Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19 von Huffman, Jennifer E., Butler-Laporte, Guillaume, Khan, Atlas, Pairo-Castineira, Erola, Drivas, Theodore G., Peloso, Gina M., Nakanishi, Tomoko, Ganna, Andrea, Verma, Anurag, Baillie, J. Kenneth, Kiryluk, Krzysztof, Richards, J. Brent, Zeberg, Hugo

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Peripheral blood immune cells distribution in biopsy-proven myocarditis: etiology and prognostic correlates von Vicenzetto, C, Giordani, A S, Baritussio, A, Brigiari, G, Peloso Cattini, M G, Pontara, E, Bison, E, Tarantini, G, Gregori, D, Carturan, E, De Gaspari, M, Rizzo, S, Basso, C, Iliceto, S, Caforio, A L P

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Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia von Stitziel, Nathan O, Fouchier, Sigrid W, Sjouke, Barbara, Peloso, Gina M, Moscoso, Alessa M, Auer, Paul L, Goel, Anuj, Gigante, Bruna, Barnes, Timothy A, Melander, Olle, Orho-Melander, Marju, Duga, Stefano, Sivapalaratnam, Suthesh, Nikpay, Majid, Martinelli, Nicola, Girelli, Domenico, Jackson, Rebecca D, Kooperberg, Charles, Lange, Leslie A, Ardissino, Diego, McPherson, Ruth, Farrall, Martin, Watkins, Hugh, Reilly, Muredach P, Rader, Daniel J, de Faire, Ulf, Schunkert, Heribert, Erdmann, Jeanette, Samani, Nilesh J, Charnas, Lawrence, Altshuler, David, Gabriel, Stacey, Kastelein, John J.P, Defesche, Joep C, Nederveen, Aart J, Kathiresan, Sekar, Hovingh, G Kees

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Analysis of protein-coding genetic variation in 60,706 humans von Lek, M, Karczewski, KJ, Minikel, EV, Samocha, KE, Banks, E, Fennell, T, O'Donnell-Luria, AH, Ware, JS, Hill, AJ, Cummings, BB, Tukiainen, T, Birnbaum, DP, Kosmicki, JA, Duncan, LE, Estrada, K, Zhao, F, Zou, J, Pierce-Hoffman, E, Berghout, J, Cooper, DN, Deflaux, N, DePristo, M, Do, R, Flannick, J, Fromer, M, Gauthier, L, Goldstein, J, Gupta, N, Howrigan, D, Kiezun, A, Kurki, MI, Moonshine, AL, Natarajan, P, Orozco, L, Peloso, GM, Poplin, R, Rivas, MA, Ruano-Rubio, V, Rose, SA, Ruderfer, DM, Shakir, K, Stenson, PD, Stevens, C, Thomas, BP, Tiao, G, Tusie-Luna, MT, Weisburd, B, Won, HH, Yu, D, Altshuler, DM, Ardissino, D, Boehnke, M, Danesh, J, Donnelly, S, Elosua, R, Florez, JC, Gabriel, SB, Getz, G, Glatt, SJ, Hultman, CM, Kathiresan, S, Laakso, M, McCarroll, S, McCarthy, MI, McGovern, D, McPherson, R, Neale, BM, Palotie, A, Purcell, SM, Saleheen, D, Scharf, JM, Sklar, P, Sullivan, PF, Tuomilehto, J, Tsuang, MT, Watkins, HC, Wilson, JG, Daly, MJ, MacArthur, DG, Exome Aggregation Consortium

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Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals von Eicher, JD, Chami, N, Kacprowski, T, Nomura, A, Chen, MH, Tajuddin, SM, Schick, UM, Slater, AJ, Pankratz, N, Polfus, L, Evans, MK, Engström, G, Orho-Melander, M, Melander, O, O'Donoghue, ML, Waterworth, DM, Wallentin, L, White, HD, Floyd, JS, Bartz, TM, Greinacher, A, Rice, KM, Liewald, DC, Hayward, C, Deary, IJ, Völker, U, Thiele, T, Van Rooij, FJ, Uitterlinden, AG, Franco, OH, Dehghan, A, Edwards, TL, Ganesh, SK, Faraday, N, Auer, PL, Reiner, AP, Lettre, G, Johnson, AD, Giri, A, Brody, JA, Lange, LA, Manichaikul, A, Hill, WD, Evangelou, E, Tzoulaki, I, Vergnaud, AC, Mathias, RA, Becker, DM, Becker, LC, Burt, A, Crosslin, DR, Lyytikäinen, LP, Nikus, K, Hernesniemi, J, Kähönen, M, Raitoharju, E, Mononen, N, Raitakari, OT, Lehtimäki, T, Zakai, NA, Nickerson, DA, Raffield, LM, Quarells, R, Willer, CJ, Peloso, GM, Liu, DJ, Global Lipids Genetics Consortium, Deloukas, P, Samani, NJ, Schunkert, H, Erdmann, J, CARDIoGRAM Exome Consortium, Fornage, M, Richard, M, Tardif, JC, Rioux, JD, Dube, MP, De Denus, S, Bottinger, EP, Loos, RJ, Smith, AV, Harris, TB, Launer, LJ, Torstenson, ES, Liu, Y, Tracy, RP, Rotter, JI, Rich, SS, Highland, HM, Boerwinkle, E, Li, J, Lange, E, Wilson, JG, Mihailov, E, Mägi, R, Hirschhorn, J, Metspalu, A, Esko, T, Nalls, MA, Zonderman, AB

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A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease von Scott, RA, Li, L, Chu, AY, Surendran, P, Stancakova, A, Yaghootkar, H, Luan, J, Zhao, JH, Wessel, J, Wang, S, Maruthur, N, Michailidou, K, Pirie, A, Van der Lee, SJ, Gillson, C, Al Olama, AA, Amouyel, P, Arveiler, D, Aviles-Olmos, I, Barricarte, A, Barroso, I, Garcia, SB, Bis, JC, Boehnke, M, Boeing, H, Boerwinkle, E, Borecki, IB, Bork-Jensen, J, Bowden, S, Caldas, C, Caslake, M, Cupples, LA, Cruchaga, C, Czajkowski, J, Dunn, JA, Earl, HM, Ehret, GB, Ferrieres, J, Foltynie, T, Ford, I, Gonzalez, C, Grioni, S, Jansson, J-H, Jorgensen, ME, Jukema, JW, Kee, F, Kerrison, ND, Key, TJ, Kontto, J, Kraja, AT, Kuusisto, J, Linneberg, A, Liu, C, Marenne, G, Mohlke, KL, Morris, AP, Munroe, PB, Navarro, C, Nielsen, SF, Nordestgaard, BG, Packard, CJ, Panico, S, Peloso, GM, Peters, A, Quiros, JR, Sacerdote, C, Sattar, N, Sharp, SJ, Sims, R, Smith, JA, Thompson, DJ, Trompet, S, Tumino, R, Van der Schouw, YT, Virtamo, J, Walker, M, Walter, K, Abraham, JE, Amundadottir, LT, Aponte, JL, Butterworth, A, Dupuis, J, Easton, DF, Eeles, RA, Erdmann, J, Franks, PW, Hansen, T, Kooner, J, Langenberg, C, Pankow, JS, Pedersen, O, Riboli, E, Saleheen, D, Schunkert, H, Vollenweider, P, O'Rahilly, S, Deloukas, P, Meigs, JB, Wareham, NJ, Waterworth, DM

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Alternative splicing of OAS1 alters the risk for severe COVID-19 von Huffman, J, Butler-Laporte, G, Khan, A, Drivas, TG, Peloso, GM, Nakanishi, T, Verma, A, Kiryluk, K, Richards, JB, Zeberg, H

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Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: The cohorts for heart and aging research in genomic epidemiology von Seyerle, AA, Sitlani, CM, Noordam, R, Gogarten, SM, Li, J, Li, X, Evans, DS, Sun, F, Laaksonen, MA, Isaacs, A, Kristiansson, K, Highland, HM, Stewart, JD, Harris, TB, Trompet, S, Bis, JC, Peloso, GM, Brody, JA, Broer, L, Busch, EL, Duan, Q, Stilp, AM, O'Donnell, CJ, Macfarlane, PW, Floyd, JS, Kors, JA, Lin, HJ, Li-Gao, R, Sofer, T, Méndez-Giráldez, R, Cummings, SR, Heckbert, SR, Hofman, A, Ford, I, Li, Y, Launer, LJ, Porthan, K, Newton-Cheh, C, Napier, MD, Kerr, KF, Reiner, AP, Rice, KM, Roach, J, Buckley, BM, Soliman, EZ, De Mutsert, R, Sotoodehnia, N, Uitterlinden, AG, North, KE, Lee, CR, Gudnason, V, Stürmer, T, Rosendaal, FR, Taylor, KD, Wiggins, KL, Wilson, JG, Chen, YD, Kaplan, RC, Wilhelmsen, K, Cupples, LA, Salomaa, V, Van Duijn, C, Jukema, JW, Liu, Y, Mook-Kanamori, DO, Lange, LA, Vasan, RS, Smith, AV, Stricker, BH, Laurie, CC, Rotter, JI, Whitsel, EA, Psaty, BM, Avery, CL

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Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease von Peloso, GM, van der Lee, SJ, Sims, R, Naj, AC, Bellenguez, C, Badarinarayan, N, Jakobsdottir, J, Kunkle, BW, Boland, A, Raybould, R, Bis, JC, Martin, ER, Grenier-Boley, B, Heilmann-Heimbach, S, Chouraki, V, Kuzma, AB, Sleegers, K, Vronskaya, M, Ruiz, A, Graham, RR, Olaso, R, Hoffmann, P, Grove, ML, Vardarajan, BN, Hiltunen, M, Nöthen, MM, White, CC, Hamilton-Nelson, KL, Epelbaum, J, Maier, W, Choi, SH, Beecham, GW, Dulary, C, Herms, S, Smith, AV, Funk, CC, Derbois, Forstner, AJ, Ahmad, S, Li, H, Bacq, D, Harold, D, Satizabal, CL, Valladares, O, Squassina, A, Thomas, R, Brody, JA, Qu, L, Sánchez-Juan, P, Morgan, T, Wolters, FJ, Zhao, Y, Garcia, FS, Denning, N, Fornage, M, Malamon, J, Naranjo, MCD, Majounie, E, Mosley, TH, Dombroski, B, Wallon, D, Lupton, MK, Dupuis, J, Whitehead, P, Fratiglioni, L, Medway, C, Jian, X, Mukherjee, S, Keller, L, Brown, K, Lin, H, Cantwell, LB, Panza, F, McGuinness, B, Moreno-Grau, S, Burgess, JD, Solfrizzi, V, Proitsi, P, Adams, HH, Allen, M, Seripa, D, Pastor, P, Cupples, LA, Price, ND, Hannequin, D, Frank-García, A, Levy, D, Chakrabarty, P, Caffarra, P, Giegling, I, Beiser, AS, Giedraitis, V, Hampel, H, Garcia, ME, Wang, X, Lannfelt, L, Mecocci, P, Eiriksdottir, G, Crane, PK

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Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease von Webb, TR, Erdmann, J, Stitziel, NO, Masca, NGD, Jansen, H, Kanoni, S, Nelson, CP, Ferrario, PG, König, IR, Johnson, AD, Betsholtz, C, Franzén, O, Schadt, EE, Björkegren, JLM, Weeke, PE, Auer, PL, Schick, UM, Lu, Y, Dube, M-P, Goel, A, Farrall, M, Peloso, GM, Won, H-H, Do, R, Iperen, EV, Scott, RA, Willenborg, C, Capelleveen, JCV, Doney, ASF, Donnelly, LA, Asselta, R, Merlini, PA, Duga, S, Marziliano, N, Denny, JC, Shaffer, C, El-Mokhtari, NE, Franke, A, Hengstenberg, C, Hoffmann, P, Jöckel, K-H, Kessler, T, Kriebel, J, Laugwitz, KL, Martinelli, N, McCarthy, MI, Zuydam, NRV, Meisinger, C, Esko, T, Mihailov, E, Escher, SA, Alver, M, Moebus, S, Morris, AD, Nikpay, M, Olivieri, O, Provost, S, AlQarawi, A, Robertson, NR, Akinsansya, KO, Reilly, DF, Vogt, TF, Yin, W, Asselbergs, FW, Kooperberg, C, Jackson, RD, Stahl, E, Müller-Nurasyid, M, Strauch, K, Varga, TV, Zeng, L, Chowdhury, R, Jukema, JW, Amouyel, P, Nordestgaard, BG, Ferrières, J, Saleheen, D, Surendran, P, Wagner, A, Howson, JMM, Butterworth, AS, Bottinger, EP, Erbel, R, Girelli, D, Hall, AS, Hovingh, GK, Kastrati, A, Meitinger, T, Kraus, WE, Metspalu, A, Palmer, CNA, Peters, A, Rader, DJ, Loos, RJF, Reiner, AP, Roden, DM, Wareham, NJ, Willer, CJ, Schunkert, H, Kathiresan, S

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Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease von Webb, TR, Erdmann, J, Stitziel, NO, Masca, NGD, Jansen, H, Kanoni, S, Nelson, CP, Ferrario, PG, Johnson, AD, Betsholtz, C, Franzen, O, Schadt, EE, Bjoerkegren, JLM, Weeke, PE, Auer, PL, Schick, UM, Lu, Y, Zhang, H, Dube, M-P, Goel, A, Farrall, M, Peloso, GM, Won, H-H, Do, R, van Iperen, E, Scott, RA, Willenborg, C, van Capelleveen, JC, Doney, ASF, Donnelly, LA, Asselta, R, Merlini, PA, Duga, S, Marziliano, N, Denny, JC, Shaffer, C, El-Mokhtari, NE, Franke, A, Hengstenberg, C, Hoffmann, P, Joeckel, K-H, Kessler, T, Kriebel, J, Laugwitz, KL, Martinelli, N, McCarthy, MI, Van Zuydam, NR, Meisinger, C, Esko, T, Mihailov, E, Escher, SA, Alver, M, Moebus, S, Morris, AD, Nikpay, M, Olivieri, O, Provost, S, AlQarawi, A, Robertson, NR, Akinsansya, KO, Reilly, DF, Vogt, TF, Yin, W, Asselbergs, FW, Kooperberg, C, Jackson, RD, Stahl, E, Mueller-Nurasyid, M, Strauch, K, Varga, TV, Zeng, L, Chowdhury, R, Jukema, JW, Amouyel, P, Nordestgaard, BG, Ferrieres, J, Saleheen, D, Surendran, P, Wagner, A, Howson, JMM, Butterworth, AS, Bottinger, EP, Erbel, R, Girelli, D, Hall, AS, Hovingh, GK, Kastrati, A, Meitinger, T, Kraus, WE, Metspalu, A, Palmer, CNA, Peters, A, Rader, DJ, Loos, RJF, Reiner, AP, Roden, DM, Wareham, NJ, Willer, CJ, Schunkert, H, Kathiresan, S

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Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease von Webb, TR, Erdmann, J, Stitziel, NO, Masca, NGD, Jansen, H, Kanoni, S, Nelson, CP, Ferrario, PG, König, IR, Betsholtz, C, Schadt, EE, Björkegren, JLM, Weeke, PE, Schick, UM, Lu, Y, Dube, M-P, Goel, A, Farrall, M, Peloso, GM, Do, R, Scott, RA, Willenborg, C, van Capelleveen, JC, Doney, ASF, Donnelly, LA, Asselta, R, Merlini, PA, Duga, S, Marziliano, N, Denny, JC, Shaffer, C, El-Mokhtari, NE, Franke, A, Hengstenberg, C, Hoffmann, P, Jöckel, K-H, Kessler, T, Kriebel, J, Laugwitz, KL, Martinelli, N, Van Zuydam, NR, Meisinger, C, Esko, T, Mihailov, E, Escher, SA, Alver, M, Moebus, S, Nikpay, M, Olivieri, O, Provost, S, AlQarawi, A, Robertson, NR, Akinsansya, KO, Reilly, DF, Vogt, TF, Yin, W, Asselbergs, FW, Kooperberg, C, Jackson, RD, Stahl, E, Müller-Nurasyid, M, Strauch, K, Salomaa, V, Jukema, JW, Amouyel, P, MORGAM Investigators, Nordestgaard, BG, Sattar, N, Surendran, P, Wagner, A, Young, R, Howson, JMM, Butterworth, AS, Ardissino, D, Bottinger, EP, Erbel, R, Franks, PW, Hall, AS, Kastrati, A, Kraus, WE, Shah, SH, Orho-Melander, M, Melander, O, Metspalu, A, Palmer, CNA, Peters, A, Rader, DJ, Reilly, MP, Loos, RJF, Reiner, AP, Tardif, J-C, Thompson, JR, Wareham, NJ, Watkins, H, Willer, CJ, Samani, NJ, Schunkert, H, Deloukas, P, Kathiresan, S, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators

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A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease von Scott, RA, Chu, AY, Surendran, P, Yaghootkar, H, Luan, J, Zhao, JH, Wessel, J, Michailidou, K, Pirie, A, Gillson, C, Al Olama, AA, Amouyel, P, Aviles-Olmos, I, Barricarte, A, Barroso, I, Garcia, SB, Bis, JC, Boehnke, M, Boerwinkle, E, Borecki, IB, Bork-Jensen, J, Caldas, C, Caslake, M, CVD50 consortium, Cupples, LA, Cruchaga, C, Czajkowski, J, Ferrannini, E, Ferrieres, J, Foltynie, T, Ford, I, Forouhi, NG, Grioni, S, Hiller, L, Jørgensen, ME, Jukema, JW, Kaaks, R, Kee, F, Kerrison, ND, Kontto, J, Kote-Jarai, Z, Kuulasmaa, K, Linneberg, A, Liu, C, Marenne, G, Mohlke, KL, Munroe, PB, Navarro, C, Nielsen, SF, Nilsson, PM, Nordestgaard, BG, Palli, D, Panico, S, Perola, M, Peters, A, Poole, CJ, Quirós, JR, Rolandsson, O, Sacerdote, C, Salomaa, V, Sánchez, MJ, Sattar, N, Sims, R, Thompson, DJ, Trompet, S, Tumino, R, van der A, DL, Virtamo, J, Walker, M, Walter, K, GERAD_EC Consortium, Neurology Working Group of the Cohorts for Heart, Aging Research in Genomic Epidemiology (CHARGE), Alzheimer’s Disease Genetics Consortium, Pancreatic Cancer Cohort Consortium, European Prospective Investigation into Cancer and Nutrition–Car, EPIC-InterAct, Abraham, JE, Aponte, JL, Butterworth, AS, Easton, DF, Eeles, RA, Frayling, TM, Howson, JM, Jørgensen, T, Kooner, J, Langenberg, C, McCarthy, MI, Pankow, JS, Pedersen, O, Rotter, JI, Samani, NJ, Vollenweider, P, O'Rahilly, S, CHD Exome+ Consortium, CARDIOGRAM Exome Consortium, Deloukas, P, Kathiresan, S, Meigs, JB, Ehm, MG

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Drug-gene interactions and the search for missing heritability: A cross-sectional pharmacogenomics study of the QT interval von Avery, CL, Sitlani, CM, Arking, DE, Arnett, DK, Bis, JC, Boerwinkle, E, Buckley, BM, Ida Chen, YD, De Craen, AJM, Eijgelsheim, M, Enquobahrie, D, Evans, DS, Ford, I, Garcia, ME, Gudnason, V, Harris, TB, Heckbert, SR, Hochner, H, Hofman, A, Hsueh, WC, Isaacs, A, Jukema, JW, Knekt, P, Kors, JA, Krijthe, BP, Kristiansson, K, Laaksonen, M, Liu, Y, Li, X, Macfarlane, PW, Newton-Cheh, C, Nieminen, MS, Oostra, BA, Peloso, GM, Porthan, K, Rice, K, Rivadeneira, FF, Rotter, JI, Salomaa, V, Sattar, N, Siscovick, DS, Slagboom, PE, Smith, AV, Sotoodehnia, N, Stott, DJ, Stricker, BH, Stürmer, T, Trompet, S, Uitterlinden, AG, Van Duijn, C, Westendorp, RGJ, Witteman, JC, Whitsel, EA, Psaty, BM

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Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia von Khera, Amit V., MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Lawson, Kim S., MS, Bartz, Traci M., MS, Deng, Xuan, MSc, van Leeuwen, Elisabeth M, Natarajan, Pradeep, MD, MMSc, Emdin, Connor A., HBSc, Bick, Alexander G., PhD, Morrison, Alanna C., PhD, Brody, Jennifer A., BA, Gupta, Namrata, PhD, Nomura, Akihiro, MD, Kessler, Thorsten, MD, Duga, Stefano, PhD, Bis, Joshua C., PhD, van Duijn, Cornelia M., PhD, Cupples, L. Adrienne, PhD, Psaty, Bruce, MD, PhD, Rader, Daniel J., MD, Danesh, John, DPhil, Schunkert, Heribert, MD, McPherson, Ruth, MD, Farrall, Martin, MD, Watkins, Hugh, MD, PhD, Lander, Eric, PhD, Wilson, James G., MD, Correa, Adolfo, MD, PhD, Boerwinkle, Eric, PhD, Merlini, Piera Angelica, MD, Ardissino, Diego, MD, Saleheen, Danish, MBBS, PhD, Gabriel, Stacey, PhD, Kathiresan, Sekar, MD

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Primordial Black Hole Dark Matter: LISA Serendipity von Bartolo, N, De Luca, V, Franciolini, G, Lewis, A, Peloso, M, Riotto, A

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Testing primordial black holes as dark matter with LISA von Bartolo, N., De Luca, V., Franciolini, G., Peloso, M., Racco, D., Riotto, A.

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Anisotropies and non-Gaussianity of the cosmological gravitational wave background von Bartolo, N., Bertacca, D., Matarrese, S., Peloso, M., Ricciardone, A., Riotto, A., Tasinato, G.

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Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium von Grove, Megan L, Yu, Bing, Cochran, Barbara J, Haritunians, Talin, Bis, Joshua C, Taylor, Kent D, Hansen, Mark, Borecki, Ingrid B, Cupples, L Adrienne, Fornage, Myriam, Gudnason, Vilmundur, Harris, Tamara B, Kathiresan, Sekar, Kraaij, Robert, Launer, Lenore J, Levy, Daniel, Liu, Yongmei, Mosley, Thomas, Peloso, Gina M, Psaty, Bruce M, Rich, Stephen S, Rivadeneira, Fernando, Siscovick, David S, Smith, Albert V, Uitterlinden, Andre, van Duijn, Cornelia M, Wilson, James G, O'Donnell, Christopher J, Rotter, Jerome I, Boerwinkle, Eric

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Gravitational wave anisotropies from primordial black holes von Bartolo, N., Bertacca, D., Luca, V. De, Franciolini, G., Matarrese, S., Peloso, M., Ricciardone, A., Riotto, A., Tasinato, G.

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