Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study von Leonard, Maureen M., Valitutti, Francesco, Karathia, Hiren, Pujolassos, Meritxell, Kenyon, Victoria, Fanelli, Brian, Troisi, Jacopo, Subramanian, Poorani, Camhi, Stephanie, Colucci, Angelo, Serena, Gloria, Cucchiara, Salvatore, Trovato, Chiara Maria, Malamisura, Basilio, Francavilla, Ruggiero, Elli, Luca, Hasan, Nur A., Zomorrodi, Ali R., Colwell, Rita, Fasano, Alessio

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Cohort profile: Celiac disease genomic, environmental, microbiome and metabolome study; a prospective longitudinal birth cohort study of children at-risk for celiac disease von Leonard, Maureen M, Kenyon, Victoria, Valitutti, Francesco, Pennacchio-Harrington, Rita, Piemontese, Pasqua, Francavilla, Ruggiero, Norsa, Lorenzo, Passaro, Tiziana, Crocco, Marco, Baldassarre, Mariella, Trovato, Chiara Maria, Fasano, Alessio

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Prevalence of delivery mode in an Italian nationwide cohort with celiac disease: a SIGENP multicenter retrospective study (the CD-deliver-IT) von Iorfida, Donatella, Valitutti, Francesco, Vestri, Annarita, D'Adamo, Grazia, Passaro, Tiziana, Crocco, Marco, Malerba, Federica, Monzani, Alice, Rabbone, Ivana, Pensabene, Licia, Giancotti, Laura, Graziano, Francesco, Citrano, Michele, Ferretti, Francesca, Trovato, Chiara Maria, Pacenza, Caterina, Iasevoli, Mario, Banzato, Claudia, Lubrano, Riccardo, Montuori, Monica

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Prevalence and detection rate of celiac disease in Italy: Results of a SIGENP multicenter screening in school-age children von Lionetti, Elena, Pjetraj, Dorina, Gatti, Simona, Catassi, Giulia, Bellantoni, Antonella, Boffardi, Massimo, Cananzi, Mara, Cinquetti, Mauro, Francavilla, Ruggiero, Malamisura, Basilio, Montuori, Monica, Zuccotti, Gianvincenzo, Cristofori, Fernanda, Gaio, Paola, Passaro, Tiziana, Penagini, Francesca, Testa, Alessandra, Trovato, Chiara Maria, Catassi, Carlo

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Zonulin as a Biomarker for the Development of Celiac Disease von DaFonte, Tracey M, Valitutti, Francesco, Kenyon, Victoria, Locascio, Joseph J, Montuori, Monica, Francavilla, Ruggiero, Passaro, Tiziana, Crocco, Marco, Norsa, Lorenzo, Piemontese, Pasqua, Baldassarre, Mariella, Fasano, Alessio, Leonard, Maureen M

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Multi-omics analysis reveals the influence of genetic and environmental risk factors on developing gut microbiota in infants at risk of celiac disease von Leonard, Maureen M., Karathia, Hiren, Pujolassos, Meritxell, Troisi, Jacopo, Valitutti, Francesco, Subramanian, Poorani, Camhi, Stephanie, Kenyon, Victoria, Colucci, Angelo, Serena, Gloria, Cucchiara, Salvatore, Montuori, Monica, Malamisura, Basilio, Francavilla, Ruggiero, Elli, Luca, Fanelli, Brian, Colwell, Rita, Hasan, Nur, Zomorrodi, Ali R., Fasano, Alessio

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Novel Bacteroides Vulgatus strain protects against gluten-induced break of human celiac gut epithelial homeostasis: a pre-clinical proof-of-concept study von Tran, Tina, Senger, Stefania, Baldassarre, Mariella, Brosnan, Rachel A., Cristofori, Fernanda, Crocco, Marco, De Santis, Stefania, Elli, Luca, Faherty, Christina S., Francavilla, Ruggero, Goodchild-Michelman, Isabella, Kenyon, Victoria A., Leonard, Maureen M., Lima, Rosiane S., Malerba, Federica, Montuori, Monica, Morelli, Annalisa, Norsa, Lorenzo, Passaro, Tiziana, Piemontese, Pasqua, Reed, James C., Sansotta, Naire, Valitutti, Francesco, Zomorrodi, Ali R., Fasano, Alessio

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820 – Prospective Longitudinal Gut Metagenomic Analysis Suggests Altered Microbiome Composition and Function in Infants Prior to Celiac Disease Onset von Leonard, Maureen M., Subramanian, Poorani, Valitutti, Francesco, Serena, Gloria, Kenyon, Victoria, Camhi, Stephanie, Piemontese, Pasquina, Trovato, Chiara Maria, Raguseo, Celeste Lidia, Passaro, Tiziana, Montuori, Monica, Malamisura, Basilio, Francavilla, Ruggero, Elli, Luca, Cucchiara, Salvatore, Karathia, Hiren, Colwell, Rita, Hasan, Nur A., Fasano, Alessio

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Are we ready to change our diagnostic habits in coeliac disease? von Malamisura, Monica, Coccorullo, Paola, D’Adamo, Grazia, Passaro, Tiziana, D’Angelo, Elisa, Salvati, Virginia Michela, Malamisura, Basilio

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Current ESPGHAN guidelines for celiac disease in pediatric age, tertiary care center experience: a proposal for further simplification von Malamisura, Monica, Colantuono, Rossella, Salvati, Virginia M, Croce, Roberta, D’Adamo, Grazia, Passaro, Tiziana, D’Angelo, Emanuela, Boffardi, Massimo, Garzi, Alfredo, Malamisura, Basilio

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Serum paraoxonase and arylesterase activities of paraoxonase‐1 (PON‐1), mild cognitive impairment, and 2‐year conversion to dementia: A pilot study von Cervellati, Carlo, Trentini, Alessandro, Romani, Arianna, Bellini, Tiziana, Bosi, Cristina, Ortolani, Beatrice, Zurlo, Amedeo, Passaro, Angelina, Seripa, Davide, Zuliani, Giovanni

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Sex difference: an important issue to consider in epidemiological and clinical studies dealing with serum paraoxonase-1 von Trentini, Alessandro, Bellini, Tiziana, Bonaccorsi, Gloria, Cavicchio, Carlotta, Hanau, Stefania, Passaro, Angelina, Cervellati, Carlo

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Predicting acute kidney injury with an artificial intelligence-driven model in a pediatric cardiac intensive care unit von Fragasso, Tiziana, Raggi, Valeria, Passaro, Davide, Tardella, Luca, Lasinio, Giovanna Jona, Ricci, Zaccaria

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Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases von Castellazzi, Massimiliano, Trentini, Alessandro, Romani, Arianna, Valacchi, Giuseppe, Bellini, Tiziana, Bonaccorsi, Gloria, Fainardi, Enrico, Cavicchio, Carlotta, Passaro, Angelina, Zuliani, Giovanni, Cervellati, Carlo

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Sex Difference Impacts on the Relationship between Paraoxonase-1 (PON1) and Type 2 Diabetes von Rosta, Valentina, Trentini, Alessandro, Passaro, Angelina, Zuliani, Giovanni, Sanz, Juana Maria, Bosi, Cristina, Bonaccorsi, Gloria, Bellini, Tiziana, Cervellati, Carlo

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De Novo Large Deletions in the PHEX Gene Caused X-Linked Hypophosphataemic Rickets in Two Italian Female Infants Successfully Treated with Burosumab von Pecoraro, Carmine, Fioretti, Tiziana, Perruno, Assunta, Klain, Antonella, Cioffi, Daniela, Ambrosio, Adelaide, Passaro, Diego, Annicchiarico Petruzzelli, Luigi, Di Domenico, Carmela, de Girolamo, Domenico, Vallone, Sabrina, Cattaneo, Fabio, Ammendola, Rosario, Esposito, Gabriella

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Development, optimization and validation of an absolute specific assay for active myeloperoxidase (MPO) and its application in a clinical context: role of MPO specific activity in... von Trentini, Alessandro, Rosta, Valentina, Spadaro, Savino, Bellini, Tiziana, Rizzo, Paola, Vieceli Dalla Sega, Francesco, Passaro, Angelina, Zuliani, Giovanni, Gentili, Valentina, Campo, Gianluca, Cervellati, Carlo

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Comprehensive Molecular Analysis of Disease-Related Genes as First-Tier Test for Early Diagnosis, Classification, and Management of Patients Affected by Nonsyndromic Ichthyosis von Fioretti, Tiziana, Martora, Fabrizio, De Maggio, Ilaria, Ambrosio, Adelaide, Piscopo, Carmelo, Vallone, Sabrina, Amato, Felice, Passaro, Diego, Acquaviva, Fabio, Gaudiello, Francesca, Di Girolamo, Daniela, Maiolo, Valeria, Zarrilli, Federica, Esposito, Speranza, Vitiello, Giuseppina, Auricchio, Luigi, Sammarco, Elena, Brasi, Daniele De, Petillo, Roberta, Gambale, Antonella, Cattaneo, Fabio, Ammendola, Rosario, Nappa, Paola, Esposito, Gabriella

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Lipoprotein(a) and family history for cardiovascular disease in paediatric patients: A new frontier in cardiovascular risk stratification. Data from the LIPIGEN paediatric group von Pederiva, Cristina, Capra, Maria Elena, Biasucci, Giacomo, Banderali, Giuseppe, Fabrizi, Enrico, Gazzotti, Marta, Casula, Manuela, Catapano, Alberico L., Arca, Marcello, Averna, Maurizio, Bertolini, Stefano, Calandra, Sebastiano, Catapano, Alberico Luigi, Tarugi, Patrizia, Pellegatta, Fabio, Arca, Marcello, Averna, Maurizio, Bartuli, Andrea, Biasucci, Giacomo, Borghi, Claudio, Calabrò, Paolo, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Del Ben, Maria, Fortunato, Giuliana, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iannuzzo, Gabriella, Iughetti, Lorenzo, Mandraffino, Giuseppe, Maroni, Lorenzo, Mombelli, Giuliana, Muntoni, Sandro, Parati, Gianfranco, Passaro, Angelina, Pederiva, Cristina, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Roscini, Anna Rita, Sarzani, Riccardo, Suppressa, Patrizia, Werba, Josè Pablo, Zambon, Sabina, Zenti, Maria Grazia, Allevi, Massimiliano, Auricchio, Renata, Baldera, Davide, Banderali, Giuseppe, Bruzzi, Patrizia, Bucci, Marco, Buonuomo, Paola Sabrina, Capra, Maria Elena, Cefalù, Angelo Baldassarre, Covetti, Giuseppe, D'Addato, Sergio, Di Taranto, Maria Donata, Franceschi, Roberto, Fimiani, Fabio, Genovesi, Simonetta, Grigore, Liliana, Lupattelli, Graziana, Madaghiele, Sara, Massini, Giulia, Minicocci, Ilenia, Montalcini, Tiziana, Nascimbeni, Fabio, Pavanello, Chiara, Perla, Francesco Massimo, Peroni, Gaia, Sani, Elena, Scicali, Roberto, Toscano, Arianna, Vigna, Giovanni Battista, Zambon, Alberto, Catapano, Alberico Luigi, Casula, Manuela, Galimberti, Federica, Gazzotti, Marta, Olmastroni, Elena, Zampoleri, Veronica

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395 - Decrease Paraoxonase-1 (PON-1) Activities in Neurodegenerative Diseases von Romani, Arianna, Trentini, Alessandro, Castellazzi, Massimiliano, Valacchi, Giuseppe, Bellini, Tiziana, Passaro, Angelina, Fainardi, Enrico, Zuliani, Giovanni, Cervellati, Carlo

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