A genetics-led approach defines the drug target landscape of 30 immune-related traits von Fang, Hai, De Wolf, Hans, Knezevic, Bogdan, Burnham, Katie L., Osgood, Julie, Sanniti, Anna, Lledó Lara, Alicia, Kasela, Silva, De Cesco, Stephane, Wegner, Jörg K., Handunnetthi, Lahiru, McCann, Fiona E., Chen, Liye, Sekine, Takuya, Brennan, Paul E., Marsden, Brian D., Damerell, David, O’Callaghan, Chris A., Bountra, Chas, Bowness, Paul, Sundström, Yvonne, Milani, Lili, Berg, Louise, Göhlmann, Hinrich W., Peeters, Pieter J., Fairfax, Benjamin P., Sundström, Michael, Knight, Julian C.

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Leveraging Cell Painting Images to Expand the Applicability Domain and Actively Improve Deep Learning Quantitative Structure–Activity Relationship Models von Herman, Dorota, Kańduła, Maciej M., Freitas, Lorena G. A., van Dongen, Caressa, Le Van, Thanh, Mesens, Natalie, Jaensch, Steffen, Gustin, Emmanuel, Micholt, Liesbeth, Lardeau, Charles-Hugues, Varsakelis, Christos, Reumers, Joke, Zoffmann, Sannah, Will, Yvonne, Peeters, Pieter J., Ceulemans, Hugo

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Sustained synchronized neuronal network activity in a human astrocyte co-culture system von Kuijlaars, Jacobine, Oyelami, Tutu, Diels, Annick, Rohrbacher, Jutta, Versweyveld, Sofie, Meneghello, Giulia, Tuefferd, Marianne, Verstraelen, Peter, Detrez, Jan R., Verschuuren, Marlies, De Vos, Winnok H., Meert, Theo, Peeters, Pieter J., Cik, Miroslav, Nuydens, Rony, Brône, Bert, Verheyen, An

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Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study von Volpato, Viola, Smith, James, Sandor, Cynthia, Ried, Janina S., Baud, Anna, Handel, Adam, Newey, Sarah E., Wessely, Frank, Attar, Moustafa, Whiteley, Emma, Chintawar, Satyan, Verheyen, An, Barta, Thomas, Lako, Majlinda, Armstrong, Lyle, Muschet, Caroline, Artati, Anna, Cusulin, Carlo, Christensen, Klaus, Patsch, Christoph, Sharma, Eshita, Nicod, Jerome, Brownjohn, Philip, Stubbs, Victoria, Heywood, Wendy E., Gissen, Paul, De Filippis, Roberta, Janssen, Katharina, Reinhardt, Peter, Adamski, Jerzy, Royaux, Ines, Peeters, Pieter J., Terstappen, Georg C., Graf, Martin, Livesey, Frederick J., Akerman, Colin J., Mills, Kevin, Bowden, Rory, Nicholson, George, Webber, Caleb, Cader, M. Zameel, Lakics, Viktor

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Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines von Cox, Michael J., Jaensch, Steffen, Van de Waeter, Jelle, Cougnaud, Laure, Seynaeve, Daan, Benalla, Soulaiman, Koo, Seong Joo, Van Den Wyngaert, Ilse, Neefs, Jean-Marc, Malkov, Dmitry, Bittremieux, Mart, Steemans, Margino, Peeters, Pieter J., Wegner, Jörg Kurt, Ceulemans, Hugo, Gustin, Emmanuel, Chong, Yolanda T., Göhlmann, Hinrich W. H.

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Using Human iPSC-Derived Neurons to Model TAU Aggregation von Verheyen, An, Diels, Annick, Dijkmans, Joyce, Oyelami, Tutu, Meneghello, Giulia, Mertens, Liesbeth, Versweyveld, Sofie, Borgers, Marianne, Buist, Arjan, Peeters, Pieter, Cik, Miroslav

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Metabolomic biosignature differentiates melancholic depressive patients from healthy controls von Liu, Yashu, Yieh, Lynn, Yang, Tao, Drinkenburg, Wilhelmus, Peeters, Pieter, Steckler, Thomas, Narayan, Vaibhav A, Wittenberg, Gayle, Ye, Jieping

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Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes von Verheyen, An, Diels, Annick, Reumers, Joke, Van Hoorde, Kirsten, Van den Wyngaert, Ilse, van Outryve d’Ydewalle, Constantin, De Bondt, An, Kuijlaars, Jacobine, De Muynck, Louis, De Hoogt, Ronald, Bretteville, Alexis, Jaensch, Steffen, Buist, Arjan, Cabrera-Socorro, Alfredo, Wray, Selina, Ebneth, Andreas, Roevens, Peter, Royaux, Ines, Peeters, Pieter J.

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Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor von Brône, Bert, Peeters, Pieter J., Marrannes, Roger, Mercken, Marc, Nuydens, Ronny, Meert, Theo, Gijsen, Harrie J.M.

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Association of SIRT1 gene variation with visceral obesity von Peeters, Armand V., Beckers, Sigri, Verrijken, An, Mertens, Ilse, Roevens, Peter, Peeters, Pieter J., Van Hul, Wim, Van Gaal, Luc F.

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The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia von Martins-de-Souza, Daniel, Alsaif, Murtada, Ernst, Agnes, Harris, Laura W, Aerts, Nancy, Lenaerts, Ilse, Peeters, Pieter J, Amess, Bob, Rahmoune, Hassan, Bahn, Sabine, Guest, Paul C

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Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2 von Van Kolen, Kristof, Verstraeten, Karin, Royaux, Ines, De Hoogt, Ronald, Gutknecht, Eric, Peeters, Pieter J.

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EEG Alpha Power as an Intermediate Measure Between Brain-Derived Neurotrophic Factor Val66Met and Depression Severity in Patients With Major Depressive Disorder von Zoon, Harriët F A, Veth, C. P M, Arns, Martijn, Drinkenburg, W. H. I M, Talloen, Willem, Peeters, Pieter J, Kenemans, J L

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Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes von Verheyen, An, Diels, Annick, Reumers, Joke, Van Hoorde, Kirsten, Van den Wyngaert, Ilse, van Outryve d’Ydewalle, Constantin, De Bondt, An, Kuijlaars, Jacobine, De Muynck, Louis, De Hoogt, Ronald, Bretteville, Alexis, Jaensch, Steffen, Buist, Arjan, Cabrera-Socorro, Alfredo, Wray, Selina, Ebneth, Andreas, Roevens, Peter, Royaux, Ines, Peeters, Pieter J.

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Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts von Veth, Cornelis P.M, Arns, Martijn, Drinkenburg, Wilhelmus, Talloen, Willem, Peeters, Pieter J, Gordon, Evian, Buitelaar, Jan K

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Efficient delivery of RNA Interference to peripheral neurons in vivo using herpes simplex virus von Anesti, Anna-Maria, Peeters, Pieter J, Royaux, Ines, Coffin, Robert S

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Translation of a Tumor Microenvironment Mimicking 3D Tumor Growth Co-culture Assay Platform to High-Content Screening von Krausz, Eberhard, de Hoogt, Ronald, Gustin, Emmanuel, Cornelissen, Frans, Grand-Perret, Thierry, Janssen, Lut, Vloemans, Nele, Wuyts, Dirk, Frans, Sandy, Axel, Amy, Peeters, Pieter Johan, Hall, Brett, Cik, Miroslav

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Alterations in the Brain–Gut Axis Underlying Visceral Chemosensitivity in Nippostrongylus brasiliensis- Infected Mice von Aerssens, Jeroen, Hillsley, Kirk, Peeters, Pieter J, de Hoogt, Ronald, Stanisz, Andrzej, Lin, Jia–Hui, Van den Wyngaert, Ilse, Göhlmann, Hinrich W, Grundy, David, Stead, Ronald H, Coulie, Bernard

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5‐HT 7 receptor efficacy distribution throughout the canine stomach von Janssen, Pieter, Prins, Nicolaas H, Peeters, Pieter J, Zuideveld, Klaas P, Lefebvre, Romain A

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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2... von Schwaller, Juerg, Frantsve, Julie, Aster, Jon, Williams, Ifor R., Tomasson, Michael H., Ross, Theodora S., Peeters, Pieter, Van Rompaey, Luc, Van Etten, Richard A., Ilaria Jr, Robert, Marynen, Peter, Gilliland, D.Gary

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