1224 Tregs constrain CD8 + T cell priming required for curative intratumorally anchored anti-4–1BB immunotherapy von Palmeri, Joseph R, Lax, Brianna M, Peters, Josh M, Duhamel, Lauren, Stinson, Jordan A, Santollani, Luciano, Lutz, Emi A, Pinney, William, Bryson, Bryan D, Dane Wittrup, K

Volltext

CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity von Rogers, Justin T, Morganti, Josh M, Bachstetter, Adam D, Hudson, Charles E, Peters, Melinda M, Grimmig, Bethany A, Weeber, Edwin J, Bickford, Paula C, Gemma, Carmelina

Volltext

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders von Võsa, Urmo, Stathopoulou, Maria G., de Vries, Paul S., Tanaka, Toshiko, Wu, Ying, Karlsson, Robert, Pool, René, Kemp, John P., Verweij, Niek, Smith, Albert V., Huq, Mahmudul, Deelen, Joris, Alizadeh, Behrooz Z., van der Harst, Pim, Navis, Gerjan, Snieder, Harold, Chasman, Daniel I., Meigs, James, Ligthart, Symen, Bis, Josh, Gross, Myron, Koenig, Wolfgang, Uher, Rudolf, Ward-Caviness, Cavin, Boerwinkle, Eric, Stacey, David, Eriksson, Johan, Lahti, Jari, Schraut, Katharina E., Suktitipat, Bhoom, Nutile, Teresa, Schork, Nicholas, Thiering, Elisabeth, Mahajan, Anubha, Aslibekyan, Stella, Yengo, Loïc, Rajan, Kumar B., Timpson, Nicholas, Huang, Hongyan, Uh, Hae-Won, Yanek, Lisa R., Verbanck, Marie, Magnusson, Patrik K.E., Ballantyne, Christie M., Montgomery, Grant W., Rueedi, Rico, Steri, Maristella, Stott, David J., Felix, Stephan B., Kraft, Peter, Seppälä, Ilkka, Williams, Stephen R., Moed, Matthijs, Langenberg, Claudia, Räikkönen, Katri, Sale, Michele M., Chen, Yii-Der I., James, Alan L., Soranzo, Nicole, Berenson, Gerald S., Liewald, David, Beilby, John, Ryan, Kathleen A., Balkau, Beverly, Paternoster, Lavinia, Kähönen, Mika, Sattar, Naveed, van Heemst, Diana, Gambaro, Giovanni, Ferrucci, Luigi, Karlsson, Magnus, Lind, Lars, Mori, Trevor A., Buckley, Brendan M., de Craen, Anton J.M., Scott, Rodney J., Strachan, David P., Jarvelin, Marjo-Riitta, Jukema, J. Wouter, Hamsten, Anders, Gudnason, Vilmundur, Qi, Lu, März, Winfried, Penninx, Brenda W.J.H., Worrall, Bradford B., Gibson, Greg, Oldehinkel, Albertine J., Murray, Sarah S., Pramstaller, Peter P., Deary, Ian J., Desch, Karl C., Hayward, Caroline, Arnett, Donna K., Jess, Tine, Psaty, Bruce M., Tracy, Russell P., Nolte, Ilja M., Visvikis-Siest, Sophie, Franke, Lude, Franco, Oscar H.

Volltext

Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI von Peters, Bas J.M, Pett, Helmi, Klungel, Olaf H, Stricker, Bruno H. Ch, Psaty, Bruce M, Glazer, Nicole L, Wiggins, Kerri L, Bis, Josh C, de Boer, Anthonius, Maitland-van der Zee, Anke-Hilse

Volltext

Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations von Lennon, Niall J., Kottyan, Leah C., Kachulis, Christopher, Abul-Husn, Noura S., Arias, Josh, Belbin, Gillian, Below, Jennifer E., Berndt, Sonja I., Chung, Wendy K., Cimino, James J., Clayton, Ellen Wright, Connolly, John J., Crosslin, David R., Dikilitas, Ozan, Velez Edwards, Digna R., Feng, QiPing, Fisher, Marissa, Freimuth, Robert R., Ge, Tian, Glessner, Joseph T., Gordon, Adam S., Patterson, Candace, Hakonarson, Hakon, Harden, Maegan, Harr, Margaret, Hirschhorn, Joel N., Hoggart, Clive, Hsu, Li, Irvin, Marguerite R., Jarvik, Gail P., Karlson, Elizabeth W., Khan, Atlas, Khera, Amit, Kiryluk, Krzysztof, Kullo, Iftikhar, Larkin, Katie, Limdi, Nita, Linder, Jodell E., Loos, Ruth J. F., Luo, Yuan, Malolepsza, Edyta, Manolio, Teri A., Martin, Lisa J., McCarthy, Li, McNally, Elizabeth M., Meigs, James B., Mersha, Tesfaye B., Mosley, Jonathan D., Musick, Anjene, Namjou, Bahram, Pai, Nihal, Pesce, Lorenzo L., Peters, Ulrike, Peterson, Josh F., Prows, Cynthia A., Puckelwartz, Megan J., Rehm, Heidi L., Roden, Dan M., Rosenthal, Elisabeth A., Rowley, Robb, Sawicki, Konrad Teodor, Schaid, Daniel J., Smit, Roelof A. J., Smith, Johanna L., Smoller, Jordan W., Thomas, Minta, Tiwari, Hemant, Toledo, Diana M., Vaitinadin, Nataraja Sarma, Veenstra, David, Walunas, Theresa L., Wang, Zhe, Wei, Wei-Qi, Weng, Chunhua, Wiesner, Georgia L., Yin, Xianyong, Kenny, Eimear E.

Volltext

Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism von BÜLLER, Harry R, DECOUSUS, Hervé, MINGGAO SHI, VERHAMME, Peter, WELLS, Phil, GROSSO, Michael A, MERCURI, Michele, MIDDELDORP, Saskia, PRINS, Martin H, RASKOB, Gary E, SCHELLONG, Sebastian M, SCHWOCHO, Lee, SEGERS, Annelise

Volltext

Notch signalling drives synovial fibroblast identity and arthritis pathology von Wei, Kevin, Korsunsky, Ilya, Marshall, Jennifer L., Gao, Anqi, Watts, Gerald F. M., Major, Triin, Croft, Adam P., Watts, Jordan, Blazar, Philip E., Lange, Jeffrey K., Thornhill, Thomas S., Filer, Andrew, Raza, Karim, Donlin, Laura T., Siebel, Christian W., Buckley, Christopher D., Raychaudhuri, Soumya, Brenner, Michael B.

Volltext

Tillage and cover crops effects on crop yield in wheat double‐cropping systems von Egbedi, Peters E., Fultz, L. M., Copes, Josh, Dodla, Syam, Parvej, Rasel, Netterville, Melanie

Volltext

Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial von Russell, Derek W, Casey, Jonathan D, Gibbs, Kevin W, Ghamande, Shekhar, Dargin, James M, Vonderhaar, Derek J, Joffe, Aaron M, Khan, Akram, Prekker, Matthew E, Brewer, Joseph M, Dutta, Simanta, Landsperger, Janna S, White, Heath D, Robison, Sarah W, Wozniak, Joanne M, Stempek, Susan, Barnes, Christopher R, Krol, Olivia F, Arroliga, Alejandro C, Lat, Tasnim, Gandotra, Sheetal, Gulati, Swati, Bentov, Itay, Walters, Andrew M, Dischert, Kevin M, Nonas, Stephanie, Driver, Brian E, Wang, Li, Lindsell, Christopher J, Self, Wesley H, Rice, Todd W, Janz, David R, Semler, Matthew W

Volltext

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation von Jaiswal, Bijay S., Janakiraman, Vasantharajan, Kljavin, Noelyn M., Chaudhuri, Subhra, Stern, Howard M., Wang, Weiru, Kan, Zhengyan, Dbouk, Hashem A., Peters, Brock A., Waring, Paul, Dela Vega, Trisha, Kenski, Denise M., Bowman, Krista K., Lorenzo, Maria, Li, Hong, Wu, Jiansheng, Modrusan, Zora, Stinson, Jeremy, Eby, Michael, Yue, Peng, Kaminker, Josh S., de Sauvage, Frederic J., Backer, Jonathan M., Seshagiri, Somasekar

Volltext

Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo von Ikram, M Kamran, Sim, Xueling, Xueling, Sim, Jensen, Richard A, Cotch, Mary Frances, Hewitt, Alex W, Ikram, M Arfan, Wang, Jie Jin, Klein, Ronald, Klein, Barbara E K, Breteler, Monique M B, Cheung, Ning, Liew, Gerald, Mitchell, Paul, Uitterlinden, Andre G, Rivadeneira, Fernando, Hofman, Albert, de Jong, Paulus T V M, van Duijn, Cornelia M, Kao, Linda, Cheng, Ching-Yu, Smith, Albert Vernon, Glazer, Nicole L, Lumley, Thomas, McKnight, Barbara, Psaty, Bruce M, Jonasson, Fridbert, Eiriksdottir, Gudny, Aspelund, Thor, Harris, Tamara B, Launer, Lenore J, Taylor, Kent D, Li, Xiaohui, Iyengar, Sudha K, Xi, Quansheng, Sivakumaran, Theru A, Mackey, David A, Macgregor, Stuart, Martin, Nicholas G, Young, Terri L, Bis, Josh C, Wiggins, Kerri L, Heckbert, Susan R, Hammond, Christopher J, Andrew, Toby, Fahy, Samantha, Attia, John, Holliday, Elizabeth G, Scott, Rodney J, Islam, F M Amirul, Rotter, Jerome I, McAuley, Annie K, Boerwinkle, Eric, Tai, E Shyong, Gudnason, Vilmundur, Siscovick, David S, Vingerling, Johannes R, Wong, Tien Y

Volltext

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease von Stitziel, Nathan O, Stirrups, Kathleen E, Masca, Nicholas G D, Erdmann, Jeanette, Ferrario, Paola G, König, Inke R, Weeke, Peter E, Webb, Thomas R, Auer, Paul L, Schick, Ursula M, Lu, Yingchang, Zhang, He, Dube, Marie-Pierre, Goel, Anuj, Farrall, Martin, Peloso, Gina M, Won, Hong-Hee, Do, Ron, van Iperen, Erik, Kanoni, Stavroula, Kruppa, Jochen, Mahajan, Anubha, Scott, Robert A, Willenberg, Christina, Braund, Peter S, van Capelleveen, Julian C, Doney, Alex S F, Donnelly, Louise A, Asselta, Rosanna, Merlini, Piera A, Duga, Stefano, Marziliano, Nicola, Denny, Josh C, Shaffer, Christian M, El-Mokhtari, Nour Eddine, Franke, Andre, Gottesman, Omri, Heilmann, Stefanie, Hengstenberg, Christian, Hoffman, Per, Holmen, Oddgeir L, Hveem, Kristian, Jansson, Jan-Håkan, Jöckel, Karl-Heinz, Kessler, Thorsten, Kriebel, Jennifer, Laugwitz, Karl L, Marouli, Eirini, Martinelli, Nicola, McCarthy, Mark I, Van Zuydam, Natalie R, Meisinger, Christa, Esko, Tõnu, Mihailov, Evelin, Escher, Stefan A, Alver, Maris, Moebus, Susanne, Morris, Andrew D, Müller-Nurasyid, Martina, Nikpay, Majid, Olivieri, Oliviero, Lemieux Perreault, Louis-Philippe, AlQarawi, Alaa, Robertson, Neil R, Akinsanya, Karen O, Reilly, Dermot F, Vogt, Thomas F, Yin, Wu, Asselbergs, Folkert W, Kooperberg, Charles, Jackson, Rebecca D, Stahl, Eli, Strauch, Konstantin, Varga, Tibor V, Waldenberger, Melanie, Zeng, Lingyao, Kraja, Aldi T, Liu, Chunyu, Ehret, George B, Newton-Cheh, Christopher, Chasman, Daniel I, Chowdhury, Rajiv, Ferrario, Marco, Ford, Ian, Jukema, J Wouter, Kee, Frank, Kuulasmaa, Kari, Nordestgaard, Børge G, Perola, Markus, Saleheen, Danish, Sattar, Naveed, Surendran, Praveen, Tregouet, David, Young, Robin, Howson, Joanna M M, Butterworth, Adam S, Danesh, John, Ardissino, Diego, Bottinger, Erwin P, Erbel, Raimund

Volltext

Unraveling the functional dark matter through global metagenomics von Pavlopoulos, Georgios A., Baltoumas, Fotis A., Liu, Sirui, Selvitopi, Oguz, Camargo, Antonio Pedro, Nayfach, Stephen, Azad, Ariful, Roux, Simon, Call, Lee, Ivanova, Natalia N., Chen, I. Min, Paez-Espino, David, Karatzas, Evangelos, Iliopoulos, Ioannis, Konstantinidis, Konstantinos, Tiedje, James M., Pett-Ridge, Jennifer, Baker, David, Visel, Axel, Ouzounis, Christos A., Ovchinnikov, Sergey, Buluç, Aydin, Kyrpides, Nikos C.

Volltext

Anterior Vertebral Body Tethering Compared with Posterior Spinal Fusion for Major Thoracic Curves: A Retrospective Comparison by the Harms Study Group von Newton, Peter O, Parent, Stefan, Miyanji, Firoz, Alanay, Ahmet, Lonner, Baron S, Neal, Kevin M, Hoernschemeyer, Daniel G, Yaszay, Burt, Blakemore, Laurel C, Shah, Suken A, Bastrom, Tracey P

Volltext

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas von Campbell, Joshua D, Alexandrov, Anton, Kim, Jaegil, Wala, Jeremiah, Berger, Alice H, Pedamallu, Chandra Sekhar, Shukla, Sachet A, Guo, Guangwu, Brooks, Angela N, Murray, Bradley A, Imielinski, Marcin, Hu, Xin, Ling, Shiyun, Akbani, Rehan, Rosenberg, Mara, Cibulskis, Carrie, Ramachandran, Aruna, Collisson, Eric A, Kwiatkowski, David J, Lawrence, Michael S, Weinstein, John N, Verhaak, Roel G W, Wu, Catherine J, Hammerman, Peter S, Cherniack, Andrew D, Getz, Gad, Artyomov, Maxim N, Schreiber, Robert, Govindan, Ramaswamy, Meyerson, Matthew

Volltext

Development, implementation and outcomes of a quality assurance system for the provision of continuous renal replacement therapy in the intensive care unit von Ruiz, Eloy F., Ortiz-Soriano, Victor M., Talbott, Monica, Klein, Bryan A., Thompson Bastin, Melissa L., Mayer, Kirby P., Price, Emily B., Dorfman, Robert, Adams, Brandi N., Fryman, Lisa, Neyra, Javier A.

Volltext

Combining Textual Pre-game Reports and Statistical Data for Predicting Success in the National Hockey League von Weissbock, Josh, Inkpen, Diana

Volltext

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity von van Setten, Jessica, Brody, Jennifer A., Jamshidi, Yalda, Butler, Anne M., Campbell, Harry, Evans, Daniel S., Gibson, Quince, Gudbjartsson, Daniel F., Kerr, Kathleen F., Krijthe, Bouwe P., Lyytikäinen, Leo-Pekka, Müller, Christian, Müller-Nurasyid, Martina, Nolte, Ilja M., Padmanabhan, Sandosh, Ritchie, Marylyn D., Robino, Antonietta, Smith, Albert V., Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, Ulivi, Sheila, Verweij, Niek, Yin, Xiaoyan, Asselbergs, Folkert W., Bader, Joel S., Barnard, John, Bis, Josh, Blankenberg, Stefan, Boerwinkle, Eric, Bradford, Yuki, Buckley, Brendan M., Chung, Mina K., Crawford, Dana, den Hoed, Marcel, Denny, Josh C., Ellinor, Patrick T., Felix, Stephan B., Franco, Oscar H., Franke, Lude, Harris, Tamara B., Holm, Hilma, Ilaria, Gandin, Kolcic, Ivana, Kors, Jan A., Lin, Honghuang, Lin, Henry J., Macfarlane, Peter W., Magnani, Jared W., Meitinger, Thomas, Mitchell, Braxton D., Munzel, Thomas, Papanicolaou, George J., Peters, Annette, Pfeufer, Arne, Pramstaller, Peter P., Rudan, Igor, Samani, Nilesh J., Silva Aldana, Claudia T., Sinner, Moritz F., Smith, Jonathan D., Snieder, Harold, Soliman, Elsayed Z., Spector, Timothy D., Stott, David J., Strauch, Konstantin, Tarasov, Kirill V., Thorsteinsdottir, Unnur, Uitterlinden, Andre G., Van Wagoner, David R., Völzke, Henry, Waldenberger, Melanie, Wild, Philipp S., Zeller, Tanja, Alonso, Alvaro, Bandinelli, Stefania, Cucca, Francesco, Dörr, Marcus, Ferrucci, Luigi, Gasparini, Paolo, Gudnason, Vilmundur, Hayward, Caroline, Jukema, J. Wouter, Kääb, Stefan, Lehtimäki, Terho, Liu, Yongmei, Parsa, Afshin, Polasek, Ozren, Psaty, Bruce M., Schnabel, Renate B., Sinagra, Gianfranco, Stefansson, Kari, Stricker, Bruno H., van der Harst, Pim, van Duijn, Cornelia M., Wilson, James F., Gharib, Sina A., de Bakker, Paul I. W., Arking, Dan E., Sotoodehnia, Nona

Volltext

Operative differences for posterior spinal fusion after vertebral body tethering: Are we fusing more levels in the end? von Boeyer, Melanie E., Groneck, Andrew, Alanay, Ahmet, Neal, Kevin M., Larson, A. Noelle, Parent, Stefan, Newton, Peter, Miyanji, Firoz, Haber, Lawrence, Hoernschemeyer, Daniel G.

Volltext

Harmonizing model organism data in the Alliance of Genome Resources von Agapite, Julie, Albou, Laurent-Philippe, Aleksander, Suzanne A, Alexander, Micheal, Anagnostopoulos, Anna V, Antonazzo, Giulia, Argasinska, Joanna, Arnaboldi, Valerio, Attrill, Helen, Becerra, Andrés, Bello, Susan M, Blake, Judith A, Blodgett, Olin, Bradford, Yvonne M, Bult, Carol J, Cain, Scott, Calvi, Brian R, Carbon, Seth, Chan, Juancarlos, Chen, Wen J, Michael Cherry, J, Cho, Jaehyoung, Christie, Karen R, Crosby, Madeline A, Davis, Paul, da Veiga Beltrame, Eduardo, De Pons, Jeffrey L, D’Eustachio, Peter, Diamantakis, Stavros, Dolan, Mary E, dos Santos, Gilberto, Douglass, Eric, Dunn, Barbara, Eagle, Anne, Ebert, Dustin, Engel, Stacia R, Fashena, David, Foley, Saoirse, Frazer, Ken, Gao, Sibyl, Gibson, Adam C, Gondwe, Felix, Goodman, Josh, Sian Gramates, L, Grove, Christian A, Hale, Paul, Harris, Todd, Thomas Hayman, G, Hill, David P, Howe, Douglas G, Howe, Kevin L, Hu, Yanhui, Jha, Sagar, Kadin, James A, Kaufman, Thomas C, Kalita, Patrick, Karra, Kalpana, Kishore, Ranjana, Kwitek, Anne E, Laulederkind, Stanley J F, Lee, Raymond, Longden, Ian, Luypaert, Manuel, MacPherson, Kevin A, Martin, Ryan, Marygold, Steven J, Matthews, Beverley, McAndrews, Monica S, Millburn, Gillian, Miyasato, Stuart, Motenko, Howie, Moxon, Sierra, Muller, Hans-Michael, Mungall, Christopher J, Muruganujan, Anushya, Mushayahama, Tremayne, Nalabolu, Harika S, Nash, Robert S, Ng, Patrick, Nuin, Paulo, Paddock, Holly, Paulini, Michael, Perrimon, Norbert, Pich, Christian, Quinton-Tulloch, Mark, Raciti, Daniela, Ramachandran, Sridhar, Richardson, Joel E, Gelbart, Susan Russo, Ruzicka, Leyla, Schaper, Kevin, Schindelman, Gary, Shimoyama, Mary, Simison, Matt, Shaw, David R, Shrivatsav, Ajay, Singer, Amy, Skrzypek, Marek, Smith, Constance M, Smith, Cynthia L

Volltext