Inhibition and induction of CYP enzymes in humans: an update von Hakkola, Jukka, Hukkanen, Janne, Turpeinen, Miia, Pelkonen, Olavi

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CYP-associated drug–drug interactions: A mission accomplished? von Pelkonen, Olavi, Hakkola, Jukka, Hukkanen, Janne, Turpeinen, Miia

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Inhibition and induction of human cytochrome P450 enzymes: current status von Pelkonen, Olavi, Turpeinen, Miia, Hakkola, Jukka, Honkakoski, Paavo, Hukkanen, Janne, Raunio, Hannu

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PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop von Bessems, Jos G, Loizou, George, Krishnan, Kannan, Clewell, 3rd, Harvey J, Bernasconi, Camilla, Bois, Frederic, Coecke, Sandra, Collnot, Eva-Maria, Diembeck, Walter, Farcal, Lucian Romeo, Geraets, Liesbeth, Gundert-Remy, Ursula, Kramer, Nynke, Küsters, Gabriele, Leite, Sofia B, Pelkonen, Olavi R, Schröder, Klaus, Testai, Emanuela, Wilk-Zasadna, Iwona, Zaldívar-Comenges, José-Manuel

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The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: Comparison of the N-in-one and single substrate approaches von Abass, Khaled, Pelkonen, Olavi

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Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study von Bernasconi, Camilla, Pelkonen, Olavi, Andersson, Tommy B., Strickland, Judy, Wilk-Zasadna, Iwona, Asturiol, David, Cole, Thomas, Liska, Roman, Worth, Andrew, Müller-Vieira, Ursula, Richert, Lysiane, Chesne, Christophe, Coecke, Sandra

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Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches von Coecke, Sandra, Pelkonen, Olavi, Leite, Sofia Batista, Bernauer, Ulrike, Bessems, Jos GM, Bois, Frederic Y., Gundert-Remy, Ursula, Loizou, George, Testai, Emanuela, Zaldívar, José-Manuel

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Rapid detection and characterization of reactive drug metabolites in vitro using several isotope-labeled trapping agents and ultra-performance liquid chromatography/time-of-flight... von Rousu, Timo, Pelkonen, Olavi, Tolonen, Ari

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Characterization of human cytochrome P450 induction by pesticides von Abass, Khaled, Lämsä, Virpi, Reponen, Petri, Küblbeck, Jenni, Honkakoski, Paavo, Mattila, Sampo, Pelkonen, Olavi, Hakkola, Jukka

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Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms von Ockleford, Colin, Adriaanse, Paulien, Berny, Philippe, Brock, Theodorus, Duquesne, Sabine, Grilli, Sandro, Hernandez‐Jerez, Antonio F, Bennekou, Susanne Hougaard, Klein, Michael, Kuhl, Thomas, Laskowski, Ryszard, Machera, Kyriaki, Pelkonen, Olavi, Pieper, Silvia, Smith, Robert H, Stemmer, Michael, Sundh, Ingvar, Tiktak, Aaldrik, Topping, Christopher J., Wolterink, Gerrit, Cedergreen, Nina, Charles, Sandrine, Focks, Andreas, Reed, Melissa, Arena, Maria, Ippolito, Alessio, Byers, Harry, Teodorovic, Ivana

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Scientific Opinion addressing the state of the science on risk assessment of plant protection products for in‐soil organisms von Ockleford, Colin, Adriaanse, Paulien, Berny, Philippe, Brock, Theodorus, Duquesne, Sabine, Grilli, Sandro, Hernandez‐Jerez, Antonio F, Bennekou, Susanne Hougaard, Klein, Michael, Kuhl, Thomas, Laskowski, Ryszard, Machera, Kyriaki, Pelkonen, Olavi, Pieper, Silvia, Stemmer, Michael, Sundh, Ingvar, Teodorovic, Ivana, Tiktak, Aaldrik, Topping, Chris J., Wolterink, Gerrit, Craig, Peter, Jong, Frank, Manachini, Barbara, Sousa, Paulo, Swarowsky, Klaus, Auteri, Domenica, Arena, Maria, Rob, Smith

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Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay von Turpeinen, Miia, Jouko, Uusitalo, Jorma, Jalonen, Olavi, Pelkonen

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Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to ev... von Autrup, Herman, Barile, Frank A., Berry, Sir Colin, Blaauboer, Bas J., Boobis, Alan, Bolt, Herrmann, Borgert, Christopher J., Dekant, Wolfgang, Dietrich, Daniel, Domingo, Jose L., Gori, Gio Batta, Greim, Helmut, Hengstler, Jan, Kacew, Sam, Marquardt, Hans, Pelkonen, Olavi, Savolainen, Kai, Heslop-Harrison, Pat, Vermeulen, Nico P.

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Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality? von Pelkonen, Olavi, Xu, Qihe, Fan, Tai-Ping

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Editorial: Relevance of dog studies for the derivation of health‐based guidance values for plant protection products approval von Panzarea, Martina, Terron, Andrea, Coja, Tamara, Pelkonen, Olavi

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Human variation and CYP enzyme contribution in benfuracarb metabolism in human in vitro hepatic models von Abass, Khaled, Reponen, Petri, Mattila, Sampo, Rautio, Arja, Pelkonen, Olavi

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Comparative metabolism of benfuracarb in in vitro mammalian hepatic microsomes model and its implications for chemical risk assessment von Abass, Khaled, Reponen, Petri, Mattila, Sampo, Rautio, Arja, Pelkonen, Olavi

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The EU chemicals strategy for sustainability: in support of the BfR position von Barile, Frank A., Berry, Sir Colin, Blaauboer, Bas, Boobis, Alan, Bolt, Herrmann M., Borgert, Christopher, Dekant, Wolfgang, Dietrich, Daniel, Domingo, Jose L., Galli, Corrado L., Gori, Gio Batta, Greim, Helmut, Hengstler, Jan G., Heslop-Harrison, Pat, Kacew, Sam, Marquardt, Hans, Mally, Angela, Pelkonen, Olavi, Savolainen, Kai, Testai, Emanuela, Tsatsakis, Aristides, Vermeulen, Nico P.

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ADMET in Drug Development: What is the Role of Animals between In Silico : In vitro and In Vivo Humans? von Pelkonen, Olavi

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Functional expression, inhibition and induction of CYP enzymes in HepaRG cells von Turpeinen, Miia, Tolonen, Ari, Chesne, Christophe, Guillouzo, André, Uusitalo, Jouko, Pelkonen, Olavi

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