Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014 von Pike, Kurt G., Malagu, Karine, Hummersone, Marc G., Menear, Keith A., Duggan, Heather M.E., Gomez, Sylvie, Martin, Niall M.B., Ruston, Linette, Pass, Sarah L., Pass, Martin

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Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2 von Pike, Kurt G, Morris, Jeff, Ruston, Linette, Pass, Sarah L, Greenwood, Ryan, Williams, Emma J, Demeritt, Julie, Culshaw, Janet D, Gill, Kristy, Pass, Martin, Finlay, M. Raymond V, Good, Catherine J, Roberts, Craig A, Currie, Gordon S, Blades, Kevin, Eden, Jonathan M, Pearson, Stuart E

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Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer von Guichard, Sylvie M., Howard, Zoe, Heathcote, Dan, Roth, Mark, Hughes, Gareth, Curwen, Jon, Yates, James, Logie, Armelle, Holt, Sarah, Chresta, Christine M., Davies, Barry R., Malagu, Karine, Hummersone, Marc, Pass, Sarah L., Green, Stephen, Pass, Martin

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Changes in Medical Errors after Implementation of a Handoff Program von Starmer, Amy J, Spector, Nancy D, Srivastava, Rajendu, West, Daniel C, Rosenbluth, Glenn, Allen, April D, Noble, Elizabeth L, Tse, Lisa L, Dalal, Anuj K, Keohane, Carol A, Lipsitz, Stuart R, Rothschild, Jeffrey M, Wien, Matthew F, Yoon, Catherine S, Zigmont, Katherine R, Wilson, Karen M, O’Toole, Jennifer K, Solan, Lauren G, Aylor, Megan, Bismilla, Zia, Coffey, Maitreya, Mahant, Sanjay, Blankenburg, Rebecca L, Destino, Lauren A, Everhart, Jennifer L, Patel, Shilpa J, Bale, James F, Spackman, Jaime B, Stevenson, Adam T, Calaman, Sharon, Cole, F. Sessions, Balmer, Dorene F, Hepps, Jennifer H, Lopreiato, Joseph O, Yu, Clifton E, Sectish, Theodore C, Landrigan, Christopher P

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The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial von Westendorp, Willeke F, MD, Vermeij, Jan-Dirk, MD, Zock, Elles, MSc, Hooijenga, Imke J, MA, Kruyt, Nyika D, MD, Bosboom, Hans J L W, MD, Kwa, Vincent I H, MD, Weisfelt, Martijn, MD, Remmers, Michel J M, MD, ten Houten, Robert, MD, Schreuder, A H C M (Tobien), MD, Vermeer, Sarah E, MD, van Dijk, Ewout J, MD, Dippel, Diederik W J, Prof, Dijkgraaf, Marcel G W, PhD, Spanjaard, Lodewijk, MD, Vermeulen, Marinus, Prof, van der Poll, Tom, Prof, Prins, Jan M, Prof, Vermeij, Frederique H, MD, Roos, Yvo B W E M, Prof, Kleyweg, Ruud P, MD, Kerkhoff, Henk, MD, Brouwer, Matthijs C, MD, Zwinderman, Aeilko H, Prof, van de Beek, Diederik, Prof, Nederkoorn, Paul J, MD

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Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis von Romero, Rodrigo, Sayin, Volkan I, Davidson, Shawn M, Bauer, Matthew R, Singh, Simranjit X, LeBoeuf, Sarah E, Karakousi, Triantafyllia R, Ellis, Donald C, Bhutkar, Arjun, Sánchez-Rivera, Francisco J, Subbaraj, Lakshmipriya, Martinez, Britney, Bronson, Roderick T, Prigge, Justin R, Schmidt, Edward E, Thomas, Craig J, Goparaju, Chandra, Davies, Angela, Dolgalev, Igor, Heguy, Adriana, Allaj, Viola, Poirier, John T, Moreira, Andre L, Rudin, Charles M, Pass, Harvey I, Vander Heiden, Matthew G, Jacks, Tyler, Papagiannakopoulos, Thales

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Tumour predisposition and cancer syndromes as models to study gene–environment interactions von Carbone, Michele, Arron, Sarah T., Beutler, Bruce, Bononi, Angela, Cavenee, Webster, Cleaver, James E., Croce, Carlo M., D’Andrea, Alan, Foulkes, William D., Gaudino, Giovanni, Groden, Joanna L., Henske, Elizabeth P., Hickson, Ian D., Hwang, Paul M., Kolodner, Richard D., Mak, Tak W., Malkin, David, Monnat, Raymond J., Novelli, Flavia, Pass, Harvey I., Petrini, John H., Schmidt, Laura S., Yang, Haining

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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci von Berndt, Sonja I., Dadaev, Tokhir, Leongamornlert, Daniel, Anokian, Ezequiel, Cieza-Borrella, Clara, Goh, Chee, Brook, Mark N., Sheng, Xin, Dennis, Joe, Tyrer, Jonathan, Gapstur, Susan M., Tangen, Catherine M., Goodman, Phyllis J., Chambers, Suzanne, Moya, Leire, Tilley, Wayne, Risbridger, Gail P., Aly, Markus, Pharoah, Paul, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, West, Catharine M. L., Mucci, Lorelei A., Giovannucci, Edward, Andriole, Gerald L., Cancel-Tassin, Géraldine, Koutros, Stella, Beane Freeman, Laura E., Sorensen, Karina Dalsgaard, Maehle, Lovise, Grindedal, Eli Marie, Neal, David E., Travis, Ruth C., Fleshner, Neil E., Stern, Mariana C., Rosenstein, Barry S., Lu, Yong-Jie, Feng, Ninghan, Mao, Xueying, Guo, Xin, Wang, Guomin, Giles, Graham G., MacInnis, Robert J., Vega, Ana, Szulkin, Robert, Eklund, Martin, Llorca, Javier, Castaño-Vinyals, Gemma, Penney, Kathryn L., Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Cybulski, Cezary, Lubinski, Jan, Ostrander, Elaine A., Nordestgaard, Børge G., Nielsen, Sune F., Weischer, Maren, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Maier, Christiane, Luedeke, Manuel, Kim, Jeri, John, Esther M., Cardoso, Marta, Steele, Linda, Ding, Yuan Chun, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Gamulin, Marija, Kaneva, Radka, Usmani, Nawaid, Slavov, Chavdar, Claessens, Frank, Joniau, Steven, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Castelao, Jose Esteban, Martinez, Maria Elena, Roobol, Monique J., Jenster, Guido, Cannon-Albright, Lisa, Michael, Agnieszka, Thibodeau, Stephen N., McDonnell, Shannon K., Lindstrom, Sara, Ma, Jing, Kolonel, Laurence N., Le Marchand, Loic, Hoover, Robert N., Wiklund, Fredrik, Henderson, Brian E., Kote-Jarai, Zsofia

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Activated Factor 7 Versus 4-Factor Prothrombin Complex Concentrate for Critical Bleeding Post–Cardiac Surgery von Mehringer, Sarah L., Klick, Zachary, Bain, Jonathan, McNeely, Elizabeth B., Subramanian, Sreekumar, Pass, Lawrence J., Drinkwater, Davis, Reddy, V. Seenu

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Correction to: 1-13C-propionate breath testing as a surrogate endpoint to assess efficacy of liver-directed therapies in methylmalonic acidemia (MMA) von Manoli, Irini, Pass, Alexandra R., Harrington, Elizabeth A., Sloan, Jennifer L., Gagné, Jack, McCoy, Samantha, Bell, Sarah L., Hattenbach, Jacob D., Leitner, Brooks P., Duckworth, Courtney J., Fletcher, Laura A., Cassimatis, Thomas M., Galarreta, Carolina I., Thurm, Audrey, Snow, Joseph, Van Ryzin, Carol, Ferry, Susan, Mew, Nicholas Ah, Shchelochkov, Oleg A., Chen, Kong Y., Venditti, Charles P.

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1-13C-propionate breath testing as a surrogate endpoint to assess efficacy of liver-directed therapies in methylmalonic acidemia (MMA) von Manoli, Irini, Pass, Alexandra R., Harrington, Elizabeth A., Sloan, Jennifer L., Gagné, Jack, McCoy, Samantha, Bell, Sarah L., Hattenbach, Jacob D., Leitner, Brooks P., Duckworth, Courtney J., Fletcher, Laura A., Cassimatis, Thomas M., Galarreta, Carolina I., Thurm, Audrey, Snow, Joseph, Van Ryzin, Carol, Ferry, Susan, Mew, Nicholas Ah, Shchelochkov, Oleg A., Chen, Kong Y., Venditti, Charles P.

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Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2‑(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor‑1 Receptor (IGF-1R) von Degorce, Sébastien L, Boyd, Scott, Curwen, Jon O, Ducray, Richard, Halsall, Christopher T, Jones, Clifford D, Lach, Franck, Lenz, Eva M, Pass, Martin, Pass, Sarah, Trigwell, Catherine

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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci (vol 50, pg 928, 2018) von Schumacher, FR, Al, Olama AA, Berndt, SI, Benlloch, S, Ahmed, M, Saunders, EJ, Dadaev, T, Leongamornlert, D, Anokian, E, Cieza-Borrella, C

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1-C-13-propionate breath testing as a surrogate endpoint to assess efficacy of liver-directed therapies in methylmalonic acidemia (MMA) von Manoli, Irini, Pass, Alexandra R., Harrington, Elizabeth A., Sloan, Jennifer L., Gagne, Jack, McCoy, Samantha, Bell, Sarah L., Hattenbach, Jacob D., Leitner, Brooks P., Duckworth, Courtney J., Fletcher, Laura A., Cassimatis, Thomas M., Galarreta, Carolina I., Thurm, Audrey, Snow, Joseph, Van Ryzin, Carol, Ferry, Susan, Mew, Nicholas Ah, Shchelochkov, Oleg A., Chen, Kong Y., Venditti, Charles P.

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ACR Appropriateness Criteria® Imaging of Deep Inferior Epigastric Arteries for Surgical Planning (Breast Reconstruction Surgery): 2022 Update von Singh, Nimarta, Aghayev, Ayaz, Ahmad, Sarah, Azene, Ezana M., Ferencik, Maros, Hedgire, Sandeep S., Kirsch, David S., Lee, Yoo Jin, Nagpal, Prashant, Pass, Helen A., Pillai, Anil K., Ripley, Beth, Tannenbaum, Andrew, Thomas, Richard, Steigner, Michael L.

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Search for Narrow Trijet Resonances in Proton-Proton Collisions at sqrt[s]=13  TeV von Hayrapetyan, A, Tumasyan, A, Adam, W, Andrejkovic, J W, Bergauer, T, Chatterjee, S, Damanakis, K, Dragicevic, M, Escalante Del Valle, A, Hussain, P S, Jeitler, M, Krammer, N, Liko, D, Mikulec, I, Schieck, J, Schöfbeck, R, Schwarz, D, Sonawane, M, Templ, S, Waltenberger, W, Wulz, C-E, Darwish, M R, Janssen, T, Van Mechelen, P, Bols, E S, D'Hondt, J, Dansana, S, De Moor, A, Delcourt, M, El Faham, H, Lowette, S, Makarenko, I, Müller, D, Sahasransu, A R, Tavernier, S, Tytgat, M, Van Putte, S, Vannerom, D, Clerbaux, B, De Lentdecker, G, Favart, L, Hohov, D, Jaramillo, J, Khalilzadeh, A, Lee, K, Mahdavikhorrami, M, Malara, A, Paredes, S, Pétré, L, Postiau, N, Thomas, L, Vanden Bemden, M, Vander Velde, C, Vanlaer, P, De Coen, M, Dobur, D, Hong, Y, Knolle, J, Lambrecht, L, Mestdach, G, Rendón, C, Samalan, A, Skovpen, K, Van Den Bossche, N, Wezenbeek, L, Benecke, A, Bruno, G, Caputo, C, Delaere, C, Donertas, I S, Giammanco, A, Jaffel, K, Jain, Sa, Lemaitre, V, Lidrych, J, Mastrapasqua, P, Mondal, K, Tran, T T, Wertz, S, Alves, G A, Coelho, E, Hensel, C, Menezes De Oliveira, T, Moraes, A, Rebello Teles, P, Soeiro, M, Aldá Júnior, W L, Alves Gallo Pereira, M, Barroso Ferreira Filho, M, Brandao Malbouisson, H, Carvalho, W, Chinellato, J, Da Costa, E M, Da Silveira, G G, De Jesus Damiao, D, Fonseca De Souza, S, Martins, J, Mora Herrera, C, Mota Amarilo, K, Mundim, L

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Search for Higgs boson pair production with one associated vector boson in proton-proton collisions at $$ \sqrt{s} $$ = 13 TeV von Hayrapetyan, A., Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Escalante Del Valle, A., Hussain, P. S., Jeitler, M., Krammer, N., Liko, D., Mikulec, I., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M., Templ, S., Waltenberger, W., Wulz, C.-E., Darwish, M. R., Janssen, T., Van Mechelen, P., Bols, E. S., D’Hondt, J., Dansana, S., De Moor, A., Delcourt, M., El Faham, H., Lowette, S., Makarenko, I., Müller, D., Sahasransu, A. R., Tavernier, S., Tytgat, M., Van Putte, S., Vannerom, D., Clerbaux, B., De Lentdecker, G., Favart, L., Hohov, D., Jaramillo, J., Khalilzadeh, A., Lee, K., Mahdavikhorrami, M., Malara, A., Paredes, S., Pétré, L., Postiau, N., Thomas, L., Vanden Bemden, M., Vander Velde, C., Vanlaer, P., De Coen, M., Dobur, D., Hong, Y., Knolle, J., Lambrecht, L., Mestdach, G., Rendón, C., Samalan, A., Skovpen, K., Van Den Bossche, N., Wezenbeek, L., Benecke, A., Bruno, G., Caputo, C., Delaere, C., Donertas, I. S., Giammanco, A., Jaffel, K., Jain, Sa, Lemaitre, V., Lidrych, J., Mastrapasqua, P., Mondal, K., Tran, T. T., Wertz, S., Alves, G. A., Coelho, E., Hensel, C., Menezes De Oliveira, T., Moraes, A., Rebello Teles, P., Soeiro, M., Aldá Júnior, W. L., Alves Gallo Pereira, M., Barroso Ferreira Filho, M., Brandao Malbouisson, H., Carvalho, W., Chinellato, J., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., Fonseca De Souza, S., Martins, J., Mora Herrera, C., Mota Amarilo, K., Mundim, L.

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1-13C-propionate breath testing as a surrogate endpoint to assess efficacy of liver-directed therapies in methylmalonic acidemia (MMA) (Apr, 10.1038/s41436-021-01143-8, 2021) von Manoli, Irini, Pass, Alexandra R., Harrington, Elizabeth A., Sloan, Jennifer L., Gagne, Jack, McCoy, Samantha, Bell, Sarah L., Hattenbach, Jacob D., Leitner, Brooks P., Duckworth, Courtney J., Fletcher, Laura A., Cassimatis, Thomas M., Galarreta, Carolina I., Thurm, Audrey, Snow, Joseph, Van Ryzin, Carol, Ferry, Susan, Mew, Nicholas Ah, Shchelochkov, Oleg A., Chen, Kong Y., Venditti, Charles P.

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Search for W′ bosons decaying to a top and a bottom quark in leptonic final states in proton-proton collisions at $$ \sqrt{s} $$ = 13 TeV von Hayrapetyan, A., Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Escalante Del Valle, A., Hussain, P. S., Jeitler, M., Krammer, N., Liko, D., Mikulec, I., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M., Templ, S., Waltenberger, W., Wulz, C.-E., Darwish, M. R., Janssen, T., Van Mechelen, P., Bols, E. S., D’Hondt, J., Dansana, S., De Moor, A., Delcourt, M., El Faham, H., Lowette, S., Makarenko, I., Müller, D., Sahasransu, A. R., Tavernier, S., Tytgat, M., Van Putte, S., Vannerom, D., Clerbaux, B., De Lentdecker, G., Favart, L., Hohov, D., Jaramillo, J., Khalilzadeh, A., Lee, K., Mahdavikhorrami, M., Malara, A., Paredes, S., Pétré, L., Postiau, N., Thomas, L., Vanden Bemden, M., Vander Velde, C., Vanlaer, P., De Coen, M., Dobur, D., Hong, Y., Knolle, J., Lambrecht, L., Mestdach, G., Rendón, C., Samalan, A., Skovpen, K., Van Den Bossche, N., Wezenbeek, L., Benecke, A., Bruno, G., Caputo, C., Delaere, C., Donertas, I. S., Giammanco, A., Jaffel, K., Jain, Sa, Lemaitre, V., Lidrych, J., Mastrapasqua, P., Mondal, K., Tran, T. T., Wertz, S., Alves, G. A., Coelho, E., Hensel, C., Menezes De Oliveira, T., Moraes, A., Rebello Teles, P., Soeiro, M., Aldá Júnior, W. L., Alves Gallo Pereira, M., Barroso Ferreira Filho, M., Brandao Malbouisson, H., Carvalho, W., Chinellato, J., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., Fonseca De Souza, S., Martins, J., Mora Herrera, C., Mota Amarilo, K., Mundim, L.

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Observation of new structure in the J/$\psi$J/$\psi$ mass spectrum in proton-proton collisions at $\sqrt{s}$ = 13 TeV von Hayrapetyan, Aram, Tumasyan, Armen, Adam, Wolfgang, Andrejkovic, Janik Walter, Bergauer, Thomas, Chatterjee, Suman, Damanakis, Konstantinos, Dragicevic, Marko, Escalante del Valle, Alberto, Hussain, Priya Sajid, Jeitler, Manfred, Krammer, Natascha, Liko, Dietrich, Mikulec, Ivan, Schieck, Jochen, Schöfbeck, Robert, Schwarz, Dennis, Sonawane, Mangesh, Templ, Sebastian, Waltenberger, Wolfgang, Wulz, Claudia-Elisabeth, Darwish, Mohamed Rashad, Janssen, Tahys, van Mechelen, Pierre, Bols, Emil Sørensen, d'Hondt, Jorgen, Dansana, Soumya, de Moor, Alexandre, Delcourt, Martin, El Faham, Hesham, Lowette, Steven, Makarenko, Inna, Müller, Denise, Sahasransu, Abanti Ranadhir, Tavernier, Stefaan, Tytgat, Michael, van Putte, Senne, Vannerom, David, Clerbaux, Barbara, de Lentdecker, Gilles, Favart, Laurent, Hohov, Dmytro, Jaramillo, Johny, Khalilzadeh, Ali, Lee, Kyeongpil, Mahdavikhorrami, Mostafa, Malara, Andrea, Paredes, Santiago, Pétré, Laurent, Postiau, Nicolas, Thomas, Laurent, Vanden Bemden, Max, Vander Velde, Catherine, Vanlaer, Pascal, de Coen, Maarten, Dobur, Didar, Hong, Yanwen, Knolle, Joscha, Lambrecht, Luka, Mestdach, Gianny, Rendón, César, Samalan, Amrutha, Skovpen, Kirill, van den Bossche, Niels, Wezenbeek, Liam, Benecke, Anna, Bruno, Giacomo, Caputo, Claudio, Delaere, Christophe, Donertas, Izzeddin Suat, Giammanco, Andrea, Jaffel, Khawla, Jain, Sandhya, Lemaitre, Vincent, Lidrych, Jindrich, Mastrapasqua, Paola, Mondal, Kuntal, Tran, Tu Thong, Wertz, Sébastien, Alves, Gilvan, Coelho, Eduardo, Hensel, Carsten, Menezes de Oliveira, Thales, Moraes, Arthur, Rebello Teles, Patricia, Soeiro, Mariana, Aldá Júnior, Walter Luiz, Alves Gallo Pereira, Miguel, Barroso Ferreira Filho, Mapse, Brandao Malbouisson, Helena, Carvalho, Wagner, Chinellato, Jose, da Costa, Eliza Melo, da Silveira, Gustavo Gil, de Jesus Damiao, Dilson, Fonseca de Souza, Sandro, Martins, Jordan, Mora Herrera, Clemencia, Mota Amarilo, Kevin, Mundim, Luiz

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