Quantitative Detection of 8‑Oxo-7,8-dihydro-2′-deoxyguanosine Using Chemical Tagging and qPCR von Bajacan, John Ernest Vallarta, Hong, In Seok, Penning, Trevor W, Greenberg, Marc M

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Clustering a Chemical Inventory for Safety Assessment of Fragrance Ingredients: Identifying Read-Across Analogs to Address Data Gaps von Date, Mihir S, O’Brien, Devin, Botelho, Danielle J, Schultz, Terry W, Liebler, Daniel C, Penning, Trevor M, Salvito, Daniel T

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AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease von Nikolaou, Nikolaos, Gathercole, Laura L., Marchand, Lea, Althari, Sara, Dempster, Niall J., Green, Charlotte J., van de Bunt, Martijn, McNeil, Catriona, Arvaniti, Anastasia, Hughes, Beverly A., Sgromo, Bruno, Gillies, Richard S., Marschall, Hanns-Ulrich, Penning, Trevor M., Ryan, John, Arlt, Wiebke, Hodson, Leanne, Tomlinson, Jeremy W.

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The DHEA-sulfate depot following P450c17 inhibition supports the case for AKR1C3 inhibition in high risk localized and advanced castration resistant prostate cancer von Tamae, Daniel, Mostaghel, Elahe, Montgomery, Bruce, Nelson, Peter S., Balk, Steven P., Kantoff, Philip W., Taplin, Mary-Ellen, Penning, Trevor M.

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Intense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadju... von Taplin, Mary-Ellen, Montgomery, Bruce, Logothetis, Christopher J, Bubley, Glenn J, Richie, Jerome P, Dalkin, Bruce L, Sanda, Martin G, Davis, John W, Loda, Massimo, True, Lawrence D, Troncoso, Patricia, Ye, Huihui, Lis, Rosina T, Marck, Brett T, Matsumoto, Alvin M, Balk, Steven P, Mostaghel, Elahe A, Penning, Trevor M, Nelson, Peter S, Xie, Wanling, Jiang, Zhenyang, Haqq, Christopher M, Tamae, Daniel, Tran, NamPhuong, Peng, Weimin, Kheoh, Thian, Molina, Arturo, Kantoff, Philip W

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An End Point-Specific Framework for Read-Across Analog Selection for Human Health Effects von Moustakas, Holger, Date, Mihir S., Kumar, Manoj, Schultz, Terry W., Liebler, Daniel C., Penning, Trevor M., Salvito, Daniel T., Api, Anne Marie

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Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Pro... von Liedtke, Andy J, Adeniji, Adegoke O, Chen, Mo, Byrns, Michael C, Jin, Yi, Christianson, David W, Marnett, Lawrence J, Penning, Trevor M

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Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate res... von Chen, Mo, Adeniji, Adegoke O., Twenter, Barry M., Winkler, Jeffrey D., Christianson, David W., Penning, Trevor M.

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Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer von Mostaghel, Elahe A, Cho, Eunpi, Zhang, Ailin, Alyamani, Mohammad, Kaipainen, Arja, Green, Sean, Marck, Brett T, Sharifi, Nima, Wright, Jonathan L, Gulati, Roman, True, Lawrence D, Loda, Massimo, Matsumoto, Alvin M, Tamae, Daniel, Penning, Trevor N, Balk, Steven P, Kantoff, Phillip W, Nelson, Peter S, Taplin, Mary-Ellen, Montgomery, R Bruce

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Dynamic Prediction of Advanced Colorectal Neoplasia in Inflammatory Bowel Disease von Wijnands, Anouk M., Penning de Vries, Bas B.L., Lutgens, Maurice W.M.D., Bakhshi, Zeinab, Al Bakir, Ibrahim, Beaugerie, Laurent, Bernstein, Charles N., Chang-ho Choi, Ryan, Coelho-Prabhu, Nayantara, Graham, Trevor A., Hart, Ailsa L., ten Hove, Joren R., Itzkowitz, Steven H., Kirchgesner, Julien, Mooiweer, Erik, Shaffer, Seth R., Shah, Shailja C., Elias, Sjoerd G., Oldenburg, Bas, van Bodegraven, Adriaan A., Fidder, Herma H., Hirdes, Meike M.C., Hoentjen, Frank, Jansen, Jeroen M., Mahmmod, Nofel, van der Meulen-de Jong, Andrea E., Ponsioen, Cyriel Y., van Schaik, Fiona D.M., van der Woude, C. Janneke

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AKR1D1 knockout mice develop a sex-dependent metabolic phenotype von Gathercole, Laura L, Nikolaou, Nikolaos, Harris, Shelley E, Arvaniti, Anastasia, Poolman, Toryn M, Hazlehurst, Jonathan M, Kratschmar, Denise V, Todorčević, Marijana, Moolla, Ahmad, Dempster, Niall, Pink, Ryan C, Saikali, Michael F, Bentley, Liz, Penning, Trevor M, Ohlsson, Claes, Cummins, Carolyn L, Poutanen, Matti, Odermatt, Alex, Cox, Roger D, Tomlinson, Jeremy W

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Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): insights into the role of the catalytic glutamic acid von Chen, Mo, Wangtrakuldee, Phumvadee, Zang, Tianzhu, Duan, Ling, Gathercole, Laura L., Tomlinson, Jeremy W., Penning, Trevor M.

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AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells von Nikolaou, Nikolaos, Gathercole, Laura L., Kirkwood, Lucy, Dunford, James E., Hughes, Beverly A., Gilligan, Lorna C., Oppermann, Udo, Penning, Trevor M., Arlt, Wiebke, Hodson, Leanne, Tomlinson, Jeremy W.

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Targeted Androgen Pathway Suppression in Localized Prostate Cancer: A Pilot Study von MOSTAGHEL, Elahe A, NELSON, Peter S, MATSUMOTO, Alvin M, TRUE, Lawrence D, VESSELLA, Robert, PENNING, Trevor, MERRILL, Rachel Hunter, GULATI, Roman, MONTGOMERY, Bruce, LANGE, Paul, LIN, Daniel W, TAPLIN, Mary Ellen, BALK, Steven, ELLIS, William, KANTOFF, Philip, MARCK, Brett, TAMAE, Daniel

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Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo von Nikolaou, Nikolaos, Arvaniti, Anastasia, Appanna, Nathan, Sharp, Anna, Hughes, Beverly A, Digweed, Dena, Whitaker, Martin J, Ross, Richard, Arlt, Wiebke, Penning, Trevor M, Morris, Karen, George, Sherly, Keevil, Brian G, Hodson, Leanne, Gathercole, Laura L, Tomlinson, Jeremy W

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Differential activity and expression of human 5β-reductase (AKR1D1) splice variants von Appanna, Nathan, Gibson, Hylton, Gangitano, Elena, Dempster, Niall J, Morris, Karen, George, Sherly, Arvaniti, Anastasia, Gathercole, Laura L, Keevil, Brian, Penning, Trevor M, Storbeck, Karl-Heinz, Tomlinson, Jeremy W, Nikolaou, Nikolaos

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Aldo-keto reductase (AKR) 1C3: Role in prostate disease and the development of specific inhibitors von Penning, Trevor M., Steckelbroeck, Stephan, Bauman, David R., Miller, Meredith W., Jin, Yi, Peehl, Donna M., Fung, Kar-Ming, Lin, Hseuh-Kung

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The role of toxicological science in meeting the challenges and opportunities of hydraulic fracturing von Goldstein, Bernard D, Brooks, Bryan W, Cohen, Steven D, Gates, Alexander E, Honeycutt, Michael E, Morris, John B, Orme-Zavaleta, Jennifer, Penning, Trevor M, Snawder, John

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Conversion of human steroid 5β-reductase (AKR1D1) into 3β-hydroxysteroid dehydrogenase by single point mutation E120H: example of perfect enzyme engineering von Chen, Mo, Drury, Jason E, Christianson, David W, Penning, Trevor M

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Crystal Structure of Human Liver delta {4}-3-Ketosteroid 5 beta-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis von Di Costanzo,L., Drury, J., Penning, T., Christianson, D.

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