Direct determination of chronic myeloid leukemia prevalence in Lombardy—Italy: Global implications von Polverelli, N., Anghilieri, M., Elena, C., Intermesoli, T., Pungolino, E., D’Adda, M., Iurlo, A., Maffioli, M., Lunghi, F., Bertolli, V., Orofino, N., Sissa, C., Fiamenghi, C., Gardellini, A., Ubezio, M., Carraro, M. C., Corradini, P., Giglio, F., Pasquini, M. C., Palazzolo, R., Calori, R., Ercolanoni, M., Gambacorti‐Passerini, C.

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SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations von Meggendorfer, M, Bacher, U, Alpermann, T, Haferlach, C, Kern, W, Gambacorti-Passerini, C, Haferlach, T, Schnittger, S

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Practical management of toxicities associated with bosutinib in patients with Philadelphia chromosome-positive chronic myeloid leukemia von Khoury, H.J., Gambacorti-Passerini, C., Brümmendorf, T.H.

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Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma von Ceccon, M, Mologni, L, Giudici, G, Piazza, R, Pirola, A, Fontana, D, Gambacorti-Passerini, C

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A Phase 2 Trial of Ponatinib in Philadelphia Chromosome–Positive Leukemias von Cortes, J.E, Kim, D.-W, Pinilla-Ibarz, J, le Coutre, P, Paquette, R, Chuah, C, Nicolini, F.E, Apperley, J.F, Khoury, H.J, Talpaz, M, DiPersio, J, DeAngelo, D.J, Abruzzese, E, Rea, D, Baccarani, M, Müller, M.C, Gambacorti-Passerini, C, Wong, S, Lustgarten, S, Rivera, V.M, Clackson, T, Turner, C.D, Haluska, F.G, Guilhot, F, Deininger, M.W, Hochhaus, A, Hughes, T, Goldman, J.M, Shah, N.P, Kantarjian, H

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Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase von Cortes, J, Kim, D-W, Raffoux, E, Martinelli, G, Ritchie, E, Roy, L, Coutre, S, Corm, S, Hamerschlak, N, Tang, J-L, Hochhaus, A, Khoury, H J, Brümmendorf, T H, Michallet, M, Rege-Cambrin, G, Gambacorti-Passerini, C, Radich, J P, Ernst, T, Zhu, C, Van Tornout, J M A, Talpaz, M

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Idiopathic erythrocytosis: a germline disease? von Elli, E. M., Mauri, M., D’Aliberti, D., Crespiatico, I., Fontana, D., Redaelli, S., Pelucchi, S., Spinelli, S., Manghisi, B., Cavalca, F., Aroldi, A., Ripamonti, A., Ferrari, S., Palamini, S., Mottadelli, F., Massimino, L., Ramazzotti, D., Cazzaniga, G., Piperno, A., Gambacorti-Passerini, C., Piazza, R.

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P719: EFFICACY AND SAFETY OF BOSUTINIB IN LATER‐LINE PATIENTS WITH CHRONIC MYELOID LEUKEMIA: A SUB‐ANALYSIS FROM THE PHASE 4 BYOND TRIAL von Gambacorti‐Passerini, C., Brümmendorf, T. H., Ernst, T., Leip, E., Purcell, S., Viqueira, A., Giles, F. J., Rosti, G., Hochhaus, A.

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P717: BOSUTINIB IN NEWLY DIAGNOSED CHRONIC MYELOID LEUKEMIA: GASTROINTESTINAL, LIVER, EFFUSION AND RENAL SAFETY CHARACTERIZATION IN THE BFORE TRIAL von Cortes, J. E., Milojkovic, D., Gambacorti‐Passerini, C., García‐Gutiérrez, V., Mauro, M. J., Leip, E., Purcell, S., Viqueira, A., Brümmendorf, T. H.

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Management and outcome of 11 pregnancies in women with polycythemia vera von Elli, E.M., Diral, E., Gambacorti-Passerini, C., Calori, R., Carmosino, I., Breccia, M., Latagliata, R., Di Veroli, A.

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S157: BCR::ABL1 DIGITAL PCR IDENTIFIES CHRONIC PHASE CML PATIENTS SUITABLE FOR AN EARLY TKI DISCONTINUATION ATTEMPT: A PATIENT‐LEVEL META‐ANALYSIS von Kockerols, C., Dulucq, S., Bernardi, S., Farina, M., Civettini, I., Colafigli, G., Mori, S., Valk, P., Mahon, F.‐X., Gambacorti‐Passerini, C., Nicolini, F.‐E., Breccia, M., Russo, D., Westerweel, P. E.

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Are Chronic Myeloid Leukemia Patients More at Risk for Second Malignancies? A Population-based Study von Rebora, Paola, Czene, Kamila, Antolini, Laura, Passerini, Carlo Gambacorti, Reilly, Marie, Valsecchi, Maria Grazia

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Efficacy and safety of bosutinib vs imatinib in Indian and non-Indian patients with newly diagnosed chronic phase chronic myeloid leukemia: Subgroup analysis from the BELA trial von Malhotra, H., Maru, A., Khattry, N., Ramanan, M.V., Leip, E., Crescenzo, R.J., Gambacorti-Passerini, C., Cortes, J.E.

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Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency von Ceccon, M, Merlo, M E Boggio, Mologni, L, Poggio, T, Varesio, L M, Menotti, M, Bombelli, S, Rigolio, R, Manazza, A D, Di Giacomo, F, Ambrogio, C, Giudici, G, Casati, C, Mastini, C, Compagno, M, Turner, S D, Gambacorti-Passerini, C, Chiarle, R, Voena, C

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P520: PHASE 1/2 STUDY OF SEL24/MEN1703, A FIRST‐IN‐CLASS DUAL PIM/FLT3 KINASE INHIBITOR, IN PATIENTS WITH IDH1/2‐MUTATED ACUTE MYELOID LEUKEMIA: THE DIAMOND‐01 TRIAL von Martinelli, G., Santoro, A., Gambacorti‐Passerini, C., Vives Polo, S., Solomon, S. R., Mukherjee, S., Lech‐Maranda, E., Yair Levy, M., Wierzbowska, A., Calbacho‐Robles, M., Marconi, G., Benedetta Giannini, M., Cano, I., Torres Miñana, L., Acuña‐Cruz, E., Angelosanto, N., Galleu, A., Baldini, S., Blotta, S., Ravandi, F., Montesinos, P.

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Cancer procoagulant and tissue factor are differently modulated by all-trans-retinoic acid in acute promyelocytic leukemia cells von FALANGA, A, CONSONNI, R, MARCHETTI, M, LOCATELLI, G, GARATTINI, E, GAMBACORTI PASSERINI, C, GORDON, S. G, BARBUI, T

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BCR and BCR-ABL regulation during myeloid differentiation in healthy donors and in chronic phase blast crisis CML patients von Marega, M, Piazza, R G, Pirola, A, Redaelli, S, Mogavero, A, Iacobucci, I, Meneghetti, I, Parma, M, Pogliani, E M, Gambacorti-Passerini, C

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Roots of clinical resistance to STI-571 cancer therapy von Barthe, C, Cony-Makhoul, P, Melo, J V, Mahon, J R

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Synergistic activity of the Src Abl inhibitor bosutinib in combination with imatinib von Redaelli, S, Boschelli, F, Perini, P, Pirola, A, Viltadi, M, Gambacorti-Passerini, C

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Chronic myeloid leukemia: reminiscences and dreams von Mughal, Tariq I, Radich, Jerald P, Deininger, Michael W, Apperley, Jane F, Hughes, Timothy P, Harrison, Christine J, Gambacorti-Passerini, Carlo, Saglio, Giuseppe, Cortes, Jorge, Daley, George Q

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