From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial... von Sinha, Vikash Kumar, Snoeys, Jan, Osselaer, Nancy Van, Peer, Achiel Van, Mackie, Claire, Heald, Donald

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In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characte... von Sjögren, Erik, Abrahamsson, Bertil, Augustijns, Patrick, Becker, Dieter, Bolger, Michael B., Brewster, Marcus, Brouwers, Joachim, Flanagan, Talia, Harwood, Matthew, Heinen, Christian, Holm, René, Juretschke, Hans-Paul, Kubbinga, Marlies, Lindahl, Anders, Lukacova, Viera, Münster, Uwe, Neuhoff, Sibylle, Nguyen, Mai Anh, Peer, Achiel van, Reppas, Christos, Hodjegan, Amin Rostami, Tannergren, Christer, Weitschies, Werner, Wilson, Clive, Zane, Patricia, Lennernäs, Hans, Langguth, Peter

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Use of physiologically relevant biopharmaceutics tools within the pharmaceutical industry and in regulatory sciences: Where are we now and what are the gaps? von Flanagan, Talia, Van Peer, Achiel, Lindahl, Anders

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Physiology-Based IVIVE Predictions of Tramadol from in Vitro Metabolism Data von T’jollyn, Huybrecht, Snoeys, Jan, Colin, Pieter, Van Bocxlaer, Jan, Annaert, Pieter, Cuyckens, Filip, Vermeulen, An, Van Peer, Achiel, Allegaert, Karel, Mannens, Geert, Boussery, Koen

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Predicting Oral Clearance in Humans: How Close Can We Get with Allometry? von Sinha, Vikash K., De Buck, Stefan S., Fenu, Luca A., Smit, Johan W., Nijsen, Marjoleen, Gilissen, Ron A. H. J., Van Peer, Achiel, Lavrijsen, Karel, Mackie, Claire E.

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Towards a Better Prediction of Peak Concentration, Volume of Distribution and Half-Life after Oral Drug Administration in Man, Using Allometry von Sinha, Vikash K., Vaarties, Karin, De Buck, Stefan S., Fenu, Luca. A., Nijsen, Marjoleen, Gilissen, Ron A. H. J., Sanderson, Wendy, Uytsel, Kelly Van, Hoeben, Eva, Peer, Achiel Van, Mackie, Claire E., Smit, Johan W.

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Variability and Impact on Design of Bioequivalence Studies von Van Peer, Achiel

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Including Information on the Therapeutic Window in Bioequivalence Acceptance von Jacobs, Tom, De Ridder, Filip, Rusch, Sarah, Van Peer, Achiel, Molenberghs, Geert, Bijnens, Luc

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Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery von Loryan, Irena, Sinha, Vikash, Mackie, Claire, Van Peer, Achiel, Drinkenburg, Wilhelmus, Vermeulen, An, Morrison, Denise, Monshouwer, Mario, Heald, Donald, Hammarlund-Udenaes, Margareta

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Galantamine Population Pharmacokinetics in Patients with Alzheimer's Disease: Modeling and Simulations von Piotrovsky, Vladimir, Van Peer, Achiel, Van Osselaer, Nancy, Armstrong, Martin, Aerssens, Jeroen

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Physiologically-Based PK/PD Modelling of Therapeutic Macromolecules von Thygesen, Peter, Macheras, Panos, Van Peer, Achiel

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Preclinical Bioavailability Strategy for Decisions on Clinical Drug Formulation Development: An In Depth Analysis von Van den Bergh, An, Van Hemelryck, Sandy, Bevernage, Jan, Van Peer, Achiel, Brewster, Marcus, Mackie, Claire, Mannaert, Erik

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Molecular Properties Determining Unbound Intracellular and Extracellular Brain Exposure of CNS Drug Candidates von Loryan, Irena, Sinha, Vikash, Mackie, Claire, Van Peer, Achiel, Drinkenburg, Wilhelmus H, Vermeulen, An, Heald, Donald, Hammarlund-Udenaes, Margareta, Wassvik, Carola M

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Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Matura... von T’jollyn, Huybrecht, Snoeys, Jan, Vermeulen, An, Michelet, Robin, Cuyckens, Filip, Mannens, Geert, Van Peer, Achiel, Annaert, Pieter, Allegaert, Karel, Van Bocxlaer, Jan, Boussery, Koen

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across... von Darwich, Adam S., Margolskee, Alison, Pepin, Xavier, Aarons, Leon, Galetin, Aleksandra, Rostami-Hodjegan, Amin, Carlert, Sara, Hammarberg, Maria, Hilgendorf, Constanze, Johansson, Pernilla, Karlsson, Eva, Murphy, Dónal, Tannergren, Christer, Thörn, Helena, Yasin, Mohammed, Mazuir, Florent, Nicolas, Olivier, Ramusovic, Sergej, Xu, Christine, Pathak, Shriram M., Korjamo, Timo, Laru, Johanna, Malkki, Jussi, Pappinen, Sari, Tuunainen, Johanna, Dressman, Jennifer, Hansmann, Simone, Kostewicz, Edmund, He, Handan, Heimbach, Tycho, Wu, Fan, Hoft, Carolin, Pang, Yan, Bolger, Michael B., Huehn, Eva, Lukacova, Viera, Mullin, James M., Szeto, Ke X., Costales, Chester, Lin, Jian, McAllister, Mark, Modi, Sweta, Rotter, Charles, Varma, Manthena, Wong, Mei, Mitra, Amitava, Bevernage, Jan, Biewenga, Jeike, Van Peer, Achiel, Lloyd, Richard, Shardlow, Carole, Langguth, Peter, Mishenzon, Irina, Nguyen, Mai Anh, Brown, Jonathan, Lennernäs, Hans, Abrahamsson, Bertil

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IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds von Margolskee, Alison, Darwich, Adam S., Pepin, Xavier, Pathak, Shriram M., Bolger, Michael B., Aarons, Leon, Rostami-Hodjegan, Amin, Angstenberger, Jonas, Graf, Franziska, Laplanche, Loic, Müller, Thomas, Carlert, Sara, Daga, Pankaj, Murphy, Dónal, Tannergren, Christer, Yasin, Mohammed, Greschat-Schade, Susanne, Mück, Wolfgang, Muenster, Uwe, van der Mey, Dorina, Frank, Kerstin Julia, Lloyd, Richard, Adriaenssen, Lieve, Bevernage, Jan, De Zwart, Loeckie, Swerts, Dominique, Tistaert, Christophe, Van Den Bergh, An, Van Peer, Achiel, Beato, Stefania, Nguyen-Trung, Anh-Thu, Bennett, Joanne, McAllister, Mark, Wong, Mei, Zane, Patricia, Ollier, Céline, Vicat, Pascale, Kolhmann, Markus, Marker, Alexander, Brun, Priscilla, Mazuir, Florent, Beilles, Stéphane, Venczel, Marta, Boulenc, Xavier, Loos, Petra, Lennernäs, Hans, Abrahamsson, Bertil

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Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability von Karalis, Vangelis, Macheras, Panos, Van Peer, Achiel, Shah, Vinod P.

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Physiology-Based IVIVE Predictions of Tramadol from in Vitro Metabolism Data von T'Jollyn, Huybrecht, Snoeys, J, Colin, P, van Boxlaer, J, Annaert, Pieter, Cuyckens, F, Vermeulen, A, van Peer, Achiel, Allegaert, Karel, Mannens, G, Boussery, Koen

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Single-Dose Pharmacokinetic Study of Tramadol Extended-Release Tablets in Children and Adolescents von Vandenbossche, Joris, Van Peer, Achiel, Richards, Henry

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A model with separate hepato-portal compartment (first-pass model) : Fitting to plasma concentration-time profiles in humans von PIOTROVSKIJ, V, VAN PEER, A

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