Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β von Hommel, Ulrich, Hurth, Konstanze, Rondeau, Jean-Michel, Vulpetti, Anna, Ostermeier, Daniela, Boettcher, Andreas, Brady, Jacob Peter, Hediger, Michael, Lehmann, Sylvie, Koch, Elke, Blechschmidt, Anke, Yamamoto, Rina, Tundo Dottorello, Valentina, Haenni-Holzinger, Sandra, Kaiser, Christian, Lehr, Philipp, Lingel, Andreas, Mureddu, Luca, Schleberger, Christian, Blank, Jutta, Ramage, Paul, Freuler, Felix, Eder, Joerg, Bornancin, Frédéric

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Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes von Kallen, Joerg, Goepfert, Arnaud, Blechschmidt, Anke, Izaac, Aude, Geiser, Martin, Tavares, Gisele, Ramage, Paul, Furet, Pascal, Masuya, Keiichi, Lisztwan, Joanna

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Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs von Rondeau, Jean-Michel, Bitsch, Francis, Bourgier, Emmanuelle, Geiser, Martin, Hemmig, Rene, Kroemer, Markus, Lehmann, Sylvie, Ramage, Paul, Rieffel, Sebastien, Strauss, André, Green, Jonathan R., Jahnke, Wolfgang

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COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study von Cazier, Jean-Baptiste, Briggs, Sarah E W, Bisht, Vartika, Campton, Naomi A, Collins, Graham, Curley, Helen M, Earwaker, Philip, Hartley, Simon, Kerr, David, Lee, Alvin J X, Lee, Rebecca J, Lee, Siow Ming, Mckenzie, Hayley, Murugaesu, Nirupa, Powles, Thomas, Protheroe, Emily A, Purshouse, Karin, Sharma-Oates, Archana, Smith, Ashley J, Topping, Oliver, Turnbull, Chris D, Kerr, Rachel, Bedair, Ahmed, Akingboye, Akinfemi, Maynard, Alec, Pawsey, Alexander, Suwaidan, Ali Abdulnabi, Okines, Alicia, Massey, Alison, Angelakas, Angelos, Wu, Anjui, Tivey, Ann, Armstrong, Anne, Pillai, Annet, Poon-King, Ashley, Usborne, Caroline, Thirlwell, Christina, Mitchell, Christian, Sng, Christopher, Scrase, Christopher, Jingree, Christopher, Brunner, Clair, Fuller, Claire, Barrington, Craig, Muller, Daniel, Ottaviani, Diego, Gilbert, Duncan, Tacconi, Eliana, Copson, Ellen, Renninson, Emily, Burke, Emma, Smith, Fiona, Holt, Francesca, Soosaipillai, Gehan, Boyce, Hayley, Hollis, Helen, Bowyer, Helen, Illingworth, Jack, Gibson, Jack, Bhosle, Jaishree, Best, James, Sacco, Joseph, Chacko, Joseph, Cammaert, Lauren, Melcher, Lucinda, Cook, Lucy, Hewish, Madeleine, Baxter, Mark, Fittall, Matthew, Tilby, Michael, Rowe, Michael, Galazi, Myria, Sheikh, Omar, Ramage, Paul, Leonard, Pauline, Naksukpaiboon, Piangfan, Sharkey, Rachel, Bolton, Rachel, Sargent, Rebecca, Jyothirmayi, Rema, Goldstein, Robert, Oakes, Roderick, Kanani, Ruhi, Pettengell, Ruth, Massalha, Samah, Kathirgamakarthigeyan, Sangary, Dolly, Saoirse, Derby, Sarah, Lowndes, Sarah, Benafif, Sarah, Brown, Sean, Ellis, Shawn, Pugh, Sian, Shamas, Simon, Wong, Yien Ning Sophia, Tillet, Tania, Rabbi, Taslima, Angelis, Vasileios, Brown, Victoria, Hudson, Zoe

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MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans von Koch, Alexander W., Schiering, Nikolaus, Melkko, Samu, Ewert, Stefan, Salter, Janeen, Zhang, Yiming, McCormack, Peter, Yu, Jianying, Huang, Xueming, Chiu, Yu-Hsin, Chen, Zhiping, Schleeger, Simone, Horny, Geraldine, DiPetrillo, Keith, Muller, Lionel, Hein, Andreas, Villard, Frederic, Scharenberg, Meike, Ramage, Paul, Hassiepen, Ulrich, Côté, Serge, DeGagne, Julie, Krantz, Carsten, Eder, Jörg, Stoll, Brian, Kulmatycki, Kenneth, Feldman, David L., Hoffmann, Peter, Basson, Craig T., Frost, Robert J.A., Khder, Yasser

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The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β von Rondeau, Jean-Michel, Ramage, Paul, Zurini, Mauro, Gram, Hermann

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Structure of neprilysin in complex with the active metabolite of sacubitril von Schiering, Nikolaus, D’Arcy, Allan, Villard, Frederic, Ramage, Paul, Logel, Claude, Cumin, Frederic, Ksander, Gary M., Wiesmann, Christian, Karki, Rajeshri G., Mogi, Muneto

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Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable... von Mainolfi, Nello, Ehara, Takeru, Karki, Rajeshri G, Anderson, Karen, Mac Sweeney, Aengus, Liao, Sha-Mei, Argikar, Upendra A, Jendza, Keith, Zhang, Chun, Powers, James, Klosowski, Daniel W, Crowley, Maura, Kawanami, Toshio, Ding, Jian, April, Myriam, Forster, Cornelia, Serrano-Wu, Michael, Capparelli, Michael, Ramqaj, Rrezarta, Solovay, Catherine, Cumin, Frederic, Smith, Thomas M, Ferrara, Luciana, Lee, Wendy, Long, Debby, Prentiss, Melissa, De Erkenez, Andrea, Yang, Louis, Liu, Fang, Sellner, Holger, Sirockin, Finton, Valeur, Eric, Erbel, Paulus, Ostermeier, Daniela, Ramage, Paul, Gerhartz, Bernd, Schubart, Anna, Flohr, Stefanie, Gradoux, Nathalie, Feifel, Roland, Vogg, Barbara, Wiesmann, Christian, Maibaum, Jürgen, Eder, Jörg, Sedrani, Richard, Harrison, Richard A, Mogi, Muneto, Jaffee, Bruce D, Adams, Christopher M

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Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches von Vulpetti, Anna, Rondeau, Jean-Michel, Bellance, Marie-Hélène, Blank, Jutta, Boesch, Ralf, Boettcher, Andreas, Bornancin, Frédéric, Buhr, Sylvia, Connor, Lauren E., Dumelin, Christoph E., Esser, Oliver, Hediger, Michael, Hintermann, Samuel, Hommel, Ulrich, Koch, Elke, Lapointe, Guillaume, Leder, Lukas, Lehmann, Sylvie, Lehr, Philipp, Meier, Peter, Muller, Lionel, Ostermeier, Daniela, Ramage, Paul, Schiebel-Haddad, Sihame, Smith, Alexander Baxter, Stojanovic, Aleksandar, Velcicky, Juraj, Yamamoto, Rina, Hurth, Konstanze

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NMR solution structure of the inserted domain of human leukocyte function associated antigen-1 von Legge, Glen B., Kriwacki, Richard W., Chung, John, Hommel, Ulrich, Ramage, Paul, Case, David A., Dyson, H.Jane, Wright, Peter E.

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Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Appr... von Lorthiois, Edwige, Roache, James, Barnes-Seeman, David, Altmann, Eva, Hassiepen, Ulrich, Turner, Gordon, Duvadie, Rohit, Hornak, Viktor, Karki, Rajeshri G, Schiering, Nikolaus, Weihofen, Wilhelm A, Perruccio, Francesca, Calhoun, Amy, Fazal, Tanzina, Dedic, Darija, Durand, Corinne, Dussauge, Solene, Fettis, Kamal, Tritsch, Fabien, Dentel, Celine, Druet, Adelaide, Liu, Donglei, Kirman, Louise, Lachal, Julie, Namoto, Kenji, Bevan, Douglas, Mo, Rose, Monnet, Gabriela, Muller, Lionel, Zessis, Richard, Huang, Xueming, Lindsley, Loren, Currie, Treeve, Chiu, Yu-Hsin, Fridrich, Cary, Delgado, Peter, Wang, Shuangxi, Hollis-Symynkywicz, Micah, Berghausen, Joerg, Williams, Eric, Liu, Hong, Liang, Guiqing, Kim, Hyungchul, Hoffmann, Peter, Hein, Andreas, Ramage, Paul, D’Arcy, Allan, Harlfinger, Stefanie, Renatus, Martin, Ruedisser, Simon, Feldman, David, Elliott, Jason, Sedrani, Richard, Maibaum, Juergen, Adams, Christopher M

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Chaperone over-expression in Escherichia coli: Apparent increased yields of soluble recombinant protein kinases are due mainly to soluble aggregates von Haacke, Annette, Fendrich, Gabriele, Ramage, Paul, Geiser, Martin

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Mortality Among Adults With Cancer Undergoing Chemotherapy or Immunotherapy and Infected With COVID-19 von Várnai, Csilla, Palles, Claire, Arnold, Roland, Curley, Helen M, Purshouse, Karin, Cheng, Vinton W T, Booth, Stephen, Campton, Naomi A, Collins, Graham P, Hughes, Daniel J, Kulasekararaj, Austin G, Lee, Alvin J X, Olsson-Brown, Anna C, Sharma-Oates, Archana, Van Hemelrijck, Mieke, Lee, Lennard Y W, Kerr, Rachel, Middleton, Gary, Cazier, Jean-Baptiste

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Structure-based design and optimization of potent inhibitors of the adenoviral protease von Grosche, Philipp, Sirockin, Finton, Mac Sweeney, Aengus, Ramage, Paul, Erbel, Paul, Melkko, Samu, Bernardi, Anna, Hughes, Nicola, Ellis, David, Combrink, Keith D., Jarousse, Nadine, Altmann, Eva

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Measuring success: Factors impacting on the implementation and use of performance measurement within Victoria's human services agencies von Ramage, Paul, Armstrong, Anona

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Chemotherapy treatment patterns and clinical outcomes in patients with metastatic soft tissue sarcoma. The SArcoma treatment and Burden of Illness in North America and Europe (SABI... von Leahy, M., Garcia del Muro, X., Reichardt, P., Judson, I., Staddon, A., Verweij, J., Baffoe-Bonnie, A., Jönsson, L., Musayev, A., Justo, N., Burke, T., Blay, J.Y.

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Discovery and Structure-Based Optimization of Adenain Inhibitors von Mac Sweeney, Aengus, Grosche, Philipp, Ellis, David, Combrink, Keith, Erbel, Paul, Hughes, Nicola, Sirockin, Finton, Melkko, Samu, Bernardi, Anna, Ramage, Paul, Jarousse, Nadine, Altmann, Eva

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Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors von Kawanami, Toshio, Karki, Rajeshri G, Cody, Emma, Liu, Qian, Liang, Guiqing, Ksander, Gary M, Rigel, Dean F, Schiering, Nikolaus, Gong, Yongjin, Coppola, Gary M, Iwaki, Yuki, Sun, Robert, Neubert, Alan, Fan, Li, Ingles, Sara, D’Arcy, Allan, Villard, Frederic, Ramage, Paul, Jeng, Arco Y, Leung-Chu, Jennifer, Liu, Jing, Beil, Michael, Fu, Fumin, Chen, Wei, Cumin, Frederic, Wiesmann, Christian, Mogi, Muneto

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Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1 von Chrencik, Jill E., Brooun, Alexei, Zhang, Hui, Mathews, Irimpan I., Hura, Greg L., Foster, Scott A., Perry, J. Jefferson P., Streiff, Markus, Ramage, Paul, Widmer, Hans, Bokoch, Gary M., Tainer, John A., Weckbecker, Gisbert, Kuhn, Peter

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The likelihood of aggregation during protein renaturation can be assessed using the second virial coefficient von Ho, Jason G.S., Middelberg, Anton P.J., Ramage, Paul, Kocher, Hans P.

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