ejsing, Christer S., Kirkegaard, Thomas, Rohde, Mikkel, Nylandsted, Jesper, Jäättelä, Marja

Volltext

LEDGF (p75) promotes DNA-end resection and homologous recombination von Daugaard, Mads, Baude, Annika, Fugger, Kasper, Povlsen, Lou Klitgaard, Beck, Halfdan, Sørensen, Claus Storgaard, Petersen, Nikolaj H T, Sorensen, Poul H B, Lukas, Claudia, Bartek, Jiri, Lukas, Jiri, Rohde, Mikkel, Jäättelä, Marja

Volltext

Autophagic Components Contribute to Hypersensitive Cell Death in Arabidopsis von Hofius, Daniel, Schultz-Larsen, Torsten, Joensen, Jan, Tsitsigiannis, Dimitrios I., Petersen, Nikolaj H.T., Mattsson, Ole, Jørgensen, Lise Bolt, Jones, Jonathan D.G., Mundy, John, Petersen, Morten

Volltext

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment von Ellegaard, Anne-Marie, Dehlendorff, Christian, Vind, Anna C., Anand, Atul, Cederkvist, Luise, Petersen, Nikolaj H.T., Nylandsted, Jesper, Stenvang, Jan, Mellemgaard, Anders, Østerlind, Kell, Friis, Søren, Jäättelä, Marja

Volltext

Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure von Corcelle-Termeau, Elisabeth, Vindeløv, Signe Diness, Hämälistö, Saara, Mograbi, Baharia, Keldsbo, Anne, Bräsen, Jan Hinrich, Favaro, Elena, Adam, Dieter, Szyniarowski, Piotr, Hofman, Paul, Krautwald, Stefan, Farkas, Thomas, Petersen, Nikolaj H.T., Rohde, Mikkel, Linkermann, Andreas, Jäättelä, Marja

Volltext

Connecting Hsp70, sphingolipid metabolism and lysosomal stability von Petersen, Nikolaj H.T., Kirkegaard, Thomas, Olsen, Ole Dines, Jäättelä, Marja

Volltext

Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology von Kirkegaard, Thomas, Mahalka, Ajay K, Moilanen, Irina, Sandhoff, Konrad, Zylicz, Alicja, Kinnunen, Paavo K. J, Olsen, Ole Dines, Jäättelä, Marja, Nylandsted, Jesper, Petersen, Nikolaj H. T, Roth, Anke G, Knudsen, Jens, Arenz, Christoph

Volltext

The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase von Fog, Cathrine K., Zago, Paola, Malini, Erika, Solanko, Lukasz M., Peruzzo, Paolo, Bornaes, Claus, Magnoni, Raffaella, Mehmedbasic, Arnela, Petersen, Nikolaj H.T., Bembi, Bruno, Aerts, Johannes F.M.G., Dardis, Andrea, Kirkegaard, Thomas

Volltext

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo von Gungor, Burcin, Vanharanta, Lauri, Hölttä-Vuori, Maarit, Pirhonen, Juho, Petersen, Nikolaj H.T., Gramolelli, Silvia, Ojala, Päivi M., Kirkegaard, Thomas, Ikonen, Elina

Volltext

Identification of proteins interacting with Arabidopsis ACD11 von Petersen, Nikolaj H.T., Joensen, Jan, McKinney, Lea V., Brodersen, Peter, Petersen, Morten, Hofius, Daniel, Mundy, John

Volltext

Human GLTP and mutant forms of ACD11 suppress cell death in the Arabidopsis acd11 mutant von Petersen, Nikolaj H.T, McKinney, Lea V, Pike, Helen, Hofius, Daniel, Zakaria, Asif, Brodersen, Peter, Petersen, Morten, Brown, Rhoderick E, Mundy, John

Volltext

Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells von Groth-Pedersen, Line, Aits, Sonja, Corcelle-Termeau, Elisabeth, Petersen, Nikolaj H T, Nylandsted, Jesper, Jäättelä, Marja

Volltext

MAP kinase substrate MKS1 is a regulator of plant defense responses von Andreasson, E, Jenkins, T, Brodersen, P, Thorgrimsen, S, Petersen, N.H.T, Zhu, S, Qiu, J.L, Micheelsen, P, Rocher, A, Petersen, M

Volltext

Clinical disease progression and biomarkers in Niemann-Pick disease type C: a prospective cohort study von Mengel, Eugen, Bembi, Bruno, del Toro, Mireia, Deodato, Federica, Gautschi, Matthias, Grunewald, Stephanie, Gronborg, Sabine, Heron, Benedicte, Maier, Esther M., Roubertie, Agathe, Santra, Saikat, Tylki-Szymanska, Anna, Day, Simon, Symonds, Tara, Hudgens, Stacie, Patterson, Marc C., Guldberg, Christina, Ingemann, Linda, Petersen, Nikolaj H. T., Kirkegaard, Thomas, i Dali, Christine

Volltext

Arimoclomol increases the transcription of lysosomal genes, including and , to facilitate lysosomal function von Petersen, Nikolaj H.T., Klein, Pontus, Valacca, Cristina, Bie, Anne, Magnoni, Raffaella, Pedersen, Marianne T., Lampp, Andrea C., Fog, Cathrine K., Kirkegaard, Thomas T.

Volltext

Arimoclomol increases the transcription of lysosomal genes, including NPC1 and NPC2, to facilitate lysosomal function von Petersen, Nikolaj H.T., Klein, Pontus, Valacca, Cristina, Bie, Anne, Magnoni, Raffaella, Pedersen, Marianne T., Lampp, Andrea C., Fog, Cathrine K., Kirkegaard, Thomas T.

Volltext

Conformational dynamics of free and membrane-bound human Hsp70 in model cytosolic and endo-lysosomal environments von Calvaresi, Valeria, Truelsen, Line T., Larsen, Sidsel B., Petersen, Nikolaj H. T., Kirkegaard, Thomas, Rand, Kasper D.

Volltext

Arimoclomol, a clinical candidate for neuronopathic Gaucher disease, increases glucocerebrosidase activity through amplification of heat shock proteins von Kirkegaard, Thomas, Fog-Tonnesen, Cathrine Kolster, Zago, Paola, Malini, Erika, Solanko, Lukasz, Bornaes, Claus, Magnoni, Raffaella, Petersen, Nikolaj H.T., Bembi, Bruno, Dardis, Andrea

Volltext

Efficacy and safety of arimoclomol in patients with Niemann-Pick disease type C: Results from a double-blind, randomized placebo-controlled trial with a novel treatment von Patterson, Marc, Mengel, Eugen, Bembi, Bruno, Del Toro, Mireia, Deodato, Federica, Gautschi, Matthias, Grunewald, Stephanie, Grønborg, Sabine, Harmatz, Paul, Heron-Longe, Benedicte, Maier, Esther M., Roubertie, Agathe, Santra, Saikat, Tylki-Szymanska, Anna, Day, Simon, Ingemann, Linda, Petersen, Nikolaj H.T., Jensen, Thomas Kirkegaard, Dali, Christine I.

Volltext

The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidaseResearch in context von Cathrine K. Fog, Paola Zago, Erika Malini, Lukasz M. Solanko, Paolo Peruzzo, Claus Bornaes, Raffaella Magnoni, Arnela Mehmedbasic, Nikolaj H.T. Petersen, Bruno Bembi, Johannes F.M.G. Aerts, Andrea Dardis, Thomas Kirkegaard

Volltext