KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism von Vaseva, Angelina V., Blake, Devon R., Gilbert, Thomas S.K., Ng, Serina, Hostetter, Galen, Azam, Salma H., Ozkan-Dagliyan, Irem, Gautam, Prson, Bryant, Kirsten L., Pearce, Kenneth H., Herring, Laura E., Han, Haiyong, Graves, Lee M., Witkiewicz, Agnieszka K., Knudsen, Erik S., Pecot, Chad V., Rashid, Naim, Houghton, Peter J., Wennerberg, Krister, Cox, Adrienne D., Der, Channing J.

Volltext

A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery von Coryell, Philip R, Hardy, Paul B, Chubinskaya, Susan, Pearce, Kenneth H, Loeser, Richard F

Volltext

In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot von An, Yi, Lim, Jiwoong, Glavatskikh, Marta, Wang, Xiaowen, Norris-Drouin, Jacqueline, Hardy, P. Brian, Leisner, Tina M., Pearce, Kenneth H., Kireev, Dmitri

Volltext

PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling von Yang, Yang, Jayaprakash, Deepika, Jhujh, Satpal S, Reynolds, John J, Chen, Steve, Gao, Yanzhe, Anand, Jay Ramanlal, Mutter-Rottmayer, Elizabeth, Ariel, Pablo, An, Jing, Cheng, Xing, Pearce, Kenneth H, Blanchet, Sophie-Anne, Nandakumar, Nandana, Zhou, Pei, Fradet-Turcotte, Amélie, Stewart, Grant S, Vaziri, Cyrus

Volltext

Author Correction: A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis von Gao, Yanzhe, Mutter-Rottmayer, Elizabeth, Greenwalt, Alicia M., Goldfarb, Dennis, Yan, Feng, Yang, Yang, Martinez-Chacin, Raquel C., Pearce, Kenneth H., Tateishi, Satoshi, Major, Michael B., Vaziri, Cyrus

Volltext

Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7 von Lamb, Kelsey N., Bsteh, Daniel, Dishman, Sarah N., Moussa, Hagar F., Fan, Huitao, Stuckey, Jacob I., Norris, Jacqueline L., Cholensky, Stephanie H., Li, Dongxu, Wang, Jingkui, Sagum, Cari, Stanton, Benjamin Z., Bedford, Mark T., Pearce, Kenneth H., Kenakin, Terry P., Kireev, Dmitri B., Wang, Gang Greg, James, Lindsey I., Bell, Oliver, Frye, Stephen V.

Volltext

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis von Gao, Yanzhe, Mutter-Rottmayer, Elizabeth, Greenwalt, Alicia M., Goldfarb, Dennis, Yan, Feng, Yang, Yang, Martinez-Chacin, Raquel C., Pearce, Kenneth H., Tateishi, Satoshi, Major, Michael B., Vaziri, Cyrus

Volltext

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM von Bashore, Frances M, Katis, Vittorio L, Du, Yuhong, Sikdar, Arunima, Wang, Dongxue, Bradshaw, William J, Rygiel, Karolina A, Leisner, Tina M, Chalk, Rod, Mishra, Swati, Williams, C Andrew, Gileadi, Opher, Brennan, Paul E, Wiley, Jesse C, Gockley, Jake, Cary, Gregory A, Carter, Gregory W, Young, Jessica E, Pearce, Kenneth H, Fu, Haian, Axtman, Alison D

Volltext

Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins von Rectenwald, Justin M, Guduru, Shiva Krishna Reddy, Dang, Zhao, Collins, Leonard B, Liao, Yi-En, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Kaufmann, Kyle W, Hammond, Scott M, Kireev, Dmitri B, Frye, Stephen V, Pearce, Kenneth H

Volltext

Structure–Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains von Stuckey, Jacob I, Simpson, Catherine, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Lee, Junghyun, Pasca, Ryan, Cheng, Nancy, Dickson, Bradley M, Pearce, Kenneth H, Frye, Stephen V, James, Lindsey I

Volltext

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV‑2 and Potential Mechanisms von Puhl, Ana C, Fritch, Ethan J, Lane, Thomas R, Tse, Longping V, Yount, Boyd L, Sacramento, Carolina Q, Fintelman-Rodrigues, Natalia, Tavella, Tatyana Almeida, Maranhão Costa, Fabio Trindade, Weston, Stuart, Logue, James, Frieman, Matthew, Premkumar, Lakshmanane, Pearce, Kenneth H, Hurst, Brett L, Andrade, Carolina Horta, Levi, James A, Johnson, Nicole J, Kisthardt, Samantha C, Scholle, Frank, Souza, Thiago Moreno L, Moorman, Nathaniel John, Baric, Ralph S, Madrid, Peter B, Ekins, Sean

Volltext

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition von Bledsoe, Randy K., Montana, Valerie G., Stanley, Thomas B., Delves, Chris J., Apolito, Christopher J., McKee, David D., Consler, Thomas G., Parks, Derek J., Stewart, Eugene L., Willson, Timothy M., Lambert, Millard H., Moore, John T., Pearce, Kenneth H., Xu, H.Eric

Volltext

The Nuclear Receptor Superfamily and Drug Discovery von Moore, John T., Collins, Jon L., Pearce, Kenneth H.

Volltext

Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader von Potjewyd, Frances, Turner, Anne-Marie W., Beri, Joshua, Rectenwald, Justin M., Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Margolis, David M., Pearce, Kenneth H., Herring, Laura E., James, Lindsey I.

Volltext

Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors von Baughman, Brandi M, Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A, Jessen, Henning J, Pearce, Kenneth H, Frye, Stephen V, Shears, Stephen B

Volltext

Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant von Larson, Jacob E., Hardy, P. Brian, Schomburg, Noah K., Wang, Xiaodong, Kireev, Dmitri, Rossman, Kent L., Pearce, Kenneth H.

Volltext

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors von Baughman, Brandi M, Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A, Jessen, Henning J, Pearce, Kenneth H, Frye, Stephen V, Shears, Stephen B

Volltext

Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology von Potjewyd, Frances M., Annor‐Gyamfi, Joel K., Aubé, Jeffrey, Chu, Shaoyou, Conlon, Ivie L., Frankowski, Kevin J., Guduru, Shiva K. R., Hardy, Brian P., Hopkins, Megan D., Kinoshita, Chizuru, Kireev, Dmitri B., Mason, Emily R., Moerk, Charles T., Nwogbo, Felix, Pearce, Kenneth H., Richardson, Timothy I., Rogers, David A., Soni, Disha M., Stashko, Michael, Wang, Xiaodong, Wells, Carrow, Willson, Timothy M., Frye, Stephen V., Young, Jessica E., Axtman, Alison D.

Volltext

Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library von Shell, Devan J., Rectenwald, Justin M., Buttery, Peter H., Johnson, Rebecca L., Foley, Caroline A., Guduru, Shiva K.R., Uguen, Mélanie, Rubiano, Juanita Sanchez, Zhang, Xindi, Li, Fengling, Norris-Drouin, Jacqueline L., Axtman, Matthew, Brian Hardy, P., Vedadi, Masoud, Frye, Stephen V., James, Lindsey I., Pearce, Kenneth H.

Volltext

Crystal structure of MAGEA4 MHD-RAD18 R6BD reveals a flipped binding mode compared to AlphaFold2 prediction von Forker, Karly, Fleming, Matthew C, Pearce, Kenneth H, Vaziri, Cyrus, Bowers, Albert A, Zhou, Pei

Volltext