Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia von Schneider, Pauline, Crump, Nicholas T, Arentsen-Peters, Susan T C J M, Smith, Alastair L, Hagelaar, Rico, Adriaanse, Fabienne R S, Bos, Romy S, de Jong, Anja, Nierkens, Stefan, Koopmans, Bianca, Milne, Thomas A, Pieters, Rob, Stam, Ronald W

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Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia von Wander, Priscilla, Cheung, Laurence C., Pinhanҫos, Sandra S., Jones, Luke, Kerstjens, Mark, Arentsen-Peters, Susan T.C.J.M., Singh, Sajla, Chua, Grace-Alyssa, Castro, Patricia Garrido, Schneider, Pauline, Dolman, M. Emmy M., Koopmans, Bianca, Molenaar, Jan J., Pieters, Rob, Zwaan, C. Michel, Kotecha, Rishi S., Stam, Ronald W.

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High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia von Wander, Priscilla, Arentsen-Peters, Susan T.C.J.M., Pinhanҫos, Sandra S., Koopmans, Bianca, Dolman, M.Emmy M., Ariese, Rijndert, Bos, Frank L., Castro, Patricia Garrido, Jones, Luke, Schneider, Pauline, Navarro, Miriam Guillen, Molenaar, Jan J., Rios, Anne C., Zwaan, C. Michel, Stam, Ronald W.

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BCOR and BCORL1 mutations in pediatric acute myeloid leukemia von de Rooij, Jasmijn D E, van den Heuvel-Eibrink, Marry M, Hermkens, Malou C H, Verboon, Lonneke J, Arentsen-Peters, Susan T C J M, Fornerod, Maarten, Baruchel, Andre, Stary, Jan, Reinhardt, Dirk, de Haas, Valerie, Pieters, Rob, Zwaan, C Michel

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Somatic thrombopoietin (THPO) gene mutations in childhood myeloid leukemias von Houwing, Maite E., Koopman-Coenen, Eva A., Kersseboom, Rogier, Gooskens, Saskia, Appel, Inge M., Arentsen-Peters, Susan T. C. J. M., de Vries, Andrica C. H., Reinhardt, Dirk, Stary, Jan, Baruchel, André, de Haas, Valerie, Blink, Marjolein, Lopes Cardozo, Rob H., Pieters, Rob, Michel Zwaan, C., van den Heuvel-Eibrink, Marry M.

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A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study von Den Boer, Monique L, Dr, van Slegtenhorst, Marjon, PhD, De Menezes, Renée X, PhD, Cheok, Meyling H, PhD, Buijs-Gladdines, Jessica GCAM, BSc, Peters, Susan TCJM, BSc, Van Zutven, Laura JCM, PhD, Beverloo, H Berna, PhD, Van der Spek, Peter J, Prof, Escherich, Gaby, PhD, Horstmann, Martin A, Prof, Janka-Schaub, Gritta E, Prof, Kamps, Willem A, Prof, Evans, William E, Prof, Pieters, Rob, Prof

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NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern von Hollink, Iris H.I.M., van den Heuvel-Eibrink, Marry M., Arentsen-Peters, Susan T.C.J.M., Pratcorona, Marta, Abbas, Saman, Kuipers, Jenny E., van Galen, Janneke F., Beverloo, H. Berna, Sonneveld, Edwin, Kaspers, Gert-Jan J.L., Trka, Jan, Baruchel, Andre, Zimmermann, Martin, Creutzig, Ursula, Reinhardt, Dirk, Pieters, Rob, Valk, Peter J.M., Zwaan, C. Michel

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Establishment and Characterization of a Model of Acquired Resistance to DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic Leukemia Cells von Schneider, Pauline, Arentsen-Peters, Susan T.C.J.M., Crump, Nicholas T., Smith, Alastair, Hagelaar, Rico, Adriaanse, Fabienne R.S., Bos, Romy S., Vrenken, Kirsten S., rockx-Brouwer, Dedeke, Tang, Ziqin, Vermeij, Wilbert P., De Jong, Anja, Koopmans, Bianca, Dolman, M.Emmy M., Milne, Thomas A., Pieters, Rob, Stam, Ronald W.

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CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in KMT2A-Rearranged Acute Lymphoblastic Leukemia von Schneider, Pauline, Wander, Priscilla, Arentsen-Peters, Susan T. C. J. M., Vrenken, Kirsten S., Rockx-Brouwer, Dedeke, Adriaanse, Fabienne R. S., Hoeve, Veerle, Paassen, Irene, Drost, Jarno, Pieters, Rob, Stam, Ronald W.

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Abstract 1925: High-throughput drug library screening identifies potent drugs and novel drug targets for high-risk acute leukemia in children von Wander, Priscilla, Pinhanços, Sandra S., Koopmans, Bianca, Dolman, M. Emmy M., Schneider, Pauline, Castro, Patricia Garrido, Jones, Luke, Arentsen-Peters, Susan T.C.J.M., Kerstjens, Mark, Molenaar, Jan, Caron, Huib N., Pieters, Rob, Zwaan, Michel C., Stam, Ronald W.

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Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia von BALGOBIND, Brian V, HOLLINK, Iris H. I. M, ZEMANOVA, Zuzana, STARY, Jan, CAYUELA, Jean-Michel, BARUCHEL, Andre, CREUTZIG, Ursula, REINHARDT, Dirk, PIETERS, Rob, MICHEL ZWAAN, C, VAN DEN HEUVEL-EIBRINK, Marry M, ARENTSEN-PETERS, Susan T. C. J. M, ZIMMERMANN, Martin, HARBOTT, Jochen, BERNA BEVERLOO, H, VON BERGH, Anne R. M, CLOOS, Jacqueline, KASPERS, Gertjan J. L, DE HAAS, Valerie

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Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia von Hollink, Iris H.I.M., van den Heuvel-Eibrink, Marry M., Zimmermann, Martin, Balgobind, Brian V., Arentsen-Peters, Susan T.C.J.M., Alders, Marielle, Willasch, Andre, Kaspers, Gertjan J.L., Trka, Jan, Baruchel, Andre, de Graaf, Siebold S.N., Creutzig, Ursula, Pieters, Rob, Reinhardt, Dirk, Zwaan, C. Michel

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Harnessing Gene Expression Profiles for the Identification of Ex Vivo Drug Response Genes in Pediatric Acute Myeloid Leukemia von Cucchi, David G J, Bachas, Costa, van den Heuvel-Eibrink, Marry M, Arentsen-Peters, Susan T C J M, Kwidama, Zinia J, Schuurhuis, Gerrit J, Assaraf, Yehuda G, de Haas, Valérie, Kaspers, Gertjan J L, Cloos, Jacqueline

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C-Terminal BRE Overexpression in 11q23-Rearranged and t(8;16) Acute Myeloid Leukemia Is Caused By Intragenic Transcription Initiation von Marneth, Anna E., Prange, Koen, Al Hinai, Adil S.A., Bergevoet, Saskia M., Tesi, Niccolo, Janssen-Megens, Eva, Kim, Bowon, Sharifi, Nilofar, Yaspo, Marie-Laure, Sanders, Mathijs A., Stoetman, Elodie C.G., Knijnenburg, Jeroen, Peters, Susan T.C.J.M., Zwaan, C. Michel, Stunnenberg, Hendrik G., van den Heuvel-Eibrink, Marry M., Haferlach, Torsten, Fornerod, Maarten, Jansen, Joop H., Valk, Peter J.M., Van der Reijden, Bert A., Martens, Joost H.A.

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High-Throughput Drug Library Screening in Primary KMT2A-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling von Wander, Priscilla, Arentsen-Peters, Susan T.C.J.M, Vrenken, Kirsten S, Pinhanҫos, Sandra Mimoso, Koopmans, Bianca, Dolman, M. Emmy M, Jones, Luke, Castro, Patricia Garrido, Schneider, Pauline, Kerstjens, Mark, Molenaar, Jan J, Pieters, Rob, Zwaan, Christian Michel, Stam, Ronald W

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Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia von HOLLINK, Iris H. I. M, VAN DEN HEUVEL-EIBRINK, Marry M, TRKA, Jan, BARUCHEL, Andre, CREUTZIG, Ursula, PIETERS, Rob, REINHARDT, Dirk, MICHEL ZWAAN, C, ARENTSEN-PETERS, Susan T. C. J. M, ZIMMERMANN, Martin, PEETERS, Justine K, VALK, Peter J. M, BALGOBIND, Brian V, SONNEVELD, Edwin, KASPERS, Gertjan J. L, DE BONT, Eveline S. J. M

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High-Throughput Drug Library Screening in Primary KMT2A -Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling von Wander, Priscilla, Arentsen-Peters, Susan T C J M, Vrenken, Kirsten S, Pinhanҫos, Sandra Mimoso, Koopmans, Bianca, Dolman, M Emmy M, Jones, Luke, Garrido Castro, Patricia, Schneider, Pauline, Kerstjens, Mark, Molenaar, Jan J, Pieters, Rob, Zwaan, Christian Michel, Stam, Ronald W

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No prognostic impact of the WT1 gene single nucleotide polymorphism rs16754 in pediatric acute myeloid leukemia von Hollink, Iris H I M, van den Heuvel-Eibrink, Marry M, Zimmermann, Martin, Balgobind, Brian V, Arentsen-Peters, Susan T C J M, Alders, Marielle, Willasch, Andre, Kaspers, Gert-Jan J L, Trka, Jan, Baruchel, Andre, Creutzig, Ursula, Pieters, Rob, Reinhardt, Dirk, Zwaan, C Michel

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CBL mutations do not frequently occur in paediatric acute myeloid leukaemia von Coenen, Eva A., Driessen, Emma M. C., Zwaan, C.Michel, Stary, Jan, Baruchel, Andre, de Haas, Valerie, de Bont, Eveline S. J. M., Reinhardt, Dirk, Kaspers, Gertjan J. L., Arentsen-Peters, Susan T. C. J. M., Meyer, Claus, Marschalek, Rolf, Pieters, Rob, Stam, Ronald W., van den Heuvel-Eibrink, Marry M.

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NUP98/JARID1A Is a New Recurrent Genetic Abnormality in Pediatric Acute Megakaryoblastic Leukemia with a Distinct HOX-Gene Expression Pattern von de Rooij, Jasmijn D.E., van den Heuvel-Eibrink, Marry M., Hollink, Iris H.I.M., Arentsen-Peters, Susan T.C.J.M., Beverloo, H. Berna, van Galen, Janneke F., Baruchel, Andre, Trka, Jan, Reinhardt, Dirk, Sonneveld, Edwin, Zimmermann, Martin, Alonzo, Todd A., Pieters, Rob, Meshinchi, Soheil, Zwaan, C. Michel

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