GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease von Oksenberg, Donna, Dufu, Kobina, Patel, Mira P., Chuang, Chihyuan, Li, Zhe, Xu, Qing, Silva‐Garcia, Abel, Zhou, Chengjing, Hutchaleelaha, Athiwat, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Sinha, Uma, Metcalf, Brian W., Archer, David R.

Volltext

Structural basis for the coevolution of a viral RNA-protein complex von Patskovsky, Yury, Almo, Steven C, Singer, Robert H, Chao, Jeffrey A

Volltext

Crystal Structure of the Actin Binding Domain of the Cyclase-Associated Protein von Dodatko, Tetyana, Fedorov, Alexander A, Grynberg, Marcin, Patskovsky, Yury, Rozwarski, Denise A, Jaroszewski, Lukasz, Aronoff-Spencer, Eliah, Kondraskina, Elena, Irving, Tom, Godzik, Adam, Almo, Steven C

Volltext

ZBP1 recognition of beta-actin zipcode induces RNA looping von Chao, Jeffrey A, Patskovsky, Yury, Patel, Vivek, Levy, Matthew, Almo, Steven C, Singer, Robert H

Volltext

Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase von Huang, Hua, Patskovsky, Yury, Toro, Rafael, Farelli, Jeremiah D, Pandya, Chetanya, Almo, Steven C, Allen, Karen N, Dunaway-Mariano, Debra

Volltext

Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family von Odokonyero, Denis, Sakai, Ayano, Patskovsky, Yury, Malashkevich, Vladimir N., Fedorov, Alexander A., Bonanno, Jeffrey B., Fedorov, Elena V., Toro, Rafael, Agarwal, Rakhi, Wang, Chenxi, Ozerova, Nicole D. S., Yew, Wen Shan, Sauder, J. Michael, Swaminathan, Subramanyam, Burley, Stephen K., Almo, Steven C., Glasner, Margaret E.

Volltext

Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily von Lukk, Tiit, Sakai, Ayano, Kalyanaraman, Chakrapani, Brown, Shoshana D, Imker, Heidi J, Song, Ling, Fedorov, Alexander A, Fedorov, Elena V, Toro, Rafael, Hillerich, Brandan, Seidel, Ronald, Patskovsky, Yury, Vetting, Matthew W, Nair, Satish K, Babbitt, Patricia C, Almo, Steven C, Gerlt, John A, Jacobson, Matthew P

Volltext

Decoy Strategies: The Structure of TL1A:DcR3 Complex von Zhan, Chenyang, Patskovsky, Yury, Yan, Qingrong, Li, Zhenhong, Ramagopal, Udupi, Cheng, Huiyong, Brenowitz, Michael, Hui, Xiao, Nathenson, Stanley G., Almo, Steven C.

Volltext

COHbC and COHbS crystallize in the R2 quaternary state at neutral pH in the presence of PEG 4000 von Patskovska, Larysa N., Patskovsky, Yury V., Almo, Steven C., Hirsch, Rhoda Elison

Volltext

Structural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis von Daughtry, Kelly D, Huang, Hua, Malashkevich, Vladimir, Patskovsky, Yury, Liu, Weifeng, Ramagopal, Udupi, Sauder, J. Michael, Burley, Stephen K, Almo, Steven C, Dunaway-Mariano, Debra, Allen, Karen N

Volltext

Deamination of 6‑Aminodeoxyfutalosine in Menaquinone Biosynthesis by Distantly Related Enzymes von Goble, Alissa M, Toro, Rafael, Li, Xu, Ornelas, Argentina, Fan, Hao, Eswaramoorthy, Subramaniam, Patskovsky, Yury, Hillerich, Brandan, Seidel, Ron, Sali, Andrej, Shoichet, Brian K, Almo, Steven C, Swaminathan, Subramanyam, Tanner, Martin E, Raushel, Frank M

Volltext

Rat glutathione S-transferase M4-4: an isoenzyme with unique structural features including a redox-reactive cysteine-115 residue that forms mixed disulphides with glutathione von Cheng, H, Tchaikovskaya, T, Tu, Y S, Chapman, J, Qian, B, Ching, W M, Tien, M, Rowe, J D, Patskovsky, Y V, Listowsky, I, Tu, C P

Volltext

Loss of Quaternary Structure is Associated with Rapid Sequence Divergence in the OSBS Family von Odokonyero, D., Sakai, A., Patskovsky, Y., Malashkevich, V., Fedorov, A., Bonanno, J., Fedorov, E., Toro, R., Agarwal, R., et al

Volltext

The Enhanced Affinity for Thiolate Anion and Activation of Enzyme-bound Glutathione Is Governed by an Arginine Residue of Human Mu Class Glutathione S-Transferases von Patskovsky, Yury V., Patskovska, Larysa N., Listowsky, Irving

Volltext

Rationale for Reclassification of a Distinctive Subdivision of Mammalian Class Mu Glutathione S-Transferases That Are Primarily Expressed in Testis von Rowe, J D, Patskovsky, Y V, Patskovska, L N, Novikova, E, Listowsky, I

Volltext

Discovery of Function in the Enolase Superfamily: d-Mannonate and d-Gluconate Dehydratases in the d-Mannonate Dehydratase Subgroup von Wichelecki, D., Balthazor, B., Chau, A., Vetting, M., Fedorov, A., Fedorov, E., Lukk, T., Patskovsky, Y., Stead, M., et al

Volltext

Biochemical and Structural Characterization of the Human TL1A Ectodomain von Zhan, Chenyang, Yan, Qingrong, Patskovsky, Yury, Li, Zhenhong, Toro, Rafael, Meyer, Amanda, Cheng, Huiyong, Brenowitz, Michael, Nathenson, Stanley G, Almo, Steven C

Volltext

Transition State Model and Mechanism of Nucleophilic Aromatic Substitution Reactions Catalyzed by Human Glutathione S-Transferase M1a-1a von Patskovsky, Yury, Patskovska, Larysa, Almo, Steven C, Listowsky, Irving

Volltext

Functions of His107 in the Catalytic Mechanism of Human Glutathione S-Transferase hGSTM1a-1a von Patskovsky, Yury V, Patskovska, Larysa N, Listowsky, Irving

Volltext

An Asparagine-Phenylalanine Substitution Accounts for Catalytic Differences between hGSTM3-3 and Other Human Class Mu Glutathione S-Transferases von Patskovsky, Yury V, Patskovska, Larysa N, Listowsky, Irving

Volltext