Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma: The PROPPR Randomized Clinical Trial von Holcomb, John B, Tilley, Barbara C, Baraniuk, Sarah, Fox, Erin E, Wade, Charles E, Podbielski, Jeanette M, del Junco, Deborah J, Brasel, Karen J, Bulger, Eileen M, Callcut, Rachael A, Cohen, Mitchell Jay, Cotton, Bryan A, Fabian, Timothy C, Inaba, Kenji, Kerby, Jeffrey D, Muskat, Peter, O’Keeffe, Terence, Rizoli, Sandro, Robinson, Bryce R. H, Scalea, Thomas M, Schreiber, Martin A, Stein, Deborah M, Weinberg, Jordan A, Callum, Jeannie L, Hess, John R, Matijevic, Nena, Miller, Christopher N, Pittet, Jean-Francois, Hoyt, David B, Pearson, Gail D, Leroux, Brian, van Belle, Gerald

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The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study: Comparative Effectiveness of a Time-Varying Treatment With Competing Risks von Holcomb, John B, del Junco, Deborah J, Fox, Erin E, Wade, Charles E, Cohen, Mitchell J, Schreiber, Martin A, Alarcon, Louis H, Bai, Yu, Brasel, Karen J, Bulger, Eileen M, Cotton, Bryan A, Matijevic, Nena, Muskat, Peter, Myers, John G, Phelan, Herb A, White, Christopher E, Zhang, Jiajie, Rahbar, Mohammad H

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Clinical and mechanistic drivers of acute traumatic coagulopathy von Cohen, Mitchell Jay, Kutcher, Matt, Redick, Britt, Nelson, Mary, Call, Mariah, Knudson, M Margaret, Schreiber, Martin A, Bulger, Eileen M, Muskat, Peter, Alarcon, Louis H, Myers, John G, Rahbar, Mohammad H, Brasel, Karen J, Phelan, Herb A, del Junco, Deborah J, Fox, Erin E, Wade, Charles E, Holcomb, John B, Cotton, Bryan A, Matijevic, Nena

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Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial von Jones, Allison R., Patel, Rakesh P., Marques, Marisa B., Donnelly, John P., Hess, John R., Wang, Henry E., Holcomb, John B., del Junco, Deborah J., Matijevic, Nena, Podbielski, Jeanette, Beeler, Angela M., Tilley, Barbara C., Baraniuk, Sarah, Zhu, Hongjian, Nixon, Joshua, Seay, Roann, Gonzalez, Michael O., Baer, Lisa, Wang, Yao-Wei W., Hula, Brittany S., Espino, Elena, Arora-Nutall, Kisha D., Sharma, Rishika, Cardenas, Jessica C., Rahbar, Elaheh, Burnett, Tyrone, Clark, David, May, Susanne, Leroux, Brian, Hoyt, David, Sheehan, Kellie, Arkin, Adam P., Hess, John R., Welch, Timothy, Pivalizza, Evan G., Gumbert, Sam D., Bai, Yu, Noland, Amy, Bulger, Eileen M., Klotz, Patricia, Warner, Keir J., Wilson, Angela, Boman, David, White, Nathan, Grabinsky, Andreas, Cohen, Mitchell J., Callcut, Rachael A., Nelson, Mary, Redick, Brittney, Conroy, Amanda, Fiebig, Eberhard, Mallari, Eireen, Muskat, Peter, Robinson, Bryce R.H., Branson, Richard D., Gomaa, Dina, Rodriguez, Carolina, Inaba, Kenji, Zhu, Jay G., Wong, Monica D., Henderson, Sean O., Nelson, Janice M., Matsushita, Cheryl Y., Scalea, Thomas M., Shaffer, Cynthia K., Herrera, Anthony V., Kallam, Seeta, Fontaine, Magali J., Cooke, Rhonda K., Fabian, Timothy C., Weinberg, Jordan A., Croce, Martin A., Wilson, Suzanne, Waddle-Smith, Lynda, Flax, Sherri, Brasel, Karen J., Walsh, Pamela, Nelson, Allia, Rokowski, Laurel L., Redford, Daniel T., Novak, Deborah J., Knoll, Susan, Kerby, Jeffrey D., Pittet, Jean-Francois, Bosarge, Patrick L., Williams, Carolyn R., Stephens, Shannon W., Wang, Henry E., Marques, Marisa B., Schreiber, Martin A., Watters, Jennifer M., Groat, Tahnee, Newgard, Craig, Miller, Beth, Rizoli, Sandro, Nascimento, Barto, Sobrian-Couroux, Skeeta, Reis, Marciano, Belo, Susan E., Merkley, Lisa

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Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial: Design, rationale and implementation von Baraniuk, Sarah, Tilley, Barbara C, del Junco, Deborah J, Fox, Erin E, van Belle, Gerald, Wade, Charles E, Podbielski, Jeanette M, Beeler, Angela M, Hess, John R, Bulger, Eileen M, Schreiber, Martin A, Inaba, Kenji, Fabian, Timothy C, Kerby, Jeffrey D, Cohen, Mitchell Jay, Miller, Christopher N, Rizoli, Sandro, Scalea, Thomas M, O’Keeffe, Terence, Brasel, Karen J, Cotton, Bryan A, Muskat, Peter, Holcomb, John B

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Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study von del Junco, Deborah J, Holcomb, John B, Fox, Erin E, Brasel, Karen J, Phelan, Herb A, Bulger, Eileen M, Schreiber, Martin A, Muskat, Peter, Alarcon, Louis H, Cohen, Mitchell J, Cotton, Bryan A, Wade, Charles E, Myers, John G, Rahbar, Mohammad H

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Clinical gestalt and the prediction of massive transfusion after trauma von Pommerening, Matthew J, Goodman, Michael D, Holcomb, John B, Wade, Charles E, Fox, Erin E, del Junco, Deborah J, Brasel, Karen J, Bulger, Eileen M, Cohen, Mitch J, Alarcon, Louis H, Schreiber, Martin A, Myers, John G, Phelan, Herb A, Muskat, Peter, Rahbar, Mohammad, Cotton, Bryan A

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Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: experience from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR... von Novak, Deborah J., Bai, Yu, Cooke, Rhonda K., Marques, Marisa B., Fontaine, Magali J., Gottschall, Jerome L., Carey, Patricia M., Scanlan, Richard M., Fiebig, Eberhard W., Shulman, Ira A., Nelson, Janice M., Flax, Sherri, Duncan, Veda, Daniel-Johnson, Jennifer A., Callum, Jeannie L., Holcomb, John B., Fox, Erin E., Baraniuk, Sarah, Tilley, Barbara C., Schreiber, Martin A., Inaba, Kenji, Rizoli, Sandro, Podbielski, Jeanette M., Cotton, Bryan A., Hess, John R.

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The PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study von Holcomb, John B, Fox, Erin E, Wade, Charles E

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Defining when to initiate massive transfusion: a validation study of individual massive transfusion triggers in PROMMTT patients von Callcut, Rachael A, Cotton, Bryan A, Muskat, Peter, Fox, Erin E, Wade, Charles E, Holcomb, John B, Schreiber, Martin A, Rahbar, Mohammad H, Cohen, Mitchell J, Knudson, M Margaret, Brasel, Karen J, Bulger, Eileen M, Del Junco, Deborah J, Myers, John G, Alarcon, Louis H, Robinson, Bryce R H

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Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study von Rahbar, Elaheh, Fox, Erin E, del Junco, Deborah J, Harvin, John A, Holcomb, John B, Wade, Charles E, Schreiber, Martin A, Rahbar, Mohammad H, Bulger, Eileen M, Phelan, Herb A, Brasel, Karen J, Alarcon, Louis H, Myers, John G, Cohen, Mitchell J, Muskat, Peter, Cotton, Bryan A

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Cryoprecipitate use in the PROMMTT study von Holcomb, John B, Fox, Erin E, Zhang, Xuan, White, Nathan, Wade, Charles E, Cotton, Bryan A, del Junco, Deborah J, Bulger, Eileen M, Cohen, Mitchell J, Schreiber, Martin A, Myers, John G, Brasel, Karen J, Phelan, Herb A, Alarcon, Louis H, Muskat, Peter, Rahbar, Mohammad H

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Prehospital intravenous fluid is associated with increased survival in trauma patients von Hampton, David A, Fabricant, Löic J, Differding, Jerry, Diggs, Brian, Underwood, Samantha, De La Cruz, Dodie, Holcomb, John B, Brasel, Karen J, Cohen, Mitchell J, Fox, Erin E, Alarcon, Louis H, Rahbar, Mohammad H, Phelan, Herb A, Bulger, Eileen M, Muskat, Peter, Myers, John G, del Junco, Deborah J, Wade, Charles E, Cotton, Bryan A, Schreiber, Martin A

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DUCT STRINGER ASSEMBLY WITH BULKHEAD von Muscat, Peter, Bryant, Anthony

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Coordination and management of multicenter clinical studies in trauma: Experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study von Rahbar, Mohammad H, Fox, Erin E, del Junco, Deborah J, Cotton, Bryan A, Podbielski, Jeanette M, Matijevic, Nena, Cohen, Mitchell J, Schreiber, Martin A, Zhang, Jiajie, Mirhaji, Parsa, Duran, Sarah J, Reynolds, Robert J, Benjamin-Garner, Ruby, Holcomb, John B

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Increasing time to operation is associated with decreased survival in patients with a positive FAST examination requiring emergent laparotomy von Barbosa, Ronald R, Rowell, Susan E, Fox, Erin E, Holcomb, John B, Bulger, Eileen M, Phelan, Herbert A, Alarcon, Louis H, Myers, John G, Brasel, Karen J, Muskat, Peter, del Junco, Deborah J, Cotton, Bryan A, Wade, Charles E, Rahbar, Mohammad H, Cohen, Mitchell J, Schreiber, Martin A

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Application of the Berlin definition in PROMMTT patients: the impact of resuscitation on the incidence of hypoxemia von Robinson, Bryce R H, Cotton, Bryan A, Pritts, Timothy A, Branson, Richard, Holcomb, John B, Muskat, Peter, Fox, Erin E, Wade, Charles E, del Junco, Deborah J, Bulger, Eileen M, Cohen, Mitchell J, Schreiber, Martin A, Myers, John G, Brasel, Karen J, Phelan, Herbert A, Alarcon, Louis H, Rahbar, Mohammad H, Callcut, Rachael A

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Recursive partitioning identifies greater than 4 U of packed red blood cells per hour as an improved massive transfusion definition von Moren, Alexis Marika, Hamptom, David, Diggs, Brian, Kiraly, Laszlo, Fox, Erin E, Holcomb, John B, Rahbar, Mohammad Hossein, Brasel, Karen J, Cohen, Mitchell Jay, Bulger, Eileen M, Schreiber, Martin A

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Seven deadly sins in trauma outcomes research: an epidemiologic post mortem for major causes of bias von del Junco, Deborah J, Fox, Erin E, Camp, Elizabeth A, Rahbar, Mohammad H, Holcomb, John B

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Damage-control resuscitation and emergency laparotomy: Findings from the PROPPR study von Undurraga Perl, Vicente J, Leroux, Brian, Cook, Mackenzie R, Watson, Justin, Fair, Kelly, Martin, David T, Kerby, Jeffrey D, Williams, Carolyn, Inaba, Kenji, Wade, Charles E, Cotton, Bryan A, Del Junco, Deborah J, Fox, Erin E, Scalea, Thomas M, Tilley, Barbara C, Holcomb, John B, Schreiber, Martin A

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