Using human genetics to understand the disease impacts of testosterone in men and women von Ruth, Katherine S, Day, Felix R, Tyrrell, Jessica, Thompson, Deborah J, Wood, Andrew R, Mahajan, Anubha, Beaumont, Robin N, Wittemans, Laura, Martin, Susan, Busch, Alexander S., Erzurumluoglu, A. Mesut, Hollis, Benjamin, O’Mara, Tracy A., McCarthy, Mark I, Langenberg, Claudia, Easton, Douglas F, Wareham, Nicholas J, Burgess, Stephen, Murray, Anna, Ong, Ken K, Frayling, Timothy M, Perry, John R. B.

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Partitioning heritability by functional annotation using genome-wide association summary statistics von Finucane, Hilary K, Bulik-Sullivan, Brendan, Gusev, Alexander, Trynka, Gosia, Reshef, Yakir, Loh, Po-Ru, Anttila, Verneri, Xu, Han, Zang, Chongzhi, Farh, Kyle, Ripke, Stephan, Day, Felix R, Purcell, Shaun, Stahl, Eli, Lindstrom, Sara, Perry, John R B, Okada, Yukinori, Raychaudhuri, Soumya, Daly, Mark J, Patterson, Nick, Neale, Benjamin M, Price, Alkes L

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Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index von Yang, Jian, Bakshi, Andrew, Zhu, Zhihong, Hemani, Gibran, Vinkhuyzen, Anna A E, Lee, Sang Hong, Robinson, Matthew R, Perry, John R B, Nolte, Ilja M, van Vliet-Ostaptchouk, Jana V, Snieder, Harold, Esko, Tonu, Milani, Lili, Mägi, Reedik, Metspalu, Andres, Hamsten, Anders, Magnusson, Patrik K E, Pedersen, Nancy L, Ingelsson, Erik, Soranzo, Nicole, Keller, Matthew C, Wray, Naomi R, Goddard, Michael E, Visscher, Peter M

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Causal associations between cardiorespiratory fitness and type 2 diabetes von Cai, Lina, Gonzales, Tomas, Wheeler, Eleanor, Kerrison, Nicola D., Day, Felix R., Langenberg, Claudia, Perry, John R. B., Brage, Soren, Wareham, Nicholas J.

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Identifying genetic variants that affect viability in large cohorts von Mostafavi, Hakhamanesh, Berisa, Tomaz, Day, Felix R, Perry, John R B, Przeworski, Molly, Pickrell, Joseph K

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Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach von MENNI, Cristina, FAUMAN, Eric, WEI YUAN, MILBURN, Mike, PALMER, Colin N. A, FRAYLING, Timothy M, TRIMMER, Jeff, BELL, Jordana T, GIEGER, Christian, MOHNEY, Rob P, BROSNAN, Mary Julia, SUHRE, Karsten, ERTE, Idil, SORANZO, Nicole, SPECTOR, Tim D, PERRY, John R. B, KASTENMÜLLER, Gabi, SHIN, So-Youn, PETERSEN, Ann-Kristin, HYDE, Craig, PSATHA, Maria, WARD, Kirsten J

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Elucidating the genetic architecture of reproductive ageing in the Japanese population von Horikoshi, Momoko, Day, Felix R., Akiyama, Masato, Hirata, Makoto, Kamatani, Yoichiro, Matsuda, Koichi, Ishigaki, Kazuyoshi, Kanai, Masahiro, Wright, Hollis, Toro, Carlos A., Ojeda, Sergio R., Lomniczi, Alejandro, Kubo, Michiaki, Ong, Ken K., Perry, John. R. B.

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GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health von Zhao, Yajie, Stankovic, Stasa, Koprulu, Mine, Wheeler, Eleanor, Day, Felix R., Lango Allen, Hana, Kerrison, Nicola D., Pietzner, Maik, Loh, Po-Ru, Wareham, Nicholas J., Langenberg, Claudia, Ong, Ken K., Perry, John R. B.

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Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work von Anderson, Greg M., Hill, Jennifer W., Kaiser, Ursula B., Navarro, Victor M., Ong, Ken K., Perry, John R. B., Prevot, Vincent, Tena-Sempere, Manuel, Elias, Carol F.

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Elucidating the genetic basis of social interaction and isolation von Day, Felix R., Ong, Ken K., Perry, John R. B.

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Saturation genome editing of DDX3X clarifies pathogenicity of germline and somatic variation von Radford, Elizabeth J., Tan, Hong-Kee, Andersson, Malin H. L., Stephenson, James D., Gardner, Eugene J., Ironfield, Holly, Waters, Andrew J., Gitterman, Daniel, Lindsay, Sarah, Abascal, Federico, Martincorena, Iñigo, Kolesnik-Taylor, Anna, Ng-Cordell, Elise, Firth, Helen V., Baker, Kate, Perry, John R. B., Adams, David J., Gerety, Sebastian S., Hurles, Matthew E.

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A genome-wide association study identifies protein quantitative trait loci (pQTLs) von Melzer, David, Perry, John R B, Hernandez, Dena, Corsi, Anna-Maria, Stevens, Kara, Rafferty, Ian, Lauretani, Fulvio, Murray, Anna, Gibbs, J Raphael, Paolisso, Giuseppe, Rafiq, Sajjad, Simon-Sanchez, Javier, Lango, Hana, Scholz, Sonja, Weedon, Michael N, Arepalli, Sampath, Rice, Neil, Washecka, Nicole, Hurst, Alison, Britton, Angela, Henley, William, van de Leemput, Joyce, Li, Rongling, Newman, Anne B, Tranah, Greg, Harris, Tamara, Panicker, Vijay, Dayan, Colin, Bennett, Amanda, McCarthy, Mark I, Ruokonen, Aimo, Jarvelin, Marjo-Riitta, Guralnik, Jack, Bandinelli, Stefania, Frayling, Timothy M, Singleton, Andrew, Ferrucci, Luigi

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Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause von Yazdanpanah, Mojgan, Yazdanpanah, Nahid, Gamache, Isabel, Ong, Ken, Perry, John R B, Manousaki, Despoina

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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types von Finucane, Hilary K., Reshef, Yakir A., Anttila, Verneri, Slowikowski, Kamil, Gusev, Alexander, Byrnes, Andrea, Gazal, Steven, Loh, Po-Ru, Lareau, Caleb, Shoresh, Noam, Genovese, Giulio, Saunders, Arpiar, Macosko, Evan, Pollack, Samuela, Perry, John R. B., Buenrostro, Jason D., Bernstein, Bradley E., Raychaudhuri, Soumya, McCarroll, Steven, Neale, Benjamin M., Price, Alkes L.

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QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction von Maharaj, Avinaash V., Ishida, Miho, Rybak, Anna, Elfeky, Reem, Andrews, Afiya, Joshi, Aakash, Elmslie, Frances, Joensuu, Anni, Kantojärvi, Katri, Jia, Raina Y., Perry, John R. B., O’Toole, Edel A., McGuffin, Liam J., Hwa, Vivian, Storr, Helen L.

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Shared and distinct genetic etiologies for different types of clonal hematopoiesis von Brown, Derek W., Cato, Liam D., Zhao, Yajie, Nandakumar, Satish K., Bao, Erik L., Gardner, Eugene J., Hubbard, Aubrey K., DePaulis, Alexander, Rehling, Thomas, Song, Lei, Yu, Kai, Chanock, Stephen J., Perry, John R. B., Sankaran, Vijay G., Machiela, Mitchell J.

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Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food von Dearden, Laura, Furigo, Isadora C, Pantaleão, Lucas C, Wong, L W P, Fernandez-Twinn, Denise S, de Almeida-Faria, Juliana, Kentistou, Katherine A, Carreira, Maria V, Bidault, Guillaume, Vidal-Puig, Antonio, Ong, Ken K, Perry, John R B, Donato, Jr, Jose, Ozanne, Susan E

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Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based i... von Wood, Andrew R, Perry, John R B, Tanaka, Toshiko, Hernandez, Dena G, Zheng, Hou-Feng, Melzer, David, Gibbs, J Raphael, Nalls, Michael A, Weedon, Michael N, Spector, Tim D, Richards, J Brent, Bandinelli, Stefania, Ferrucci, Luigi, Singleton, Andrew B, Frayling, Timothy M

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An atlas of genetic correlations across human diseases and traits von Bulik-Sullivan, Brendan, Finucane, Hilary K, Anttila, Verneri, Gusev, Alexander, Day, Felix R, Loh, Po-Ru, Duncan, Laramie, Perry, John R B, Patterson, Nick, Robinson, Elise B, Daly, Mark J, Price, Alkes L, Neale, Benjamin M

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Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes von Yuan, Xin, Waterworth, Dawn, Perry, John R.B., Lim, Noha, Song, Kijoung, Chambers, John C., Zhang, Weihua, Vollenweider, Peter, Stirnadel, Heide, Johnson, Toby, Bergmann, Sven, Beckmann, Noam D., Li, Yun, Ferrucci, Luigi, Melzer, David, Hernandez, Dena, Singleton, Andrew, Scott, James, Elliott, Paul, Waeber, Gerard, Cardon, Lon, Frayling, Timothy M., Kooner, Jaspal S., Mooser, Vincent

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