Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles von Wang, Yingcai, Liu, Jiwen (Jim), Dransfield, Paul J, Zhu, Liusheng, Wang, Zhongyu, Du, Xiaohui, Jiao, Xianyun, Su, Yongli, Li, An-rong, Brown, Sean P, Kasparian, Annie, Vimolratana, Marc, Yu, Ming, Pattaropong, Vatee, Houze, Jonathan B, Swaminath, Gayathri, Tran, Thanhvien, Nguyen, Khanh, Guo, Qi, Zhang, Jane, Zhuang, Run, Li, Frank, Miao, Lynn, Bartberger, Michael D, Correll, Tiffany L, Chow, David, Wong, Simon, Luo, Jian, Lin, Daniel C.-H, Medina, Julio C

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Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis von Himmelbauer, Martin K., Bajrami, Bekim, Basile, Rebecca, Capacci, Andrew, Chen, TeYu, Choi, Colin K., Gilfillan, Rab, Gonzalez-Lopez de Turiso, Felix, Gu, Chungang, Hoemberger, Marc, Johnson, Douglas S., Jones, J. Howard, Kadakia, Ekta, Kirkland, Melissa, Lin, Edward Y., Liu, Ying, Ma, Bin, Magee, Tom, Mantena, Srinivasa, Marx, Isaac E., Metrick, Claire M., Mingueneau, Michael, Murugan, Paramasivam, Muste, Cathy A., Nadella, Prasad, Nevalainen, Marta, Parker Harp, Chelsea R., Pattaropong, Vatee, Pietrasiewicz, Alicia, Prince, Robin J., Purgett, Thomas J., Santoro, Joseph C., Schulz, Jurgen, Sciabola, Simone, Tang, Hao, Vandeveer, H. George, Wang, Ti, Yousaf, Zain, Helal, Christopher J., Hopkins, Brian T.

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Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune D... von Cushing, Timothy D., Hao, Xiaolin, Shin, Youngsook, Andrews, Kristin, Brown, Matthew, Cardozo, Mario, Chen, Yi, Duquette, Jason, Fisher, Ben, Gonzalez-Lopez de Turiso, Felix, He, Xiao, Henne, Kirk R., Hu, Yi-Ling, Hungate, Randall, Johnson, Michael G., Kelly, Ron C., Lucas, Brian, McCarter, John D., McGee, Lawrence R., Medina, Julio C., San Miguel, Tisha, Mohn, Deanna, Pattaropong, Vatee, Pettus, Liping H., Reichelt, Andreas, Rzasa, Robert M., Seganish, Jennifer, Tasker, Andrew S., Wahl, Robert C., Wannberg, Sharon, Whittington, Douglas A., Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Dawei, Metz, Daniela P.

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Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist von Brown, Sean P, Dransfield, Paul J, Vimolratana, Marc, Jiao, XianYun, Zhu, Liusheng, Pattaropong, Vatee, Sun, Ying, Liu, Jinqian, Luo, Jian, Zhang, Jane, Wong, Simon, Zhuang, Run, Guo, Qi, Li, Frank, Medina, Julio C, Swaminath, Gayathri, Lin, Daniel C.-H, Houze, Jonathan B

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Cardiovascular response to small-molecule APJ activation von Ason, Brandon, Chen, Yinhong, Guo, Qi, Hoagland, Kimberly M, Chui, Ray W, Fielden, Mark, Sutherland, Weston, Chen, Rhonda, Zhang, Ying, Mihardja, Shirley, Ma, Xiaochuan, Li, Xun, Sun, Yaping, Liu, Dongming, Nguyen, Khanh, Wang, Jinghong, Li, Ning, Rajamani, Sridharan, Qu, Yusheng, Gao, BaoXi, Boden, Andrea, Chintalgattu, Vishnu, Turk, Jim R, Chan, Joyce, Hu, Liaoyuan A, Dransfield, Paul, Houze, Jonathan, Wong, Jingman, Ma, Ji, Pattaropong, Vatee, Véniant, Murielle M, Vargas, Hugo M, Swaminath, Gayathri, Khakoo, Aarif Y

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Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors von Gonzalez-Lopez de Turiso, Felix, Shin, Youngsook, Brown, Matthew, Cardozo, Mario, Chen, Yi, Fong, David, Hao, Xiaolin, He, Xiao, Henne, Kirk, Hu, Yi-Ling, Johnson, Michael G, Kohn, Todd, Lohman, Julia, McBride, Helen J, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, Miner, Kent, Mohn, Deanna, Pattaropong, Vatee, Seganish, Jennifer, Simard, Jillian L, Wannberg, Sharon, Whittington, Douglas A, Yu, Gang, Cushing, Timothy D

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Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates von Brown, Sean P., Dransfield, Paul, Vimolratana, Marc, Zhu, Liusheng, Luo, Jian, Zhang, Jane, Jiao, XianYun, Pattaropong, Vatee, Wong, Simon, Zhuang, Run, Swaminath, Gayathri, Houze, Jonathan B., Lin, Daniel C.-H.

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Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines von Ouyang, Xiaohu, Piatnitski, Evgueni L., Pattaropong, Vatee, Chen, Xiaoling, He, Hai-Ying, Kiselyov, Alexander S., Velankar, Avdhoot, Kawakami, Joel, Labelle, Marc, Smith, Leon, Lohman, Julia, Lee, Sui Ping, Malikzay, Asra, Fleming, James, Gerlak, Jason, Wang, Ying, Rosler, Robin L., Zhou, Kai, Mitelman, Stan, Camara, Margarita, Surguladze, David, Doody, Jacqueline F., Tuma, M. Carolina

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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties von Kohn, Todd J, Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E, Kraser, Christopher F, Hinklin, Ronald J, Boys, Mark L, Medina, Julio C, Houze, Jonathan, Dransfield, Paul, Coward, Peter

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Discovery and in Vivo Evaluation of ( S )- N -(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9 H -purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoim... von Cushing, Timothy D., Hao, Xiaolin, Shin, Youngsook, Andrews, Kristin, Brown, Matthew, Cardozo, Mario, Chen, Yi, Duquette, Jason, Fisher, Ben, Gonzalez-Lopez de Turiso, Felix, He, Xiao, Henne, Kirk R., Hu, Yi-Ling, Hungate, Randall, Johnson, Michael G., Kelly, Ron C., Lucas, Brian, McCarter, John D., McGee, Lawrence R., Medina, Julio C., San Miguel, Tisha, Mohn, Deanna, Pattaropong, Vatee, Pettus, Liping H., Reichelt, Andreas, Rzasa, Robert M., Seganish, Jennifer, Tasker, Andrew S., Wahl, Robert C., Wannberg, Sharon, Whittington, Douglas A., Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Dawei, Metz, Daniela P.

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Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394 von Dransfield, Paul J, Pattaropong, Vatee, Lai, Sujen, Fu, Zice, Kohn, Todd J, Du, Xiaohui, Cheng, Alan, Xiong, Yumei, Komorowski, Renee, Jin, Lixia, Conn, Marion, Tien, Eric, DeWolf, Walter E, Hinklin, Ronald J, Aicher, Thomas D, Kraser, Christopher F, Boyd, Steven A, Voegtli, Walter C, Condroski, Kevin R, Veniant-Ellison, Murielle, Medina, Julio C, Houze, Jonathan, Coward, Peter

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C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators von Du, Xiaohui, Hinklin, Ronald J, Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J, Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M, Anderson, Deborah A, Baer, Brian R, Bencsik, Josef R, Boyd, Steven A, Chicarelli, Mark Joseph, Mohr, Peter J, Wang, Bin, Condroski, Kevin R, DeWolf, Walter E, Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D, Medina, Julio C, Coward, Peter, Houze, Jonathan B

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Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy von Chekler, Eugene L. Piatnitski, Kiselyov, Alexander S, Ouyang, Xiaohu, Chen, Xiaoling, Pattaropong, Vatee, Wang, Ying, Tuma, M. Carolina, Doody, Jacqueline F

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Substituted pyrimidinones as agonists of the APJ receptor von Pattaropong, Vatee, Ramsden, Philip Dean

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Synthesis and structure–activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors von Ouyang, Xiaohu, Chen, Xiaoling, Piatnitski, Evgueni L., Kiselyov, Alexander S., He, Hai-Ying, Mao, Yunyu, Pattaropong, Vatee, Yu, Yang, Kim, Ki H., Kincaid, John, Smith, Leon, Wong, Wai C., Lee, Sui Ping, Milligan, Daniel L., Malikzay, Asra, Fleming, James, Gerlak, Jason, Deevi, Dhanvanthri, Doody, Jacqueline F., Chiang, Hui-Hsien, Patel, Sheetal N., Wang, Ying, Rolser, Robin L., Kussie, Paul, Labelle, Marc, Tuma, M. Carolina

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SUBSTITUTED PYRIMIDINONES AS AGONISTS OF THE APJ RECEPTOR von RAMSDEN, Philip Dean, PATTAROPONG, Vatee

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PYRIMIDINONES SUBSTITUÉES EN TANT QU'AGONISTES DU RÉCEPTEUR APJ von RAMSDEN, Philip Dean, PATTAROPONG, Vatee

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SUBSTITUTED PYRIMIDINONES AS AGONISTS OF THE APJ RECEPTOR von RAMSDEN, Philip Dean, PATTAROPONG, Vatee

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SUBSTITUTED PYRIMIDINONES AS AGONISTS OF THE APJ RECEPTOR von RAMSDEN, Philip Dean, PATTAROPONG, Vatee

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Facile synthesis and cleavage of imidazolidines in a novel protection strategy for the preparation of peptides containing a reduced amide bioisostere von Zhao, Jun, Pattaropong, Vatee, Jiang, Yongying, Hu, Longqin

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