PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop von Bessems, Jos G, Loizou, George, Krishnan, Kannan, Clewell, 3rd, Harvey J, Bernasconi, Camilla, Bois, Frederic, Coecke, Sandra, Collnot, Eva-Maria, Diembeck, Walter, Farcal, Lucian Romeo, Geraets, Liesbeth, Gundert-Remy, Ursula, Kramer, Nynke, Küsters, Gabriele, Leite, Sofia B, Pelkonen, Olavi R, Schröder, Klaus, Testai, Emanuela, Wilk-Zasadna, Iwona, Zaldívar-Comenges, José-Manuel

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Applicability of Generic Assays Based on Liquid Chromatography-Electrospray Mass Spectrometry to Study in vitro Metabolism of 55 Structurally Diverse Compounds von Rousu, Timo, Hokkanen, Juho, Pelkonen, Olavi R, Tolonen, Ari

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PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment von Bessems, Jos G., Loizou, George, Krishnan, Kannan, Clewell, Harvey J., Bernasconi, Camilla, Bois, Frederic, Coecke, Sandra, Collnot, Eva-Maria, Diembeck, Walter, Farcal, Lucian Romeo, Geraets, Liesbeth, Gundert-Remy, Ursula, Kramer, Nynke, Küsters, Gabriele, Leite, Sofia B., Pelkonen, Olavi R., Schröder, Klaus, Testai, Emanuela, Wilk-Zasadna, Iwona, Zaldívar-Comenges, José-Manuel

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Relationship between lipid composition and drug metabolizing capacity of human liver von SAVOLAINEN, M. J, ARRANTO, A. J, HASSINEN, I. E, LUOMA, P. V, PELKONEN, R. O, SOTANIEMI, E. A

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Relationship between in vivo and in vitro drug metabolism in man von Sotaniemi, Eero A., Pelkonen, R. Olavi, Ahokas, Jorma T., Pirttiaho, Heikki I., Ahlqvist, Johan

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Effect of Liver Function on β-Blocker Kinetics von Sotaniemi, Eero A., Pelkonen, R. Olavi, Arranto, Arno J., Säkö, Sakari, Anttila, Markku

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Influence of liver size on the relationship between in vivo and in vitro studies of drug metabolism von Pirttiaho, Heikki I., Sotaniemi, Eero A., Olavi Pelkonen, R., Pitkänen, Uolevi

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Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study von Bernasconi, Camilla, Pelkonen, Olavi, Andersson, Tommy B., Strickland, Judy, Wilk-Zasadna, Iwona, Asturiol, David, Cole, Thomas, Liska, Roman, Worth, Andrew, Müller-Vieira, Ursula, Richert, Lysiane, Chesne, Christophe, Coecke, Sandra

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Development of adverse outcome pathways relevant for the identification of substances having endocrine disruption properties Uterine adenocarcinoma as adverse outcome von Hernandez‐Jerez, Antonio F, Adriaanse, Paulien, Aldrich, Annette, Berny, Philippe, Coja, Tamara, Duquesne, Sabine, Focks, Andreas, Millet, Maurice, Pelkonen, Olavi, Pieper, Silvia, Tiktak, Aaldrik, Topping, Christopher J, Widenfalk, Anneli, Wilks, Martin, Wolterink, Gerrit, Angeli, Karine, Recordati, Camilla, Van Duursen, Majorie, Aiassa, Elisa, Lanzoni, Anna, Lostia, Alfonso, Martino, Laura, Guajardo, Irene Pilar Munoz, Panzarea, Martina, Terron, Andrea, Marinovich, Marina

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Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment princip... von Dietrich, Daniel R, von Aulock, Sonja, Marquardt, Hans, Blaauboer, Bas, Dekant, Wolfgang, Kehrer, James, Hengstler, Jan, Collier, Abby, Gori, Gio Batta, Pelkonen, Olavi Pelkonen, Lang, Florian, Nijkamp, Frans P, Stemmer, Kerstin, Li, Albert, Savolainen, Kai, Hayes, A Wallace, Gooderham, Nigel, Harvey, Alan

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US regulations to curb alleged cancer causes are ineffectual and compromised by scientific, constitutional and ethical violations von Gori, Gio B., Aschner, Michael, Borgert, Christopher J., Cohen, Samuel M., Dietrich, Daniel R., Galli, Corrado L., Greim, Helmut, Heslop-Harrison, John S., Kacew, Sam, Kaminski, Norbert E., Klaunig, James E., Marquardt, Hans W.J., Pelkonen, Olavi, Roberts, Ruth, Savolainen, Kai M., Tsatsakis, Aristidis, Yamazaki, Hiroshi

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Scientific Opinion on the setting of health‐based reference values for metabolites of the active substance terbuthylazine von Hernandez‐Jerez, Antonio F, Adriaanse, Paulien, Aldrich, Annette Patrizia, Berny, Philippe, Duquesne, Sabine, Gimsing, Anne Louise, Millet, Maurice, Pelkonen, Olavi, Pieper, Silvia, Tiktak, Aaldrik, Topping, Christopher John, Tzoulaki, Ioanna, Widenfalk, Anneli, Wolterink, Gerrit, Kuhl, Thomas, Friel, Anja, Istace, Frederique, Kardassi, Dimitra, Lythgo, Christopher, Serafimova, Rositsa, Coja, Tamara

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Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment princip... von Dietrich, Daniel R, von Aulock, Sonja, Marquardt, Hans, Blaauboer, Bas, Dekant, Wolfgang, Kehrer, James, Hengstler, Jan, Collier, Abby, Gori, Gio Batta, Pelkonen, Olavi, Lang, Florian, Nijkamp, Frans P, Stemmer, Kerstin, Li, Albert, Savolainen, Kai, Hayes, A Wallace, Gooderham, Nigel, Harvey, Alan

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Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment princip... von Dietrich, Daniel R, Aulock, Sonja von, Marquardt, Hans, Blaauboer, Bas, Dekant, Wolfgang, Kehrer, James, Hengstler, Jan, Collier, Abby, Gori, Gio Batta, Pelkonen, Olavi, Lang, Florian, Barile, Frank A, Nijkamp, Frans P, Stemmer, Kerstin, Li, Albert, Savolainen, Kai, Hayes, A Wallace, Gooderham, Nigel, Harvey, Alan

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Obfuscating transparency? von Aschner, Michael, Autrup, Herman, Berry, Colin L., Boobis, Alan R., Cohen, Samuel M., Dekant, Wolfgang, Galli, Corrado L., Goodman, Jay I., Gori, Gio B., Greim, Helmut A., Kaminski, Norbert E., Klaassen, Curtis D., Klaunig, James E., Lotti, Marcello, Marquardt, Hans WJ, Moretto, Angelo, Pelkonen, Olavi, Sipes, I. Glenn, Wallace, Kendall B., Yamazaki, Hiroshi

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Upholding science in health, safety and environmental risk assessments and regulations von Aschner, Michael, Autrup, Herman N, Berry, Sir Colin L, Boobis, Alan R, Cohen, Samuel M, Creppy, Edmond E, Dekant, Wolfgang, Doull, John, Galli, Corrado L, Goodman, Jay I, Gori, Gio B, Greim, Helmut A, Joudrier, Philippe, Kaminski, Norbert E, Klaassen, Curtis D, Klaunig, James E, Lotti, Marcello, Marquardt, Hans W.J, Pelkonen, Olavi, Sipes, I. Glenn, Wallace, Kendall B, Yamazaki, Hiroshi

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Expression of xenobiotic-metabolizing cytochrome P450 Forms in human full-term placenta von Hakkola, Jukka, Pasanen, Markku, Hukkanen, Janne, Pelkonen, Olavi, Mäenpää, Jukka, Edwards, Robert J., Boobis, Alan R., Raunio, Hannu

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Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism von Oscarson, Mikael, McLellan, Roman A., Gullstén, Harriet, Agúndez, José A.G., Benı́tez, Julio, Rautio, Arja, Raunio, Hannu, Pelkonen, Olavi, Ingelman-Sundberg, Magnus

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Scientific opinion on pesticides in foods for infants and young children von Ockleford, Colin, Adriaanse, Paulien, Hougaard Bennekou, Susanne, Berny, Philippe, Brock, Theodorus, Duquesne, Sabine, Grilli, Sandro, Hernandez‐Jerez, Antonio F., Klein, Michael, Kuhl, Thomas, Laskowski, Ryszard, Machera, Kyriaki, Pelkonen, Olavi, Pieper, Silvia, Smith, Robert, Stemmer, Michael, Sundh, Ingvar, Teodorovic, Ivana, Tiktak, Aaldrik, Topping, Christopher J, Gundert‐Remy, Ursula, Kersting, Mathilde, Waalkens‐Berendsen, Ine, Chiusolo, Arianna, Court Marques, Danièle, Dujardin, Bruno, Kass, Georges E N, Mohimont, Luc, Nougadère, Alexandre, Reich, Hermine, Wolterink, Gerrit

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Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population von Oscarson, Mikael, McLellan, Roman A, Gullstén, Harriet, Yue, Qun-Ying, Lang, Matti A, Luisa Bernal, Maria, Sinues, Blanca, Hirvonen, Ari, Raunio, Hannu, Pelkonen, Olavi, Ingelman-Sundberg, Magnus

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