Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase von Powell, Rebecca D., Holland, Paul J., Hollis, Thomas, Perrino, Fred W.

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Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease von Grieves, Jessica L., Fye, Jason M., Harvey, Scott, Grayson, Jason M., Hollis, Thomas, Perrino, Fred W.

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TREX1 – Apex predator of cytosolic DNA metabolism von Simpson, Sean R., Hemphill, Wayne O., Hudson, Teesha, Perrino, Fred W.

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TREX1 as a Novel Immunotherapeutic Target von Hemphill, Wayne O, Simpson, Sean R, Liu, Mingyong, Salsbury, Jr, Freddie R, Hollis, Thomas, Grayson, Jason M, Perrino, Fred W

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Identification of Inhibitors of the dNTP Triphosphohydrolase SAMHD1 Using a Novel and Direct High-Throughput Assay von Mauney, Christopher H, Perrino, Fred W, Hollis, Thomas

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Measuring TREX1 and TREX2 exonuclease activities von Hemphill, Wayne O, Perrino, Fred W

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Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T‐follicular helper cells and germinal center B cells von Venkatadri, Rajkumar, Sabapathy, Vikram, Dogan, Murat, Mohammad, Saleh, Harvey, Scott E., Simpson, Sean R., Grayson, Jason M., Yan, Nan, Perrino, Fred W., Sharma, Rahul

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The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease von Lehtinen, Duane A., Harvey, Scott, Mulcahy, Matthew J., Hollis, Thomas, Perrino, Fred W.

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Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus von Gong, Maolian, Lee, Young-Ae, Wong, Andrew, Hollis, Thomas, Lieberman, Judy, Pfeiffer, Christiane, Schmidt, Reinhold E, Koskenmies, Sari, Engel, Kerstin, Lee-Kirsch, Min Ae, Rohde, Klaus, Hübner, Norbert, Hummel, Oliver, Harvey, Scott, Dominiczak, Anna F, Perrino, Fred W, Chowdhury, Dipanjan, Vyse, Timothy J, Bailey, Suzanna L, Senenko, Lydia, de Silva, Udesh, Gahr, Manfred, Kere, Juha, Witte, Torsten

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The Exonuclease TREX1 Is in the SET Complex and Acts in Concert with NM23-H1 to Degrade DNA during Granzyme A-Mediated Cell Death von Chowdhury, Dipanjan, Beresford, Paul J., Zhu, Pengcheng, Zhang, Dong, Sung, Jung-Suk, Demple, Bruce, Perrino, Fred W., Lieberman, Judy

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Heterozygous Mutations in TREX1 Cause Familial Chilblain Lupus and Dominant Aicardi-Goutières Syndrome von Rice, Gillian, Newman, William G., Dean, John, Patrick, Teresa, Parmar, Rekha, Flintoff, Kim, Robins, Peter, Harvey, Scott, Hollis, Thomas, O’Hara, Ann, Herrick, Ariane L., Bowden, Andrew P., Perrino, Fred W., Lindahl, Tomas, Barnes, Deborah E., Crow, Yanick J.

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T Cells Produce IFN-α in the TREX1 D18N Model of Lupus-like Autoimmunity von Simpson, Sean R, Rego, Stephen L, Harvey, Scott E, Liu, Mingyong, Hemphill, Wayne O, Venkatadri, Rajkumar, Sharma, Rahul, Grayson, Jason M, Perrino, Fred W

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The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch von Mauney, Christopher H, Rogers, LeAnn C, Harris, Reuben S, Daniel, Larry W, Devarie-Baez, Nelmi O, Wu, Hanzhi, Furdui, Cristina M, Poole, Leslie B, Perrino, Fred W, Hollis, Thomas

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A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells von Casteel, Darren E., Zhuang, Shunhui, Zeng, Ying, Perrino, Fred W., Boss, Gerry R., Goulian, Mehran, Pilz, Renate B.

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Solid-State Nanopore Analysis of Diverse DNA Base Modifications Using a Modular Enzymatic Labeling Process von Wang, Fanny, Zahid, Osama K, Swain, Brandi E, Parsonage, Derek, Hollis, Thomas, Harvey, Scott, Perrino, Fred W, Kohli, Rahul M, Taylor, Ethan W, Hall, Adam R

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Structure of the Mammalian RNase H2 Complex Provides Insight into RNA·DNA Hybrid Processing to Prevent Immune Dysfunction von Shaban, Nadine M, Harvey, Scott, Perrino, Fred W, Hollis, Thomas

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The TREX1 Exonuclease R114H Mutation in Aicardi-Goutières Syndrome and Lupus Reveals Dimeric Structure Requirements for DNA Degradation Activity von Orebaugh, Clinton D., Fye, Jason M., Harvey, Scott, Hollis, Thomas, Perrino, Fred W.

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Functional Consequences of the RNase H2A Subunit Mutations That Cause Aicardi-Goutières Syndrome von Coffin, Stephanie R., Hollis, Thomas, Perrino, Fred W.

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The Crystal Structure of TREX1 Explains the 3′ Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering von de Silva, Udesh, Choudhury, Sumana, Bailey, Suzanna L., Harvey, Scott, Perrino, Fred W., Hollis, Thomas

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The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination von Orebaugh, Clinton D., Fye, Jason M., Harvey, Scott, Hollis, Thomas, Wilkinson, John C., Perrino, Fred W.

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