Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation von Izat, Nihan, Bolleddula, Jayaprakasam, Abbasi, Armina, Cheruzel, Lionel, Jones, Robert S., Moss, Darren, Ortega-Muro, Fatima, Parmentier, Yannick, Peterkin, Vincent C., Tian, Dan-Dan, Venkatakrishnan, Karthik, Zientek, Michael A., Barber, Jill, Houston, J. Brian, Galetin, Aleksandra, Scotcher, Daniel

Volltext

Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates von Izat, Nihan, Bolleddula, Jayaprakasam, Carione, Pasquale, Huertas Valentin, Leticia, Jones, Robert S, Kulkarni, Priyanka, Moss, Darren, Peterkin, Vincent C, Tian, Dan-Dan, Treyer, Andrea, Venkatakrishnan, Karthik, Zientek, Michael A, Barber, Jill, Houston, J Brian, Galetin, Aleksandra, Scotcher, Daniel

Volltext

Limited influence of UGT1A128 and no effect of UGT2B72 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes von Peterkin, Vincent C., Bauman, Jonathan N., Goosen, Theunis C., Menning, Lee, Man, Michael Z., Paulauskis, Joseph D., Williams, J. Andrew, Myrand, Scott P.

Volltext

Challenges and opportunities for in vitro-in vivo extrapolation of aldehyde oxidase-mediated clearance: Towards a roadmap for quantitative translation von Izat, Nihan, Bolleddula, Jayaprakasam, Abbasi, Armina, Cheruzel, Lionel, Jones, Robert, Moss, Darren, Ortega-Muro, Fatima, Parmentier, Yannick, Peterkin, Vincent C, Tian, Dan-Dan, Venkatakrishnan, Karthik, Zientek, Michael, Barber, Jill, Houston, James, Galetin, Aleksandra, Scotcher, Daniel

Volltext

A Humanized UGT1 Mouse Model Expressing the UGT1A128 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation von HONGLIANG CAI, NGUYEN, Nghia, PETERKIN, Vincent, YANG, Young-Sun, HOTZ, Kathy, BEATON LA PLACA, Deirdre, SHUJUAN CHEN, TUKEY, Robert H, STEVENS, Jeffrey C

Volltext

Synthesis and evaluation of 2′-dihalo ribonucleotide prodrugs with activity against hepatitis C virus von Chris Krueger, A., Chen, Hui-Ju, Randolph, John T., Brown, Brian S., Halvorsen, Geoff T., Heyman, Howard R., Li, Tongmei, Marvin, Christopher C., Shanley, Jason P., Voight, Eric A., Bow, Daniel A.J., Van Handel, Cecilia, Peterkin, Vincent, Carr, Robert A., Stolarik, DeAnne, Dekhtyar, Tatyana, Irvin, Michelle L., Krishnan, Preethi, Henry, Rodger F., Wagner, Rolf, DeGoey, David A.

Volltext

Immune response of the hibiscus mealybug, Maconellicoccus hirsutus Green (Homoptera: Pseudococcidae), to oviposition of the parasitoid Anagyrus kamali Moursi (Hymenoptera: Encyrtid... von Sagarra, L.A, Peterkin, D.D, Vincent, C, Stewart, R.K

Volltext

A Humanized UGT1 Mouse Model Expressing the UGT1A1 28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation von Cai, Hongliang, Nguyen, Nghia, Peterkin, Vincent, Yang, Young-Sun, Hotz, Kathy, Beaton La Placa, Deirdre, Chen, Shujuan, Tukey, Robert H., Stevens, Jeffrey C.

Volltext