Access to Unnatural α‑Amino Acids via Visible-Light-Mediated Decarboxylative Conjugate Addition to Dehydroalanine von Shah, Akshay A, Kelly, Michael J, Perkins, James J

Volltext

Photoredox Catalysis for Silyl‐Mediated C–H Alkylation of Heterocycles with Non‐Activated Alkyl Bromides von Perkins, James J., Schubert, Jeffrey W., Streckfuss, Eric C., Balsells, Jaume, ElMarrouni, Abdellatif

Volltext

Discovery of the Selective Androgen Receptor Modulator MK-0773 Using a Rational Development Strategy Based on Differential Transcriptional Requirements for Androgenic Anabolism Ver... von Schmidt, Azriel, Kimmel, Donald B., Bai, Chang, Scafonas, Angela, Rutledge, SuJane, Vogel, Robert L., McElwee-Witmer, Sheila, Chen, Fang, Nantermet, Pascale V., Kasparcova, Viera, Leu, Chih-tai, Zhang, Hai-Zhuan, Duggan, Mark E., Gentile, Michael A., Hodor, Paul, Pennypacker, Brenda, Masarachia, Patricia, Opas, Evan E., Adamski, Sharon A., Cusick, Tara E., Wang, Jiabing, Mitchell, Helen J., Kim, Yuntae, Prueksaritanont, Thomayant, Perkins, James J., Meissner, Robert S., Hartman, George D., Freedman, Leonard P., Harada, Shun-ichi, Ray, William J.

Volltext

Synthesis of C6-Substituted Purine Nucleoside Analogues via Late-Stage Photoredox/Nickel Dual Catalytic Cross-Coupling von Perkins, James J, Shurtleff, Valerie W, Johnson, Alayna M, El Marrouni, Abdellatif

Volltext

Development of a sp 2 -sp 3 Stille Cross-Coupling for Rapid Synthesis of HIV NNRTI Doravirine Analogues von ElMarrouni, Abdellatif, Campbell, Mark, Perkins, James J, Converso, Antonella

Volltext

Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic von Shurtleff, Valerie W., Layton, Mark E., Parish, Craig A., Perkins, James J., Schreier, John D., Wang, Yunyi, Adam, Gregory C., Alvarez, Nadine, Bahmanjah, Soheila, Bahnck-Teets, Carolyn M., Boyce, Christopher W., Burlein, Christine, Cabalu, Tamara D., Campbell, Brian T., Carroll, Steven S., Chang, Wonsuk, de Lera Ruiz, Manuel, Dolgov, Enriko, Fay, John F., Fox, Nicholas G., Goh, Shih Lin, Hartingh, Timothy J., Hurzy, Danielle M., Kelly, Michael J., Klein, Daniel J., Klingler, Franca-Maria, Krishnamurthy, Harini, Kudalkar, Shalley, Mayhood, Todd W., McKenna, Philip M., Murray, Edward M., Nahas, Debbie, Nawrat, Christopher C., Park, Steven, Qian, Dongming, Roecker, Anthony J., Sharma, Vijeta, Shipe, William D., Su, Jing, Taggart, Robert V., Truong, Quang, Wu, Yin, Zhou, Xiaoyan, Zhuang, Ningning, Perlin, David S., Olsen, David B., Howe, John A., McCauley, John A.

Volltext

Discovery of [ 11 C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR 2 Negative Allosteric Modulators von Perkins, James J, McQuade, Paul, Bungard, Christopher J, Diamond, Tracy L, Gantert, Liza T, Gotter, Anthony L, Hanney, Barbara, Hills, Ivory D, Hurzy, Danielle M, Joshi, Aniket, Kern, Jonathan T, Schlegel, Kelly-Ann S, Manikowski, Jesse J, Meng, Zhaoyang, O'Brien, Julie A, Roecker, Anthony J, Smith, Sean M, Uslaner, Jason M, Hostetler, Eric, Meissner, Robert S

Volltext

Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator von Rudd, Michael T., Manley, Peter J., Hanney, Barbara, Meng, Zhaoyang, Shu, Youheng, de Leon, Pablo, Frie, Jessica L., Han, Yongxin, Wai, Jenny Miu-Chun, Yang, Zhi-Qiang, Perkins, James J., Hurzy, Danielle M., Manikowski, Jesse J., Zhu, Hong, Bungard, Christopher J., Converso, Antonella, Meissner, Robert S., Cosden, Mali L., Hayashi, Ikuo, Ma, Lei, O’Brien, Julie, Uebele, Victor N., Schachter, Joel B., Bhandari, Neetesh, Ward, Gwendolyn J., Fillgrove, Kerry L., Lu, Bing, Liang, Yuexia, Dubost, David C., Puri, Vanita, Eddins, Donnie M., Vardigan, Joshua D., Drolet, Robert E., Kern, Jonathan T., Uslaner, Jason M.

Volltext

Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells von Schmidt, Azriel, Meissner, Robert S, Gentile, Michael A, Chisamore, Michael J, Opas, Evan E, Scafonas, Angela, Cusick, Tara E, Gambone, Carlo, Pennypacker, Brenda, Hodor, Paul, Perkins, James J, Bai, Chang, Ferraro, Damien, Bettoun, David J, Wilkinson, Hilary A, Alves, Stephen E, Flores, Osvaldo, Ray, William J

Volltext

Discovery of selective glucocorticoid receptor modulator MK-5932 von Bungard, Christopher J., Hartman, George D., Manikowski, Jesse J., Perkins, James J., Bai, Chang, Brandish, Philip E., Euler, Danielle H., Hershey, James C., Schmidt, Azriel, Fang, Yulin, Norcross, Ryan T., Rushmore, Tom H., Thompson, Charles D., Meissner, Robert S.

Volltext

Nonpeptide αvβ3 Antagonists. 8. In Vitro and in Vivo Evaluation of a Potent αvβ3 Antagonist for the Prevention and Treatment of Osteoporosis von Hutchinson, John H, Halczenko, Wasyl, Brashear, Karen M, Breslin, Michael J, Coleman, Paul J, Duong, Le T, Fernandez-Metzler, Carmen, Gentile, Michael A, Fisher, John E, Hartman, George D, Huff, Joel R, Kimmel, Donald B, Leu, Chih-Tai, Meissner, Robert S, Merkle, Kara, Nagy, Rose, Pennypacker, Brenda, Perkins, James J, Prueksaritanont, Thomayant, Rodan, Gideon A, Varga, Sandor L, Wesolowski, Greg A, Zartman, Amy E, Rodan, Sevgi B, Duggan, Mark E

Volltext

Development of a sp2–sp3 Stille Cross-Coupling for Rapid Synthesis of HIV NNRTI Doravirine Analogues von ElMarrouni, Abdellatif, Campbell, Mark, Perkins, James J, Converso, Antonella

Volltext

Nonpeptide αvβ3 antagonists. Part 2: Constrained glycyl amides derived from the RGD tripeptide von MEISSNER, Robert S, PERKINS, James J, RODAN, Gideon A, RODAN, Sevgi B, WHITMAN, David B, WESOLOWSKI, Gregg A, DUGGAN, Mark E, DUONG, Le T, HARTMAN, George D, HOFFMAN, William F, HUFF, Joel R, IHLE, Nathan C, LEU, Chih-Tai, NAGY, Rose M, NAYLOR-OLSEN, Adel

Volltext

Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators von Perkins, James J., McQuade, Paul, Bungard, Christopher J., Diamond, Tracy L., Gantert, Liza T., Gotter, Anthony L., Hanney, Barbara, Hills, Ivory D., Hurzy, Danielle M., Joshi, Aniket, Kern, Jonathan T., Schlegel, Kelly-Ann S., Manikowski, Jesse J., Meng, Zhaoyang, O’Brien, Julie A., Roecker, Anthony J., Smith, Sean M., Uslaner, Jason M., Hostetler, Eric, Meissner, Robert S.

Volltext

Discovery of 11CMK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators von Perkins, James J, McQuade, Paul, Bungard, Christopher J, Diamond, Tracy L, Gantert, Liza T, Gotter, Anthony L, Hanney, Barbara, Hills, Ivory D, Hurzy, Danielle M, Joshi, Aniket, Kern, Jonathan T, Schlegel, Kelly-Ann S, Manikowski, Jesse J, Meng, Zhaoyang, O'Brien, Julie A, Roecker, Anthony J, Smith, Sean M, Uslaner, Jason M, Hostetler, Eric, Meissner, Robert S

Volltext

Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist von Duggan, Mark E, Naylor-Olsen, Adel M, Perkins, James J, Anderson, Paul S, Chang, Charles T.-C, Cook, Jacquelynn J, Gould, Robert J, Ihle, Nathan C, Hartman, George D

Volltext

Non-peptide αvβ3 antagonists: Identification of potent, chain-shortened RGD mimetics that incorporate a central pyrrolidinone constraint von PERKINS, James J, DUONG, Le T, DUGGAN, Mark E, MEISSNER, Robert S, FERNANDEZ-METZLER, Carmen, HARTMAN, George D, KIMMEL, Donald B, LEU, Chih-Tai, LYNCH, Joseph J, PRUEKSARITANONT, Thomayant, RODAN, Gideon A, RODAN, Sevgi B

Volltext

The Reform of Macroeconomic Policy: From Stagflation to Low or Zero Inflation von Perkins, J

Volltext

Nonpeptide αvβ3 Antagonists. 1. Transformation of a Potent, Integrin-Selective αIIbβ3 Antagonist into a Potent αvβ3 Antagonist von Duggan, Mark E, Duong, Le T, Fisher, John E, Hamill, Terence G, Hoffman, William F, Huff, Joel R, Ihle, Nathan C, Leu, Chih-Tai, Nagy, Rose M, Perkins, James J, Rodan, Sevgi B, Wesolowski, Gregg, Whitman, David B, Zartman, Amy E, Rodan, Gideon A, Hartman, George D

Volltext

Severe malarial anemia: innate immunity and pathogenesis von Perkins, Douglas J, Were, Tom, Davenport, Gregory C, Kempaiah, Prakasha, Hittner, James B, Ong'echa, John Michael

Volltext