Mode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor von KAPLAN, Nachum, ALBERT, Monique, SCHMID, Molly B, THALAKADA, Rosanne, YETHON, Jeremy, PAULS, Henry W, AWREY, Donald, BARDOUNIOTIS, Elias, BERMAN, Judd, CLARKE, Teresa, DORSEY, Mandy, HAFKIN, Barry, RAMNAUTH, Jaillal, ROMANOV, Vladimir

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The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3‑(4-(heterocyclyl)phenyl)‑1H‑indazole-5-carboxamides as Anticancer Agents von Liu, Yong, Lang, Yunhui, Patel, Narendra Kumar, Ng, Grace, Laufer, Radoslaw, Li, Sze-Wan, Edwards, Louise, Forrest, Bryan, Sampson, Peter B, Feher, Miklos, Ban, Fuqiang, Awrey, Donald E, Beletskaya, Irina, Mao, Guodong, Hodgson, Richard, Plotnikova, Olga, Qiu, Wei, Chirgadze, Nickolay Y, Mason, Jacqueline M, Wei, Xin, Lin, Dan Chi-Chia, Che, Yi, Kiarash, Reza, Madeira, Brian, Fletcher, Graham C, Mak, Tak W, Bray, Mark R, Pauls, Henry W

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The Discovery of PLK4 Inhibitors: (E)‑3-((1H‑Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents von Laufer, Radoslaw, Forrest, Bryan, Li, Sze-Wan, Liu, Yong, Sampson, Peter, Edwards, Louise, Lang, Yunhui, Awrey, Donald E, Mao, Guodong, Plotnikova, Olga, Leung, Genie, Hodgson, Richard, Beletskaya, Irina, Mason, Jacqueline M, Luo, Xunyi, Wei, Xin, Yao, Yi, Feher, Miklos, Ban, Fuqiang, Kiarash, Reza, Green, Erin, Mak, Tak W, Pan, Guohua, Pauls, Henry W

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Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides von Laufer, Radoslaw, Ng, Grace, Liu, Yong, Patel, Narendra Kumar B., Edwards, Louise G., Lang, Yunhui, Li, Sze-Wan, Feher, Miklos, Awrey, Don E., Leung, Genie, Beletskaya, Irina, Plotnikova, Olga, Mason, Jacqueline M., Hodgson, Richard, Wei, Xin, Mao, Guodong, Luo, Xunyi, Huang, Ping, Green, Erin, Kiarash, Reza, Lin, Dan Chi-Chia, Harris-Brandts, Marees, Ban, Fuqiang, Nadeem, Vincent, Mak, Tak W., Pan, Guohua J., Qiu, Wei, Chirgadze, Nickolay Y., Pauls, Henry W.

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Discovery of Pyrazolo[1,5‑a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent von Liu, Yong, Laufer, Radoslaw, Patel, Narendra Kumar, Ng, Grace, Sampson, Peter B, Li, Sze-Wan, Lang, Yunhui, Feher, Miklos, Brokx, Richard, Beletskaya, Irina, Hodgson, Richard, Plotnikova, Olga, Awrey, Donald E, Qiu, Wei, Chirgadze, Nickolay Y, Mason, Jacqueline M, Wei, Xin, Lin, Dan Chi-Chia, Che, Yi, Kiarash, Reza, Fletcher, Graham C, Mak, Tak W, Bray, Mark R, Pauls, Henry W

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Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy von Li, Sze-Wan, Liu, Yong, Sampson, Peter B., Patel, Narendra Kumar, Forrest, Bryan T., Edwards, Louise, Laufer, Radoslaw, Feher, Miklos, Ban, Fuqiang, Awrey, Donald E., Hodgson, Richard, Beletskaya, Irina, Mao, Guodong, Mason, Jacqueline M., Wei, Xin, Luo, Xunyi, Kiarash, Reza, Green, Erin, Mak, Tak W., Pan, Guohua, Pauls, Henry W.

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Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK von Laufer, Radoslaw, Li, Sze-Wan, Liu, Yong, Ng, Grace, Lang, Yunhui, Feher, Miklos, Brokx, Richard, Beletskaya, Irina, Hodgson, Richard, Mao, Guodong, Plotnikova, Olga, Awrey, Donald E., Mason, Jacqueline M., Wei, Xin, Lin, Dan Chi-Chia, Che, Yi, Kiarash, Reza, Madeira, Brian, Fletcher, Graham C., Mak, Tak W., Bray, Mark R., Pauls, Henry W.

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The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents von Sampson, Peter B, Liu, Yong, Patel, Narendra Kumar, Feher, Miklos, Forrest, Bryan, Li, Sze-Wan, Edwards, Louise, Laufer, Radoslaw, Lang, Yunhui, Ban, Fuqiang, Awrey, Donald E, Mao, Guodong, Plotnikova, Olga, Leung, Genie, Hodgson, Richard, Mason, Jacqueline M, Wei, Xin, Kiarash, Reza, Green, Erin, Qiu, Wei, Chirgadze, Nickolay Y, Mak, Tak W, Pan, Guohua, Pauls, Henry W

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Structure-based library design and the discovery of a potent and selective mast cell β-tryptase inhibitor as an oral therapeutic agent von Liang, Guyan, Aldous, Suzanne, Merriman, Gregory, Levell, Julian, Pribish, James, Cairns, Jennifer, Chen, Xin, Maignan, Sebastien, Mathieu, Magali, Tsay, Joseph, Sides, Keith, Rebello, Sam, Whitely, Brian, Morize, Isabelle, Pauls, Henry W.

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Molecular Structures of Human Factor Xa Complexed with Ketopiperazine Inhibitors:  Preference for a Neutral Group in the S1 Pocket von Maignan, Sébastien, Guilloteau, Jean-Pierre, Choi-Sledeski, Yong Mi, Becker, Michael R, Ewing, William R, Pauls, Henry W, Spada, Alfred P, Mikol, Vincent

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Dimerization of β-tryptase inhibitors, does it work for both basic and neutral P1 groups? von Liang, Guyan, Choi-Sledeski, Yong Mi, Chen, Xin, Gong, Yong, MacMillan, Eric W., Tsay, Joseph, Sides, Keith, Cairns, Jennifer, Kulitzscher, Berndt, Aldous, David J., Morize, Isabelle, Pauls, Henry W.

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2,3,4,5-Tetrahydro-1H-pyrido[2,3- b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI von Ramnauth, Jailall, Surman, Mathew D., Sampson, Peter B., Forrest, Bryan, Wilson, Jeff, Freeman, Emily, Manning, David D., Martin, Fernando, Toro, Andras, Domagala, Megan, Awrey, Donald E., Bardouniotis, Elias, Kaplan, Nachum, Berman, Judd, Pauls, Henry W.

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Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors von Maignan, Sébastien, Guilloteau, Jean-Pierre, Pouzieux, Stéphanie, Choi-Sledeski, Yong Mi, Becker, Michael R, Klein, Scott I, Ewing, William R, Pauls, Henry W, Spada, Alfred P, Mikol, Vincent

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Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI) von Sampson, Peter B., Picard, Christine, Handerson, Sean, McGrath, Teresa E., Domagala, Megan, Leeson, Andrew, Romanov, Vladimir, Awrey, Donald E., Thambipillai, Dhushy, Bardouniotis, Elias, Kaplan, Nachum, Berman, Judd M., Pauls, Henry W.

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Product involvement and the evaluation of wine quality von Charters, Steve, Pettigrew, Simone

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The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)‑2-(3-((E)‑4-(((cis)‑2,6-Dimethylmorpholino)methyl)styryl)‑1H‑indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,... von Sampson, Peter B., Liu, Yong, Forrest, Bryan, Cumming, Graham, Li, Sze-Wan, Patel, Narendra Kumar, Edwards, Louise, Laufer, Radoslaw, Feher, Miklos, Ban, Fuqiang, Awrey, Donald E., Mao, Guodong, Plotnikova, Olga, Hodgson, Richard, Beletskaya, Irina, Mason, Jacqueline M., Luo, Xunyi, Nadeem, Vincent, Wei, Xin, Kiarash, Reza, Madeira, Brian, Huang, Ping, Mak, Tak W., Pan, Guohua, Pauls, Henry W.

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The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1 R ,2 S )-2-(3-(( E )-4-((( cis )-2,6-Dimethylmorpholino)methyl)styryl)-1 H -indazol-6-yl)-5′-methoxyspiro[cyclo... von Sampson, Peter B., Liu, Yong, Forrest, Bryan, Cumming, Graham, Li, Sze-Wan, Patel, Narendra Kumar, Edwards, Louise, Laufer, Radoslaw, Feher, Miklos, Ban, Fuqiang, Awrey, Donald E., Mao, Guodong, Plotnikova, Olga, Hodgson, Richard, Beletskaya, Irina, Mason, Jacqueline M., Luo, Xunyi, Nadeem, Vincent, Wei, Xin, Kiarash, Reza, Madeira, Brian, Huang, Ping, Mak, Tak W., Pan, Guohua, Pauls, Henry W.

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The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)‑ones as Orally Bioavailable Antitumor Agents von Sampson, Peter B., Liu, Yong, Patel, Narendra Kumar, Feher, Miklos, Forrest, Bryan, Li, Sze-Wan, Edwards, Louise, Laufer, Radoslaw, Lang, Yunhui, Ban, Fuqiang, Awrey, Donald E., Mao, Guodong, Plotnikova, Olga, Leung, Genie, Hodgson, Richard, Mason, Jacqueline, Wei, Xin, Kiarash, Reza, Green, Erin, Qiu, Wei, Chirgadze, Nickolay Y., Mak, Tak W., Pan, Guohua, Pauls, Henry W.

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A study of hoarding behavior and attachment to material possessions von Cherrier, Hélène, Ponnor, Tresa

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Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk von Dunlop, Malcolm G, Dobbins, Sara E, Farrington, Susan Mary, Jones, Angela M, Palles, Claire, Whiffin, Nicola, Tenesa, Albert, Spain, Sarah, Broderick, Peter, Ooi, Li-Yin, Domingo, Enric, Smillie, Claire, Henrion, Marc, Frampton, Matthew, Martin, Lynn, Grimes, Graeme, Gorman, Maggie, Semple, Colin, Ma, Yusanne P, Barclay, Ella, Prendergast, James, Cazier, Jean-Baptiste, Olver, Bianca, Penegar, Steven, Lubbe, Steven, Chander, Ian, Carvajal-Carmona, Luis G, Ballereau, Stephane, Lloyd, Amy, Vijayakrishnan, Jayaram, Zgaga, Lina, Rudan, Igor, Theodoratou, Evropi, Starr, John M, Deary, Ian, Kirac, Iva, Kovacević, Dujo, Aaltonen, Lauri A, Renkonen-Sinisalo, Laura, Mecklin, Jukka-Pekka, Matsuda, Koichi, Nakamura, Yusuke, Okada, Yukinori, Gallinger, Steven, Duggan, David J, Conti, David, Newcomb, Polly, Hopper, John, Jenkins, Mark A, Schumacher, Fredrick, Casey, Graham, Easton, Douglas, Shah, Mitul, Pharoah, Paul, Lindblom, Annika, Liu, Tao, Smith, Christopher G, West, Hannah, Cheadle, Jeremy P, Midgley, Rachel, Kerr, David J, Campbell, Harry, Tomlinson, Ian P, Houlston, Richard S

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