Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription von Al-Mehdi, Abu-Bakr, Pastukh, Viktor M, Swiger, Brad M, Reed, Darla J, Patel, Mita R, Bardwell, Gina C, Pastukh, Viktoriya V, Alexeyev, Mikhail F, Gillespie, Mark N

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Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance von Yuzefovych, Larysa V, Pastukh, Viktor M, Ruchko, Mykhaylo V, Simmons, Jon D, Richards, William O, Rachek, Lyudmila I

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Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region von Pastukh, Viktor M., Gorodnya, Olena M., Gillespie, Mark N., Ruchko, Mykhaylo V.

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1152-P: Elucidating Protective Mechanisms of Targeting of hOGG1 to Mitochondria on the HFD-Induced Insulin Resistance in Mice Lacking OGG1 von YUZEFOVYCH, LARYSA, PASTUKH, VIKTOR M., RACHEK, LYUDMILA

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282-LB: Analysis of Cell-Free Mitochondrial DNA in Obese Patients With and Without Type 2 Diabetes after Bariatric Surgery von YUZEFOVYCH, LARYSA, PASTUKH, VIKTOR M., RICHARDS, WILLIAM, RACHEK, LYUDMILA

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Effect of Bariatric Surgery on Plasma Cell-Free Mitochondrial DNA, Insulin Sensitivity and Metabolic Changes in Obese Patients von Yuzefovych, Larysa V, Pastukh, Viktor M, Mulekar, Madhuri S, Ledbetter, Kate, Richards, William O, Rachek, Lyudmila I

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Novel attributes of cell‐free plasma mitochondrial DNA in traumatic injury von Daly, Grant T., Pastukh, Viktor M., Tan, Yong B., Francis, C. Michael, Aggen, C. Zack, Groark, S. Chris, Edwards, Carson, Mulekar, Madhuri S., Hamo, Mohammad, Simmons, Jon D., Kutcher, Matthew E., Hartsell, Emily M., Dinwiddie, Darrell L., Turpin, Zachary M., Bass, Hank W., Roberts, Justin T., Gillespie, Mark N., Langley, Raymond J.

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Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences von Pastukh, Viktor M, Zhang, Li, Ruchko, Mykhaylo V, Gorodnya, Olena, Bardwell, Gina C, Tuder, Rubin M, Gillespie, Mark N

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Mitochondria-Targeted DNA Repair Glycosylase hOGG1 Protects Against HFD-Induced Liver Oxidative Mitochondrial DNA Damage and Insulin Resistance in OGG1-Deficient Mice von Yuzefovych, Larysa V., Noh, Hye Lim, Suk, Sujin, Schuler, Anne Michele, Mulekar, Madhuri S., Pastukh, Viktor M., Kim, Jason K., Rachek, Lyudmila I.

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PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells von Lee, Ji Young, Stevens, Reece P, Pastukh, Viktoriya V, Pastukh, Viktor M, Kozhukhar, Natalya, Alexeyev, Mikhail F, Reisz, Julie A, Nerguizian, David, D'Alessandro, Angelo, Koloteva, Anna, Gwin, Meredith S, Roberts, Justin T, Borchert, Glen M, Wagener, Brant M, Pittet, Jean-François, Graham, Brian B, Stenmark, Kurt R, Stevens, Troy

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Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs von Kuck, Jamie L, Obiako, Boniface O, Gorodnya, Olena M, Pastukh, Viktor M, Kua, Justin, Simmons, Jon D, Gillespie, Mark N

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Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple tr... von Simmons, Jon D, Lee, Yann-Leei L, Pastukh, Viktor M, Capley, Gina, Muscat, Cherry A, Muscat, David C, Marshall, Michael L, Brevard, Sidney B, Gillespie, Mark N

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Mitochondrial DNA damage associated molecular patterns in ventilator-associated pneumonia: Prevention and reversal by intratracheal DNase I von Simmons, Jon D, Freno, Daniel R, Muscat, C Annie, Obiako, Boniface, Lee, Yann-Leei L, Pastukh, Viktor M, Brevard, Sidney B, Gillespie, Mark N

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Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-Tracheal Pseudomonas Aeruginosa von Lee, Yann-Leei, Obiako, Boniface, Gorodnya, Olena M, Ruchko, Mykhaylo V, Kuck, Jamie L, Pastukh, Viktor M, Wilson, Glenn L, Simmons, Jon D, Gillespie, Mark N

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Enhanced Mitochondrial DNA Repair Resuscitates Transplantable Lungs Donated After Circulatory Death von Tan, Yong B., Pastukh, Viktor M., Gorodnya, Olena M., Mulekar, Madhuri S., Simmons, Jon D., Machuca, Tiago N., Beaver, Thomas M., Wilson, Glenn L., Gillespie, Mark N.

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Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs von Chouteau, Joshua M, Obiako, Boniface, Gorodnya, Olena M, Pastukh, Viktor M, Ruchko, Mykhaylo V, Wright, Anthony J, Wilson, Glenn L, Gillespie, Mark N

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Controlled DNA “damage” and repair in hypoxic signaling von Gillespie, Mark N, Pastukh, Viktor M, Ruchko, Mykhaylo V

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Hypoxia-induced oxidative base modifications in the VEGF hypoxia-response element are associated with transcriptionally active nucleosomes von Ruchko, Mykhaylo V., Gorodnya, Olena M., Pastukh, Viktor M., Swiger, Brad M., Middleton, Natavia S., Wilson, Glenn L., Gillespie, Mark N.

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The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells von Ruchko, Mykhaylo V., Gorodnya, Olena M., Zuleta, Andres, Pastukh, Viktor M., Gillespie, Mark N.

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Mitochondrial DNA DAMPs Induce Inflammation and Insulin Resistance von YUZEFOVYCH, LARYSA, PASTUKH, VIKTOR M., RACHEK, LYUDMILA

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