OC-0236: DTP-006: a novel, orally bioavailable hypoxia-activated prodrug von Niemans, R, Yaromina, A, Theys, J, Ashoorzadeh, A, Anderson, R, Bull, M, Guise, C, Hsu, H.L, Abbattista, M, Mowday, A, Patterson, A.V, Smaill, J.B, Ackerley, D.F, Dubois, L, Lambin, P

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uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954 von Prosser, G.A., Patterson, A.V., Ackerley, D.F.

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1015 POSTER Evaluation of the Role of the Novel Glucose-phosphorylating Enzyme ADP-dependent Glucokinase in Human Tumour Cell Lines Using Zinc Finger Nuclease Gene Knockouts von Richter, S, Patterson, A.V, Stowell, K.M, Ronimus, R.S, Wilson, W.R

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Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954 von Prosser, G.A., Copp, J.N., Syddall, S.P., Williams, E.M., Smaill, J.B., Wilson, W.R., Patterson, A.V., Ackerley, D.F.

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Toward a high-throughput screening platform for directed evolution of enzymes that activate genotoxic prodrugs von Copp, J.N., Williams, E.M., Rich, M.H., Patterson, A.V., Smaill, J.B., Ackerley, D.F.

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OC-0591: Hypoxic cell killing by SN36506, a novel hypoxia-activated prodrug von Niemans, R., Yaromina, A., Theys, J., Ashoorzadeh, A., Anderson, R., Bull, M., Guise, C., Hsu, H.L., Abbattista, M., Mowday, A., Patterson, A.V., Smaill, J.B., Dubois, L., Lambin, P.

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EP-2327: Hypoxic cell killing by CP-506, a novel hypoxia-activated prodrug von Niemans, R., Yaromina, A., Theys, J., Marcus, D., Ashoorzadeh, A., Abbattista, M., Mowday, A., Biemans, R., Lieuwes, N., Deschoemaeker, S., Heyerick, A., Guise, C., Smaill, J.B., Patterson, A.V., Dubois, L., Lambin, P.

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305 POSTER Structure–activity relationships for lipophilic dinitrobenzamide mustards as prodrugs for Escherichia coli NfsB nitroreductase von Sydall, S, Ashoorzadeh, A, Atwell, G.A, Smaill, J.B, Wilson, W.R, Denny, W.A, Patterson, A.V

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300 POSTER Oncolytic adenovirus ONYX-411NTR enhances the antitumour efficacy of the bioreductive alkylator prodrug PR-104 von Singleton, D.C, Syddall, S.P, Bai, S.Y, Li, D, Denny, W.A, Wilson, W.R, Patterson, A.V

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474 POSTER Relationships between reductive metabolism, DNA crosslinks and antitumor activity of the hypoxia-activated prodrug PR-104 in preclinical models von Singleton, R.S, Pullen, S.M, Ferry, D.M, Guise, C.P, Patterson, A.V, Wilson, W.R

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Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954 von Swe, P.M., Copp, J.N., Green, L.K., Guise, C.P., Mowday, A.M., Smaill, J.B., Patterson, A.V., Ackerley, D.F.

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473 POSTER The bioreductive prodrug PR-104 is activated under aerobic conditions by human aldo-keto reductase 1C3 (prostaglandin F synthase) von Patterson, A.V, Guise, C.P, Abbattista, M, van Leeuwen, W, Pullen, S.M, Ferry, D.M, Denny, W.A, Guilford, P, Wilson, W.R

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The nitroreductase prodrug SN 28343 enhances the potency of systemically administered armed oncolytic adenovirus ONYX-[411.sup.NTR] von Singleton, D.C, Li, D, Bai, S.Y, Syddall, S.P, Smaill, J.B, Shen, Y, Denny, W.A, Wilson, W.R, Patterson, A.V

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Cytotoxicity of the bioreductive agent RH1 and its lack of interaction with radiation von Kim, Joo-Young, West, C.M.L., Valentine, H., Ward, T.H., Patterson, A.V., Stratford, I.J., Roberts, S.A., Hendry, J.H.

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Novel chimeric gene promoters responsive to hypoxia and ionizing radiation von Greco, O, Marples, B, Dachs, G.U, Williams, K.J, Patterson, A.V, Scott, S.D, Hsieh, J.T

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496 Water-soluble dinitrobenzamide mustard phosphate pre-prodrugs as hypoxic cytotoxins von Wilson, W.R., Pullen, S.M., Degenkolbe, A., Ferry, D.M., Helsby, N.A., Hicks, K.O., Atwell, G.J., Yang, S., Denny, W.A., Patterson, A.V.

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Enhanced prodrug activation von I.J. STRATFORD, S.M. KINGSMAN, A.V. PATTERSON

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Behavioral and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat von Hoban, A.E, Moloney, R.D, Golubeva, A.V, McVey Neufeld, K.A, O’Sullivan, O, Patterson, E, Stanton, C, Dinan, T.G, Clarke, G, Cryan, J.F

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Ramp compression of diamond to five terapascals von Smith, R. F., Eggert, J. H., Jeanloz, R., Duffy, T. S., Braun, D. G., Patterson, J. R., Rudd, R. E., Biener, J., Lazicki, A. E., Hamza, A. V., Wang, J., Braun, T., Benedict, L. X., Celliers, P. M., Collins, G. W.

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Contaminated sediment in the Detroit River provokes acclimated responses in wild brown bullhead (Ameiurus nebulosus) populations von Assad, J, Cho, S, Dileo, V, Gascoigne, G, Hubberstey, A V, Patterson, D, Williams, R

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