Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries von Bhatta, Pallavi, Whale, Kevin D, Sawtell, Amy K, Thompson, Clare L, Rapecki, Stephen E, Cook, David A, Twomey, Breda M, Mennecozzi, Milena, Starkie, Laura E, Barry, Emily M C, Peters, Shirley J, Kamal, Ahmad M, Finney, Helene M

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On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation von Sopp, Joshua M., Peters, Shirley J., Rowley, Tania F., Oldham, Robert J., James, Sonya, Mockridge, Ian, French, Ruth R., Turner, Alison, Beers, Stephen A., Humphreys, David P., Cragg, Mark S.

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Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry von Pacholarz, Kamila J., Peters, Shirley J., Garlish, Rachel A., Henry, Alistair J., Taylor, Richard J., Humphreys, David P., Barran, Perdita E.

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Engineering an Improved IgG4 Molecule with Reduced Disulfide Bond Heterogeneity and Increased Fab Domain Thermal Stability von Peters, Shirley J., Smales, C. Mark, Henry, Alistair J., Stephens, Paul E., West, Shauna, Humphreys, David P.

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Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions von Rowley, Tania F., Peters, Shirley J., Aylott, Mike, Griffin, Robert, Davies, Nicola L., Healy, Louise J., Cutler, Rona M., Eddleston, Alison, Pither, Thomas L., Sopp, Joshua M., Zaccheo, Oliver, Fossati, Gianluca, Cain, Katharine, Ventom, Andrew M., Hailu, Hanna, Ward, Eleanor J., Sherington, John, Brennan, Frank R., Fallah-Arani, Farnaz, Humphreys, David P.

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Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries von Bhatta, Pallavi, Whale, Kevin D., Sawtell, Amy K., Thompson, Clare L., Rapecki, Stephen E., Cook, David A., Twomey, Breda M., Mennecozzi, Milena, Starkie, Laura E., Barry, Emily M. C., Peters, Shirley J., Kamal, Ahmad M., Finney, Helene M.

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SEQUENCE SYMMETRIC MODIFIED IGG4 BISPECIFIC ANTIBODIES IGG4 von PETERS, SHIRLEY, JANE SJ, HUMPHREYS, DAIVD, PAUL DP

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SEQUENCE SYMMETRIC MODIFIED IGG4 BISPECIFIC ANTIBODIES IGG4 von PETERS, SHIRLEY JANE SJ, HUMPHREYS, DAVID PAUL DP

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The Effect of a New Multimodal Perioperative Anesthetic Regimen on Postoperative Pain, Side Effects, Rehabilitation, and Length of Hospital Stay After Total Joint Arthroplasty von Peters, Christopher L., Shirley, Brayton, Erickson, Jill

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Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas von Palles, Claire, Cazier, Jean-Baptiste, Howarth, Kimberley M, Domingo, Enric, Jones, Angela M, Broderick, Peter, Kemp, Zoe, Spain, Sarah L, Guarino, Estrella, Salguero, Israel, Sherborne, Amy, Chubb, Daniel, Carvajal-Carmona, Luis G, Ma, Yusanne, Kaur, Kulvinder, Dobbins, Sara, Barclay, Ella, Gorman, Maggie, Martin, Lynn, Kovac, Michal B, Humphray, Sean, Lucassen, Anneke, Holmes, Christopher C, Bentley, David, Donnelly, Peter, Taylor, Jenny, Petridis, Christos, Roylance, Rebecca, Sawyer, Elinor J, Kerr, David J, Clark, Susan, Grimes, Jonathan, Kearsey, Stephen E, Thomas, Huw J W, McVean, Gilean, Houlston, Richard S, Tomlinson, Ian

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Prehospital Tranexamic Acid for Severe Trauma von Gruen, Russell L, Mitra, Biswadev, Bernard, Stephen A, McArthur, Colin J, Burns, Brian, Gantner, Dashiell C, Maegele, Marc, Cameron, Peter A, Dicker, Bridget, Forbes, Andrew B, Hurford, Sally, Martin, Catherine A, Mazur, Stefan M, Medcalf, Robert L, Murray, Lynnette J, Myles, Paul S, Ng, Sze J, Pitt, Veronica, Rashford, Stephen, Reade, Michael C, Swain, Andrew H, Trapani, Tony, Young, Paul J

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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms von Gordon, David E, Hiatt, Joseph, Bouhaddou, Mehdi, Rezelj, Veronica V, Ulferts, Svenja, Braberg, Hannes, Jureka, Alexander S, Obernier, Kirsten, Guo, Jeffrey Z, Batra, Jyoti, Kaake, Robyn M, Weckstein, Andrew R, Owens, Tristan W, Gupta, Meghna, Pourmal, Sergei, Titus, Erron W, Cakir, Merve, Soucheray, Margaret, McGregor, Michael, Cakir, Zeynep, Jang, Gwendolyn, O'Meara, Matthew J, Tummino, Tia A, Zhang, Ziyang, Foussard, Helene, Rojc, Ajda, Zhou, Yuan, Kuchenov, Dmitry, Hüttenhain, Ruth, Xu, Jiewei, Eckhardt, Manon, Swaney, Danielle L, Fabius, Jacqueline M, Ummadi, Manisha, Tutuncuoglu, Beril, Rathore, Ujjwal, Modak, Maya, Haas, Paige, Haas, Kelsey M, Naing, Zun Zar Chi, Pulido, Ernst H, Shi, Ying, Barrio-Hernandez, Inigo, Memon, Danish, Petsalaki, Eirini, Dunham, Alistair, Marrero, Miguel Correa, Burke, David, Koh, Cassandra, Vallet, Thomas, Silvas, Jesus A, Azumaya, Caleigh M, Billesbølle, Christian, Brilot, Axel F, Campbell, Melody G, Diallo, Amy, Dickinson, Miles Sasha, Diwanji, Devan, Herrera, Nadia, Hoppe, Nick, Kratochvil, Huong T, Liu, Yanxin, Merz, Gregory E, Moritz, Michelle, Nguyen, Henry C, Nowotny, Carlos, Puchades, Cristina, Rizo, Alexandrea N, Schulze-Gahmen, Ursula, Smith, Amber M, Sun, Ming, Young, Iris D, Zhao, Jianhua, Asarnow, Daniel, Biel, Justin, Bowen, Alisa, Braxton, Julian R, Chen, Jen, Chio, Cynthia M, Chio, Un Seng, Deshpande, Ishan, Doan, Loan, Faust, Bryan, Flores, Sebastian, Jin, Mingliang, Kim, Kate, Lam, Victor L, Li, Fei, Li, Junrui, Li, Yen-Li, Li, Yang, Liu, Xi, Lo, Megan, Lopez, Kyle E, Melo, Arthur A, Moss, 3rd, Frank R, Nguyen, Phuong, Paulino, Joana, Pawar, Komal Ishwar, Peters, Jessica K

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Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury von Bagshaw, Sean M, Wald, Ron, Adhikari, Neill K J, Bellomo, Rinaldo, da Costa, Bruno R, Dreyfuss, Didier, Du, Bin, Gallagher, Martin P, Gaudry, Stéphane, Hoste, Eric A, Lamontagne, François, Joannidis, Michael, Landoni, Giovanni, Liu, Kathleen D, McAuley, Daniel F, McGuinness, Shay P, Neyra, Javier A, Nichol, Alistair D, Ostermann, Marlies, Palevsky, Paul M, Pettilä, Ville, Quenot, Jean-Pierre, Qiu, Haibo, Rochwerg, Bram, Schneider, Antoine G, Smith, Orla M, Thomé, Fernando, Thorpe, Kevin E, Vaara, Suvi, Weir, Matthew, Wang, Amanda Y, Young, Paul, Zarbock, Alexander

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Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation von Perez, Marco V, Mahaffey, Kenneth W, Hedlin, Haley, Rumsfeld, John S, Garcia, Ariadna, Ferris, Todd, Balasubramanian, Vidhya, Russo, Andrea M, Rajmane, Amol, Cheung, Lauren, Hung, Grace, Lee, Justin, Kowey, Peter, Talati, Nisha, Nag, Divya, Gummidipundi, Santosh E, Beatty, Alexis, Hills, Mellanie True, Desai, Sumbul, Granger, Christopher B, Desai, Manisha, Turakhia, Mintu P

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An integrated encyclopedia of DNA elements in the human genome von Kundaje, Anshul, Collins, Patrick J, Davis, Carrie A, Khatun, Jainab, Lajoie, Bryan R, Landt, Stephen G, Safi, Alexias, Altshuler, Robert C, Cheng, Chao, Greven, Melissa, Hoffman, Michael M, Lassmann, Timo, Thurman, Robert E, Wu, Weisheng, Xi, Hualin S, Zhuang, Jiali, Gunter, Chris, Dekker, Job, Elnitski, Laura, Giddings, Morgan C, Margulies, Elliott H, Stamatoyannopoulos, John A, Wold, Barbara, Kuiper, Heather C, Dobin, Alex, Tanzer, Andrea, Xue, Chenghai, Zaleski, Chris, Roder, Maik, Baer, Michael T, Bell, Kimberly, Gordon, Assaf, Howald, Cedric, Johnson, Rory, Kingswood, Colin, Li, Guoliang, Luo, Oscar J, Robyr, Daniel, Ruan, Xiaoan, Skancke, Jorgen, Suzuki, Ana Maria, Takahashi, Hazuki, Tilgner, Hagen, Wang, Huaien, Hayashizaki, Yoshihide, Hannon, Gregory J, Malladi, Venkat S, Dreszer, Timothy R, Showers, Kimberly A, London, Darin, Zhang, Zhancheng, Keefe, Damian, Zheng, Meizhen, Vielmetter, Jost, Jain, Preti, Pusey, Barbara, Meadows, Sarah K, Absher, Devin M, Pennachio, Len A, Abyzov, Alexej, Barrell, Daniel, Bignell, Alexandra, Diekhans, Mark, Ezkurdia, Iakes, Frankish, Adam, Hunt, Toby, Jungreis, Irwin, Loveland, Jane, Manthravadi, Deepa, Pei, Baikang, Snow, Catherine, Zhang, Zhengdong, Alexander, Roger P, Balasubramanian, Suganthi, Bettinger, Keith, Cayting, Philip, Habegger, Lukas, Lamarre-Vincent, Nathan, Lindahl-Allen, Marianne, Monahan, Hannah, Patacsil, Dorrelyn, Struhl, Kevin, Ma, Lijia, Inoue, Daigo, Kellner, Tanja, Kirchmaier, Stephan, Bates, Daniel L, Canfield, Theresa K, Boatman, Lisa, Neph, Shane J, Roach, Vaughn, Sanchez, Minerva E, Shafer, Anthony O, Vernot, Benjamin, Weaver, Molly A, Akey, Joshua M, Bender, Michael, Navas, Patrick, Hussami, Nadine, Schaub, Marc A

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Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI von Yuh, Esther L, Jain, Sonia, Sun, Xiaoying, Pisica, Dana, Harris, Mark H, Taylor, Sabrina R, Markowitz, Amy J, Mukherjee, Pratik, Verheyden, Jan, Giacino, Joseph T, Levin, Harvey S, McCrea, Michael, Stein, Murray B, Temkin, Nancy R, Diaz-Arrastia, Ramon, Robertson, Claudia S, Lingsma, Hester F, Okonkwo, David O, Maas, Andrew I.R, Manley, Geoffrey T, Adeoye, Opeolu, Badjatia, Neeraj, Boase, Kim, Bodien, Yelena, Corrigan, John D, Crawford, Karen, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, V. Ramana, Ferguson, Adam R, Foreman, Brandon, Gardner, Raquel, Gaudette, Etienne, Gonzalez, Luis, Gopinath, Shankar, Gullapalli, Rao, Hemphill, J. Claude, Hotz, Gillian, Keene, C. Dirk, Kramer, Joel, Kreitzer, Natalie, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Martin, Alastair, McAllister, Thomas, Merchant, Randall, Nelson, Lindsay, Ngwenya, Laura B, Noel, Florence, Nolan, Amber, Palacios, Eva, Perl, Daniel, Rabinowitz, Miri, Rosand, Jonathan, Sander, Angelle, Satris, Gabriella, Schnyer, David, Seabury, Seth, Toga, Arthur, Valadka, Alex, Vassar, Mary, Zafonte, Ross

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High bias gas flows increase lung injury in the ventilated preterm lamb von Bach, Katinka P, Kuschel, Carl A, Hooper, Stuart B, Bertram, Jean, McKnight, Sue, Peachey, Shirley E, Zahra, Valerie A, Flecknoe, Sharon J, Oliver, Mark H, Wallace, Megan J, Bloomfield, Frank H

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Defining the Newborn Blood Spot Screening Reference Interval for TSH: Impact of Ethnicity von Peters, Catherine, Brooke, Ivan, Heales, Simon, Ifederu, Adeboye, Langham, Shirley, Hindmarsh, Peter, Cole, Tim J

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Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma von Motzer, Robert, Alekseev, Boris, Rha, Sun-Young, Porta, Camillo, Eto, Masatoshi, Powles, Thomas, Grünwald, Viktor, Hutson, Thomas E, Kopyltsov, Evgeny, Méndez-Vidal, María J, Kozlov, Vadim, Alyasova, Anna, Hong, Sung-Hoo, Kapoor, Anil, Alonso Gordoa, Teresa, Merchan, Jaime R, Winquist, Eric, Maroto, Pablo, Goh, Jeffrey C, Kim, Miso, Gurney, Howard, Patel, Vijay, Peer, Avivit, Procopio, Giuseppe, Takagi, Toshio, Melichar, Bohuslav, Rolland, Frederic, De Giorgi, Ugo, Wong, Shirley, Bedke, Jens, Schmidinger, Manuela, Dutcus, Corina E, Smith, Alan D, Dutta, Lea, Mody, Kalgi, Perini, Rodolfo F, Xing, Dongyuan, Choueiri, Toni K

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Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study von Frisvold, Shirin, Menon, David Krishna, Moore, Elizabeth Madeleine, Steyerberg, Ewout Willem, van der Jagt, Mathieu, Cooper, Jamie D., Schoechl, Herbert, Van Praag, Dominique, Maas, Andrew I.R., Vande Vyvere, Thijs, Depreitere, Bart, Van Hecke, Wim, Ghuysen, Alexandre, Gao, Guoyi, Jiang, Ji-yao, Fabricius, Martin, Raj, Rahul, Pirinen, Matti, Audibert, Gérard, Degos, Vincent, Benali, Habib, Galanaud, Damien, Legrand, Valerie, Dahyot-Fizelier, Claire, Kowark, Ana, Vajkoczy, Peter, Maegele, Marc, Gratz, Johannes, Bullinger, Monika, Younsi, Alexander, Sakowitz, Oliver, Melegh, Béla, Sorinola, Abayomi, Kovács, Noémi, Nyirádi, József, Amrein, Krisztina, Azzolini, Maria Luisa, Stocchetti, Nino, Carbonara, Marco, Citerio, Giuseppe, Chieregato, Arturo, Chevallard, Giorgio, Della Corte, Francesco, Rossi, Sandra, Tamosuitis, Tomas, Rocka, Saulius, Steyerberg, Ewout W., Kompanje, Erwin, Timmers, Marjolijn, Haitsma, Iain, van der Jagt, Mathieu, Voormolen, Daphne, Wiegers, Eveline, Polinder, Suzanne, Tibboel, Dick, van Wijk, Roel, van Dijck, Jeroen T.J.M., Schoonman, Guus, Te Ao, Braden, Andelic, Nada, Frisvold, Shirin, Vik, Anne, Ples, Horia, Vulekovic, Peter, Karan, Mladen, Golubovic, Jagoš, Taylor, Mark Steven, Majdan, Marek, Sahuquillo, Juan, Radoi, Andreea, Lanyon, Linda, George, Pradeep, Muraleedharan, Visakh, Ackerlund, Cecilia, Koskinen, Lars-Owe, Sundström, Nina, Manara, Alex, Coles, Jonathan, Stamatakis, Emmanuel, Williams, Guy, Ercole, Ari, Dixit, Abhishek, Newcombe, Virginia, McFadyen, Charles, Adams, Hadie, McMahon, Catherine, Rueckert, Daniel, Esser, Patrick, van Heugten, Caroline, Stanworth, Simon, Otesile, Olubukola, Lightfoot, Roger, Horton, Lindsay, Rosand, Jonathan, Wang, Kevin K.W., Yang, Zhihui, Gruen, Russell L., Cameron, Peter, Varma, Dinesh, Jordan, Andrea

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