Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities von Zhang, Jian, Lieu, Yen K, Ali, Abdullah M, Penson, Alex, Reggio, Kathryn S, Rabadan, Raul, Raza, Azra, Mukherjee, Siddhartha, Manley, James L

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Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma von Tiacci, Enrico, Ladewig, Erik, Schiavoni, Gianluca, Penson, Alex, Fortini, Elisabetta, Pettirossi, Valentina, Wang, Yuchun, Rosseto, Ariele, Venanzi, Alessandra, Vlasevska, Sofija, Pacini, Roberta, Piattoni, Simonetta, Tabarrini, Alessia, Pucciarini, Alessandra, Bigerna, Barbara, Santi, Alessia, Gianni, Alessandro M., Viviani, Simonetta, Cabras, Antonello, Ascani, Stefano, Crescenzi, Barbara, Mecucci, Cristina, Pasqualucci, Laura, Rabadan, Raul, Falini, Brunangelo

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Spliceosomal disruption of the non-canonical BAF complex in cancer von Inoue, Daichi, Chew, Guo-Liang, Liu, Bo, Michel, Brittany C., Pangallo, Joseph, D’Avino, Andrew R., Hitchman, Tyler, North, Khrystyna, Lee, Stanley Chun-Wei, Bitner, Lillian, Block, Ariele, Moore, Amanda R., Yoshimi, Akihide, Escobar-Hoyos, Luisa, Cho, Hana, Penson, Alex, Lu, Sydney X., Taylor, Justin, Chen, Yu, Kadoch, Cigall, Abdel-Wahab, Omar, Bradley, Robert K.

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SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes von Lieu, Yen K., Liu, Zhaoqi, Ali, Abdullah M., Wei, Xin, Penson, Alex, Zhang, Jian, An, Xiuli, Rabadan, Raul, Raza, Azra, Manley, James L., Mukherjee, Siddhartha

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Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia von Oshima, Koichi, Khiabanian, Hossein, da Silva-Almeida, Ana C., Tzoneva, Gannie, Abate, Francesco, Ambesi-Impiombato, Alberto, Sanchez-Martin, Marta, Carpenter, Zachary, Penson, Alex, Perez-Garcia, Arianne, Eckert, Cornelia, Nicolas, Concepción, Balbin, Milagros, Sulis, Maria Luisa, Kato, Motohiro, Koh, Katsuyoshi, Paganin, Maddalena, Basso, Giuseppe, Gastier-Foster, Julie M., Devidas, Meenakshi, Loh, Mignon L., Kirschner-Schwabe, Renate, Palomero, Teresa, Rabadan, Raul, Ferrando, Adolfo A.

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Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia von Tanaka, Atsushi, Nakano, Taizo A., Nomura, Masaki, Yamazaki, Hiromi, Bewersdorf, Jan P., Mulet-Lazaro, Roger, Hogg, Simon, Liu, Bo, Penson, Alex, Yokoyama, Akihiko, Zang, Weijia, Havermans, Marije, Koizumi, Miho, Hayashi, Yasutaka, Cho, Hana, Kanai, Akinori, Lee, Stanley C., Xiao, Muran, Koike, Yui, Zhang, Yifan, Fukumoto, Miki, Aoyama, Yumi, Konuma, Tsuyoshi, Kunimoto, Hiroyoshi, Inaba, Toshiya, Nakajima, Hideaki, Honda, Hiroaki, Kawamoto, Hiroshi, Delwel, Ruud, Abdel-Wahab, Omar, Inoue, Daichi

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ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance von Strillacci, Antonio, Sansone, Pasquale, Rajasekhar, Vinagolu K., Turkekul, Mesruh, Boyko, Vitaly, Meng, Fanli, Houck-Loomis, Brian, Brown, David, Berger, Michael F., Hendrickson, Ronald C., Chang, Qing, de Stanchina, Elisa, Pareja, Fresia, Reis-Filho, Jorge S., Rajappachetty, Ramya Segu, Del Priore, Isabella, Liu, Bo, Cai, Yanyan, Penson, Alex, Mastroleo, Chiara, Berishaj, Marjan, Borsetti, Francesca, Spisni, Enzo, Lyden, David, Chandarlapaty, Sarat, Bromberg, Jacqueline

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Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells von Mi, Xiaoli, Penson, Alex, Abdel-Wahab, Omar, Mailankody, Sham

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Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells von Mi, Xiaoli, Penson, Alex, Abdel-Wahab, Omar, Mailankody, Sham

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Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors von Wang, Eric, Mi, Xiaoli, Thompson, Meghan C, Montoya, Skye, Notti, Ryan Q, Afaghani, Jumana, Durham, Benjamin H, Penson, Alex, Witkowski, Matthew T, Lu, Sydney X, Bourcier, Jessie, Hogg, Simon J, Erickson, Caroline, Cui, Dan, Cho, Hana, Singer, Michael, Totiger, Tulasigeri M, Chaudhry, Sana, Geyer, Mark, Alencar, Alvaro, Linley, Adam J, Palomba, M. Lia, Coombs, Catherine C, Park, Jae H, Zelenetz, Andrew, Roeker, Lindsey, Rosendahl, Mary, Tsai, Donald E, Ebata, Kevin, Brandhuber, Barbara, Hyman, David M, Aifantis, Iannis, Mato, Anthony, Taylor, Justin, Abdel-Wahab, Omar

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Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation von Fong, Jia Yi, Pignata, Luca, Goy, Pierre-Alexis, Kawabata, Kimihito Cojin, Lee, Stanley Chun-Wei, Koh, Cheryl M., Musiani, Daniele, Massignani, Enrico, Kotini, Andriana G., Penson, Alex, Wun, Cheng Mun, Shen, Yudao, Schwarz, Megan, Low, Diana HP, Rialdi, Alexander, Ki, Michelle, Wollmann, Heike, Mzoughi, Slim, Gay, Florence, Thompson, Christine, Hart, Timothy, Barbash, Olena, Luciani, Genna M., Szewczyk, Magdalena M., Wouters, Bas J., Delwel, Ruud, Papapetrou, Eirini P., Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Minden, Mark D., Jin, Jian, Melnick, Ari, Bonaldi, Tiziana, Abdel-Wahab, Omar, Guccione, Ernesto

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Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition von Inoue, Daichi, Polaski, Jacob T., Taylor, Justin, Castel, Pau, Chen, Sisi, Kobayashi, Susumu, Hogg, Simon J., Hayashi, Yasutaka, Pineda, Jose Mario Bello, El Marabti, Ettaib, Erickson, Caroline, Knorr, Katherine, Fukumoto, Miki, Yamazaki, Hiromi, Tanaka, Atsushi, Fukui, Chie, Lu, Sydney X., Durham, Benjamin H., Liu, Bo, Wang, Eric, Mehta, Sanjoy, Zakheim, Daniel, Garippa, Ralph, Penson, Alex, Chew, Guo-Liang, McCormick, Frank, Bradley, Robert K., Abdel-Wahab, Omar

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Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer von Escobar-Hoyos, Luisa F., Penson, Alex, Kannan, Ram, Cho, Hana, Pan, Chun-Hao, Singh, Rohit K., Apken, Lisa H., Hobbs, G. Aaron, Luo, Renhe, Lecomte, Nicolas, Babu, Sruthi, Pan, Fong Cheng, Alonso-Curbelo, Direna, Morris, John P., Askan, Gokce, Grbovic-Huezo, Olivera, Ogrodowski, Paul, Bermeo, Jonathan, Saglimbeni, Joseph, Cruz, Cristian D., Ho, Yu-Jui, Lawrence, Sharon A., Melchor, Jerry P., Goda, Grant A., Bai, Karen, Pastore, Alessandro, Hogg, Simon J., Raghavan, Srivatsan, Bailey, Peter, Chang, David K., Biankin, Andrew, Shroyer, Kenneth R., Wolpin, Brian M., Aguirre, Andrew J., Ventura, Andrea, Taylor, Barry, Der, Channing J., Dominguez, Daniel, Kümmel, Daniel, Oeckinghaus, Andrea, Lowe, Scott W., Bradley, Robert K., Abdel-Wahab, Omar, Leach, Steven D.

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Systematic Evaluation of AML-Associated Antigens Identifies Novel Anti-U5 snRNP200 Therapeutic Antibodies for the Treatment of AML von Knorr, Katherine, Erickson, Caroline, Wang, Eric, Rahman, Jahan, Mi, Xiaoli, Lu, Sydney, Fox, Nina, Penson, Alex, Hogg, Simon, Stanley, Robert, Inoue, Daichi, Knorr, David, Ravetch, Jeffrey, Abdel-Wahab, Omar

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SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice von Willekens, Christophe, Laplane, Lucie, Dagher, Tracy, Benlabiod, Camelia, Papadopoulos, Nicolas, Lacout, Catherine, Rameau, Philippe, Catelain, Cyril, Alfaro, Alexia, Edmond, Valérie, Signolle, Nicolas, Marchand, Valentine, Droin, Nathalie, Hoogenboezem, Remco, Schneider, Rebekka K., Penson, Alex, Abdel-Wahab, Omar, Giraudier, Stephane, Pasquier, Florence, Marty, Caroline, Plo, Isabelle, Villeval, Jean-Luc, Constantinescu, Stefan N., Porteu, Françoise, Vainchenker, William, Solary, Eric

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Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts von Kim, Kwanghee, Hu, Wenhuo, Audenet, François, Almassi, Nima, Hanrahan, Aphrothiti J., Murray, Katie, Bagrodia, Aditya, Wong, Nathan, Clinton, Timothy N., Dason, Shawn, Mohan, Vishnu, Jebiwott, Sylvia, Nagar, Karan, Gao, Jianjiong, Penson, Alex, Hughes, Chris, Gordon, Benjamin, Chen, Ziyu, Dong, Yiyu, Watson, Philip A., Alvim, Ricardo, Elzein, Arijh, Gao, Sizhi P., Cocco, Emiliano, Santin, Alessandro D., Ostrovnaya, Irina, Hsieh, James J., Sagi, Irit, Pietzak, Eugene J., Hakimi, A. Ari, Rosenberg, Jonathan E., Iyer, Gopa, Vargas, Herbert A., Scaltriti, Maurizio, Al-Ahmadie, Hikmat, Solit, David B., Coleman, Jonathan A.

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Abstract PO-040: Therapeutic targeting of keratin 17 functional domains and nuclear export uncover therapeutic vulnerabilities of pancreatic cancer von Leiton, Cindy V., Pan, Chun-Hao, Bai, Ji Dong, Roa-Peña, Lucia, Babu, Sruthi, Penson, Alex, Turkman, Nashaat, Moffitt, Richard, Seeliger, Markus, Talmage, David, Shroyer, Kenneth R., Escobar-Hoyos, Luisa F.

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Abstract C32: Therapeutic targeting of keratin 17 and nuclear export uncover therapeutic vulnerabilities of pancreatic cancer von Leiton, Cindy V., Pan, Chun-Hao, Bai, Ji Dong, Roa-Peña, Lucia, Babu, Sruthi, Penson, Alex, Turkman, Nashaat, Moffitt, Richard, Seeliger, Markus, Talmage, David, Shroyer, Kenneth R., Escobar-Hoyos, Luisa F.

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Abstract 729: Zygosity, lineage, and penetrance dictate the role of germline pathogenicity in tumorigenesis von Bandlamudi, Chaitanya, Srinivasan, Preethi, Jonsson, Philip, Kemel, Yelena M., Chavan, Shweta S., Richards, Allison L., Penson, Alex, Bielski, Craig M., Fong, Chris, Syed, Aijazuddin, Jayakumaran, Gowtham, Prasad, Meera, Hwee, Jason, Schultz, Nikolaus, Mukherjee, Semanti, Joseph, Vijai, Mandelkar, Diana, Birsoy, Ozge, Zhang, Liying, Shia, Jinru, Zehir, Ahmet, Ladanyi, Marc, Hyman, David M., Offit, Kenneth, Robson, Mark E., Solit, David B., Stadler, Zsofia K., Berger, Michael F., Taylor, Barry S.

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Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia von Knorr, Katherine, Rahman, Jahan, Erickson, Caroline, Wang, Eric, Monetti, Mara, Li, Zhuoning, Ortiz-Pacheco, Juliana, Jones, Andrew, Lu, Sydney X, Stanley, Robert F, Baez, Maria, Fox, Nina, Castro, Cynthia, Marino, Alessandra E, Jiang, Caroline, Penson, Alex, Hogg, Simon J, Mi, Xiaoli, Nakajima, Hideaki, Kunimoto, Hiroyoshi, Nishimura, Koutarou, Inoue, Daichi, Greenbaum, Benjamin, Knorr, David, Ravetch, Jeffrey, Abdel-Wahab, Omar

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