Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model von Fang, Tracy-Shi Zhang, Sun, Yu, Pearce, Andrew C., Eleuteri, Simona, Kemp, Mark, Luckhurst, Christopher A., Williams, Rachel, Mills, Ross, Almond, Sarah, Burzynski, Laura, Márkus, Nóra M., Lelliott, Christopher J., Karp, Natasha A., Adams, David J., Jackson, Stephen P., Zhao, Jin-Feng, Ganley, Ian G., Thompson, Paul W., Balmus, Gabriel, Simon, David K.

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Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin von Lomas, David A, Irving, James A, Arico‐Muendel, Christopher, Belyanskaya, Svetlana, Brewster, Andrew, Brown, Murray, Chung, Chun‐wa, Dave, Hitesh, Denis, Alexis, Dodic, Nerina, Dossang, Anthony, Eddershaw, Peter, Klimaszewska, Diana, Haq, Imran, Holmes, Duncan S, Hutchinson, Jonathan P, Jagger, Alistair M, Jakhria, Toral, Jigorel, Emilie, Liddle, John, Lind, Ken, Marciniak, Stefan J, Messer, Jeff, Neu, Margaret, Olszewski, Allison, Ordonez, Adriana, Ronzoni, Riccardo, Rowedder, James, Rüdiger, Martin, Skinner, Steve, Smith, Kathrine J, Terry, Rebecca, Trottet, Lionel, Uings, Iain, Wilson, Steve, Zhu, Zhengrong, Pearce, Andrew C

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DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets von Chaipan, Chawaree, Soilleux, Elizabeth J, Simpson, Peter, Hofmann, Heike, Gramberg, Thomas, Marzi, Andrea, Geier, Martina, Stewart, Elizabeth A, Eisemann, Jutta, Steinkasserer, Alexander, Suzuki-Inoue, Katsue, Fuller, Gemma L, Pearce, Andrew C, Watson, Steve P, Hoxie, James A, Baribaud, Frederic, Pöhlmann, Stefan

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The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent Signaling Cascade von Fuller, Gemma L.J., Williams, Jennifer A.E., Tomlinson, Michael G., Eble, Johannes A., Hanna, Sheri L., Pöhlmann, Stefan, Suzuki-Inoue, Katsue, Ozaki, Yukio, Watson, Steve P., Pearce, Andrew C.

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Renal cells activate the platelet receptor CLEC-2 through podoplanin von Christou, Charita M, Pearce, Andrew C, Watson, Aleksandra A, Mistry, Anita R, Pollitt, Alice Y, Fenton-May, Angharad E, Johnson, Louise A, Jackson, David G, Watson, Steve P, O'Callaghan, Chris A

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Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow von McCarty, Owen J.T., Larson, Mark K., Auger, Jocelyn M., Kalia, Neena, Atkinson, Ben T., Pearce, Andrew C., Ruf, Sandra, Henderson, Robert B., Tybulewicz, Victor L.J., Machesky, Laura M., Watson, Steve P.

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G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2 von Mori, Jun, Pearce, Andrew C., Spalton, Jennifer C., Grygielska, Beata, Eble, Johannes A., Tomlinson, Michael G., Senis, Yotis A., Watson, Steve P.

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Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins von García, Angel, Prabhakar, Sripadi, Hughan, Sascha, Anderson, Tom W., Brock, Chris J., Pearce, Andrew C., Dwek, Raymond A., Watson, Steve P., Hebestreit, Holger F., Zitzmann, Nicole

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Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry von García, Angel, Prabhakar, Sripadi, Brock, Chris J., Pearce, Andrew C., Dwek, Raymond A., Watson, Steve P., Hebestreit, Holger F., Zitzmann, Nicole

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Vav1 and Vav3 Have Critical but Redundant Roles in Mediating Platelet Activation by Collagen von Pearce, Andrew C., Senis, Yotis A., Billadeau, Daniel D., Turner, Martin, Watson, Steve P., Vigorito, Elena

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Towards complete analysis of the platelet proteome von O'Neill, Eric E., Brock, Chris J., von Kriegsheim, Alexander F., Pearce, Andrew C., Dwek, Raymond A., Watson, Steve P., Hebestreit, Holger F.

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The molecular species responsible for α1‐antitrypsin deficiency are suppressed by a small molecule chaperone von Ronzoni, Riccardo, Heyer‐Chauhan, Nina, Fra, Annamaria, Pearce, Andrew C., Rüdiger, Martin, Miranda, Elena, Irving, James A., Lomas, David A.

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A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome von Liddle, John, Beneton, Veronique, Benson, Matthew, Bingham, Ryan, Bouillot, Anne, Boullay, Anne-Benedicte, Brook, Eloisa, Cryan, Jenni, Denis, Alexis, Edgar, Emma, Ferrie, Alan, Fouchet, Marie-Helene, Grillot, Didier, Holmes, Duncan S., Howes, Ashleigh, Krysa, Gael, Laroze, Alain, Lennon, Mark, McClure, Fiona, Moquette, Alexandre, Nicodeme, Edwige, Santiago, Brandon, Santos, Leandro, Smith, Kathrine J., Thorpe, James H., Thripp, Gary, Trottet, Lionel, Walker, Ann L., Ward, Simon A., Wang, Yichen, Wilson, Steve, Pearce, Andrew C., Hovnanian, Alain

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The molecular species responsible for α 1 -antitrypsin deficiency are suppressed by a small molecule chaperone von Ronzoni, Riccardo, Heyer-Chauhan, Nina, Fra, Annamaria, Pearce, Andrew C, Rüdiger, Martin, Miranda, Elena, Irving, James A, Lomas, David A

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GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice von Pearce, Andrew C., Bamford, Mark J., Barber, Ruth, Bridges, Angela, Convery, Maire A., Demetriou, Constantinos, Evans, Sian, Gobbetti, Thomas, Hirst, David J., Holmes, Duncan S., Hutchinson, Jonathan P., Jayne, Sandrine, Lezina, Larissa, McCabe, Michael T., Messenger, Cassie, Morley, Joanne, Musso, Melissa C., Scott-Stevens, Paul, Manso, Ana Sousa, Schofield, Jennifer, Slocombe, Tom, Somers, Don, Walker, Ann L., Wyce, Anastasia, Zhang, Xi-Ping, Wagner, Simon D.

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The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding von Liddle, John, Pearce, Andrew C., Arico-Muendel, Christopher, Belyanskaya, Svetlana, Brewster, Andrew, Brown, Murray, Chung, Chun-wa, Denis, Alexis, Dodic, Nerina, Dossang, Anthony, Eddershaw, Peter, Klimaszewska, Diana, Haq, Imran, Holmes, Duncan S., Jagger, Alistair, Jakhria, Toral, Jigorel, Emilie, Lind, Ken, Messer, Jeff, Neu, Margaret, Olszewski, Allison, Ronzoni, Riccardo, Rowedder, James, Rüdiger, Martin, Skinner, Steve, Smith, Kathrine J., Trottet, Lionel, Uings, Iain, Zhu, Zhengrong, Irving, James A., Lomas, David A.

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A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2 von Suzuki-Inoue, Katsue, Fuller, Gemma L.J., García, Ángel, Eble, Johannes A., Pöhlmann, Stefan, Inoue, Osamu, Gartner, T. Kent, Hughan, Sascha C., Pearce, Andrew C., Laing, Gavin D., Theakston, R. David G., Schweighoffer, Edina, Zitzmann, Nicole, Morita, Takashi, Tybulewicz, Victor L.J., Ozaki, Yukio, Watson, Steve P.

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The development of highly potent and selective small molecule correctors of Z alpha 1-antitrypsin misfolding von Liddle, John, Pearce, Andrew C., Arico-Muendel, Christopher, Belyanskaya, Svetlana, Brewster, Andrew, Brown, Murray, Chung, Chun-wa, Denis, Alexis, Dodic, Nerina, Dossang, Anthony, Eddershaw, Peter, Klimaszewska, Diana, Haq, Imran, Holmes, Duncan S., Jagger, Alistair, Jakhria, Toral, Jigorel, Emilie, Lind, Ken, Messer, Jeff, Neu, Margaret, Olszewski, Allison, Ronzoni, Riccardo, Rowedder, James, Rudiger, Martin, Skinner, Steve, Smith, Kathrine J., Trottet, Lionel, Uings, Iain, Zhu, Zhengrong, Irving, James A., Lomas, David A.

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Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors von Walker, Ann L., Denis, Alexis, Bingham, Ryan P., Bouillot, Anne, Edgar, Emma V., Ferrie, Alan, Holmes, Duncan S., Laroze, Alain, Liddle, John, Fouchet, Marie-Helene, Moquette, Alexandre, Nassau, Pam, Pearce, Andrew C., Polyakova, Oxana, Smith, Kathrine J., Thomas, Pamela, Thorpe, James H., Trottet, Lionel, Wang, Yichen, Hovnanian, Alain

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Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II von Burton, Victoria J., Holmes, Alan M., Ciuclan, Loredana I., Robinson, Alexander, Roger, Jan S., Jarai, Gabor, Pearce, Andrew C., Budd, David C.

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