Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls von Simonsen, Lotte, Lau, Jesper, Kruse, Thomas, Guo, Tingqing, McGuire, Jim, Jeppesen, Jacob Fuglsbjerg, Niss, Kristoffer, Sauerberg, Per, Raun, Kirsten, Dornonville de la Cour, Charlotta

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Dissociation of antihyperglycaemic and adverse effects of partial perioxisome proliferator-activated receptor (PPAR-γ) agonist balaglitazone von Larsen, Philip J., Lykkegaard, Kirsten, Larsen, Leif K., Fleckner, Jan, Sauerberg, Per, Wassermann, Karsten, Wulff, Erik Max

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Prediction of PPAR-α ligand-mediated physiological changes using gene expression profiles von Frederiksen, Klaus Stensgaard, Wulff, Erik Max, Sauerberg, Per, Mogensen, John Patrick, Jeppesen, Lone, Fleckner, Jan

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Xanomeline, an M1/M4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice von Shannon, Harlan E., Rasmussen, Kurt, Bymaster, Frank P., Hart, John C., Peters, Steven C., Swedberg, Michael D.B., Jeppesen, Lone, Sheardown, Malcolm J., Sauerberg, Per, Fink-Jensen, Anders

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Glucose-sensitive insulin with attenuation of hypoglycaemia von Hoeg-Jensen, Thomas, Kruse, Thomas, Brand, Christian L., Sturis, Jeppe, Fledelius, Christian, Nielsen, Peter K., Nishimura, Erica, Madsen, Alice R., Lykke, Lennart, Halskov, Kim S., Koščová, Simona, Kotek, Vladislav, Davis, Anthony P., Tromans, Robert A., Tomsett, Michael, Peñuelas-Haro, Guillem, Leonard, Daniel J., Orchard, Michael G., Chapman, Andy, Invernizzi, Gaetano, Johansson, Eva, Granata, Daniele, Hansen, Bo F., Pedersen, Thomas A., Kildegaard, Jonas, Pedersen, Karen-Margrethe, Refsgaard, Hanne H. F., Alifrangis, Lene, Fels, Johannes J., Neutzsky-Wulff, Anita V., Sauerberg, Per, Slaaby, Rita

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Process Development and Scale-Up of the PPAR Agonist NNC 61-4655 von Deussen, Heinz-Josef, Jeppesen, Lone, Schärer, Norbert, Junager, Finn, Bentzen, Bjørn, Weber, Beat, Weil, Volker, Mozer, Sandor Josef, Sauerberg, Per

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Structure–activity relationships of dimeric PPAR agonists von Sauerberg, Per, Mogensen, John P., Jeppesen, Lone, Svensson, L. Anders, Fleckner, Jan, Nehlin, Jan, Wulff, Erik M., Pettersson, Ingrid

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Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls von Lotte Simonsen, Jesper Lau, Thomas Kruse, Tingqing Guo, Jim McGuire, Jacob Fuglsbjerg Jeppesen, Kristoffer Niss, Per Sauerberg, Kirsten Raun, Charlotta Dornonville de la Cour

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Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines von Sauerberg, Per, Olesen, Preben H, Nielsen, Susanne, Treppendahl, Svend, Sheardown, Malcolm J, Honore, Tage, Mitch, Charles H, Ward, John S, Pike, Andrew J

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Synthesis and Biological and Structural Characterization of the Dual-Acting Peroxisome Proliferator-Activated Receptor α/γ Agonist Ragaglitazar von Ebdrup, Søren, Pettersson, Ingrid, Rasmussen, Hanne B, Deussen, Heinz-Josef, Frost Jensen, Anette, Mortensen, Steen B, Fleckner, Jan, Pridal, Lone, Nygaard, Lars, Sauerberg, Per

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Improved insulin sensitivity and islet function after PPARδ activation in diabetic db/db mice von Winzell, Maria Sörhede, Wulff, Erik Max, Olsen, Grith Skytte, Sauerberg, Per, Gotfredsen, Carsten F., Ahrén, Bo

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PPARδ agonists have opposing effects on insulin resistance in high fat‐fed rats and mice due to different metabolic responses in muscle von Ye, Ji‐Ming, Tid‐Ang, Jennifer, Turner, Nigel, Zeng, Xiao‐Yi, Li, Hai‐Yan, Cooney, Gregory J., Wulff, Erik Max, Sauerberg, Per, Kraegen, Edward W.

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Novel Tricyclic-α-alkyloxyphenylpropionic Acids:  Dual PPARα/γ Agonists with Hypolipidemic and Antidiabetic Activity von Sauerberg, Per, Pettersson, Ingrid, Jeppesen, Lone, Bury, Paul S, Mogensen, John P, Wassermann, Karsten, Brand, Christian L, Sturis, Jeppe, Wöldike, Helle F, Fleckner, Jan, Andersen, Anne-Sofie T, Mortensen, Steen B, Svensson, L. Anders, Rasmussen, Hanne B, Lehmann, Søren V, Polivka, Zdenek, Sindelar, Karel, Panajotova, Vladimira, Ynddal, Lars, Wulff, Erik M

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Xanomeline, an M 1/M 4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice von Shannon, Harlan E., Rasmussen, Kurt, Bymaster, Frank P., Hart, John C., Peters, Steven C., Swedberg, Michael D.B., Jeppesen, Lone, Sheardown, Malcolm J., Sauerberg, Per, Fink-Jensen, Anders

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GLP-1 derivatives and uses thereof von Sauerberg, Per, Kofoed, Jacob

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PPAR[delta] agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle von Ye, Ji-Ming, Tid-Ang, Jennifer, Turner, Nigel, Zeng, Xiao-Yi, Li, Hai-Yan, Cooney, Gregory J, Wulff, Erik Max, Sauerberg, Per, Kraegen, Edward W

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E/ Z Isomerization of 3,3-disubstituted allylic thioethers von Havranek, Miroslav, Sauerberg, Per, Kratina, Pavel, Pihera, Pavel

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Dual PPARα/γ activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats von Brand, Christian L., Sturis, Jeppe, Gotfredsen, Carsten F., Fleckner, Jan, Fledelius, Christian, Hansen, Bo F., Andersen, Birgitte, Ye, Ji-Ming, Sauerberg, Per, Wassermann, Karsten

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Structure-Activity Relationships for Negative Allosteric mGluR5 Modulators von Kaae, Birgitte H., Harpsøe, Kasper, Kvist, Trine, Mathiesen, Jesper M., Mølck, Christina, Gloriam, David, Jimenez, Hermogenes N., Uberti, Michelle A., Nielsen, Søren M., Nielsen, Birgitte, Bräuner-Osborne, Hans, Sauerberg, Per, Clausen, Rasmus P., Madsen, Ulf

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Identification and Synthesis of a Novel Selective Partial PPARδ Agonist with Full Efficacy on Lipid Metabolism In Vitro and In Vivo von Sauerberg, Per, Olsen, Grith S, Jeppesen, Lone, Mogensen, John P, Pettersson, Ingrid, Jeppesen, Claus B, Daugaard, Jens R, Galsgaard, Elisabeth D, Ynddal, Lars, Fleckner, Jan, Panajotova, Vladimira, Polivka, Zdenek, Pihera, Pavel, Havranek, Miroslav, Wulff, Erik M

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