Synthesis of substituted [1,3]thiazolo[4,5- b]pyridines and [1,3]thiazolo[4,5- d][1,2,3]triazines von Thomae, David, Perspicace, Enrico, Hesse, Stéphanie, Kirsch, Gilbert, Seck, Pierre

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17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog von Gargano, Emanuele M, Allegretta, Giuseppe, Perspicace, Enrico, Carotti, Angelo, Van Koppen, Chris, Frotscher, Martin, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W

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One-pot synthesis of new 2,4,5-trisubstituted 1,3-thiazoles and 1,3-selenazoles von Thomae, David, Perspicace, Enrico, Xu, Zhanjie, Henryon, Dorothée, Schneider, Serge, Hesse, Stéphanie, Kirsch, Gilbert, Seck, Pierre

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Synthesis and biological evaluation of thieno[3,2-d]- pyrimidinones, thieno[3,2-d]pyrimidines and quinazolinones: conformationally restricted 17b-hydroxysteroid dehydrogenase type... von Perspicace, Enrico, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W

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Synthesis of new selenophene and thiazole analogues of the Tacrine series von Seck, Pierre, Thomae, David, Perspicace, Enrico, Hesse, Stéphanie, Kirsch, Gilbert

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Direct metallation of thienopyrimidines using a mixed lithium-cadmium base and antitumor activity of functionalized derivatives von Snégaroff, Katia, Lassagne, Frédéric, Bentabed-Ababsa, Ghenia, Nassar, Ekhlass, Ely, Sidaty Cheikh Sid, Hesse, Stéphanie, Perspicace, Enrico, Derdour, Aïcha, Mongin, Florence

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Microwave-assisted synthesis of 2-aminothiophene-3-carboxylic acid derivatives, 3H-thieno[2,3-d]pyrimidin-4-one and 4-chlorothieno[2,3-d]pyrimidine von Hesse, Stéphanie, Perspicace, Enrico, Kirsch, Gilbert

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Addressing cytotoxicity of 1,4-biphenyl amide derivatives: Discovery of new potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors von Gargano, Emanuele Marco, Perspicace, Enrico, Carotti, Angelo, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.

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Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEG... von Perspicace, Enrico, Jouan-Hureaux, Valérie, Ragno, Rino, Ballante, Flavio, Sartini, Stefania, La Motta, Concettina, Da Settimo, Federico, Chen, Binbin, Kirsch, Gilbert, Schneider, Serge, Faivre, Béatrice, Hesse, Stéphanie

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Novel N-methylsulfonamide and retro-N-methylsulfonamide derivatives as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors with good ADME-related physicochemical paramete... von Perspicace, Enrico, Giorgio, Annalaura, Carotti, Angelo, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.

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Introduction of an Electron Withdrawing Group on the Hydroxyphenylnaphthol Scaffold Improves the Potency of 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2) Inhibitors von Wetzel, Marie, Marchais-Oberwinkler, Sandrine, Perspicace, Enrico, Möller, Gabriele, Adamski, Jerzy, Hartmann, Rolf W

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Synthesis and Biological Evaluation of Thieno[3,2-d]- pyrimidinones, Thieno[3,2-d]pyrimidines and Quinazolinones: Conformationally Restricted 17β-Hydroxysteroid Dehydrogenase Type... von Perspicace, Enrico, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.

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Metabolic stability optimization and metabolite identification of 2,5-thiophene amide 17β-hydroxysteroid dehydrogenase type 2 inhibitors von Gargano, Emanuele M., Perspicace, Enrico, Hanke, Nina, Carotti, Angelo, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.

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Novel, potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities von Perspicace, Enrico, Cozzoli, Liliana, Gargano, Emanuele M., Hanke, Nina, Carotti, Angelo, Hartmann, Rolf W., Marchais-Oberwinkler, Sandrine

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One-pot synthesis of new tetrasubstituted thiophenes and selenophenes von Thomae, David, Perspicace, Enrico, Henryon, Dorothée, Xu, Zhanjie, Schneider, Serge, Hesse, Stéphanie, Kirsch, Gilbert, Seck, Pierre

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Structural Optimization of 2,5-Thiophene Amides as Highly Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors for the Treatment of Osteoporosis von Marchais-Oberwinkler, Sandrine, Xu, Kuiying, Wetzel, Marie, Perspicace, Enrico, Negri, Matthias, Meyer, Arne, Odermatt, Alex, Möller, Gabriele, Adamski, Jerzy, Hartmann, Rolf W

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Vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors: development and validation of predictive 3-D QSAR models through extensive ligand- and structure-based approache... von Ragno, Rino, Ballante, Flavio, Pirolli, Adele, Wickersham, Richard B., Patsilinakos, Alexandros, Hesse, Stéphanie, Perspicace, Enrico, Kirsch, Gilbert

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17[beta]-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog von Gargano, Emanuele M, Allegretta, Giuseppe, Perspicace, Enrico, Carotti, Angelo, Van Koppen, Chris, Frotscher, Martin, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W

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New Nortriterpenoid and Ceramides From Stems and Leaves of Cultivated Triumfetta cordifolia A Rich (Tiliaceae) von Sandjo, Louis Pergaud, Tchoukoua, Abdou, Ntede, Hippolyte Nga, Yemloul, Mehdi, Perspicace, Enrico, Keumedjio, Felix, Couty, François, Kirsch, Gilbert, Ngadjui, Bonaventure Tchaleu

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Microwave-assisted synthesis of 2-aminothiophene-3-carboxylic acid derivatives, 3 H-thieno[2,3- d]pyrimidin-4-one and 4-chlorothieno[2,3- d]pyrimidine von Hesse, Stéphanie, Perspicace, Enrico, Kirsch, Gilbert

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