Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells von Shapiro, Melanie R, Peters, Leeana D, Brown, Matthew E, Cabello-Kindelan, Cecilia, Posgai, Amanda L, Bayer, Allison L, Brusko, Todd M

Volltext

Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function von Brown, Matthew E., Thirawatananond, Puchong, Peters, Leeana D., Kern, Elizabeth J., Vijay, Sonali, Sachs, Lindsey K., Posgai, Amanda L., Brusko, Maigan A., Shapiro, Melanie R., Mathews, Clayton E., Bacher, Rhonda, Brusko, Todd M.

Volltext

1663-P: Gene Editing of the Human T-Cell Receptor Locus Enables Optimized In Vitro Testing of Autoreactive T-Cell Function in Type 1 Diabetes von PETERS, LEEANA D., POSGAI, AMANDA L., BRUSKO, TODD M.

Volltext

Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood von Motwani, Keshav, Peters, Leeana D, Vliegen, Willem H, El-Sayed, Ahmed Gomaa, Seay, Howard R, Lopez, M Cecilia, Baker, Henry V, Posgai, Amanda L, Brusko, Maigan A, Perry, Daniel J, Bacher, Rhonda, Larkin, Joseph, Haller, Michael J, Brusko, Todd M

Volltext

Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8 + T cells von Peters, Leeana D, Yeh, Wen-I, Arnoletti, Juan M, Brown, Matthew E, Posgai, Amanda L, Mathews, Clayton E, Brusko, Todd M

Volltext

Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4 + T Cell Activation von Perry, Daniel J, Peters, Leeana D, Lakshmi, Priya Saikumar, Zhang, Lin, Han, Zhao, Wasserfall, Clive H, Mathews, Clayton E, Atkinson, Mark A, Brusko, Todd M

Volltext

Innate inflammation drives NK cell activation to impair Treg activity von Dean, Joseph W., Peters, Leeana D., Fuhrman, Christopher A., Seay, Howard R., Posgai, Amanda L., Stimpson, Scott E., Brusko, Maigan A., Perry, Daniel J., Yeh, Wen-I., Newby, Brittney N., Haller, Michael J., Muir, Andrew B., Atkinson, Mark A., Mathews, Clayton E., Brusko, Todd M.

Volltext

Human CD4+CD25+CD226- Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4+CD25+CD127lo/- Tregs for Adoptive Cell Therapy von Brown, Matthew E., Peters, Leeana D., Hanbali, Seif R., Arnoletti, Juan M., Sachs, Lindsey K., Nguyen, Kayla Q., Carpenter, Emma B., Seay, Howard R., Fuhrman, Christopher A., Posgai, Amanda L., Shapiro, Melanie R., Brusko, Todd M.

Volltext

Immune engineered extracellular vesicles to modulate T cell activation in the context of type 1 diabetes von Becker, Matthew W, Peters, Leeana D, Myint, Thinzar, Smurlick, Dylan, Powell, Andrece, Brusko, Todd M, Phelps, Edward A

Volltext

Human immune phenotyping reveals accelerated aging in type 1 diabetes von Shapiro, Melanie R, Dong, Xiaoru, Perry, Daniel J, McNichols, James M, Thirawatananond, Puchong, Posgai, Amanda L, Peters, Leeana D, Motwani, Keshav, Musca, Richard S, Muir, Andrew, Concannon, Patrick, Jacobsen, Laura M, Mathews, Clayton E, Wasserfall, Clive H, Haller, Michael J, Schatz, Desmond A, Atkinson, Mark A, Brusko, Maigan A, Bacher, Rhonda, Brusko, Todd M

Volltext

A genomic data archive from the Network for Pancreatic Organ donors with Diabetes von Perry, Daniel J., Shapiro, Melanie R., Chamberlain, Sonya W., Kusmartseva, Irina, Chamala, Srikar, Balzano-Nogueira, Leandro, Yang, Mingder, Brant, Jason O., Brusko, Maigan, Williams, MacKenzie D., McGrail, Kieran M., McNichols, James, Peters, Leeana D., Posgai, Amanda L., Kaddis, John S., Mathews, Clayton E., Wasserfall, Clive H., Webb-Robertson, Bobbie-Jo M., Campbell-Thompson, Martha, Schatz, Desmond, Evans-Molina, Carmella, Pugliese, Alberto, Concannon, Patrick, Anderson, Mark S., German, Michael S., Chamberlain, Chester E., Atkinson, Mark A., Brusko, Todd M.

Volltext

Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy von Seay, Howard R, Putnam, Amy L, Cserny, Judit, Posgai, Amanda L, Rosenau, Emma H, Wingard, John R, Girard, Kate F, Kraus, Morey, Lares, Angela P, Brown, Heather L, Brown, Katherine S, Balavage, Kristi T, Peters, Leeana D, Bushdorf, Ashley N, Atkinson, Mark A, Bluestone, Jeffrey A, Haller, Michael J, Brusko, Todd M

Volltext

Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism von Li, Wei, Gong, Minghao, Park, Yuk Pheel, Elshikha, Ahmed S, Choi, Seung-Chul, Brown, Josephine, Kanda, Nathalie, Yeh, Wen-I, Peters, Leeana, Titov, Anton A, Teng, Xiangyu, Brusko, Todd M, Morel, Laurence

Volltext

The signal regulatory protein gamma (SIRPγ) signaling constrains naïve CD8+ T cell activation with T1D risk associated polymorphisms leading to augmented T cell activation von Sharp, Robert C, Brown, Matthew, Peters, Leeana, Brusko, Todd

Volltext

De‐coding genetic risk variants in type 1 diabetes von Shapiro, Melanie R, Thirawatananond, Puchong, Peters, Leeana, Sharp, Robert C, Ogundare, Similoluwa, Posgai, Amanda L, Perry, Daniel J, Brusko, Todd M

Volltext

Human CD4 + CD25 + CD226 - Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4 + CD25 + CD127 lo/- Tregs for Adoptive Cell Therapy von Brown, Matthew E, Peters, Leeana D, Hanbali, Seif R, Arnoletti, Juan M, Sachs, Lindsey K, Nguyen, Kayla Q, Carpenter, Emma B, Seay, Howard R, Fuhrman, Christopher A, Posgai, Amanda L, Shapiro, Melanie R, Brusko, Todd M

Volltext