Understanding Idiosyncratic Toxicity: Lessons Learned from Drug-Induced Liver Injury von Mosedale, Merrie, Watkins, Paul B

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Incidence and Etiology of Drug-Induced Liver Injury in Mainland China von Shen, Tao, Liu, Yingxia, Shang, Jia, Xie, Qing, Li, Jun, Yan, Ming, Xu, Jianming, Niu, Junqi, Liu, Jiajun, Watkins, Paul B., Aithal, Guruprasad P., Andrade, Raúl J., Dou, Xiaoguang, Yao, Lvfeng, Lv, Fangfang, Wang, Qi, Li, Yongguo, Zhou, Xinmin, Zhang, Yuexin, Zong, Peilan, Wan, Bin, Zou, Zhengsheng, Yang, Dongliang, Nie, Yuqiang, Li, Dongliang, Wang, Yuya, Han, Xi’an, Zhuang, Hui, Mao, Yimin, Chen, Chengwei

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The transformation in biomarker detection and management of drug‐induced liver injury von Church, Rachel J., Watkins, Paul B.

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Hepatic histological findings in suspected drug‐induced liver injury: Systematic evaluation and clinical associations von Kleiner, David E., Chalasani, Naga P., Lee, William M., Fontana, Robert J., Bonkovsky, Herbert L., Watkins, Paul B., Hayashi, Paul H., Davern, Timothy J., Navarro, Victor, Reddy, Rajender, Talwalkar, Jayant A., Stolz, Andrew, Gu, Jiezhun, Barnhart, Huiman, Hoofnagle, Jay H.

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Polygenic architecture informs potential vulnerability to drug-induced liver injury von Koido, Masaru, Kawakami, Eri, Fukumura, Junko, Noguchi, Yui, Ohori, Momoko, Nio, Yasunori, Nicoletti, Paola, Aithal, Guruprasad P., Daly, Ann K., Watkins, Paul B., Anayama, Hisashi, Dragan, Yvonne, Shinozawa, Tadahiro, Takebe, Takanori

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Candidate biomarkers for the diagnosis and prognosis of drug‐induced liver injury: An international collaborative effort von Church, Rachel J., Kullak‐Ublick, Gerd A., Aubrecht, Jiri, Bonkovsky, Herbert L., Chalasani, Naga, Fontana, Robert J., Goepfert, Jens C., Hackman, Frances, King, Nicholas M. P., Kirby, Simon, Kirby, Patrick, Marcinak, John, Ormarsdottir, Sif, Schomaker, Shelli J., Schuppe‐Koistinen, Ina, Wolenski, Francis, Arber, Nadir, Merz, Michael, Sauer, John‐Michael, Andrade, Raul J., van Bömmel, Florian, Poynard, Thierry, Watkins, Paul B.

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Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis von Norona, Leah M, Nguyen, Deborah G, Gerber, David A, Presnell, Sharon C, Mosedale, Merrie, Watkins, Paul B

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In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials von Church, Rachel J, Watkins, Paul B

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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective von Kenna, J. Gerry, Taskar, Kunal S., Battista, Christina, Bourdet, David L., Brouwer, Kim L.R., Brouwer, Kenneth R., Dai, David, Funk, Christoph, Hafey, Michael J., Lai, Yurong, Maher, Jonathan, Pak, Y. Anne, Pedersen, Jenny M., Polli, Joseph W., Rodrigues, A. David, Watkins, Paul B., Yang, Kyunghee, Yucha, Robert W.

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Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles von Lucena, M. Isabel, Molokhia, Mariam, Shen, Yufeng, Urban, Thomas J, Aithal, Guruprasad P, Andrade, Raúl J, Day, Christopher P, Ruiz–Cabello, Francisco, Donaldson, Peter T, Stephens, Camilla, Pirmohamed, Munir, Romero–Gomez, Manuel, Navarro, Jose Maria, Fontana, Robert J, Miller, Michael, Groome, Max, Bondon–Guitton, Emmanuelle, Conforti, Anita, Stricker, Bruno H.C, Carvajal, Alfonso, Ibanez, Luisa, Yue, Qun–Ying, Eichelbaum, Michel, Floratos, Aris, Pe'er, Itsik, Daly, Mark J, Goldstein, David B, Dillon, John F, Nelson, Matthew R, Watkins, Paul B, Daly, Ann K

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Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group von Bonkovsky, Herbert L, Barnhart, Huiman X, Foureau, David M, Steuerwald, Nury, Lee, William M, Gu, Jiezhun, Fontana, Robert J, Hayashi, Paul J, Chalasani, Naga, Navarro, Victor M, Odin, Joseph, Stolz, Andrew, Watkins, Paul B, Serrano, Jose

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Assessing Liver Effects of Cannabidiol and Valproate Alone and in Combination Using Quantitative Systems Toxicology von Lakhani, Vinal V., Generaux, Grant, Howell, Brett A., Longo, Diane M., Watkins, Paul B.

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Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences von McLaughlin, Jacqueline E, Layton, Rebekah L, Watkins, Paul B, Nicholas, Robert A, Brouwer, Kim L R

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Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables von Tyson, Rachel J, Park, Christine C, Powell, J Robert, Patterson, J Herbert, Weiner, Daniel, Watkins, Paul B, Gonzalez, Daniel

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Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse von Church, Rachel J, Schomaker, Shelli J, Eaddy, J Scott, Boucher, Germaine G, Kreeger, John M, Aubrecht, Jiri, Watkins, Paul B

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Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors von Woodhead, Jeffrey L, Brock, William J, Roth, Sharin E, Shoaf, Susan E, Brouwer, Kim L R, Church, Rachel, Grammatopoulos, Tom N, Stiles, Linsey, Siler, Scott Q, Howell, Brett A, Mosedale, Merrie, Watkins, Paul B, Shoda, Lisl K M

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Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury von Holman, Natalie S, Church, Rachel J, Nautiyal, Manisha, Rose, Kelly A, Thacker, Sarah E, Otieno, Monicah A, Wolf, Kristina K, LeCluyse, Edward, Watkins, Paul B, Mosedale, Merrie

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Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury von Rochon, James, Protiva, Petr, Seeff, Leonard B., Fontana, Robert J., Liangpunsakul, Suthat, Watkins, Paul B., Davern, Timothy, McHutchison, John G.

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Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization von Fu, Dong, Cardona, Panli, Ho, Henry, Watkins, Paul B, Brouwer, Kim L R

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Liver Injury Due to Drugs and Viruses: Mechanistic Similarities and Implications for AAV Gene Therapy von Watkins, Paul B.

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